{"id":"https://openalex.org/W2596410359","doi":"https://doi.org/10.1182/blood.v118.21.1823.1823","title":"The Interaction of Response and FISH-Based Risk Stratification to Better Define Clinical Outcome in Myeloma","display_name":"The Interaction of Response and FISH-Based Risk Stratification to Better Define Clinical Outcome in Myeloma","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2596410359","doi":"https://doi.org/10.1182/blood.v118.21.1823.1823","mag":"2596410359"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v118.21.1823.1823","doi":"https://doi.org/10.1182/blood.v118.21.1823.1823","is_oa":false,"landing_page_url":"http://doi.org/10.1182/blood.v118.21.1823.1823","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34176969","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016899907","display_name":"Kevin D. Boyd","orcid":"https://orcid.org/0000-0002-5362-6934","observed_orcids":["https://orcid.org/0000-0002-5362-6934"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin D Boyd","raw_affiliation_strings":["Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109919329","display_name":"Fiona M. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fiona M Ross","raw_affiliation_strings":["Wessex Regional Genetics Lab., University of Southampton, Salisbury, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wessex Regional Genetics Lab., University of Southampton, Salisbury, United Kingdom,","institution_ids":["https://openalex.org/I4210129558","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053100242","display_name":"Mark Trehane Drayson","orcid":"https://orcid.org/0000-0002-1528-7564","observed_orcids":["https://orcid.org/0000-0002-1528-7564"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark T Drayson","raw_affiliation_strings":["School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom,","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063301766","display_name":"Roger G. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger G Owen","raw_affiliation_strings":["St James's Institute of Oncology, St James's University Hospital, Leeds, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Institute of Oncology, St James's University Hospital, Leeds, United Kingdom,","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012570136","display_name":"Alexander J. Szubert","orcid":"https://orcid.org/0000-0002-2082-0861","observed_orcids":["https://orcid.org/0000-0002-2082-0861"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex J Szubert","raw_affiliation_strings":["Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017165070","display_name":"Walter Martin Gregory","orcid":"https://orcid.org/0000-0003-2641-8416","observed_orcids":["https://orcid.org/0000-0003-2641-8416"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Walter M Gregory","raw_affiliation_strings":["Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher P Wardell","raw_affiliation_strings":["Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faith E Davies","raw_affiliation_strings":["Division of Cancer Therapeutics, Molecular Pathology and Clinical Studies, Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Therapeutics, Molecular Pathology and Clinical Studies, Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081247376","display_name":"Graham Hunter Jackson","orcid":"https://orcid.org/0000-0003-0756-969X","observed_orcids":["https://orcid.org/0000-0003-0756-969X"]},"institutions":[{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham H Jackson","raw_affiliation_strings":["Department of Clinical Haematology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Haematology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I2801663869","https://openalex.org/I4210124950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110596384","display_name":"J. Anthony Child","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Anthony Child","raw_affiliation_strings":["Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom,","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth J Morgan","raw_affiliation_strings":["Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39423077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"21","first_page":"1823","last_page":"1823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.9779999852180481},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/international-staging-system","display_name":"International Staging System","score":0.8159999847412109},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8980000019073486},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7400000095367432},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.7710000276565552},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7909994125366211},{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.7180560231208801},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7052082419395447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.658379316329956},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.609495997428894},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5349295139312744},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47675570845603943},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.471162885427475},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4678885042667389},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.37387627363204956},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3548099994659424},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.323167085647583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06849810481071472},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.v118.21.1823.1823","doi":"https://doi.org/10.1182/blood.v118.21.1823.1823","is_oa":false,"landing_page_url":"http://doi.org/10.1182/blood.v118.21.1823.1823","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10027111","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10027111/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: (Proceedings) 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis. (pp. p. 795). AMER SOC HEMATOLOGY (2011)","raw_type":"Proceedings paper"},{"id":"doi:10.25405/ncl.34176969","doi":"https://doi.org/10.25405/ncl.34176969","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34176969","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ConferenceProceeding"},{"id":"doi:10.25405/ncl.34176969.v1","doi":"https://doi.org/10.25405/ncl.34176969.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34176969.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ConferenceProceeding"}],"best_oa_location":{"id":"doi:10.25405/ncl.34176969","doi":"https://doi.org/10.25405/ncl.34176969","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34176969","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ConferenceProceeding"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205646897","https://openalex.org/W3212546625","https://openalex.org/W2046408556","https://openalex.org/W1991660588","https://openalex.org/W7097227585","https://openalex.org/W3012512668","https://openalex.org/W2562685394","https://openalex.org/W2993736637","https://openalex.org/W2276757615","https://openalex.org/W2139260559"],"abstract_inverted_index":{"Abstract":[0,1],"1823":[2],"Background:":[3],"The":[4,18,315,344,519,561,612],"achievement":[5,59,328,548],"of":[6,60,75,80,89,145,234,244,251,280,317,329,347,430,461,481,512,521,549,554,563,614,628],"a":[7,66,90,121,131,193,277,296,401,422,571],"complete":[8],"response":[9,38,419],"(CR)":[10],"is":[11,34,62,483,617],"an":[12,457,484,575,635],"important":[13,64,186,485],"prognostic":[14,83,246,345,354,486,507],"factor":[15,439,487],"in":[16,65,77,85,98,187,241,341,352,362,377,394,421,492,503,558],"myeloma.":[17],"international":[19],"staging":[20],"system":[21],"(ISS)":[22],"and":[23,115,148,160,177,208,313,327,376,393,397,444,497,516,534],"tumor":[24],"genetic":[25,161,274,542,596],"lesions":[26,162,255,275,294,320,368,434,515,543],"detected":[27],"by":[28,43,128,547],"FISH":[29,254,293,319,367,391,433,452,514,568],"also":[30,529],"impact":[31,346],"survival.":[32],"It":[33],"not":[35,226,257,410,545],"known":[36],"whether":[37,46],"rates":[39,238,262,584],"are":[40],"adversely":[41],"affected":[42],"these":[44,55,81,540,586,615,642],"factors,":[45,56],"achieving":[47,348,414,580],"CR":[48,61,76,183,194,210,261,278,298,330,349,356,407,415,482,583],"overcomes":[49],"the":[50,73,78,86,188,242,249,426,428,436,535,552,555,625],"adverse":[51,165,273,292,318,366,390,451,513,541,567,595],"prognosis":[52],"associated":[53,163,213,227,258,337,358,440,455,488,531,538],"with":[54,130,164,192,214,228,259,291,338,359,364,389,406,441,447,456,489,495,505,532,539,574,634],"or":[57,123,267,463,526],"if":[58],"more":[63,448,564],"specific":[67],"biological":[68],"subgroup.":[69],"We":[70],"have":[71],"examined":[72],"importance":[74],"context":[79,243,553],"other":[82,245],"factors":[84,508],"intensive":[87],"arm":[88],"phase":[91],"III":[92],"randomized":[93,119],"trial,":[94],"MRC":[95],"Myeloma":[96],"IX,":[97],"which":[99,283],"all":[100],"patients":[101,191,290,363,388,413,493,504,589,593],"were":[102,118,170,200,239,335,454,590,601],"planned":[103],"to":[104,106,120,134,202,285,301,592,603,623],"proceed":[105],"autologous":[107],"stem":[108],"cell":[109],"transplant":[110],"(ASCT)":[111],"after":[112,143,608],"induction.":[113],"Patients":[114,117,271,446],"Methods:":[116],"conventional":[122],"thalidomide-based":[124],"induction":[125,146,264],"regimen":[126],"followed":[127],"ASCT,":[129,496],"second":[132],"randomization":[133],"maintenance":[135],"thalidomide":[136],"versus":[137],"no":[138,308,365],"maintenance.":[139],"Response":[140,237],"was":[141,153,184,211,225,256,307,350,357,400,409,435,500,528,544,610],"assessed":[142,240,351],"completion":[144],"therapy":[147,265,609],"100":[149,196],"days":[150,197],"post-ASCT.":[151,287],"iFISH":[152],"performed":[154],"on":[155],"diagnostic":[156],"bone":[157],"marrow":[158],"samples":[159],"progression":[166,462],"free":[167],"survival":[168],"(PFS)":[169],"defined":[171],"as":[172,416,510],"t(4;14),":[173,522],"t(14;16),":[174,523],"t(14;20),":[175,524],"+1q":[176,525],"17p-.":[178],"Results:":[179],"To":[180],"confirm":[181],"that":[182,408,479,599,618],"prognostically":[185],"data":[189,477,616],"set,":[190],"at":[195,231,640],"post-ASCT":[198],"(N=355)":[199],"compared":[201],"non-CR":[203],"(N=344)":[204],"(comprising":[205],"VGPR,":[206],"PR":[207],"SD).":[209],"strongly":[212,530],"improved":[215,229,284,339,360,404,490],"PFS":[216,340,361,370,381,405,443,491],"(median":[217],"30.8":[218],"months":[219],"vs":[220,372,383],"38.7":[221],"months,":[222,374,385],"P<0.001)":[223,326],"but":[224,605],"OS":[230,470],"median":[232],"follow-up":[233],"3.7":[235],"years.":[236],"factors.":[247],"Interestingly,":[248],"presence":[250,429,520,562],"high":[252,431,459,587,631],"risk":[253,432,460,588,632],"impaired":[260,442,536],"following":[263,268],"(P=0.584)":[266],"ASCT":[269],"(P=0.314).":[270],"without":[272,594],"had":[276,295],"rate":[279],"11.1%":[281],"post-induction":[282],"48.3%":[286],"In":[288,387],"comparison,":[289],"13.3%":[297],"rate,":[299],"rising":[300],"44.9%":[302],"post":[303],"ASCT.":[304],"Similarly,":[305],"there":[306,399],"correlation":[309],"between":[310],"ISS":[311,378,395,517],"stage":[312],"response.":[314],"absence":[316],"(hazard":[321],"ratio":[322],"(HR)":[323],"2.68":[324],"(1.94-3.70)":[325],"(HR":[331],"1.58":[332],"(1.15-2.17)":[333],"P=0.005)":[334],"independently":[336],"multivariate":[342,423],"analysis.":[343],"various":[353],"groups.":[355],"(N=179)(median":[369],"58.4":[371],"37.1":[373],"P=0.031),":[375],"I":[379],"(N=182)(median":[380],"51.2":[382],"33.2":[384],"P=0.008).":[386],"lesions,":[392],"II":[396],"III,":[398],"trend":[402],"towards":[403],"significant.":[411],"For":[412],"their":[417],"maximum":[418],"(N=398),":[420],"analysis":[424],"including":[425],"ISS,":[427],"most":[437,501],"significant":[438,502],"OS.":[445],"than":[449,565],"1":[450,566],"lesion":[453,569],"especially":[458,576],"death":[464],"(PFS":[465],"HR":[466,471],"6.63":[467],"(3.23-13.53)":[468],"P<0.001;":[469],"5.35":[472],"(1.98-14.45)":[473],"P=0.001).":[474],"Conclusion:":[475],"These":[476],"show":[478],"attainment":[480],"treated":[494],"this":[498,559,629],"benefit":[499],"favorable":[506],"such":[509],"lack":[511],"I.":[518],"17p-":[527],"PFS,":[533],"outcome":[537,627],"overcome":[546],"CR,":[550],"within":[551,585],"therapies":[556],"used":[557],"trial.":[560],"identified":[570],"patient":[572],"group":[573,633],"poor":[577,626],"prognosis,":[578],"despite":[579],"CR.":[581],"However,":[582],"similar":[591],"features,":[597],"showing":[598],"they":[600],"sensitive":[602],"chemotherapy,":[604],"progressed":[606],"quickly":[607],"stopped.":[611],"implication":[613],"it":[619],"may":[620],"be":[621],"possible":[622],"improve":[624],"genetically-defined":[630],"alternative":[636],"treatment":[637],"strategy":[638],"aimed":[639],"maintaining":[641],"responses.":[643],"Disclosures:":[644],"Gregory:":[645],"Celgene:":[646],"Honoraria.":[647,649],"Child:Celgene:":[648]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-23T00:00:00"}