{"id":"https://openalex.org/W2596710319","doi":null,"title":"Probiotic therapy alleviates hyperuricemia in C57BL/6 mouse model","display_name":"Probiotic therapy alleviates hyperuricemia in C57BL/6 mouse model","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2596710319","mag":"2596710319"},"language":"en","primary_location":{"id":"mag:2596710319","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/probiotic-therapy-alleviates-hyperuricemia-in-c57bl6-mouse-model.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010059812","display_name":"Tong Cao","orcid":"https://orcid.org/0000-0002-1442-3122","observed_orcids":["https://orcid.org/0000-0002-1442-3122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tong Cao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1442-3122","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786535","display_name":"Xiaoyu Li","orcid":"https://orcid.org/0000-0003-4872-6110","observed_orcids":["https://orcid.org/0000-0003-4872-6110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyu Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4872-6110","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114058497","display_name":"Tao Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321326","display_name":"Hua Liu","orcid":"https://orcid.org/0000-0003-0358-8455","observed_orcids":["https://orcid.org/0000-0003-0358-8455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0358-8455","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100952898","display_name":"Qing-Xi Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-Xi Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101770614","display_name":"Xueli Ding","orcid":"https://orcid.org/0000-0003-4021-2246","observed_orcids":["https://orcid.org/0000-0003-4021-2246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueli Ding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4021-2246","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101697762","display_name":"Changgui Li","orcid":"https://orcid.org/0000-0002-4622-3731","observed_orcids":["https://orcid.org/0000-0002-4622-3731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changgui Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4622-3731","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444047","display_name":"Lijuan Zhang","orcid":"https://orcid.org/0000-0002-4357-6566","observed_orcids":["https://orcid.org/0000-0002-4357-6566","https://orcid.org/0000-0002-3234-6757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijuan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1325-2437","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100654003","display_name":"Zibin Tian","orcid":"https://orcid.org/0000-0002-3211-2934","observed_orcids":["https://orcid.org/0000-0002-3211-2934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zibin Tian","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3211-2934","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2094,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77485967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"5","first_page":"2244","last_page":"2249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/probiotic-therapy","display_name":"probiotic therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactobacilli","display_name":"lactobacilli","score":1.0},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.8159999847412109},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.984000027179718},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8960000276565552},{"id":"https://openalex.org/keywords/16s-rrna-gene","display_name":"16S rRNA gene","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.9641892313957214},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.7342109084129333},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.6069096326828003},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.5643590092658997},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.546117901802063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.413382351398468},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3781065046787262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3662749230861664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2568023204803467},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24308666586875916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17571964859962463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06534656882286072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2596710319","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/probiotic-therapy-alleviates-hyperuricemia-in-c57bl6-mouse-model.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W652021775","https://openalex.org/W1074809087","https://openalex.org/W1538878282","https://openalex.org/W1970035161","https://openalex.org/W2024107091","https://openalex.org/W2055765490","https://openalex.org/W2071730213","https://openalex.org/W2074027560","https://openalex.org/W2098146588","https://openalex.org/W2107144085","https://openalex.org/W2109744701","https://openalex.org/W2117130914","https://openalex.org/W2119021947","https://openalex.org/W2129917444","https://openalex.org/W2150326634","https://openalex.org/W2155917733","https://openalex.org/W2192830081","https://openalex.org/W2465917350","https://openalex.org/W2503096174"],"related_works":["https://openalex.org/W4224297222","https://openalex.org/W4390231854","https://openalex.org/W4404538825","https://openalex.org/W4393081361","https://openalex.org/W4385473264","https://openalex.org/W4407243478","https://openalex.org/W4400697438","https://openalex.org/W4407525932","https://openalex.org/W7201955597","https://openalex.org/W4412998190"],"abstract_inverted_index":{"Aim:":[0],"The":[1,44,101,146],"present":[2,147],"study":[3,148],"is":[4],"to":[5,131],"investigate":[6],"differences":[7],"in":[8,40,97,107,127,168],"gut":[9,155],"bacteria":[10],"especially":[11],"bifidobacteria":[12,31,81,104],"and":[13,19,32,55,82,92,105,121,154,160],"lactobacilli":[14,33,106],"between":[15,152],"C57BL/6":[16,53,67],"mice":[17,54,112,129],"with":[18,30],"without":[20],"hyperuricemia,":[21],"as":[22,24],"well":[23],"the":[25,41,150,161],"effect":[26,162],"of":[27,47,80,103,133,143,163],"probiotic":[28,144,164],"therapy":[29,165],"on":[34,166],"hyperuricemia-associated":[35],"serum":[36,98],"markers":[37],"over":[38,158],"time":[39,159],"mouse":[42,45,169],"model.\r\nMethods:":[43],"model":[46],"hyperuricemia":[48,153,167],"was":[49,60,113],"established":[50],"by":[51],"using":[52],"a":[56],"reported":[57],"protocol.":[58],"DNA":[59],"extracted":[61],"from":[62,66,110],"fecal":[63,108],"samples":[64,109],"collected":[65],"mice.":[68,135],"Specific":[69],"primers":[70],"for":[71,77],"16S":[72],"rRNA":[73],"gene":[74],"were":[75,99,124,138],"designed":[76],"PCR-based":[78],"detection":[79],"lactobacilli,":[83],"respectively.":[84],"Uric":[85],"acid":[86],"(UA)":[87],"level,":[88,91,118],"lipopolysaccharides":[89],"(LPS)":[90],"xanthine":[93],"oxidase":[94],"(XO)":[95],"activity":[96],"measured.\r\nResults:":[100],"amount":[102],"hyperuricemic":[111,128],"significantly":[114,125],"decreased,":[115],"while":[116],"UA":[117],"XO":[119],"activity,":[120],"LPS":[122],"level":[123],"increased":[126],"compared":[130],"those":[132],"normal":[134],"These":[136],"changes":[137,157],"attenuated":[139],"after":[140],"five":[141],"weeks":[142],"therapy.\r\nConclusion:":[145],"demonstrates":[149],"relationship":[151],"microbial":[156],"model.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-23T00:00:00"}