{"id":"https://openalex.org/W25960906","doi":null,"title":"Ontogeny of the immune response: effect of protein energy malnutrition in neonatal calves.","display_name":"Ontogeny of the immune response: effect of protein energy malnutrition in neonatal calves.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W25960906","mag":"25960906","pmid":"https://pubmed.ncbi.nlm.nih.gov/3134116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1255359"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:388339","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1255359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1255359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111919730","display_name":"PHILIP J. GRIEBEL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P J Griebel","raw_affiliation_strings":["Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054232530","display_name":"Matt Schoonderwoerd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Schoonderwoerd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111991298","display_name":"LORNE A. BABIUK","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Babiuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3611,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.93658981,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"51","issue":"4","first_page":"428","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-energy-malnutrition","display_name":"protein-energy malnutrition","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neonatal-calves","display_name":"neonatal calves","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immunocompetence","display_name":"immunocompetence","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.656000018119812},{"id":"https://openalex.org/keywords/neutrophilia","display_name":"neutrophilia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8560000061988831},{"id":"https://openalex.org/keywords/holstein-bull-calves","display_name":"Holstein bull calves","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.709152102470398},{"id":"https://openalex.org/C2777422395","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immunocompetence","level":3,"score":0.6687108278274536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6664876341819763},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6628220677375793},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6316302418708801},{"id":"https://openalex.org/C2779613291","wikidata":"https://www.wikidata.org/wiki/Q4082071","display_name":"Protein\u2013energy malnutrition","level":3,"score":0.5861101746559143},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5585412383079529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5237738490104675},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42993372678756714},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34213459491729736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26276424527168274}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007121","descriptor_name":"Immunocompetence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011502","descriptor_name":"Protein-Energy Malnutrition","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011502","descriptor_name":"Protein-Energy Malnutrition","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:388339","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1255359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1255359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1255359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Vet Res","raw_type":"Text"},{"id":"pmid:3134116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3134116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","raw_type":"Journal Article"},{"id":"mag:25960906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3134116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:388339","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1255359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.968500018119812},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W55124361","https://openalex.org/W103100692","https://openalex.org/W1529295180","https://openalex.org/W1841313928","https://openalex.org/W1992699376","https://openalex.org/W1993440085","https://openalex.org/W2004842826","https://openalex.org/W2036128781","https://openalex.org/W2043472897","https://openalex.org/W2048871053","https://openalex.org/W2053261198","https://openalex.org/W2055275614","https://openalex.org/W2079525639","https://openalex.org/W2081290166","https://openalex.org/W2138440262","https://openalex.org/W2143480041","https://openalex.org/W2233592857","https://openalex.org/W2396999029","https://openalex.org/W2407815207","https://openalex.org/W2423630202","https://openalex.org/W4300754164","https://openalex.org/W4313313341","https://openalex.org/W4407201242","https://openalex.org/W4407201916","https://openalex.org/W4409121539","https://openalex.org/W4409131090","https://openalex.org/W4409140203"],"related_works":["https://openalex.org/W4407201819","https://openalex.org/W172409468","https://openalex.org/W1523225539","https://openalex.org/W61966945","https://openalex.org/W2414896328","https://openalex.org/W1598363771","https://openalex.org/W1977661402","https://openalex.org/W4407201653","https://openalex.org/W2412771048","https://openalex.org/W2411786224"],"abstract_inverted_index":{"Immunocompetence":[0],"of":[1,77,135],"neonatal,":[2],"Holstein":[3],"bull":[4],"calves":[5,34,46,82],"fed":[6],"for":[7,23,39,114],"maximal":[8],"growth":[9],"(Control;":[10],"n":[11,20],"=":[12,21],"4)":[13,22],"or":[14],"protein":[15,78,102,129,137],"energy":[16,79,103,130,138],"malnutrition":[17,80,104,131,139],"feeding":[18],"(PEM;":[19],"four":[24],"weeks":[25,76,100],"was":[26,64,112,118,145,163],"assayed":[27],"in":[28,31,122],"vitro":[29],"and":[30,50,61,91,109,128],"vivo.":[32],"All":[33],"exhibited":[35],"elevated":[36],"cortisol":[37,124],"levels":[38,151],"ten":[40],"days":[41,160],"postnatally.":[42],"At":[43],"this":[44,67],"time":[45,68],"also":[47],"were":[48,155],"neutrophilic":[49],"lymphopenic.":[51],"In":[52],"addition":[53],"lymphocyte":[54,59,88,92,110],"function,":[55],"as":[56,69],"measured":[57],"by":[58],"proliferation":[60,93,111],"interleukin-2":[62,89,107],"activity,":[63],"reduced":[65],"at":[66],"compared":[70,95],"to":[71,152,158,173],"older":[72],"calves.":[73,132],"After":[74],"two":[75],"feeding,":[81],"had":[83],"significantly":[84,148],"lower":[85,149],"body":[86],"weight,":[87],"activity":[90,108],"when":[94,169],"with":[96],"age-matched":[97],"controls.":[98],"Two":[99],"after":[101],"ration":[105],"reversal,":[106],"comparable":[113],"both":[115],"groups.":[116],"There":[117,162],"no":[119,164],"significant":[120,165],"difference":[121,166],"serum":[123],"concentration":[125],"between":[126,167],"control":[127],"The":[133],"kinetics":[134],"the":[136],"group's":[140],"primary":[141],"humoral":[142],"immune":[143],"response":[144,172],"retarded,":[146],"thus":[147],"antibody":[150],"K99":[153,174],"antigen":[154],"observed":[156],"8":[157],"12":[159],"postimmunization.":[161],"groups":[168],"comparing":[170],"secondary":[171],"antigen.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}