{"id":"https://openalex.org/W2595045979","doi":null,"title":"Endocytosis mechanism of poly- and lipoplexes in siRNA delivery in HeLa cells","display_name":"Endocytosis mechanism of poly- and lipoplexes in siRNA delivery in HeLa cells","publication_year":2012,"publication_date":"2012-09-18","ids":{"openalex":"https://openalex.org/W2595045979","mag":"2595045979"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/34435","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/34435","pdf_url":"https://www.ideals.illinois.edu/items/34709/bitstreams/110904/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/34709/bitstreams/110904/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060834668","display_name":"Mihael Lazebnik","orcid":"https://orcid.org/0000-0002-7597-1827","observed_orcids":["https://orcid.org/0000-0002-7597-1827"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mihael Lazebnik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7597-1827","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060834668"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.105,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44836913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9660000205039978},{"id":"https://openalex.org/keywords/endocytic-pathway","display_name":"endocytic pathway","score":0.8840000033378601},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":1.0},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cationic-lipids","display_name":"cationic lipids","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.8619999885559082},{"id":"https://openalex.org/keywords/caveolin-mediated-endocytosis","display_name":"caveolin-mediated endocytosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/arf6","display_name":"ARF6","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plasma-membrane-fusion","display_name":"plasma membrane fusion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sirna-uptake","display_name":"siRNA uptake","score":0.6380000114440918},{"id":"https://openalex.org/keywords/sirna-release","display_name":"siRNA release","score":0.6039999723434448},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.905055046081543},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7919676899909973},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6603886485099792},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5845551490783691},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5675162672996521},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.43503522872924805},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3552412986755371},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3063803017139435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2203090488910675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1930008828639984},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0733807384967804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07327944040298462},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/34435","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/34435","pdf_url":"https://www.ideals.illinois.edu/items/34709/bitstreams/110904/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2595045979","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/34435","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/34435","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/34435","pdf_url":"https://www.ideals.illinois.edu/items/34709/bitstreams/110904/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707917047","display_name":null,"funder_award_id":"11PRE5960002","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2595045979.pdf","grobid_xml":"https://content.openalex.org/works/W2595045979.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2074161384","https://openalex.org/W2324105842"],"related_works":["https://openalex.org/W2507219810","https://openalex.org/W2534614437","https://openalex.org/W2983910901","https://openalex.org/W2097202791","https://openalex.org/W1511669342","https://openalex.org/W2155239981","https://openalex.org/W2102110918","https://openalex.org/W7037480519","https://openalex.org/W2108710691","https://openalex.org/W2331247067"],"abstract_inverted_index":{"RNA":[0,31],"interference":[1],"(RNAi)":[2,249],"is":[3,26,35,70,73,145,202,313],"a":[4,36,74,355],"method":[5,16,356],"that":[6,61,91,95,172,296],"can":[7,17,179],"be":[8,51],"used":[9,174,252,279],"to":[10,44,50,53,101,142,146,151,193,204,253,280],"treat":[11],"various":[12],"medical":[13],"conditions.":[14],"This":[15,85],"silence":[18],"expression":[19,308],"of":[20,58,66,88,120,137,186,197,228,262,267,309,337,357,386,391],"virtually":[21],"any":[22],"gene,":[23],"and":[24,80,126,160,183,216,235,247,258,268,273,306,323,335,351,369,381],"it":[25,154,201],"initiated":[27],"by":[28,76,98,109,271,289],"small":[29],"interfering":[30],"(siRNA)":[32],"molecule.":[33],"siRNA":[34,48,68,130,144,187,230,287,312,340,353],"19":[37],"nucleotides-long":[38],"double":[39],"stranded":[40],"RNA-molecule.":[41],"In":[42,191,221],"order":[43,192],"begin":[45],"gene":[46],"silencing,":[47],"needs":[49],"delivered":[52,311,339],"the":[54,59,64,67,83,93,99,110,116,121,134,138,176,181,184,189,198,210,222,229,236,260,282,286,299,307,310,314,333,338,345,349,361,378,384,387],"cytosol.":[55,190],"The":[56,105,170,293,367],"first":[57],"barriers":[60],"stand":[62],"on":[63,115,264,344,383],"path":[65],"delivery":[69,177,199,231,288,334],"endocytosis.":[71,366],"Endocytosis":[72],"process":[75,86],"which":[77,207,217],"nutrients,":[78],"signals":[79],"pathogens":[81],"enter":[82,133,298,319,348],"cells.":[84,135,342],"consists":[87],"multiple":[89,302,330],"pathways":[90,209,257,284,304],"lead":[92],"objects":[94,112],"were":[96,233,251],"ingested":[97],"cells":[100,243,300,350],"different":[102,291],"intracellular":[103],"destinations.":[104],"chemical":[106,128],"environment":[107],"encountered":[108],"endocytosed":[111],"also":[113,278],"depends":[114],"specific":[117],"pathways.":[118,326],"Because":[119],"large":[122],"size,":[123],"negative":[124],"charge":[125],"other":[127,346],"properties,":[129],"cannot":[131],"readily":[132],"One":[136],"most":[139,315],"promising":[140],"techniques":[141],"deliver":[143,213],"employ":[147],"its":[148],"anionic":[149],"property":[150],"electrostatically":[152],"complex":[153],"with":[155,360,377],"cationic":[156],"lipids":[157],"or":[158,163,168],"polymers":[159],"create":[161],"lipid-":[162],"polymer":[164],"based":[165],"particles":[166],"(lipoplexes":[167],"polyplexes).":[169],"materials":[171,212],"are":[173,375],"as":[175],"vectors":[178,232],"mediate":[180],"uptake":[182,266],"release":[185,336,352],"in":[188,241,285,332,341,372],"synthesize":[194],"newer":[195],"generation":[196],"materials,":[200],"paramount":[203],"know":[205],"through":[206,301,320,354],"endocytosis":[208,240,256,303,325,389],"current":[211,379],"their":[214,239],"cargo":[215],"limitations":[218],"they":[219],"encounter.":[220],"study":[223,374],"presented":[224,371],"here,":[225],"two":[226,290],"representatives":[227],"chosen,":[234],"investigation":[237],"into":[238],"HeLa":[242],"was":[244,277],"performed.":[245],"Chemical":[246],"biological":[248],"methods":[250],"selectively":[254],"inhibit":[255],"investigate":[259],"influence":[261],"inhibition":[263],"total":[265],"RNAi":[269],"mediated":[270],"polyplexes":[272,297,318],"lipoplexes.":[274],"Fluorescence":[275],"microscopy":[276],"determine":[281],"predominant":[283],"materials.":[292],"experiments":[294],"revealed":[295],"simultaneously,":[305],"prominent":[316],"when":[317],"caveolin-,":[321],"flotillin-":[322],"ARF6-mediated":[324],"ARF6":[327],"might":[328],"play":[329],"roles":[331],"Lipoplexes,":[343],"hand,":[347],"direct":[358],"fusion":[359],"plasma":[362],"membrane":[363],"rather":[364],"than":[365],"data":[368],"conclusions":[370],"this":[373],"consistent":[376],"knowledge":[380],"expand":[382],"understanding":[385],"complicated":[388],"mechanisms":[390],"siRNA-based":[392],"particles.":[393]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-03-23T00:00:00"}
