{"id":"https://openalex.org/W2594595677","doi":"https://doi.org/10.1182/blood.v112.11.2154.2154","title":"Novel Tyrosine Kinase Inhibitor Therapy Before Allogeneic Stem Cell Transplantation in Patients with Chronic Myeloid Leukemia.","display_name":"Novel Tyrosine Kinase Inhibitor Therapy Before Allogeneic Stem Cell Transplantation in Patients with Chronic Myeloid Leukemia.","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2594595677","doi":"https://doi.org/10.1182/blood.v112.11.2154.2154","mag":"2594595677"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.2154.2154","doi":"https://doi.org/10.1182/blood.v112.11.2154.2154","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.2154.2154","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043237291","display_name":"Leandro de P\u00e1dua Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leandro de Padua Silva","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015101485","display_name":"J\u00f6rge E. Cortes","orcid":"https://orcid.org/0000-0002-8636-1071","observed_orcids":["https://orcid.org/0000-0002-8636-1071"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Cortes","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049385583","display_name":"Elias Joseph Jabbour","orcid":"https://orcid.org/0000-0003-4465-6119","observed_orcids":["https://orcid.org/0000-0003-4465-6119"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Jabbour","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070096873","display_name":"Sergio  A. Giralt","orcid":"https://orcid.org/0000-0003-1944-5053","observed_orcids":["https://orcid.org/0000-0003-1944-5053"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Giralt","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069460930","display_name":"Partow Kebriaei","orcid":"https://orcid.org/0000-0002-8607-9404","observed_orcids":["https://orcid.org/0000-0002-8607-9404"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Partow Kebriaei","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743501","display_name":"Susan Mary O'Brien","orcid":"https://orcid.org/0000-0003-3386-6540","observed_orcids":["https://orcid.org/0000-0003-3386-6540"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan O\u2019Brien","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104852","display_name":"Amin Majid Alousi","orcid":"https://orcid.org/0000-0002-2498-8573","observed_orcids":["https://orcid.org/0000-0002-2498-8573"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin Alousi","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015342719","display_name":"Muzaffar H. Qazilbash","orcid":"https://orcid.org/0000-0003-2876-2886","observed_orcids":["https://orcid.org/0000-0003-2876-2886"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muzaffar Qazilbash","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016928938","display_name":"Gabriela Rond\u00f3n","orcid":"https://orcid.org/0000-0003-3841-3567","observed_orcids":["https://orcid.org/0000-0003-3841-3567"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Rondon","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750846","display_name":"Farhad Ravandi","orcid":"https://orcid.org/0000-0002-7621-377X","observed_orcids":["https://orcid.org/0000-0002-7621-377X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhad Ravandi","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112446201","display_name":"Rachel de Oliveira Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Ribeiro","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050962913","display_name":"Chitra M. Hosing","orcid":"https://orcid.org/0000-0003-0409-5556","observed_orcids":["https://orcid.org/0000-0003-0409-5556"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Hosing","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop Kantarjian","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048913229","display_name":"Richard E. Champlin","orcid":"https://orcid.org/0000-0002-4314-5037","observed_orcids":["https://orcid.org/0000-0002-4314-5037"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Champlin","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Marcos De Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcos De Lima","raw_affiliation_strings":["Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38763604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"112","issue":"11","first_page":"2154","last_page":"2154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.4318999946117401,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":1.0},{"id":"https://openalex.org/keywords/bosutinib","display_name":"bosutinib","score":0.9879999756813049},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.4449999928474426},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/graft-versus-leukemia-effect","display_name":"graft-versus-leukemia effect","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8586294651031494},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.7994999885559082},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.7240934371948242},{"id":"https://openalex.org/C2778208673","wikidata":"https://www.wikidata.org/wiki/Q894611","display_name":"Bosutinib","level":5,"score":0.7025421857833862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6739041805267334},{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.598081111907959},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5709801912307739},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5394021272659302},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5297789573669434},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.5216796398162842},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5134862065315247},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.49924635887145996},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.4641631245613098},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4325605034828186},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.40672898292541504},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.40397554636001587},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3924216628074646},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2405746877193451},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11547976732254028},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.11540579795837402}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.2154.2154","doi":"https://doi.org/10.1182/blood.v112.11.2154.2154","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.2154.2154","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2550069897","https://openalex.org/W2551937125","https://openalex.org/W2588023721","https://openalex.org/W2590133909","https://openalex.org/W3021165824","https://openalex.org/W2095275715","https://openalex.org/W2734356510","https://openalex.org/W816045032","https://openalex.org/W2001668042","https://openalex.org/W2620246845"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"A":[2],"significant":[3],"proportion":[4],"of":[5,45,51,66,139,209,222,224,241,243,328,341,369,501,512,547,551,555,598],"patients":[6,52,68,496,518,533,599],"undergoing":[7],"allogeneic":[8],"hematopoietic":[9],"stem":[10,389],"cell":[11],"transplantation":[12],"(HSCT)":[13],"for":[14,462],"CML":[15,71,583],"will":[16,36,600],"have":[17],"received":[18,54,96,380,394],"a":[19,55,97,107,367,395,417,466,473,499,509],"novel":[20],"tyrosine":[21],"kinase":[22],"inhibitor":[23],"(NTKI)":[24],"after":[25,152],"failing":[26],"imatinib":[27],"mesylate.":[28],"It":[29],"is":[30],"unclear,":[31],"however,":[32],"if":[33],"these":[34,605],"drug":[35],"influence":[37],"HSCT":[38,185,213],"outcomes":[39,50],"by":[40,486],"changing":[41],"the":[42,64,203,207,220,239,329,336,339,392,409,458],"toxicity":[43],"profile":[44],"transplantation.":[46],"Aims:":[47],"To":[48],"describe":[49],"that":[53,86],"NTKI":[56,195,210,568],"prior":[57,117,584],"to":[58,118,212,258,319,585,603],"HSCT.":[59,119,153,337,490,507],"Methods:":[60],"We":[61],"retrospectively":[62],"analyzed":[63],"outcome":[65],"30":[67,488],"(pts)":[69],"with":[70,376,387,416,529,567],"[8":[72],"chronic":[73],"phase":[74,78,84],"(CP),":[75],"9":[76,231,343],"accelerated":[77],"(AP),":[79],"and":[80,94,128,130,141,150,174,202,234,250,304,324,357,391,405,413,423,482,527,536,540,553,587,595],"13":[81,235,532],"in":[82,125,132,159,164,167,172,178,229,232,236,248,252,346,350,355,359,432,437,441,445,451,455,522,525,575],"blastic":[83],"(BP)]":[85],"were":[87,122,155,228,247,345,349,354,414,519],"so":[88],"treated.":[89],"All":[90],"pts":[91,127,255,317,344,362,375,399,434,453,461],"failed":[92],"imatinib,":[93],"then":[95],"second":[98,225,351,393],"TKI":[99,109],"{dasatinib":[100,110],"(n=14),":[101],"nilotinib":[102,112],"(n=13),":[103],"bosutinib":[104],"(n=3)},":[105],"or":[106,114],"third":[108,320],"(n=2),":[111],"(n=1),":[113],"INNO-406":[115],"(n=1)}":[116],"Preparative":[120],"regimens":[121],"intravenous":[123],"busulfan-based":[124],"24":[126],"fludarabine":[129],"melphalan":[131],"6.":[133],"Graft-versus-host":[134],"disease":[135,484,548],"(GVHD)":[136],"prophylaxis":[137],"consisted":[138],"tacrolimus":[140],"mini-methotrexate":[142],"5":[143,272,281,464],"mg/m2":[144],"on":[145,194],"days":[146,371],"1,":[147,168,173],"3,":[148],"6,":[149,442],"11":[151],"Donors":[154],"match":[156,161],"related":[157,171,418],"(MRD)":[158],"12,":[160],"unrelated":[162,175],"(MUD)":[163],"14,":[165],"haplo-identical":[166,396],"1-antigen":[169,419],"mismatched":[170,420],"cord":[176,381],"blood":[177,382],"2":[179,246,251,263,277,291,293,295,310,312,404,524],"cases.":[180],"Results:":[181],"Median":[182],"age":[183],"at":[184],"was":[186,197,214,385,430,449,562],"42":[187],"years":[188],"(range,":[189,200,217,372,504,515],"22\u201363).":[190],"The":[191,558],"median":[192,204,368,500,510],"time":[193,205,221,240,340],"treatment":[196,566],"27":[198],"weeks":[199,216],"2\u201386),":[201],"from":[206,408,506],"end":[208],"therapy":[211],"10":[215,452],"1\u201332).":[218],"At":[219,238,338],"start":[223,242],"TKI,":[226,245],"8":[227,348,537,546],"CP,":[230,278,290,301,311,347,352],"AP,":[233,249,269,292,313,356],"BP.":[237,253,360],"3rd":[244],"Twenty-one":[254],"(70%)":[256],"responded":[257,318],"2nd":[259],"TKI;":[260],"this":[261,576,588],"included:":[262],"partial":[264,296],"hematologic":[265,274],"response":[266,275,284,287,298,308,334,469,476],"(PHR;":[267],"1":[268,270,289,300,302,322,325],"BP),":[271,280,294],"complete":[273,306,467,474],"(CHR;":[276],"3":[279,314,478,528,539],"minor":[282],"cytogenetic":[283,286,297,307,468],"(minor":[285],"(mCyR):":[288],"(PCyR;":[299],"AP),":[303],"7":[305,358],"(CCyR;":[309],"BP).":[315],"Two":[316,398],"TKI:":[321],"PHR":[323],"CCyR.":[326],"Eight":[327,491],"responders":[330],"(38%)":[331],"maintained":[332],"their":[333],"till":[335],"HSCT,":[342,411,544,586],"6":[353,406],"Twenty-eight":[361],"(93%)":[363],"engrafted":[364],"neutrophils":[365],"within":[366,498,538],"12":[370,521,541],"5\u201320).":[373],"Both":[374],"primary":[377],"graft":[378,402],"failure":[379,403],"transplants:":[383],"one":[384,554],"rescued":[386,415],"autologous":[388],"cells":[390],"transplant.":[397],"had":[400,483],"secondary":[401],"months":[407,503,514],"first":[410],"respectively,":[412],"donor":[421],"transplant":[422],"same":[424],"MUD":[425],"transplant,":[426],"respectively.":[427],"Acute":[428],"GVHD":[429,448],"observed":[431,450],"19":[433],"(Grade":[435],"I":[436],"11,":[438],"Grade":[439,443],"II/III":[440],"IV":[444],"2).":[446],"Chronic":[447],"(extensive":[454],"5).":[456],"Of":[457],"28":[459],"evaluable":[460],"response,":[463],"achieved":[465,472],"(CCyR),":[470],"20":[471,513],"molecular":[475],"(CMR);":[477],"did":[479,569],"not":[480,570],"respond":[481],"progression":[485],"day":[487],"post":[489,543],"(4":[492],"CCyR,":[493,526],"4":[494,502,550],"CMR)":[495],"relapsed":[497],"3\u20137)":[505],"After":[508],"follow-up":[511,594],"5\u201344),":[516],"17":[517],"alive:":[520],"CMR,":[523],"active":[530],"disease;":[531],"died":[534],"(2":[535],"mos":[542],"respectively),":[545],"progression,":[549],"GVHD,":[552],"uncontrollable":[556],"infection.":[557],"estimated":[559],"2-year":[560],"survival":[561],"51%.":[563],"Conclusion:":[564],"Previous":[565],"increase":[571],"early":[572],"transplant-related":[573],"morbidity/mortality":[574],"preliminary":[577],"experience.":[578],"These":[579],"drugs":[580],"may":[581,590],"\u201cdownstage\u2019":[582],"effect":[589],"be":[591,601],"beneficial.":[592],"Further":[593],"larger":[596],"number":[597],"necessary":[602],"expand":[604],"observations.":[606]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-03-16T00:00:00"}