{"id":"https://openalex.org/W2595542005","doi":"https://doi.org/10.1021/acs.biochem.7b00213","title":"Probing for and Quantifying Agonist Hydrogen Bonds in \u03b16\u03b22 Nicotinic Acetylcholine Receptors","display_name":"Probing for and Quantifying Agonist Hydrogen Bonds in \u03b16\u03b22 Nicotinic Acetylcholine Receptors","publication_year":2017,"publication_date":"2017-03-13","ids":{"openalex":"https://openalex.org/W2595542005","doi":"https://doi.org/10.1021/acs.biochem.7b00213","mag":"2595542005","pmid":"https://pubmed.ncbi.nlm.nih.gov/28287260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6075822"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.7b00213","doi":"https://doi.org/10.1021/acs.biochem.7b00213","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00213","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6075822","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044058751","display_name":"Michael R. Post","orcid":"https://orcid.org/0000-0002-3214-7619","observed_orcids":["https://orcid.org/0000-0002-3214-7619"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Post","raw_affiliation_strings":["Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024286952","display_name":"Henry A. Lester","orcid":"https://orcid.org/0000-0002-5470-5255","observed_orcids":["https://orcid.org/0000-0002-5470-5255"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry A. Lester","raw_affiliation_strings":["Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002660163","display_name":"Dennis A. Dougherty","orcid":"https://orcid.org/0000-0003-1464-2461","observed_orcids":["https://orcid.org/0000-0003-1464-2461"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis A. Dougherty","raw_affiliation_strings":["Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States"],"raw_orcid":"https://orcid.org/0000-0003-1464-2461","affiliations":[{"raw_affiliation_string":"Division\rof Chemistry and Chemical Engineering and \u2021Division of Biology and Biological\rEngineering, California Institute of Technology, Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002660163"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3349,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54142415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"56","issue":"13","first_page":"1836","last_page":"1840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agonist-binding","display_name":"agonist binding","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.35199999809265137},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cation-pi-interactions","display_name":"cation-\u03c0 interactions","score":0.8659999966621399},{"id":"https://openalex.org/keywords/double-mutant-cycle-analysis","display_name":"double-mutant cycle analysis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/binding-free-energy","display_name":"binding free energy","score":0.515999972820282},{"id":"https://openalex.org/keywords/subtype-selective-agonists","display_name":"subtype-selective agonists","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.703872799873352},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6991750001907349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6900150775909424},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6472577452659607},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.6307231187820435},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5636983513832092},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.48494723439216614},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38063979148864746},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3788311183452606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3376613259315491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18936440348625183},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.12048661708831787},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09896603226661682}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.biochem.7b00213","doi":"https://doi.org/10.1021/acs.biochem.7b00213","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00213","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:28287260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28287260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5024812","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6075822","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6075822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6075822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:75083","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20170314-072647704","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5024812","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6075822","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2090218184","display_name":"Nicotinic Ligands for Smoking Cessation","funder_award_id":"U19DA019375","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G239511019","display_name":null,"funder_award_id":"NS34407","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G260839292","display_name":"PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY","funder_award_id":"T32GM007616","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G423590273","display_name":"Probing Receptor Structures with Unnatural Amino Acids","funder_award_id":"R01NS034407","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5012562322","display_name":null,"funder_award_id":"DA019375","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7386667960","display_name":"Tools for inside-out pharmacology: nicotinic agents","funder_award_id":"R01DA037161","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7696355378","display_name":"Probing Receptor Structures with Unnatural Amino Acids","funder_award_id":"R37NS034407","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W165066620","https://openalex.org/W289670290","https://openalex.org/W1483942114","https://openalex.org/W1841858761","https://openalex.org/W1928871450","https://openalex.org/W1974958755","https://openalex.org/W1982371070","https://openalex.org/W1995002087","https://openalex.org/W2002139917","https://openalex.org/W2022211203","https://openalex.org/W2033041174","https://openalex.org/W2034035509","https://openalex.org/W2041459336","https://openalex.org/W2045997555","https://openalex.org/W2046763527","https://openalex.org/W2049084706","https://openalex.org/W2066193597","https://openalex.org/W2074662484","https://openalex.org/W2076338351","https://openalex.org/W2081391428","https://openalex.org/W2081446858","https://openalex.org/W2089874992","https://openalex.org/W2092042225","https://openalex.org/W2095536623","https://openalex.org/W2102415344","https://openalex.org/W2109666543","https://openalex.org/W2111627512","https://openalex.org/W2121462383","https://openalex.org/W2124759299","https://openalex.org/W2146298489","https://openalex.org/W2148598721","https://openalex.org/W2160251618","https://openalex.org/W2201997235","https://openalex.org/W2326635028","https://openalex.org/W2524130802","https://openalex.org/W2951804561","https://openalex.org/W4242435936"],"related_works":["https://openalex.org/W2054464211","https://openalex.org/W2074662484","https://openalex.org/W2418566456","https://openalex.org/W2005181420","https://openalex.org/W2340073994","https://openalex.org/W1995002087","https://openalex.org/W4242435936","https://openalex.org/W2416011013","https://openalex.org/W2048894494","https://openalex.org/W2033041174"],"abstract_inverted_index":{"Designing":[0],"subtype-selective":[1],"agonists":[2],"for":[3],"neuronal":[4],"nicotinic":[5],"acetylcholine":[6,30,95],"receptors":[7],"is":[8],"a":[9,32,45,84,91,104,112,118,139],"challenging":[10],"and":[11,40,94],"significant":[12],"goal":[13],"aided":[14],"by":[15],"intricate":[16],"knowledge":[17],"of":[18,87,120],"each":[19],"subtype's":[20],"binding":[21,47,53],"patterns.":[22],"We":[23],"previously":[24],"reported":[25],"that":[26],"in":[27,115],"\u03b16\u03b22":[28,60,116],"receptors,":[29],"makes":[31,138],"functional":[33,140],"cation-\u03c0":[34,132],"interaction":[35,133],"with":[36,59,68,117,134],"Trp149,":[37,135],"but":[38],"nicotine":[39,82,126],"TC299423":[41,89],"do":[42],"not,":[43],"suggesting":[44],"distinctive":[46],"site.":[48],"This":[49],"work":[50],"explores":[51],"hydrogen":[52,76,113,141],"at":[54],"the":[55,74,130],"backbone":[56,146],"carbonyl":[57],"associated":[58,145],"Trp149.":[61],"Substituting":[62],"residue":[63],"i":[64],"+":[65],"1,":[66],"Thr150,":[67],"its":[69,144],"\u03b1-hydroxy":[70],"analogue":[71],"(Tah)":[72],"attenuates":[73],"carbonyl's":[75],"bond":[77,114,142],"accepting":[78],"ability.":[79],"At":[80],"\u03b16(T150Tah)\u03b22,":[81],"shows":[83,90,96],"24-fold":[85],"loss":[86],"function,":[88],"modest":[92],"loss,":[93],"no":[97],"effect.":[98],"Nicotine":[99],"was":[100],"further":[101],"analyzed":[102],"via":[103],"double-mutant":[105],"cycle":[106],"analysis":[107],"utilizing":[108],"N'-methylnicotinium,":[109],"which":[110],"indicated":[111],"\u0394\u0394G":[119],"2.6":[121],"kcal/mol.":[122],"Thus,":[123],"even":[124],"though":[125],"does":[127],"not":[128],"make":[129],"conserved":[131],"it":[136],"still":[137],"to":[143],"carbonyl.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2017-03-23T00:00:00"}
