{"id":"https://openalex.org/W2596095744","doi":"https://doi.org/10.1182/blood.v124.21.640.640","title":"The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment","display_name":"The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2596095744","doi":"https://doi.org/10.1182/blood.v124.21.640.640","mag":"2596095744"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.640.640","doi":"https://doi.org/10.1182/blood.v124.21.640.640","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.640.640","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34245927.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035296945","display_name":"Lorenzo Melchor","orcid":"https://orcid.org/0000-0002-5322-2817","observed_orcids":["https://orcid.org/0000-0002-5322-2817"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lorenzo Melchor","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112032670","display_name":"Alexander J. Murison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexander Murison","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013925872","display_name":"Eileen Mary Boyle","orcid":"https://orcid.org/0000-0001-8791-1744","observed_orcids":["https://orcid.org/0000-0001-8791-1744"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Eileen M Boyle","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher P Wardell","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058317897","display_name":"John R Jones","orcid":"https://orcid.org/0000-0002-1401-6105","observed_orcids":["https://orcid.org/0000-0002-1401-6105"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John Jones","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073477610","display_name":"Martin Kaiser","orcid":"https://orcid.org/0000-0002-3677-4804","observed_orcids":["https://orcid.org/0000-0002-3677-4804"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin F Kaiser","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072977279","display_name":"Charlotte Pawlyn","orcid":"https://orcid.org/0000-0002-7190-0028","observed_orcids":["https://orcid.org/0000-0002-7190-0028"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte Pawlyn","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108460251","display_name":"David C. Johnson","orcid":"https://orcid.org/0000-0003-0887-3343","observed_orcids":["https://orcid.org/0000-0003-0887-3343"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David C Johnson","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110454718","display_name":"Dil B Begum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dil Begum","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012010653","display_name":"Paula Proszek","orcid":"https://orcid.org/0000-0002-0780-6790","observed_orcids":["https://orcid.org/0000-0002-0780-6790"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paula Proszek","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113496610","display_name":"Nasrin B. Dahir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nasrin Dahir","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042419236","display_name":"David Allan Cairns","orcid":"https://orcid.org/0000-0002-2338-0179","observed_orcids":["https://orcid.org/0000-0002-2338-0179"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David A Cairns","raw_affiliation_strings":["University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017165070","display_name":"Walter Martin Gregory","orcid":"https://orcid.org/0000-0003-2641-8416","observed_orcids":["https://orcid.org/0000-0003-2641-8416"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Walter Gregory","raw_affiliation_strings":["University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063301766","display_name":"Roger G. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger G Owen","raw_affiliation_strings":["St James's University Hospital, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's University Hospital, Leeds, United Kingdom","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038580329","display_name":"Gordon Cook","orcid":"https://orcid.org/0000-0003-1717-0412","observed_orcids":["https://orcid.org/0000-0003-1717-0412"]},"institutions":[{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon Cook","raw_affiliation_strings":["Leeds Teaching Hospitals Trust, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Teaching Hospitals Trust, Leeds, United Kingdom","institution_ids":["https://openalex.org/I2799390153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053100242","display_name":"Mark Trehane Drayson","orcid":"https://orcid.org/0000-0002-1528-7564","observed_orcids":["https://orcid.org/0000-0002-1528-7564"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark T Drayson","raw_affiliation_strings":["University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081247376","display_name":"Graham Hunter Jackson","orcid":"https://orcid.org/0000-0003-0756-969X","observed_orcids":["https://orcid.org/0000-0003-0756-969X"]},"institutions":[{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham H Jackson","raw_affiliation_strings":["Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I4210124950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Faith E Davies","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom","University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian A Walker","raw_affiliation_strings":["The Royal Marsden NHS FT, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden NHS FT, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Gareth J. Morgan","raw_affiliation_strings":["The Institute of Cancer Research, London, United Kingdom","University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5012010653","https://openalex.org/A5013925872","https://openalex.org/A5017165070","https://openalex.org/A5035296945","https://openalex.org/A5042419236","https://openalex.org/A5058317897","https://openalex.org/A5073477610","https://openalex.org/A5084133067","https://openalex.org/A5108460251","https://openalex.org/A5110454718","https://openalex.org/A5112032670","https://openalex.org/A5113496610"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I142947616"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2357,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65631362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"124","issue":"21","first_page":"640","last_page":"640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clonal-diversity","display_name":"clonal diversity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7210000157356262},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apobec-signature","display_name":"APOBEC signature","score":0.9089999794960022},{"id":"https://openalex.org/keywords/myc-mutations","display_name":"MYC mutations","score":0.47600001096725464},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7039637565612793},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.674461841583252},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6543142795562744},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5662776231765747},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.48916223645210266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48191383481025696},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.42285510897636414},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34068286418914795},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33887192606925964},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2940561771392822},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2788048982620239},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.20950394868850708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16793745756149292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15293416380882263}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v124.21.640.640","doi":"https://doi.org/10.1182/blood.v124.21.640.640","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.640.640","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.25405/ncl.34245927.v1","doi":"https://doi.org/10.25405/ncl.34245927.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34245927.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ConferenceProceeding"}],"best_oa_location":{"id":"doi:10.25405/ncl.34245927.v1","doi":"https://doi.org/10.25405/ncl.34245927.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34245927.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ConferenceProceeding"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2581357176","https://openalex.org/W2004300203","https://openalex.org/W3092899955","https://openalex.org/W2559098034","https://openalex.org/W2320865288","https://openalex.org/W2535451111","https://openalex.org/W2530506542","https://openalex.org/W2559298228","https://openalex.org/W3213175207","https://openalex.org/W2023833346"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"myeloma":[2,29,63,103,371,434,616,622],"(MM)":[3],"is":[4,40,660,676],"a":[5,80,92,179,185,300,327,475,501,541,558,565,576],"disease":[6,44],"characterized":[7],"by":[8],"the":[9,16,25,34,41,51,57,84,96,112,128,133,223,227,232,265,413,426,440,444,471,624,661,665],"abnormal":[10],"proliferation":[11],"of":[12,27,56,61,83,99,102,162,174,181,195,199,226,229,235,267,303,321,332,337,429,443,448,456,460,480,486,495,547,552,573,578,615,626,649,667,674],"plasma":[13,617],"cells":[14,164,549,574,618],"in":[15,127,178,239,287,330,370,415,432,450,478,604,644,678],"bone":[17],"marrow.":[18],"We":[19,247,365,423,641],"and":[20,48,53,59,88,121,156,172,206,211,231,243,254,308,379,387,419,438,446,518,597,611,635,681],"others":[21],"have":[22,540,636,642,652],"recently":[23],"demonstrated":[24,643],"existence":[26],"different":[28,62,193,631],"subclones":[30,64,175,449,633],"phylogenetically":[31],"related":[32],"to":[33,94,106,148,221,639],"founding":[35],"clone.":[36],"This":[37],"intra-clonal":[38],"heterogeneity":[39],"basis":[42],"for":[43,138,545,569],"progression,":[45],"treatment":[46],"resistance,":[47],"relapse.":[49],"However,":[50],"clinical":[52,224,654],"biological":[54],"relevance":[55],"presence":[58,171],"diversity":[60,209,234,447,498,599,651,669],"has":[65],"not":[66,349,539],"been":[67],"fully":[68],"established.":[69],"In":[70],"this":[71,433,645,659],"study,":[72],"we":[73,219,275,315],"used":[74,126,147],"whole":[75],"exome":[76,129],"sequencing":[77,610],"(WES)":[78],"plus":[79],"pull":[81],"down":[82],"MYC,":[85],"IGH,":[86],"IGL":[87],"IGK":[89],"loci":[90],"as":[91,464,671],"tool":[93],"analyze":[95],"largest":[97],"series":[98,435],"presenting":[100],"cases":[101],"(463":[104],"patients)":[105],"date,":[107],"which":[108,190],"were":[109,125,146,176,392,468],"entered":[110],"into":[111],"Myeloma":[113],"XI":[114],"trial":[115],"(NCT01554852).":[116],"DNA":[117],"from":[118,608],"both":[119,377],"tumor":[120,163,650],"peripheral":[122],"blood":[123],"samples":[124,268],"capture":[130],"protocol":[131],"following":[132],"SureSelect":[134],"Target":[135],"Enrichment":[136],"System":[137],"Illumina":[139],"Paired-End":[140],"Sequencing":[141],"Library":[142],"v1.5.":[143],"Exome":[144],"reads":[145],"call":[149],"single":[150,612],"nucleotide":[151],"variants":[152],"(SNVs),":[153],"indels,":[154],"translocations,":[155],"copy":[157],"number":[158,198,228,302,320,428,445,459],"aberrations.":[159],"The":[160,170,453],"proportion":[161,173],"containing":[165],"an":[166,281,627],"SNV":[167],"was":[168,436,462,474],"inferred.":[169],"defined":[177],"subset":[180],"437":[182],"patients":[183,251,279,294,317,491,536],"using":[184],"genetic":[186,203,297],"algorithm":[187],"based-tool":[188],"(GAUCHO),":[189],"also":[191],"calculated":[192],"indices":[194,670],"clonal":[196,378,396,668],"diversity:":[197],"clones,":[200],"mean":[201],"pairwise":[202],"divergence,":[204],"Shannon":[205],"Inverse":[207],"Simpson":[208,497],"index":[210,499],"Berger-Parker":[212,553],"dominance":[213],"index.":[214],"Based":[215],"on":[216],"these":[217,296],"results,":[218],"aimed":[220],"determine":[222],"implications":[225],"mutations":[230,259,286,292,305,322,373],"subclonal":[233,380,403,421,487,598],"MM":[236,250,278,451,490,535,548],"at":[237,376,395,530],"presentation":[238],"progression":[240,350,675],"free":[241,351],"(PFS)":[242],"overall":[244],"survival":[245,352],"(OS).":[246],"found":[248,276],"that":[249,277,325,425,594,621,647,664],"with":[252,280,285,299,318,372,492,564,575],"t(14;16)":[253],"t(14;20)":[255],"had":[256,289,326,500,557,623],"more":[257,291,570,682],"exonic":[258],"(not":[260],"including":[261],"Ig":[262],"variants)":[263],"than":[264,293,562,571],"rest":[266],"(median":[269,353,505],"87":[270],"versus":[271],"43,":[272],"p<0.001).":[273],"Additionally,":[274],"APOBEC":[282],"signature":[283],"or":[284,400,402],"ATM/ATR":[288],"significantly":[290,502,559],"without":[295],"lesions":[298],"median":[301,427,577],"137":[304],"(range":[306,310],"20-569)":[307],"84.5":[309],"33-319)":[311],"respectively":[312],"(p<0.001).":[313],"Subsequently,":[314],"identified":[316],"high":[319,458,493],"(>59":[323],"mutations)":[324],"worse":[328],"outcome":[329,481],"terms":[331,479],"OS":[333,335,519],"(2-year":[334],"rate":[336],"71%":[338],"(95%":[339,344,355,360,507,513,521,526,580,586],"CI,":[340,345,361,508,514,522,527,581,587],"63-80%)":[341],"vs.":[342,358,510,524,583],"82%":[343],"78-87%),":[346],"p=0.02),":[347],"but":[348],"22.5":[354],"CI":[356],"18.7-30.2)":[357],"27.5":[359,584],"25.8-30.5)":[362],"months,":[363,516],"p=0.1)":[364],"reported":[366],"recurrent":[367],"mutated":[368,393],"genes":[369,391],"being":[374],"present":[375,431],"levels":[381,404],"(IRF4,":[382],"RB1,":[383],"DIS3,":[384],"BRAF,":[385],"KRAS,":[386],"NRAS),":[388],"whereas":[389],"other":[390],"only":[394],"(HIST1H1E,":[397],"LTB,":[398],"TP53":[399],"EGR1),":[401],"(CYLD,":[405],"TRAF3,":[406],"MAX).":[407],"These":[408],"results":[409,592],"give":[410],"insights":[411],"about":[412],"differences":[414,467],"mutation":[416],"acquisition":[417],"times":[418],"potential":[420],"fitness.":[422],"inferred":[424],"clones":[430,461],"5,":[437],"determined":[439],"prognostic":[441,454,602],"value":[442],"patients.":[452],"impact":[455],"having":[457],"unclear":[463],"no":[465],"significant":[466,476],"found.":[469],"On":[470],"contrary,":[472],"there":[473],"difference":[477],"when":[482],"calculating":[483],"distinct":[484],"measurements":[485],"diversity.":[488],"Briefly,":[489],"values":[494,551],"inverse":[496],"poorer":[503],"PFS":[504,561],"13.2":[506],"9.4-\u221e)":[509],"26.9":[511],"months":[512,585],"24-30.2)":[515],"p=0.02)":[517],"(66%":[520],"52-82%)":[523],"81%":[525],"77-85%)":[528],"alive":[529],"2-years,":[531],"p=0.01);":[532],"and,":[533],"alternatively,":[534],"who":[537],"did":[538],"dominant":[542,566],"subclone":[543],"accounting":[544,568],">25%":[546],"(low":[550],"Dominance":[554],"index,":[555],"n=56)":[556],"shorter":[560],"those":[563],"clone":[567],"25%":[572],"22":[579],"12.3-26.3)":[582],"23.9-30.9)":[588],"respectively,":[589],"p=0.02.":[590],"Our":[591],"show":[593],"mutational":[595],"load":[596],"are":[600],"poor":[601],"factors":[603],"myeloma.":[605,684],"Previous":[606],"studies":[607],"massive-parallel":[609],"cell":[613],"analyses":[614],"already":[619],"revealed":[620],"features":[625],"evolutionary":[628],"ecosystem,":[629],"where":[630],"tumour":[632],"coexist":[634],"differential":[637],"response":[638],"treatment.":[640],"study":[646],"measures":[648],"important":[653],"consequences.":[655],"To":[656],"our":[657],"knowledge,":[658],"first":[662],"time":[663],"use":[666],"predictive":[672],"biomarkers":[673],"proposed":[677],"haematological":[679],"malignancies,":[680],"specifically,":[683],"Disclosures":[685],"Walker:":[686],"Onyx":[687],"Pharmaceuticals:":[688],"Consultancy,":[689],"Honoraria.":[690]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2017-03-23T00:00:00"}
