{"id":"https://openalex.org/W2596571283","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","title":"Phase I study of nab-paclitaxel (NP) in combination with biochemotherapy (BCT) in patients (pts) with metastatic melanoma (MM).","display_name":"Phase I study of nab-paclitaxel (NP) in combination with biochemotherapy (BCT) in patients (pts) with metastatic melanoma (MM).","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W2596571283","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","mag":"2596571283"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.e19009","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061848220","display_name":"Anas Alrwas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anas Alrwas","raw_affiliation_strings":["Unversity of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unversity of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103439037","display_name":"Nicholas E. Papadopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Papadopoulos","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072276912","display_name":"Suzanne Cain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Cain","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035218748","display_name":"Sapna Pradyuman Patel","orcid":"https://orcid.org/0000-0003-1339-1517","observed_orcids":["https://orcid.org/0000-0003-1339-1517"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sapna Pradyuman Patel","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015498468","display_name":"Kevin B. Kim","orcid":"https://orcid.org/0000-0003-0694-0530","observed_orcids":["https://orcid.org/0000-0003-0694-0530"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin B. Kim","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052847871","display_name":"Tawania L Deburr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tawania L Deburr","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027845051","display_name":"Roland L. Bassett","orcid":"https://orcid.org/0000-0002-4534-2042","observed_orcids":["https://orcid.org/0000-0002-4534-2042"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland Bassett","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110089","display_name":"Wen\u2010Jen Hwu","orcid":"https://orcid.org/0000-0003-1674-0751","observed_orcids":["https://orcid.org/0000-0003-1674-0751"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Jen Hwu","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060563693","display_name":"Agop Y. Bedikian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agop Y. Bedikian","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Davies","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006246174","display_name":"Scott Eric Woodman","orcid":"https://orcid.org/0000-0002-1157-6991","observed_orcids":["https://orcid.org/0000-0002-1157-6991"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Eric Woodman","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033798832","display_name":"Patrick Hwu","orcid":"https://orcid.org/0000-0002-8293-1313","observed_orcids":["https://orcid.org/0000-0002-8293-1313","https://orcid.org/0000-0003-0554-2856"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Hwu","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"e19009","last_page":"e19009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biochemotherapy","display_name":"biochemotherapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":1.0},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9950000047683716},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6000000238418579},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.41499999165534973},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.628000020980835},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9225989580154419},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.6370944976806641},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5653631687164307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5234469771385193},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.49390536546707153},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47186654806137085},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4511515200138092},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4439544677734375},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39530354738235474},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36253559589385986},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.36240842938423157},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35192006826400757},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33752739429473877}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.e19009","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.e19009","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087160901","https://openalex.org/W2480251737","https://openalex.org/W2560814985","https://openalex.org/W2058667907","https://openalex.org/W2249275183","https://openalex.org/W2037221770","https://openalex.org/W1969738419","https://openalex.org/W2028607345","https://openalex.org/W2244771852","https://openalex.org/W2385554572"],"abstract_inverted_index":{"e19009":[0],"Background:":[1],"NP":[2,24,92,202,239,351],"has":[3],"shown":[4],"anti-tumor":[5,46],"activity":[6,47,360],"in":[7,9,51,56,172,190,262],"MM":[8,67],"a":[10,178,353],"phase":[11],"II":[12],"trial.":[13],"The":[14,106,127,308,315],"objective":[15],"of":[16,23,27,30,48,76,82,103,129,133,152,174,180,220,241,244,300,332,350,355,374],"this":[17,49,366],"study":[18],"was":[19,93,111,120,170,199,260,273,311,319],"to":[20,43,177,269,343],"determine":[21,344],"MTD":[22],"as":[25,352],"part":[26,354],"BCT,":[28],"consisted":[29,132],"cisplatin":[31],"(C),":[32],"temozolomide":[33],"(T),":[34],"interleukin-2":[35],"(IL2)":[36],"and":[37,53,84,86,101,115,161,210,281,297,348],"interferon-alpha":[38],"(IFN).":[39],"Secondary":[40],"objectives":[41],"were":[42,90,187,208,284],"evaluate":[44],"the":[45,80,116,130,191,224,234,256,345,364,372],"combination":[50,367],"MM,":[52],"its":[54],"benefit":[55],"preventing":[57],"central":[58],"nervous":[59],"system":[60],"(CNS)":[61],"metastasis":[62],"(mets).":[63],"Methods:":[64],"Previously":[65],"untreated":[66],"patients":[68,264],"evaluable":[69,211,302],"by":[70],"RECIST":[71],"1.0":[72],"with":[73,87,327],"no":[74,274],"history":[75],"CNS":[77,325,375],"mets":[78,326],"between":[79],"ages":[81],"18":[83],"65":[85],"ECOG":[88],"0-1":[89],"enrolled.":[91],"given":[94],"intravenously":[95],"(IV)":[96],"on":[97,109,118,361],"Day":[98],"(d)":[99],"1":[100],"5":[102,163,221,245,258,276],"each":[104],"cycle.":[105,193],"starting":[107,225],"dose":[108,117,226,240,249,259],"d1":[110,203,238],"100":[112],"mg/":[113,122,137,144],"m2,":[114,123],"d5":[119],"70":[121],"if":[124],"toxicities":[125,230,283],"permitted.":[126],"remainder":[128],"regimen":[131],"IV":[134,156],"C":[135],"20":[136],"m2":[138,145],"daily":[139],"d1-4,":[140],"oral":[141],"T":[142],"250":[143],"d1-3,":[146],"9":[147,301],"million":[148],"international":[149],"units":[150],"(MIU)/m2":[151],"IL2":[153],"via":[154,165],"continuous":[155],"infusion":[157],"for":[158,201,212],"96":[159],"hours,":[160],"IFN":[162],"MIU/m2":[164],"subcutaneous":[166],"injection":[167],"d1-5.":[168],"Treatment":[169],"repeated":[171],"cycles":[173],"21":[175],"d":[176],"maximum":[179],"6":[181],"cycles.":[182],"Prophylactic":[183],"hematologic":[184],"growth":[185],"factors":[186],"not":[188,370],"allowed":[189],"first":[192],"A":[194],"standard":[195],"3+3":[196],"escalation":[197],"method":[198],"used":[200],"dose.":[204],"Results:":[205],"Ten":[206],"pts":[207,222,246,303,323],"enrolled":[209],"toxicities.":[213],"Five":[214,299],"completed":[215],"six":[216],"courses.":[217],"Because":[218],"2":[219],"at":[223,247],"level":[227,250],"had":[228,251,304],"dose-limiting":[229],"(DLTs)":[231],"(diarrhea;":[232],"transaminasemia-TA),":[233],"next":[235],"cohort":[236],"received":[237],"80mg/m2.":[242],"Two":[243],"that":[248],"DLTs":[252],"(TA;":[253],"neutropenia).":[254],"Overall,":[255],"day":[257],"omitted":[261],"3":[263,280],"post":[265],"third":[266],"cycle":[267],"due":[268],"thrombocytopenia":[270],"(TP).":[271],"There":[272],"grade":[275,279],"toxicity.":[277],"Common":[278],"4":[282],"leucopenia,":[285],"neutropenia,":[286],"lymphopenia,":[287],"anemia,":[288],"TP,":[289],"hyponatremia,":[290],"diarrhea,":[291],"skin":[292],"rash,":[293],"infection,":[294],"tinnitus,":[295],"neuropathy":[296],"TA.":[298],"partial":[305],"response":[306],"(PR).":[307],"median":[309,316,330],"time-to-progression":[310],"5.3":[312],"months":[313],"(m).":[314],"overall":[317,329],"survival":[318],"8.73":[320],"m.":[321],"Six":[322],"developed":[324],"an":[328],"time":[331],"5.33":[333],"m":[334],"from":[335],"treatment":[336],"start.":[337],"Conclusions:":[338],"Additional":[339],"studies":[340],"are":[341],"needed":[342],"optimal":[346],"dosing":[347],"schedule":[349],"BCT.":[356],"Despite":[357],"significant":[358],"antitumor":[359],"sites":[362],"outside":[363],"CNS,":[365],"therapy":[368],"did":[369],"prevent":[371],"development":[373],"mets.":[376]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-03-23T00:00:00"}