{"id":"https://openalex.org/W2596838969","doi":null,"title":"Studies on immunostimulants and innate immune gene expression in Atlantic salmon: candidate tools for marker selection","display_name":"Studies on immunostimulants and innate immune gene expression in Atlantic salmon: candidate tools for marker selection","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2596838969","mag":"2596838969"},"language":"en","primary_location":{"id":"pmh:oai:skemman.is:1946/23037","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1946/23037","pdf_url":null,"source":{"id":"https://openalex.org/S4377196131","display_name":"Skemman","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005755348","display_name":"Miriam G. Contreras Mostazo","orcid":"https://orcid.org/0000-0003-0506-7602","observed_orcids":["https://orcid.org/0000-0003-0506-7602"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mostazo, Miriam Guadalupe Contreras, 1991-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005755348"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atlantic-salmon","display_name":"Atlantic salmon","score":0.9940000176429749},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/immunostimulants","display_name":"immunostimulants","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gill","display_name":"gill","score":0.4620000123977661},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.6520000100135803},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.9240000247955322},{"id":"https://openalex.org/keywords/snp-markers","display_name":"SNP markers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/marker-assisted-selection","display_name":"marker-assisted selection","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7491336464881897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6239529848098755},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5974557995796204},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5443598031997681},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4903571605682373},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46883028745651245},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4193613827228546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.394695520401001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2956698536872864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14948409795761108},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11885631084442139}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:skemman.is:1946/23037","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1946/23037","pdf_url":null,"source":{"id":"https://openalex.org/S4377196131","display_name":"Skemman","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7778000235557556,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"},{"score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W633735835","https://openalex.org/W1486335995","https://openalex.org/W1488731849","https://openalex.org/W1516830966","https://openalex.org/W1560219415","https://openalex.org/W1560571961","https://openalex.org/W1562033242","https://openalex.org/W1580127326","https://openalex.org/W1588120420","https://openalex.org/W1607942113","https://openalex.org/W1625456249","https://openalex.org/W1927671826","https://openalex.org/W1943160106","https://openalex.org/W1964991450","https://openalex.org/W1965401843","https://openalex.org/W1968423560","https://openalex.org/W1970307623","https://openalex.org/W1971514047","https://openalex.org/W1977346058","https://openalex.org/W1977698433","https://openalex.org/W1982729281","https://openalex.org/W1982737915","https://openalex.org/W1983987058","https://openalex.org/W1984006643","https://openalex.org/W1985840227","https://openalex.org/W1986836541","https://openalex.org/W1988738875","https://openalex.org/W1990857524","https://openalex.org/W1991464867","https://openalex.org/W1991634991","https://openalex.org/W1991671300","https://openalex.org/W1993105631","https://openalex.org/W1994560190","https://openalex.org/W1994858966","https://openalex.org/W2000513200","https://openalex.org/W2001112166","https://openalex.org/W2002706411","https://openalex.org/W2006752974","https://openalex.org/W2007331929","https://openalex.org/W2009214395","https://openalex.org/W2009584243","https://openalex.org/W2009651579","https://openalex.org/W2009662910","https://openalex.org/W2013833224","https://openalex.org/W2016330420","https://openalex.org/W2020799333","https://openalex.org/W2022020355","https://openalex.org/W2025063713","https://openalex.org/W2025795405","https://openalex.org/W2026999177","https://openalex.org/W2028379781","https://openalex.org/W2029558533","https://openalex.org/W2035443605","https://openalex.org/W2037708841","https://openalex.org/W2037928170","https://openalex.org/W2038003976","https://openalex.org/W2043241102","https://openalex.org/W2043911718","https://openalex.org/W2044007007","https://openalex.org/W2047401331","https://openalex.org/W2048780836","https://openalex.org/W2051142131","https://openalex.org/W2051781207","https://openalex.org/W2058088166","https://openalex.org/W2060815224","https://openalex.org/W2066937425","https://openalex.org/W2067658972","https://openalex.org/W2067778091","https://openalex.org/W2075177447","https://openalex.org/W2076934697","https://openalex.org/W2081873300","https://openalex.org/W2082863976","https://openalex.org/W2084954530","https://openalex.org/W2090165219","https://openalex.org/W2090290516","https://openalex.org/W2091366683","https://openalex.org/W2095297220","https://openalex.org/W2096971083","https://openalex.org/W2106449126","https://openalex.org/W2107021471","https://openalex.org/W2108524369","https://openalex.org/W2109570941","https://openalex.org/W2112841209","https://openalex.org/W2113982278","https://openalex.org/W2115575023","https://openalex.org/W2122137183","https://openalex.org/W2124580054","https://openalex.org/W2124985265","https://openalex.org/W2126451667","https://openalex.org/W2128443399","https://openalex.org/W2142177412","https://openalex.org/W2146312600","https://openalex.org/W2148966488","https://openalex.org/W2149401354","https://openalex.org/W2149813463","https://openalex.org/W2149843865","https://openalex.org/W2153138756","https://openalex.org/W2156737662","https://openalex.org/W2160557484","https://openalex.org/W2160780417","https://openalex.org/W2161184021","https://openalex.org/W2166311543","https://openalex.org/W2169773990","https://openalex.org/W2170820215","https://openalex.org/W2188710262","https://openalex.org/W2274887475","https://openalex.org/W2529759332","https://openalex.org/W2595040220","https://openalex.org/W4213393555"],"related_works":["https://openalex.org/W2467166164","https://openalex.org/W2768063198","https://openalex.org/W7062894572","https://openalex.org/W2771861210","https://openalex.org/W4401628428","https://openalex.org/W2962801530","https://openalex.org/W591389384","https://openalex.org/W4387002257","https://openalex.org/W3093921906","https://openalex.org/W3202250664"],"abstract_inverted_index":{"The":[0,20,28,79,454],"aim":[1],"of":[2,36,46,57,74,76,88,146,164,174,200,205,214,218,234,251,258,268,287,346,360,412,415,456,466,472,489,504,524,567,602],"this":[3,387,457],"project":[4,21,526],"was":[5,22,31,82,104,207,299,315,511,527,607],"to":[6,9,32,83,105,117,160,196,231,239,265,330,372,469,574,591],"create":[7],"tools":[8,329],"select":[10],"robust":[11,334],"fish":[12,124,148,153,603],"with":[13,184,324,379,390,394,403,442,464,563,578],"better":[14],"innate":[15],"immunity":[16],"for":[17,109,123,170,342,377,493,557,600],"breeding":[18],"stock.":[19],"divided":[23],"into":[24],"three":[25],"main":[26],"stages.":[27],"first":[29,132,141,172],"stage":[30,81,103,523],"study":[33,161,197,354,458],"basal":[34,162,203,565],"expression":[35,75,87,163,204,215,307,345,471,566,583],"antimicrobial":[37],"peptides":[38],"(AMP)":[39],"and":[40,53,63,70,97,100,151,192,209,248,272,284,292,294,326,349,368,384,400,435,474,479,484,559,580],"inducible":[41,273],"nitric":[42,274],"oxide":[43,275],"synthase":[44,276],"(iNOS)":[45],"different":[47,135,447,564],"Atlantic":[48,259],"salmon":[49,260,405],"(Salmo":[50],"salar)":[51],"families":[52,150,180,253],"investigate":[54,266],"the":[55,68,101,131,140,171,198,219,232,241,244,282,303,332,344,380,502,525,534,551],"effect":[56],"calcium":[58],"supplemented":[59],"\u03b2-Hydroxy-\u03b2-methyl":[60,64],"butyrate":[61,65],"(calcium-HMB)":[62],"(HMB)":[66],"in":[67,115,158,194,216,263,281,289,296,301,308,316,355,423,427,445,452],"diet":[69,283],"water,":[71],"as":[72,120,227,598],"inductors":[73],"these":[77,89,347],"genes.":[78],"second":[80,245,535],"test":[84],"if":[85],"increased":[86],"genes":[90],"has":[91],"a":[92,107,353,357,410,424,431,436,446,497,576],"defense":[93],"role":[94],"against":[95,126],"bacterial":[96,490],"virus":[98,398,407],"infection":[99,413,491,499],"third":[102,522],"initiate":[106],"search":[108],"single":[110],"nucleotide":[111],"polymorphism":[112],"(SNP)":[113],"markers":[114,122],"order":[116,159,195,264],"use":[118],"them":[119],"selection":[121,601],"high-tolerance":[125],"pathogen":[127],"infections.":[128],"\\n":[129,336,520,616],"\\nFor":[130],"stage,":[133],"two":[134,217],"experiments":[136,571],"were":[137,156,181,190,261,375,392,440,544],"performed.":[138],"In":[139,177,243,429],"experiment,":[142,246],"gill":[143,188,247,290],"lamella":[144],"tissue":[145],"1330":[147],"(133":[149],"10":[152],"per":[154,256,421],"family)":[155,257],"collected":[157,191,262,545],"Cathelicidin-2":[165],"(CATH-2),":[166],"an":[167],"important":[168],"component":[169],"line":[173],"immune":[175],"defenses.":[176],"addition,":[178,430],"14":[179,220],"selected,":[182],"treated":[183],"calcium-HMB":[185],"and,":[186,500],"then,":[187],"tissues":[189,250],"analyze":[193],"induction":[199,213,267],"CATH-2.":[201,568],"Different":[202],"CATH-2":[206,288,293],"observed":[208,300],"we":[210,237,338,351,589],"could":[211],"see":[212],"families.":[221,304,335,584],"Calcium-HMB":[222],"treatment":[223],"did":[224],"not":[225],"work":[226],"expected,":[228],"possibly":[229],"due":[230],"presence":[233],"calcium;":[235],"therefore,":[236],"decided":[238],"change":[240],"treatment.":[242],"skin":[249,297,309],"12":[252,547],"(12":[254],"individuals":[255],"CATH-2,":[269],"Hepcidin-1":[270],"(Hep-1)":[271],"(iNOS),":[277],"by":[278,482,529,539],"adding":[279],"HMB":[280,467],"water.":[285],"Up-regulation":[286],"samples":[291,298,532,543],"iNOS":[295],"all":[302,562],"Interestingly,":[305],"Hep-1":[306],"samples,":[310],"rather":[311],"than":[312],"being":[313],"enhanced,":[314],"some":[317],"cases":[318],"down-regulated.":[319],"These":[320],"studies":[321],"provide":[322],"us":[323,515,573],"possible":[325],"powerful":[327],"molecular":[328],"choose":[331],"most":[333],"\\nOnce":[337],"had":[339],"established":[340],"conditions":[341],"inducing":[343],"AMPs":[348,473],"iNOS,":[350,475],"conducted":[352],"which":[356,594],"calculated":[358],"number":[359],"24-wells":[361],"plates":[362,389],"containing":[363,550],"CHSE-214":[364,432],"cells,":[365],"ASK":[366,401],"cells":[367,370,402,463],"RTS-11":[369,437],"grown":[371],"80%":[373],"confluency,":[374],"pre-treated":[376],"48h":[378],"inducers":[381],"HMB,":[382],"PBA":[383],"vitaminD3.":[385],"After":[386],"pre-treatment":[388],"CHSE214":[391],"infected":[393,441],"infectious":[395],"pancreatic":[396],"necrosis":[397],"(IPNV)":[399],"infections":[404],"anemia":[406],"(ISAV)":[408],"at":[409,501],"multiplicity":[411],"(MOI)":[414],"0.1":[416],"(0.1":[417],"plaque":[418],"forming":[419],"units":[420],"cell)":[422],"reference":[425,448],"laboratory":[426],"Chile.":[428,453],"cell":[433,438],"plate":[434,439],"Pisciricketssia":[443],"salmonis":[444,495],"laboratory,":[449],"also":[450],"located":[451],"findings":[455],"strongly":[459],"suggest":[460],"that":[461],"pre-treating":[462],"concentrations":[465],"known":[468],"induce":[470],"can":[476,595],"lower":[477],"IPNV":[478,558],"ISAV":[480],"infectivity":[481],"53%":[483],"26%":[485],"respectively.":[486],"Unfortunately":[487],"dilution":[488],"used":[492,597],"P.":[494],"caused":[496],"violent":[498],"moment":[503],"analysis,":[505],"our":[506],"internal":[507],"housekeeping":[508],"gene":[509],"control":[510],"severely":[512],"degraded":[513],"preventing":[514],"from":[516,533,546],"drawing":[517],"any":[518],"conclusions.":[519],"\\nThe":[521],"approached":[528],"analyzing":[530],"fin":[531],"experiment":[536],"(144":[537],"samples)":[538],"ddRAD":[540,587,605],"sequencing.":[541],"Fin":[542],"families,":[548],"6":[549,560],"major":[552],"quantitative":[553],"trait":[554],"locus":[555],"(QTL)":[556],"non-QTLs,":[561],"Our":[569],"previous":[570],"allow":[572],"build":[575],"phenotype":[577],"high":[579],"low":[581],"CATH-2-basal":[582],"By":[585],"performing":[586],"sequencing":[588,606],"hope":[590],"find":[592],"SNPs,":[593],"be":[596],"biomarkers":[599],"robustness.":[604],"successfully":[608],"performed":[609],"but":[610],"data":[611],"analysis":[612],"is":[613],"still":[614],"underway.":[615]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}