{"id":"https://openalex.org/W2597027675","doi":"https://doi.org/10.4103/ijmm.ijmm_16_370","title":"Characterisation of the Human Oral Microbiome in Patients with Coronary Artery Disease Using Next-generation Sequencing of 16SrRNA Amplicons","display_name":"Characterisation of the Human Oral Microbiome in Patients with Coronary Artery Disease Using Next-generation Sequencing of 16SrRNA Amplicons","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2597027675","doi":"https://doi.org/10.4103/ijmm.ijmm_16_370","mag":"2597027675","pmid":"https://pubmed.ncbi.nlm.nih.gov/28303827"},"language":"en","primary_location":{"id":"doi:10.4103/ijmm.ijmm_16_370","doi":"https://doi.org/10.4103/ijmm.ijmm_16_370","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijmm.ijmm_16_370","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0255085720302450/pdf","source":{"id":"https://openalex.org/S131141226","display_name":"Indian Journal of Medical Microbiology","issn_l":"0255-0857","issn":["0255-0857","1998-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0255085720302450/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044420181","display_name":"Thangam Menon","orcid":"https://orcid.org/0000-0002-5836-7177","observed_orcids":["https://orcid.org/0000-0002-5836-7177"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Thangam Menon","raw_affiliation_strings":["Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I215927"]},{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022498080","display_name":"Sathya Narayanan Gopalakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sathya Narayanan Gopalakrishnan","raw_affiliation_strings":["Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I215927"]},{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078084180","display_name":"Rayvathy Balasubramanian","orcid":"https://orcid.org/0000-0002-9944-2890","observed_orcids":["https://orcid.org/0000-0002-9944-2890"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rayvathy Balasubramanian","raw_affiliation_strings":["Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I215927"]},{"raw_affiliation_string":"Department of Microbiology, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002251916","display_name":"Stalin Roy","orcid":"https://orcid.org/0000-0002-9450-2452","observed_orcids":["https://orcid.org/0000-0002-9450-2452"]},"institutions":[{"id":"https://openalex.org/I159337121","display_name":"Madras Medical College","ror":"https://ror.org/050ztxn78","country_code":"IN","type":"education","lineage":["https://openalex.org/I159337121"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Stalin Roy Justin","raw_affiliation_strings":["Department of Cardiology, Madras Medical College and Rajiv Gandhi General Hospital, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Madras Medical College and Rajiv Gandhi General Hospital, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I159337121"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044420181"],"corresponding_institution_ids":["https://openalex.org/I215927"],"apc_list":{"value":2210,"currency":"USD","value_usd":2210},"apc_paid":{"value":2210,"currency":"USD","value_usd":2210},"fwci":1.2151,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7723755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"35","issue":"1","first_page":"101","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.9940000176429749},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.9980000257492065},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/bacterial-diversity","display_name":"bacterial diversity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/16s-rrna","display_name":"16S rRNA","score":0.7279999852180481},{"id":"https://openalex.org/keywords/firmicutes","display_name":"Firmicutes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fusobacteria","display_name":"Fusobacteria","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.8130000233650208},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tm7","display_name":"TM7","score":0.7429999709129333},{"id":"https://openalex.org/keywords/oral-bacteria","display_name":"oral bacteria","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776202939","wikidata":"https://www.wikidata.org/wiki/Q1137677","display_name":"Fusobacteria","level":5,"score":0.924267053604126},{"id":"https://openalex.org/C2910160754","wikidata":"https://www.wikidata.org/wiki/Q1500347","display_name":"Oral Microbiome","level":3,"score":0.765118420124054},{"id":"https://openalex.org/C2777695942","wikidata":"https://www.wikidata.org/wiki/Q149075","display_name":"Firmicutes","level":4,"score":0.7606886625289917},{"id":"https://openalex.org/C2777385719","wikidata":"https://www.wikidata.org/wiki/Q1061265","display_name":"Bacteroidetes","level":4,"score":0.7603195905685425},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6795663237571716},{"id":"https://openalex.org/C2779676784","wikidata":"https://www.wikidata.org/wiki/Q130999","display_name":"Proteobacteria","level":4,"score":0.5597662329673767},{"id":"https://openalex.org/C91066513","wikidata":"https://www.wikidata.org/wiki/Q38348","display_name":"Phylum","level":3,"score":0.5528410077095032},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5524159073829651},{"id":"https://openalex.org/C2778169975","wikidata":"https://www.wikidata.org/wiki/Q130914","display_name":"Actinobacteria","level":4,"score":0.5360159873962402},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.5103372931480408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45135626196861267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4338160753250122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39468592405319214},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34062591195106506},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23207345604896545},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2257891595363617},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.2061809003353119},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18826231360435486}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4103/ijmm.ijmm_16_370","doi":"https://doi.org/10.4103/ijmm.ijmm_16_370","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijmm.ijmm_16_370","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0255085720302450/pdf","source":{"id":"https://openalex.org/S131141226","display_name":"Indian Journal of Medical Microbiology","issn_l":"0255-0857","issn":["0255-0857","1998-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical Microbiology","raw_type":"journal-article"},{"id":"pmid:28303827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28303827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of medical microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/ijmm.ijmm_16_370","doi":"https://doi.org/10.4103/ijmm.ijmm_16_370","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijmm.ijmm_16_370","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0255085720302450/pdf","source":{"id":"https://openalex.org/S131141226","display_name":"Indian Journal of Medical Microbiology","issn_l":"0255-0857","issn":["0255-0857","1998-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2597027675.pdf","grobid_xml":"https://content.openalex.org/works/W2597027675.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1646004289","https://openalex.org/W2007957660","https://openalex.org/W2016952802","https://openalex.org/W2055076212","https://openalex.org/W2174186379","https://openalex.org/W2296282463","https://openalex.org/W2316129205","https://openalex.org/W2343040962","https://openalex.org/W2417270331"],"related_works":["https://openalex.org/W3119207382","https://openalex.org/W4282572257","https://openalex.org/W4379013084","https://openalex.org/W6906559531","https://openalex.org/W7169685028","https://openalex.org/W4319263793","https://openalex.org/W2055394907","https://openalex.org/W4207061315","https://openalex.org/W4390946237","https://openalex.org/W2076728075"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Oral":[1],"health":[2],"is":[3],"suspected":[4],"to":[5,8,40],"be":[6],"linked":[7],"heart":[9],"disease":[10,50],"since":[11],"species":[12],"of":[13,36,64,103,159,164,180,189],"bacteria":[14],"that":[15],"cause":[16],"periodontitis":[17],"and":[18,52,78,119,142,172],"dental":[19,57],"caries":[20,58],"have":[21],"been":[22],"found":[23,107,115,148],"in":[24,28,30,45,53,108,116,151,155,168,177,186],"the":[25,31,42,71,76,110,152,156,165,178,181,187],"atherosclerotic":[26],"plaque":[27],"arteries":[29],"heart.":[32],"OBJECTIVES:":[33],"The":[34,91,112],"aim":[35],"this":[37],"study":[38],"was":[39,68,80,96,121],"characterize":[41],"oral":[43,72,166,182],"microbiome":[44,167],"patients":[46,77,169],"with":[47,56,170,184],"coronary":[48],"artery":[49],"(CAD)":[51],"a":[54,149,175,190],"patient":[55],"(DC)":[59],"without":[60],"any":[61],"clinical":[62],"symptoms":[63],"CAD.":[65],"METHODS:":[66],"DNA":[67],"extracted":[69],"from":[70,75],"swabs":[73],"collected":[74],"sequencing":[79,85,93],"performed":[81],"by":[82],"next":[83],"generation":[84],"method":[86],"using":[87,98],"Illumina":[88],"(MiSeq)":[89],"platform.":[90],"resulting":[92],"data":[94],"set":[95],"analysed":[97],"QIIME.":[99],"RESULTS:":[100],"A":[101,162],"total":[102],"31":[104],"phyla":[105],"were":[106],"all":[109],"samples.":[111],"predominant":[113],"phylum":[114],"both":[117],"CAD":[118,171],"DC":[120,173],"Firmicutes":[122],"(46.09%":[123],"&":[124,128,132,136,140,145],"38.98%),":[125],"Proteobacteria":[126],"(17.73%":[127],"9.79%),":[129],"Fusobacteria":[130],"(13.44%":[131],"17.95%),":[133],"Bacteroidetes":[134],"(11.82%":[135],"22.73%),":[137],"Actinobacteria":[138],"(8.33%":[139],"7.71%)":[141],"TM7":[143],"(2.25%":[144],"2.71%).":[146],"We":[147],"similarity":[150,176],"bacterial":[153],"diversity":[154],"two":[157],"groups":[158],"patients.":[160],"CONCLUSION:":[161],"comparison":[163],"shows":[174],"composition":[179],"microbiota":[183],"variations":[185],"proportion":[188],"few":[191],"genera.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-03-23T00:00:00"}