{"id":"https://openalex.org/W2595875359","doi":null,"title":"Cardiac energetics in the isolated heart by NMR spectroscopy and mathematical modeling.","display_name":"Cardiac energetics in the isolated heart by NMR spectroscopy and mathematical modeling.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2595875359","mag":"2595875359"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:case1270221813","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103050797","display_name":"Ming Lu","orcid":"https://orcid.org/0000-0003-4639-7851","observed_orcids":["https://orcid.org/0000-0003-4639-7851"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming Lu","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":"https://orcid.org/0000-0003-4639-7851","affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103050797"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30133755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.3515999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.3515999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.1809999942779541,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.16060000658035278,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-energetics","display_name":"cardiac energetics","score":0.8659999966621399},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.6259999871253967},{"id":"https://openalex.org/keywords/malate-aspartate-shuttle","display_name":"malate-aspartate shuttle","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6439999938011169},{"id":"https://openalex.org/keywords/metabolic-modeling","display_name":"metabolic modeling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5590000152587891},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C97514900","wikidata":"https://www.wikidata.org/wiki/Q719597","display_name":"Energetics","level":2,"score":0.8368604183197021},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.6132860779762268},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.47259530425071716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37509647011756897},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3371274471282959},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2707219123840332},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.16197806596755981},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.061437785625457764}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:case1270221813","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","raw_type":"text"},{"id":"mag:2595875359","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/ETH/4370","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:case1270221813","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=case1270221813","raw_type":"text"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2595875359.pdf","grobid_xml":"https://content.openalex.org/works/W2595875359.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W128035732","https://openalex.org/W144886596","https://openalex.org/W183190858","https://openalex.org/W213164885","https://openalex.org/W643482356","https://openalex.org/W1220628738","https://openalex.org/W1485223239","https://openalex.org/W1497671643","https://openalex.org/W1498264766","https://openalex.org/W1499007388","https://openalex.org/W1503737447","https://openalex.org/W1505838412","https://openalex.org/W1518164444","https://openalex.org/W1518428823","https://openalex.org/W1528699463","https://openalex.org/W1540937567","https://openalex.org/W1544106935","https://openalex.org/W1547169091","https://openalex.org/W1554653315","https://openalex.org/W1555540695","https://openalex.org/W1569527052","https://openalex.org/W1608709490","https://openalex.org/W1844259691","https://openalex.org/W1879701056","https://openalex.org/W1904256546","https://openalex.org/W1966565450","https://openalex.org/W1966943328","https://openalex.org/W1975615748","https://openalex.org/W1976099054","https://openalex.org/W1977470493","https://openalex.org/W1979759472","https://openalex.org/W1988546395","https://openalex.org/W1991685113","https://openalex.org/W1992434103","https://openalex.org/W1993303421","https://openalex.org/W1994739180","https://openalex.org/W1995387722","https://openalex.org/W1997537431","https://openalex.org/W2000126518","https://openalex.org/W2002461623","https://openalex.org/W2002542406","https://openalex.org/W2008370637","https://openalex.org/W2012972829","https://openalex.org/W2016675859","https://openalex.org/W2023590619","https://openalex.org/W2023863258","https://openalex.org/W2024564250","https://openalex.org/W2027325058","https://openalex.org/W2029773018","https://openalex.org/W2030132260","https://openalex.org/W2033336897","https://openalex.org/W2036219577","https://openalex.org/W2036956496","https://openalex.org/W2037079754","https://openalex.org/W2038219691","https://openalex.org/W2044657834","https://openalex.org/W2045185691","https://openalex.org/W2053655750","https://openalex.org/W2054159223","https://openalex.org/W2054620060","https://openalex.org/W2055448375","https://openalex.org/W2059603427","https://openalex.org/W2060829865","https://openalex.org/W2063832801","https://openalex.org/W2066700364","https://openalex.org/W2067442947","https://openalex.org/W2071518542","https://openalex.org/W2073054029","https://openalex.org/W2075126525","https://openalex.org/W2077307563","https://openalex.org/W2077883552","https://openalex.org/W2078075091","https://openalex.org/W2078087446","https://openalex.org/W2079343380","https://openalex.org/W2081436837","https://openalex.org/W2083993817","https://openalex.org/W2087066278","https://openalex.org/W2087922339","https://openalex.org/W2089430469","https://openalex.org/W2092269528","https://openalex.org/W2092730699","https://openalex.org/W2096269840","https://openalex.org/W2097674872","https://openalex.org/W2098978387","https://openalex.org/W2102780353","https://openalex.org/W2103255333","https://openalex.org/W2103703201","https://openalex.org/W2111285897","https://openalex.org/W2113311037","https://openalex.org/W2118539741","https://openalex.org/W2118716105","https://openalex.org/W2120138860","https://openalex.org/W2122284156","https://openalex.org/W2124009251","https://openalex.org/W2124507273","https://openalex.org/W2124941371","https://openalex.org/W2129533522","https://openalex.org/W2130368504","https://openalex.org/W2132044633","https://openalex.org/W2133359186","https://openalex.org/W2134824066","https://openalex.org/W2140378659","https://openalex.org/W2140564760","https://openalex.org/W2141721370","https://openalex.org/W2144946962","https://openalex.org/W2147607863","https://openalex.org/W2148267025","https://openalex.org/W2148614114","https://openalex.org/W2149310111","https://openalex.org/W2150171020","https://openalex.org/W2154258710","https://openalex.org/W2156386533","https://openalex.org/W2158330490","https://openalex.org/W2163103985","https://openalex.org/W2166374135","https://openalex.org/W2167543899","https://openalex.org/W2176345490","https://openalex.org/W2178930977","https://openalex.org/W2189690655","https://openalex.org/W2259592891","https://openalex.org/W2342891076","https://openalex.org/W2345284463","https://openalex.org/W2375268017","https://openalex.org/W2395617416","https://openalex.org/W2400213213","https://openalex.org/W2404139447","https://openalex.org/W2404459749","https://openalex.org/W2405644573","https://openalex.org/W2408858892","https://openalex.org/W2409819947","https://openalex.org/W2410892011","https://openalex.org/W2412108050","https://openalex.org/W2418711138","https://openalex.org/W2428067722","https://openalex.org/W2467529338","https://openalex.org/W2506582769","https://openalex.org/W3025642248"],"related_works":["https://openalex.org/W2051880145","https://openalex.org/W2143776864","https://openalex.org/W2068884297","https://openalex.org/W3093182794","https://openalex.org/W3107950985","https://openalex.org/W2092973974","https://openalex.org/W747357114","https://openalex.org/W4283834964","https://openalex.org/W1949574653","https://openalex.org/W1982728956"],"abstract_inverted_index":{"The":[0],"heart":[1,13,50],"is":[2],"the":[3,27,43,55,98,106,117,124,130,139],"most":[4],"metabolically":[5],"active":[6],"organ.Several":[7],"prevalent":[8],"cardiac":[9,94],"diseases,":[10],"such":[11],"as":[12],"failure,":[14],"ischemic":[15],"and":[16,36,84],"diabetic":[17],"cardiomyopathy,":[18],"are":[19],"associated":[20],"with":[21,72],"abnormal":[22],"energy":[23],"metabolism.However,":[24],"due":[25,137],"to":[26,32,104,111,138],"lack":[28],"of":[29,42,78,93,109,141],"nondestructive":[30],"methods":[31],"quantify":[33],"metabolic":[34,46,79,107],"activities":[35],"mitochondrial":[37,85],"function,":[38],"an":[39],"integrative":[40],"understanding":[41,77],"mechanisms":[44],"underlying":[45],"dysfunction":[47],"in":[48,54,87,120],"diseased":[49],"has":[51],"been":[52],"incomplete.Therefore,":[53],"current":[56],"thesis,":[57],"we":[58],"aimed":[59],"at":[60],"developing":[61],"a":[62,121],"novel":[63],"approach":[64],"that":[65,96,129],"combines":[66],"magnetic":[67],"resonance":[68],"spectroscopy":[69],"(MRS)":[70],"technique":[71],"system":[73],"biology":[74],"for":[75],"quatitative":[76],"communication":[80],"between":[81],"subcellular":[82],"compartments":[83],"function":[86],"intact":[88],"hearts.A":[89],"comprehensive":[90],"multi-domain":[91],"model":[92,126],"metabolism":[95],"encompasses":[97],"malate-aspartate":[99],"(M-A)":[100],"shuttle":[101,119,132],"was":[102,136],"developed":[103],"investigate":[105],"responses":[108],"cardiomyocytes":[110],"ischemia":[112,135],"(Chapter":[113],"2).By":[114],"functionally":[115],"localizing":[116],"M-A":[118],"subdomain":[122],"within":[123],"cardiomyocytes,":[125],"simulations":[127],"suggested":[128],"decreased":[131],"flux":[133],"during":[134],"redistribution":[140],"shuttle-associated":[142]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2017-03-23T00:00:00"}
