{"id":"https://openalex.org/W2595700612","doi":"https://doi.org/10.1182/blood.v128.22.3878.3878","title":"Ribosomal Protein Rpl22 Regulates Development and Transformation Via Altering RNA Processing","display_name":"Ribosomal Protein Rpl22 Regulates Development and Transformation Via Altering RNA Processing","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2595700612","doi":"https://doi.org/10.1182/blood.v128.22.3878.3878","mag":"2595700612"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.3878.3878","doi":"https://doi.org/10.1182/blood.v128.22.3878.3878","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.3878.3878","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023337354","display_name":"Minshi Wang","orcid":"https://orcid.org/0000-0002-0225-0586","observed_orcids":["https://orcid.org/0000-0002-0225-0586"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minshi Wang","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079952504","display_name":"Zheng Ser","orcid":"https://orcid.org/0000-0003-4297-7525","observed_orcids":["https://orcid.org/0000-0003-4297-7525"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zheng Ser","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054498115","display_name":"Shuyun Rao","orcid":"https://orcid.org/0000-0002-1073-6682","observed_orcids":["https://orcid.org/0000-0002-1073-6682"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuyun Rao","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078677394","display_name":"Shawn P. Fahl","orcid":"https://orcid.org/0000-0002-0489-2048","observed_orcids":["https://orcid.org/0000-0002-0489-2048"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shawn Fahl","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110479758","display_name":"Yong Zhang","orcid":"https://orcid.org/0009-0005-4532-6930","observed_orcids":["https://orcid.org/0009-0005-4532-6930"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089126790","display_name":"Suraj Peri","orcid":"https://orcid.org/0000-0002-1909-8218","observed_orcids":["https://orcid.org/0000-0002-1909-8218"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suraj Peri","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055053315","display_name":"Alex Kentsis","orcid":"https://orcid.org/0000-0002-8063-9191","observed_orcids":["https://orcid.org/0000-0002-8063-9191"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Kentsis","raw_affiliation_strings":["Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002152110","display_name":"David L. Wiest","orcid":"https://orcid.org/0000-0002-0792-3188","observed_orcids":["https://orcid.org/0000-0002-0792-3188"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L Wiest","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023337354","https://openalex.org/A5054498115","https://openalex.org/A5078677394","https://openalex.org/A5079952504","https://openalex.org/A5089126790","https://openalex.org/A5110479758"],"corresponding_institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1334819555"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12441715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"128","issue":"22","first_page":"3878","last_page":"3878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosomal-protein-l22","display_name":"ribosomal protein L22","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.8769999742507935},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.8529999852180481},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9679999947547913},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/thymic-lymphoma","display_name":"thymic lymphoma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6604716181755066},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5903599858283997},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.5812016725540161},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5290621519088745},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5287166237831116},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5220544338226318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5119448900222778},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.4836179316043854},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.48164620995521545},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4560970067977905},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44942614436149597},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38074612617492676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25828343629837036}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.3878.3878","doi":"https://doi.org/10.1182/blood.v128.22.3878.3878","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.3878.3878","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2331932700","https://openalex.org/W2020574069","https://openalex.org/W7099450656","https://openalex.org/W2412385882","https://openalex.org/W2562730771","https://openalex.org/W2478620951","https://openalex.org/W2980277942","https://openalex.org/W2329102460","https://openalex.org/W2555489724","https://openalex.org/W2581856754"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"it":[2],"has":[3],"long":[4],"been":[5],"reported":[6],"that":[7,37,72,197,222,261],"mutations":[8,27],"in":[9,19,105,125,162,168,179,189,209,224,246,249,284],"ribosome":[10,53,80],"proteins":[11,206],"(RP)":[12],"are":[13,43,60,148],"associated":[14,115],"with":[15,116,173],"increased":[16],"cancer":[17],"risk":[18],"humans,":[20],"the":[21,33,73,90,163,190,198,203,215,276],"molecular":[22],"basis":[23],"why":[24],"which":[25,250],"RP":[26,38],"do":[28],"so":[29],"remains":[30],"unclear.":[31],"Nevertheless,":[32],"prevailing":[34],"view":[35],"is":[36,76,103,114,296],"mutations,":[39],"such":[40],"as":[41,66,240],"Rps19,":[42],"thought":[44],"to":[45,62,231,235,271,306],"alter":[46],"transformation":[47,99],"potential":[48],"through":[49,266,286],"general":[50],"impairment":[51],"of":[52,92,123,134,145,200,205,214,229,269,278,304],"biogenesis":[54,81],"or":[55,82],"function.":[56],"Importantly,":[57],"recent":[58],"observations":[59],"beginning":[61],"challenge":[63],"this":[64,113],"notion":[65],"too":[67],"simplistic.":[68],"We":[69],"have":[70],"determined":[71],"RP,":[74],"Rpl22,":[75],"not":[77],"essential":[78],"for":[79,218],"global":[83],"protein":[84,280],"synthesis;":[85],"however,":[86,186],"its":[87,267],"inactivation":[88,142],"impairs":[89],"development":[91,122,144],"normal":[93],"T":[94,107],"lymphocytes":[95],"and":[96,112,152,157,167,274],"increases":[97],"their":[98,279],"potential.":[100],"Indeed,":[101],"RPL22":[102],"inactivated":[104],"human":[106],"acute":[108],"lymphoblastic":[109],"leukemia":[110,124],"(T-ALL)":[111],"reduced":[117],"survival.":[118],"Moreover,":[119],"Rpl22-deficiency":[120],"accelerates":[121],"a":[126],"myristylated":[127],"Akt2":[128],"transgenic":[129],"(MyrAkt2":[130],"Tg)":[131],"mouse":[132],"model":[133],"T-ALL.":[135],"To":[136],"gain":[137],"insight":[138],"into":[139],"how":[140],"Rpl22":[141,201,230,251,262,291],"facilitates":[143],"leukemia,":[146],"we":[147,259],"performing":[149],"unbiased":[150],"transcriptomic":[151],"proteomic":[153],"analysis":[154,195],"on":[155],"Rpl22+/+":[156],"Rpl22-/-":[158,170],"thymic":[159],"lymphomas":[160],"arising":[161],"MyrAkt2":[164],"Tg":[165],"model,":[166],"an":[169],"lymphoma":[171],"reconstituted":[172],"Rpl22.":[174],"Interestingly,":[175,212],"relatively":[176],"few":[177],"changes":[178,292],"mRNA":[180,288,293],"transcript":[181],"read":[182],"depth":[183],"were":[184,192],"observed;":[185],"substantial":[187],"differences":[188],"proteome":[191],"observed.":[193],"Pathway":[194],"revealed":[196,221],"loss":[199],"altered":[202],"expression":[204,277],"regulating":[207],"RNA-processing,":[208],"particular":[210],"RNA-splicing.":[211],"interrogation":[213],"transrciptome":[216],"data":[217],"alternative":[219,241],"splicing":[220,233,242,294],"alterations":[223],"exon":[225],"usage.":[226],"The":[227],"ability":[228,268],"influence":[232],"appears":[234],"be":[236],"conserved":[237],"across":[238],"species":[239],"was":[243,252],"also":[244],"observed":[245],"zebrafish":[247],"embryos":[248],"knocked":[253],"down":[254],"using":[255],"morpholino":[256],"oligonucleotides.":[257],"Consequently,":[258],"hypothesize":[260],"regulates":[263],"biological":[264],"events":[265],"binding":[270],"RNA":[272],"targets,":[273],"controlling":[275],"products":[281],"at":[282],"least":[283],"part":[285],"altering":[287],"splicing.":[289],"How":[290],"pattern":[295],"currently":[297],"under":[298],"investigation.":[299],"Disclosures":[300],"No":[301],"relevant":[302],"conflicts":[303],"interest":[305],"declare.":[307]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2017-03-23T00:00:00"}
