{"id":"https://openalex.org/W2597190293","doi":null,"title":"Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid","display_name":"Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid","publication_year":2013,"publication_date":"2013-12-17","ids":{"openalex":"https://openalex.org/W2597190293","mag":"2597190293"},"language":"en","primary_location":{"id":"mag:2597190293","doi":null,"is_oa":false,"landing_page_url":"http://smallbluemarble.org.uk/wp-content/uploads/2013/12/EFSA-Opinion-on-Neurotoxic-Potential-Imidacloprid-Acetamiprid.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069740140","display_name":"Colin Ockleford","orcid":"https://orcid.org/0000-0002-0410-8233","observed_orcids":["https://orcid.org/0000-0002-0410-8233"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Colin Ockleford","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0410-8233","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069740140"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5221,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.94099473,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.22949999570846558,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/acetamiprid","display_name":"acetamiprid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/imidacloprid","display_name":"imidacloprid","score":1.0},{"id":"https://openalex.org/keywords/neonicotinoids","display_name":"neonicotinoids","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.6460000276565552},{"id":"https://openalex.org/keywords/acute-reference-dose","display_name":"acute reference dose","score":0.7400000095367432},{"id":"https://openalex.org/keywords/acceptable-daily-intake","display_name":"acceptable daily intake","score":0.9580000042915344},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.5540000200271606},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2776077829","wikidata":"https://www.wikidata.org/wiki/Q421598","display_name":"Acetamiprid","level":4,"score":0.977668285369873},{"id":"https://openalex.org/C2776784398","wikidata":"https://www.wikidata.org/wiki/Q420098","display_name":"Imidacloprid","level":3,"score":0.8836988210678101},{"id":"https://openalex.org/C2777500947","wikidata":"https://www.wikidata.org/wiki/Q902225","display_name":"Neonicotinoid","level":4,"score":0.7828496694564819},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.5903924703598022},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5586543083190918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4874134361743927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3695656657218933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24327883124351501},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.214980810880661},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.15986573696136475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08505523204803467},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2597190293","doi":null,"is_oa":false,"landing_page_url":"http://smallbluemarble.org.uk/wp-content/uploads/2013/12/EFSA-Opinion-on-Neurotoxic-Potential-Imidacloprid-Acetamiprid.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W16753956","https://openalex.org/W56469980","https://openalex.org/W79943469","https://openalex.org/W123264792","https://openalex.org/W128151115","https://openalex.org/W1497832075","https://openalex.org/W1562796888","https://openalex.org/W1892056617","https://openalex.org/W1963914792","https://openalex.org/W1964729421","https://openalex.org/W1967131207","https://openalex.org/W1971087529","https://openalex.org/W1971369839","https://openalex.org/W1974596946","https://openalex.org/W1974651975","https://openalex.org/W1977473971","https://openalex.org/W1980631925","https://openalex.org/W1981393953","https://openalex.org/W1983090112","https://openalex.org/W1983180773","https://openalex.org/W1983307734","https://openalex.org/W1984147326","https://openalex.org/W1988388370","https://openalex.org/W1989023854","https://openalex.org/W1997190824","https://openalex.org/W2002763722","https://openalex.org/W2003874630","https://openalex.org/W2007880547","https://openalex.org/W2011253696","https://openalex.org/W2023340635","https://openalex.org/W2025300385","https://openalex.org/W2025809696","https://openalex.org/W2027124686","https://openalex.org/W2029972861","https://openalex.org/W2036216077","https://openalex.org/W2037076830","https://openalex.org/W2037079152","https://openalex.org/W2038027765","https://openalex.org/W2039755329","https://openalex.org/W2039867424","https://openalex.org/W2040213449","https://openalex.org/W2045751048","https://openalex.org/W2047795557","https://openalex.org/W2055818067","https://openalex.org/W2056314319","https://openalex.org/W2056680204","https://openalex.org/W2060188196","https://openalex.org/W2061516091","https://openalex.org/W2061961563","https://openalex.org/W2063488922","https://openalex.org/W2064378389","https://openalex.org/W2075761659","https://openalex.org/W2075825425","https://openalex.org/W2081391428","https://openalex.org/W2085654735","https://openalex.org/W2086710797","https://openalex.org/W2101488656","https://openalex.org/W2104838343","https://openalex.org/W2106720796","https://openalex.org/W2115089758","https://openalex.org/W2121649505","https://openalex.org/W2126971912","https://openalex.org/W2128442744","https://openalex.org/W2130354830","https://openalex.org/W2136699448","https://openalex.org/W2140445474","https://openalex.org/W2141534876","https://openalex.org/W2147270524","https://openalex.org/W2147774399","https://openalex.org/W2151079096","https://openalex.org/W2159146679","https://openalex.org/W2159733258","https://openalex.org/W2167542986","https://openalex.org/W2169053074","https://openalex.org/W2316188743","https://openalex.org/W2320327264","https://openalex.org/W2321052550","https://openalex.org/W2404274487","https://openalex.org/W4296577018"],"related_works":["https://openalex.org/W7125767805","https://openalex.org/W6901898906","https://openalex.org/W1983180773","https://openalex.org/W4367309692","https://openalex.org/W2912436428","https://openalex.org/W3043706601","https://openalex.org/W2995160616","https://openalex.org/W4403079710","https://openalex.org/W2055805365","https://openalex.org/W2604461896"],"abstract_inverted_index":{"The":[0,90,147,235],"European":[1],"Food":[2],"Safety":[3],"Authority":[4],"asked":[5],"the":[6,22,28,67,74,78,81,110,159,175,187,190,195,213,232,239,281,288],"Panel":[7,76,91,148,237],"on":[8,21,186],"Plant":[9],"Protection":[10],"Products":[11],"(PPR)":[12],"and":[13,32,72,85,100,116,122,141,164,166,243,270,275],"their":[14],"residues":[15],"to":[16,135,203,249,280],"deliver":[17],"a":[18,138,228],"Scientific":[19],"Opinion":[20],"developmental":[23,208],"neurotoxicity":[24],"(DNT)":[25],"potential":[26,69,140,207,290],"of":[27,47,70,162,189,212,241,252,260,267,291],"neonicotinoid":[29],"insecticides":[30],"acetamiprid":[31,71,163],"imidacloprid.":[33],"An":[34],"in":[35,124,214,231,272,282],"vitro":[36,215,273],"study":[37],"(Kimura-Kuroda":[38],"et":[39,220],"al.,":[40],"2012)":[41],"suggested":[42],"that":[43,93,150],"excitation":[44],"and/or":[45],"desensitisation":[46],"nicotinic":[48],"acetylcholine":[49],"receptors":[50],"(nAChRs)":[51],"by":[52,218],"these":[53],"compounds":[54,95],"might":[55],"affect":[56,97],"developing":[57],"mammalian":[58],"nervous":[59],"systems":[60],"as":[61,173,227],"occurs":[62],"with":[63],"nicotine.":[64],"To":[65],"evaluate":[66],"DNT":[68,112,139,161,254,263,289],"imidacloprid,":[73],"PPR":[75,236],"scrutinised":[77],"open":[79],"literature,":[80],"draft":[82],"assessments":[83],"reports":[84],"dossiers":[86],"submitted":[87],"for":[88,114,145,158,177,198,286],"approval.":[89],"concludes":[92],"both":[94],"may":[96,153],"neuronal":[98],"development":[99,259],"function,":[101],"although":[102],"several":[103],"methodological":[104],"limitations":[105],"have":[106],"been":[107],"identified.":[108],"Considering":[109],"available":[111],"studies":[113,126],"imidacloprid":[115,165,199],"acetamiprid,":[117],"important":[118],"uncertainties":[119],"still":[120],"remain":[121],"further":[123],"vivo":[125,283],"following":[127],"OECD":[128],"test":[129],"guideline":[130],"(TG)":[131],"426":[132,285],"are":[133,183],"required":[134],"robustly":[136],"characterise":[137],"dose-response":[142],"relationships,":[143],"particularly":[144],"acetamiprid.":[146,178],"considers":[149],"current":[151,196,225],"ARfDs":[152],"not":[154],"be":[155,171],"protective":[156],"enough":[157],"possible":[160],"no":[167],"reliable":[168,269],"conclusion":[169],"can":[170],"drawn":[172],"regards":[174],"ADI":[176,197],"More":[179],"conservative":[180],"reference":[181],"values":[182],"proposed":[184],"based":[185],"analysis":[188],"existing":[191],"toxicological":[192],"data.":[193],"However,":[194],"is":[200],"considered":[201],"adequate":[202],"protect":[204],"against":[205],"its":[206,224],"neurotoxic":[209],"effects.":[210],"Limitations":[211],"system":[216],"used":[217],"Kimura-Kuroda":[219],"al.":[221],"(2012)":[222],"prevent":[223],"use":[226],"screening":[229],"tool":[230],"regulatory":[233],"arena.":[234],"encourages":[238],"definition":[240],"clear":[242],"consistent":[244],"criteria":[245],"at":[246],"EU":[247],"level":[248],"trigger":[250],"submission":[251],"mandatory":[253],"studies,":[255],"which":[256],"could":[257],"include":[258],"an":[261],"integrated":[262],"testing":[264],"strategy":[265],"composed":[266],"robust,":[268],"validated":[271],"assays":[274],"other":[276],"alternative":[277],"methods":[278],"complementary":[279],"TG":[284],"assessing":[287],"substances.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-23T00:00:00"}