{"id":"https://openalex.org/W25968151","doi":null,"title":"Long-term renal function in heart transplant recipients receiving cyclosporine therapy.","display_name":"Long-term renal function in heart transplant recipients receiving cyclosporine therapy.","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W25968151","mag":"25968151","pmid":"https://pubmed.ncbi.nlm.nih.gov/9402509"},"language":"en","primary_location":{"id":"pmid:9402509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9402509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080208809","display_name":"Simin G\u00f6ral","orcid":"https://orcid.org/0000-0002-2873-1599","observed_orcids":["https://orcid.org/0000-0002-2873-1599"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Goral","raw_affiliation_strings":["Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tenn. 37232-2372, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tenn. 37232-2372, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063852374","display_name":"Christina Ynares","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ynares","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shyr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021653291","display_name":"Thomas Yeoh","orcid":"https://orcid.org/0000-0001-9809-7303","observed_orcids":["https://orcid.org/0000-0001-9809-7303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T K Yeoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109090767","display_name":"Howard Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H K Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7296,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92605745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"11","first_page":"1106","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.2151000052690506,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cyclosporine-nephrotoxicity","display_name":"cyclosporine nephrotoxicity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cyclosporine-dose-reduction","display_name":"cyclosporine dose reduction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cockcroft-gault-equation","display_name":"Cockcroft-Gault formula","score":0.7350000143051147},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9181067943572998},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8199220895767212},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.7725611925125122},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.741790771484375},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6989071369171143},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6502736210823059},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.6293520331382751},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.4367102384567261},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.41240745782852173},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3864203989505768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3690752387046814},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3379729986190796},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007483","descriptor_name":"Iothalamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9402509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9402509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","raw_type":"Journal Article"},{"id":"mag:25968151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9402509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2127643165","https://openalex.org/W2124623781","https://openalex.org/W2165384969","https://openalex.org/W2003821675","https://openalex.org/W2006725253","https://openalex.org/W1981935700","https://openalex.org/W2318802513","https://openalex.org/W2015812563","https://openalex.org/W1994703135"],"related_works":["https://openalex.org/W2419127988","https://openalex.org/W2103437603","https://openalex.org/W2404594708","https://openalex.org/W2408353759","https://openalex.org/W2464643416","https://openalex.org/W2398129919","https://openalex.org/W2000632306","https://openalex.org/W4245526891","https://openalex.org/W2416101698","https://openalex.org/W2158048717"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunosuppression":[1],"with":[2,245],"cyclosporine":[3,35,83,102,202,247],"has":[4],"improved":[5],"allograft":[6],"function":[7,38,242],"and":[8,12,54,79,82,101,140,168,187,228],"reduced":[9],"both":[10],"morbidity":[11],"mortality":[13],"in":[14,39,71,221,249],"organ":[15],"transplantation.":[16,232],"However,":[17],"cyclosporine-induced":[18],"nephrotoxicity":[19],"still":[20],"is":[21,243],"a":[22],"concern.":[23],"The":[24,114,146,200],"purpose":[25],"of":[26,34,94,176,211,240],"our":[27],"study":[28],"was":[29,121,155,204],"to":[30,52,107,163,178],"evaluate":[31],"the":[32,72,125,143,173,185,191,197,208,238],"effects":[33],"on":[36],"renal":[37,241],"orthotopic":[40],"heart":[41,250],"transplant":[42,251],"recipients.":[43,252],"METHODS:":[44],"Thirty-nine":[45],"patients":[46,220],"who":[47],"received":[48],"transplants":[49],"from":[50],"1985":[51],"1991":[53],"had":[55],"at":[56,90,118,165,225],"least":[57],"three":[58],"yearly":[59],"glomerular":[60,148,193],"filtration":[61,149,194],"rate":[62,150,195],"measurements":[63],"posttransplantation":[64],"by":[65,110,151,184],"125I-iothalamate":[66,152],"clearance":[67,153,182],"method":[68,154],"were":[69,85],"included":[70],"study.":[73],"In":[74],"addition,":[75],"serum":[76,116,128],"creatinine":[77,117,129],"(before":[78],"after":[80,142,196,207,231],"transplantation)":[81],"doses":[84],"analyzed.":[86],"RESULTS:":[87],"Maintenance":[88],"immunosuppression":[89],"1":[91,119,166],"year":[92,120,167],"consisted":[93],"prednisone":[95],"(0.1":[96],"mg/kg/day),":[97,100],"azathioprine":[98],"(2":[99],"(12-hour":[103],"trough":[104],"level":[105],"100":[106],"150":[108],"ng/ml":[109],"fluorescence":[111],"polarization":[112],"immunoassay).":[113],"mean":[115,126,147,201],"significantly":[122,205],"higher":[123],"than":[124],"pretransplantation":[127],"(1.51":[130],"+/-":[131,135,157,213],"0.32":[132],"versus":[133],"1.28":[134],"0.38,":[136],"p":[137],"<":[138,217],"0.05)":[139],"stabilized":[141],"first":[144],"year.":[145,199],"70.6":[156],"20.3":[158],"ml/min/1.73":[159],"m2":[160],"(range":[161],"32":[162],"105)":[164],"remained":[169],"relatively":[170],"stable":[171],"during":[172],"follow-up":[174],"period":[175],"up":[177],"7":[179],"years.":[180],"Creatinine":[181],"calculated":[183],"Cockcroft":[186],"Gault":[188],"formula":[189],"overestimated":[190],"true":[192],"third":[198],"dosage":[203],"lower":[206],"first-year":[209],"dose":[210],"3.9":[212],"1.8":[214],"mg/kg/day":[215],"(p":[216],"0.05).":[218],"Three":[219],"39":[222],"started":[223],"hemodialysis":[224],"5,":[226],"7,":[227],"10":[229],"years":[230],"CONCLUSION:":[233],"Our":[234],"data":[235],"indicate":[236],"that":[237],"adequacy":[239],"preserved":[244],"long-term":[246],"therapy":[248]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
