{"id":"https://openalex.org/W2596852467","doi":"https://doi.org/10.1182/blood.v106.11.3262.3262","title":"Assessment of Minimal Residual Disease (MRD) by Qualitative RT-PCR (Q-PCR) vs Real-Time Quantitative RT-PCR (RQ-PCR) in a Phase II Study of Acute Promyelocytic Leukemia (APL).","display_name":"Assessment of Minimal Residual Disease (MRD) by Qualitative RT-PCR (Q-PCR) vs Real-Time Quantitative RT-PCR (RQ-PCR) in a Phase II Study of Acute Promyelocytic Leukemia (APL).","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2596852467","doi":"https://doi.org/10.1182/blood.v106.11.3262.3262","mag":"2596852467"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.3262.3262","doi":"https://doi.org/10.1182/blood.v106.11.3262.3262","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.3262.3262","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040340688","display_name":"Robert E. Gallagher","orcid":"https://orcid.org/0000-0002-1476-8833","observed_orcids":["https://orcid.org/0000-0002-1476-8833"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Gallagher","raw_affiliation_strings":["Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016164924","display_name":"Esther L. Schachter-Tokarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther L. Schachter-Tokarz","raw_affiliation_strings":["Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062168421","display_name":"Daniel A. Jones","orcid":"https://orcid.org/0000-0003-1441-0417","observed_orcids":["https://orcid.org/0000-0003-1441-0417"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan A. Jones","raw_affiliation_strings":["Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057920623","display_name":"Elihu H. Estey","orcid":"https://orcid.org/0000-0002-0987-8077","observed_orcids":["https://orcid.org/0000-0002-0987-8077"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elihu H. Estey","raw_affiliation_strings":["Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Oncology, Albert Einstein Cancer Center, Bronx, NY, USA; Hematopathology, M.D. Anderson Cancer Center, Houston, TX, USA and Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26872656,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"3262","last_page":"3262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/real-time-rt-pcr","display_name":"real-time RT-PCR","score":0.9860000014305115},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.597000002861023},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8920000195503235},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chemotherapy-reduction","display_name":"chemotherapy reduction","score":0.4569999873638153},{"id":"https://openalex.org/keywords/high-risk-apl","display_name":"high-risk APL","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prognostic-tests","display_name":"prognostic tests","score":0.4869999885559082},{"id":"https://openalex.org/keywords/detection-sensitivity","display_name":"detection sensitivity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/gapdh-normalization","display_name":"GAPDH normalization","score":0.5619999766349792},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.5049999952316284},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.7878398895263672},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.6992861032485962},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.6126236319541931},{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.5675433874130249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4733284115791321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4593008756637573},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39480555057525635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3906678855419159},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3429372310638428},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32875561714172363},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32240140438079834},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.30413109064102173},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.25798624753952026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17579656839370728},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.3262.3262","doi":"https://doi.org/10.1182/blood.v106.11.3262.3262","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.3262.3262","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2551211853","https://openalex.org/W3000812509","https://openalex.org/W4230163949","https://openalex.org/W2284376404","https://openalex.org/W2135938821","https://openalex.org/W2560908859","https://openalex.org/W7009741824","https://openalex.org/W2595766056","https://openalex.org/W2270346409","https://openalex.org/W2078054197"],"abstract_inverted_index":{"Abstract":[0],"Assessment":[1],"of":[2,14,20,74,92,157,187,324,374,384,404],"MRD":[3,406],"in":[4,23,60,113,162,303,358,394,408],"APL":[5],"by":[6,100,195],"Q-PCR":[7,93,174,293],"analysis":[8],"for":[9,44,96,154,297,314],"the":[10,18,85,90,182,190,196,260,264,304,321,328,359,382,402],"presence":[11],"or":[12,130],"absence":[13],"PML-RAR\u03b1":[15,75,191],"mRNA":[16,76],"after":[17],"completion":[19],"consolidation":[21],"therapy":[22],"treatment":[24],"regimens":[25],"employing":[26],"all-trans":[27],"retinoic":[28],"acid":[29],"(ATRA)":[30],"and":[31,140,150,167,175,272,280,310,331],"chemotherapy":[32],"(CT)":[33],"has":[34,50],"provided":[35],"a":[36,105,117,155,365,388],"reasonably":[37],"accurate":[38],"but":[39,356],"not":[40,78],"infallible":[41],"prognostic":[42],"test":[43],"disease":[45],"recurrence":[46],"(DR).":[47],"This":[48],"assessment":[49,399],"been":[51,152],"made":[52],"at":[53,364,371,387],"detection":[54,329],"sensitivity":[55],"levels":[56,73],"up":[57],"to":[58,65,81,109,123,210,289,307,400],"1":[59,233,252],"104,":[61],"which":[62],"is":[63],"considered":[64],"have":[66,151],"optimal":[67],"predictive":[68],"value,":[69],"since":[70],"non-quantified":[71],"lower":[72],"may":[77,369],"be":[79,370,392],"relevant":[80],"clinical":[82,120,397],"outcome.":[83],"In":[84,286],"current":[86],"study,":[87],"we":[88],"compared":[89],"results":[91,110,267,348,383],"(touchdown":[94],"PCR":[95,325],"40":[97],"cycles":[98],"followed":[99,153],"post-PCR":[101],"blot":[102],"hybridization":[103],"with":[104,396],"RAR\u03b1":[106],"chemiluminescent":[107],"probe)":[108],"from":[111,206],"RQ-PCR":[112,176,290,334,385],"15":[114],"patients":[115,145,352],"on":[116],"Phase":[118],"II":[119],"trial":[121],"designed":[122],"eliminate":[124],"CT":[125,132],"(low-risk/LR":[126],"patients,":[127,134,263],"WBC":[128,135],"<10K)":[129],"minimize":[131],"(high-risk/HR":[133],">10K),":[136],"using":[137],"combined":[138],"ATRA":[139],"arsenic":[141],"trioxide":[142],"therapy.":[143],"All":[144],"achieved":[146],"complete":[147],"remission":[148],"(CR)":[149],"median":[156],"1.2":[158],"years.":[159],"DR":[160,237,375],"occurred":[161],"0/8":[163],"LR,":[164],"0/1":[165],"unclassified":[166],"2/6":[168],"HR":[169,351],"patients.":[170,410],"At":[171],"CR,":[172],"all":[173,292,311],"assays":[177,294,326],"were":[178,295,301,312],"positive.":[179],"For":[180,259],"RQ-PCR,":[181,274],"normalized":[183],"quotient":[184],"(NQ)":[185],"value":[186],"PML-RAR\u03b1,":[188],"i.e.,":[189],"copy":[192,202],"number":[193],"divided":[194],"housekeeping":[197],"gene":[198],"glyceraldehyde-3\u2032-phosphate":[199],"dehydrogenase":[200],"(GAPDH)":[201],"number,":[203],"ranged":[204],"widely":[205],"1.5":[207],"x":[208,212,230,234,242,246,253,257,278,284],"10\u22126":[209,306],"7.0":[211],"10\u22123.":[213],"Post-CR":[214],"follow-up":[215],"data":[216],"were:":[217],"Patient":[218],"Group":[219],"Number":[220],"Q-PCR+":[221],"RQ-PCR+":[222],"NQ":[223,275,281,298,305,315],"Range":[224],"LR/Unclassified":[225],"9":[226,229],"0/24":[227],"16/24":[228],"10\u22129":[231,243],"\u2013":[232,244,255,361],"10\u22127":[235,247],"HR/no":[236],"4":[238],"0/23":[239],"8/23":[240],"2":[241,249,261],"3":[245],"HR/DR":[248,262],"1/7":[250],"5/7":[251],"10\u22128":[254],"5":[256,277],"10\u22125":[258,279,308],"last":[265],"pre-DR":[266],"were,":[268],"respectively:":[269],"Q-PCR,":[270],"positive":[271,296,302],"negative;":[273],"=":[276,282],"2.3":[283],"10\u22127.":[285],"overall":[287],"comparisons":[288],"results,":[291],">10\u22125,":[299],"3/4":[300],"range,":[309],"negative":[313],"<10\u22126.":[316],"Additionally,":[317],"dilution-reconstruction":[318],"experiments":[319],"confirmed":[320],"stochastic":[322],"nature":[323],"near":[327],"limit":[330],"indicated":[332],"that":[333,350,381],"was":[335],"about":[336],"10-fold":[337],"more":[338,377],"sensitive":[339],"than":[340],"Q-PCR.":[341],"Although":[342],"larger":[343],"studies":[344],"are":[345,354],"needed,":[346],"our":[347],"suggest":[349,380],"who":[353],"Q-PCR-negative":[355],"RQ-PCR-positive":[357],">10\u22127":[360],"<10\u22125":[362],"range":[363],"critical":[366,389],"post-CR":[367],"checkpoint":[368,390],"increased":[372],"risk":[373,398],"and,":[376],"generally,":[378],"they":[379],"testing":[386],"can":[391],"used":[393],"combination":[395],"stratify":[401],"intensity":[403],"subsequent":[405],"monitoring":[407],"individual":[409]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-03-23T00:00:00"}
