{"id":"https://openalex.org/W2595834545","doi":"https://doi.org/10.1182/blood.v104.11.3885.3885","title":"Variability of PECAM-1 Expression on Blood Cells.","display_name":"Variability of PECAM-1 Expression on Blood Cells.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2595834545","doi":"https://doi.org/10.1182/blood.v104.11.3885.3885","mag":"2595834545"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.3885.3885","doi":"https://doi.org/10.1182/blood.v104.11.3885.3885","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3885.3885","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044316555","display_name":"Melanie S. Berken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie S. Berken","raw_affiliation_strings":["1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041058094","display_name":"Debra K. Newman","orcid":"https://orcid.org/0000-0001-9674-0801","observed_orcids":["https://orcid.org/0000-0001-9674-0801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra K. Newman","raw_affiliation_strings":["1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043749891","display_name":"Peter J. Newman","orcid":"https://orcid.org/0000-0001-8853-7707","observed_orcids":["https://orcid.org/0000-0001-8853-7707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Newman","raw_affiliation_strings":["1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38161779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"3885","last_page":"3885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd147","display_name":"CD147","score":0.7170000076293945},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":1.0},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.4580000042915344},{"id":"https://openalex.org/keywords/quantitative-flow-cytometry","display_name":"quantitative flow cytometry","score":0.5239999890327454},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6570000052452087},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7789999842643738},{"id":"https://openalex.org/keywords/vascular-integrity","display_name":"vascular integrity","score":0.5099999904632568},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5210000276565552},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5799999833106995},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.4620000123977661},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7317311763763428},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6837897300720215},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6617220044136047},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6018392443656921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5967923402786255},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5101285576820374},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.489327609539032},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.42115306854248047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17783498764038086},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.3885.3885","doi":"https://doi.org/10.1182/blood.v104.11.3885.3885","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3885.3885","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1200353786","https://openalex.org/W2127551455","https://openalex.org/W1660791652","https://openalex.org/W2502479984","https://openalex.org/W2152532559","https://openalex.org/W2347114980","https://openalex.org/W2120691494","https://openalex.org/W2158583394","https://openalex.org/W1022847078","https://openalex.org/W7098100577"],"abstract_inverted_index":{"Abstract":[0],"PECAM-1":[1,26,56,67,109,219,231,251,266,288,311,329],"is":[2,13,342],"a":[3,89,99,176,253,281],"130":[4],"kDa":[5],"member":[6],"of":[7,25,108,115,135,160,190,199,218,224,264,274,283,286,297,306,320,328,334],"the":[8,61,106,113,167,196,216,222,287,295,310,318,331],"Immunoglobulin":[9],"gene":[10,289],"superfamily":[11],"that":[12,44,179,230],"expressed":[14,111,247,261],"on":[15,112,221,252,317],"circulating":[16],"platelets,":[17,32,146],"neutrophils,":[18,147],"monocytes,":[19,148],"and":[20,35,41,64,117,139,149,172,242,277,322,337,346],"certain":[21],"lymphocyte":[22],"subpopulations.":[23],"Deficiency":[24],"in":[27,30,51,60,92,349],"mice":[28],"results":[29],"hyper-reactive":[31],"B":[33],"cells,":[34,37],"mast":[36],"compromised":[38],"vascular":[39,118,323],"integrity,":[40],"endothelial":[42],"cells":[43,324],"are":[45],"more":[46,71,250],"susceptible":[47,74],"to":[48,75,86,104,174,182,187,203,214,330,344],"radiation-induced":[49],"apoptosis":[50],"vivo.":[52],"Whether":[53],"or":[54,72,80],"not":[55,83,268],"expression":[57,68,232,316,341],"levels":[58,233,263,273],"vary":[59],"human":[62],"population,":[63],"whether":[65],"variable":[66,315],"renders":[69],"one":[70],"less":[73],"cardiovascular":[76],"disease,":[77,304],"autoimmune":[78],"disorders,":[79],"sepsis":[81],"has":[82],"been":[84,292],"investigated":[85],"date.":[87],"As":[88],"first":[90],"step":[91],"examining":[93],"these":[94],"questions,":[95],"we":[96,211],"have":[97,290],"developed":[98],"quantitative":[100],"flow":[101,152],"cytometry-based":[102],"assay":[103],"determine":[105],"number":[107,217,282],"molecules":[110,220],"surface":[114,223,319],"blood":[116,121,128,255,321],"cells.":[119],"Whole":[120],"samples":[122],"obtained":[123],"from":[124],"anonymous":[125],"normal":[126],"volunteer":[127],"donors":[129],"were":[130,143,164,212],"stained":[131],"with":[132,157,166,294,313],"saturating":[133],"amounts":[134],"fluorochrome-conjugated":[136,169],"anti-PECAM-1":[137,170,200],"antibody,":[138],"relative":[140,184],"fluorescence":[141,185,197],"intensities":[142,186],"determined":[144],"for":[145],"lymphocytes":[150],"by":[151],"cytometry.":[153],"Polystyrene":[154],"microbeads":[155],"coated":[156],"calibrated":[158],"numbers":[159,189],"antibody":[161,171,191,201],"binding":[162,192,202],"sites":[163],"saturated":[165],"same":[168],"used":[173],"create":[175],"standard":[177,209],"curve":[178],"allowed":[180],"us":[181],"relate":[183],"known":[188],"sites.":[193],"By":[194],"plotting":[195],"intensity":[198],"each":[204,225],"cell":[205,226,256,335],"population":[206],"against":[207],"this":[208],"curve,":[210],"able":[213],"quantify":[215],"population.":[227],"We":[228],"found":[229],"most":[234],"often":[235],"ranged":[236],"between":[237],"5,000\u201312,000":[238],"molecules/platelet,":[239],"6,000\u201310,000/lymphocyte,":[240],"30,000\u201340,000/neutrophil,":[241],"50,000\u201380,000/monocyte.":[243],"Some":[244],"individuals,":[245],"however,":[246],"2\u20135":[248],"times":[249],"given":[254],"subtype.":[257],"Interestingly,":[258],"individuals":[259],"who":[260],"high":[262,272],"platelet":[265],"did":[267],"necessarily":[269],"also":[270],"express":[271],"leukocyte":[275],"PECAM-1,":[276],"vice":[278],"versa.":[279],"Since":[280],"naturally-occurring":[284],"alleles":[285],"recently":[291],"associated":[293],"progression":[296],"atherosclerosis,":[298],"myocardial":[299],"infarction,":[300],"and/or":[301],"coronary":[302],"artery":[303],"correlation":[305],"genetic":[307],"variation":[308],"within":[309],"locus":[312],"its":[314],"may":[325],"permit":[326],"addition":[327],"growing":[332],"list":[333],"adhesion":[336],"signaling":[338],"receptors":[339],"whose":[340],"linked":[343],"bleeding":[345],"clotting":[347],"disorders":[348],"humans.":[350]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-03-23T00:00:00"}
