{"id":"https://openalex.org/W2594516111","doi":"https://doi.org/10.1080/23808993.2017.1298969","title":"Using genetics to predict patient response to platinum-based chemotherapy","display_name":"Using genetics to predict patient response to platinum-based chemotherapy","publication_year":2017,"publication_date":"2017-01-02","ids":{"openalex":"https://openalex.org/W2594516111","doi":"https://doi.org/10.1080/23808993.2017.1298969","mag":"2594516111"},"language":"en","primary_location":{"id":"doi:10.1080/23808993.2017.1298969","doi":"https://doi.org/10.1080/23808993.2017.1298969","is_oa":false,"landing_page_url":"https://doi.org/10.1080/23808993.2017.1298969","pdf_url":null,"source":{"id":"https://openalex.org/S4210210132","display_name":"Expert Review of Precision Medicine and Drug Development","issn_l":"2380-8993","issn":["2380-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Precision Medicine and Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084359163","display_name":"Niki Karachaliou","orcid":"https://orcid.org/0000-0002-2378-0498","observed_orcids":["https://orcid.org/0000-0002-2378-0498"]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210133548","display_name":"Hospital Universitari Sagrat Cor","ror":"https://ror.org/03fzyry86","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210133548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Niki Karachaliou","raw_affiliation_strings":["Instituto of Oncology Rosell (IOR), University Hospital Sagrat Cor, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto of Oncology Rosell (IOR), University Hospital Sagrat Cor, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210133548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088066738","display_name":"Maria de los Llanos GIL Gil Moreno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria de los Llanos Gil Moreno","raw_affiliation_strings":["Instituto of Oncology Rosell (IOR), Quir\u00f3n-Dexeus University Institute, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto of Oncology Rosell (IOR), Quir\u00f3n-Dexeus University Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054001604","display_name":"Aaron E. Sosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210133548","display_name":"Hospital Universitari Sagrat Cor","ror":"https://ror.org/03fzyry86","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210133548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aaron E. Sosa","raw_affiliation_strings":["Instituto of Oncology Rosell (IOR), University Hospital Sagrat Cor, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto of Oncology Rosell (IOR), University Hospital Sagrat Cor, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210133548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059144188","display_name":"Mariacarmela Santarp\u00eda","orcid":"https://orcid.org/0000-0003-1942-2134","observed_orcids":["https://orcid.org/0000-0003-1942-2134"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariacarmela Santarpia","raw_affiliation_strings":["Medical Oncology Unit, Department of Human Pathology \u2018\u2018G. Barresi\u2019\u2019, University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Department of Human Pathology \u2018\u2018G. Barresi\u2019\u2019, University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017856488","display_name":"Chiara Lazzari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Lazzari","raw_affiliation_strings":["Department of Oncology, Division of Experimental Medicine, IRCCS San Raffaele, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Division of Experimental Medicine, IRCCS San Raffaele, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016844673","display_name":"Alejandra Rodr\u00edguez Capote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandra Rodriguez Capote","raw_affiliation_strings":["Medical Oncology Department, University Hospital of Canary Islands, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, University Hospital of Canary Islands, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013884017","display_name":"Bartomeu Massut\u00ed","orcid":"https://orcid.org/0000-0002-6247-4493","observed_orcids":["https://orcid.org/0000-0002-6247-4493","https://orcid.org/0000-0002-7608-3952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bartomeu Massuti","raw_affiliation_strings":["Medical Oncology Service, Hospital General de Alicante, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Service, Hospital General de Alicante, Alicante, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044887899","display_name":"Rafael Rosell","orcid":"https://orcid.org/0000-0003-0817-3400","observed_orcids":["https://orcid.org/0000-0003-0817-3400"]},"institutions":[{"id":"https://openalex.org/I4210095200","display_name":"Instituto Oncol\u00f3gico Dr. Rosell","ror":"https://ror.org/00r9kn296","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095200"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210137002","display_name":"Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol","ror":"https://ror.org/03bzdww12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210137002","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rafael Rosell","raw_affiliation_strings":["Cancer Biology & Precision Medicine Laboratory, Catalan Institute of Oncology (ICO), Germans Trias i Pujol University Hospital, Badalona, Spain","Instituto of Oncology Rosell (IOR), Quir\u00f3n-Dexeus University Institute, Barcelona, Spain","Laboratory of Cancer Molecular Biology, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain\u200b","Cancer Biology & Precision Medicine Laboratory, Catalan Institute of Oncology (ICO), Germans Trias i Pujol University Hospital, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology & Precision Medicine Laboratory, Catalan Institute of Oncology (ICO), Germans Trias i Pujol University Hospital, Badalona, Spain","institution_ids":["https://openalex.org/I4210107147","https://openalex.org/I4210153460"]},{"raw_affiliation_string":"Instituto of Oncology Rosell (IOR), Quir\u00f3n-Dexeus University Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095200"]},{"raw_affiliation_string":"Laboratory of Cancer Molecular Biology, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain\u200b","institution_ids":["https://openalex.org/I4210137002"]},{"raw_affiliation_string":"Cancer Biology & Precision Medicine Laboratory, Catalan Institute of Oncology (ICO), Germans Trias i Pujol University Hospital, Badalona, Spain","institution_ids":["https://openalex.org/I4210107147","https://openalex.org/I4210153460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5044887899"],"corresponding_institution_ids":["https://openalex.org/I4210095200","https://openalex.org/I4210107147","https://openalex.org/I4210137002","https://openalex.org/I4210153460"],"apc_list":null,"apc_paid":null,"fwci":0.5236,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66300555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"21","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7689999938011169},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.8939999938011169},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.925000011920929},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7519999742507935},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.6380000114440918},{"id":"https://openalex.org/keywords/dna-repair-gene-expression","display_name":"DNA repair gene expression","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5295038223266602},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.49660855531692505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39390653371810913},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3936246931552887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36290881037712097},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3289680480957031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32732635736465454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2852601706981659},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/23808993.2017.1298969","doi":"https://doi.org/10.1080/23808993.2017.1298969","is_oa":false,"landing_page_url":"https://doi.org/10.1080/23808993.2017.1298969","pdf_url":null,"source":{"id":"https://openalex.org/S4210210132","display_name":"Expert Review of Precision Medicine and Drug Development","issn_l":"2380-8993","issn":["2380-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Precision Medicine and Drug Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312058","display_name":"\u201cla Caixa\u201d Foundation","ror":"https://ror.org/03zhx9h04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W1604895913","https://openalex.org/W1828222623","https://openalex.org/W1860412575","https://openalex.org/W1929295557","https://openalex.org/W1964065076","https://openalex.org/W1965239527","https://openalex.org/W1969777426","https://openalex.org/W1971517620","https://openalex.org/W1971681479","https://openalex.org/W1971745560","https://openalex.org/W1973268287","https://openalex.org/W1974693247","https://openalex.org/W1979960665","https://openalex.org/W1985585396","https://openalex.org/W1987604182","https://openalex.org/W1989123634","https://openalex.org/W1994926993","https://openalex.org/W2003361136","https://openalex.org/W2004718750","https://openalex.org/W2005428197","https://openalex.org/W2005588323","https://openalex.org/W2005599761","https://openalex.org/W2007663015","https://openalex.org/W2008191260","https://openalex.org/W2010624323","https://openalex.org/W2012108057","https://openalex.org/W2013768132","https://openalex.org/W2015360671","https://openalex.org/W2016735858","https://openalex.org/W2018588892","https://openalex.org/W2019156893","https://openalex.org/W2021363911","https://openalex.org/W2022176772","https://openalex.org/W2025254447","https://openalex.org/W2027640690","https://openalex.org/W2054248299","https://openalex.org/W2058493425","https://openalex.org/W2062464469","https://openalex.org/W2064336610","https://openalex.org/W2074459357","https://openalex.org/W2080408515","https://openalex.org/W2081431907","https://openalex.org/W2088374322","https://openalex.org/W2091073356","https://openalex.org/W2091086437","https://openalex.org/W2092502855","https://openalex.org/W2095618958","https://openalex.org/W2098514397","https://openalex.org/W2099072173","https://openalex.org/W2099082193","https://openalex.org/W2110487265","https://openalex.org/W2110783372","https://openalex.org/W2113363667","https://openalex.org/W2114238186","https://openalex.org/W2114860131","https://openalex.org/W2115157373","https://openalex.org/W2116005493","https://openalex.org/W2117278104","https://openalex.org/W2119321434","https://openalex.org/W2120512254","https://openalex.org/W2124392685","https://openalex.org/W2131670056","https://openalex.org/W2132165198","https://openalex.org/W2134181681","https://openalex.org/W2135409663","https://openalex.org/W2135836212","https://openalex.org/W2137896831","https://openalex.org/W2138763064","https://openalex.org/W2139819296","https://openalex.org/W2140105522","https://openalex.org/W2142658272","https://openalex.org/W2144480632","https://openalex.org/W2147180151","https://openalex.org/W2147943691","https://openalex.org/W2157570211","https://openalex.org/W2157899948","https://openalex.org/W2159796173","https://openalex.org/W2160917799","https://openalex.org/W2161508400","https://openalex.org/W2164277862","https://openalex.org/W2164529446","https://openalex.org/W2164708087","https://openalex.org/W2164742545","https://openalex.org/W2166399931","https://openalex.org/W2167638040","https://openalex.org/W2168168277","https://openalex.org/W2169939490","https://openalex.org/W2171972386","https://openalex.org/W2192054982","https://openalex.org/W2193618871","https://openalex.org/W2197175873","https://openalex.org/W2215528453","https://openalex.org/W2253204326","https://openalex.org/W2281741938","https://openalex.org/W2282989227","https://openalex.org/W2352578155","https://openalex.org/W2397079377","https://openalex.org/W2398047601","https://openalex.org/W2418361789","https://openalex.org/W2418673240","https://openalex.org/W2503060781","https://openalex.org/W2528228811","https://openalex.org/W2529820258","https://openalex.org/W4211006558","https://openalex.org/W4239714259"],"related_works":["https://openalex.org/W2589039930","https://openalex.org/W2397079377","https://openalex.org/W2737740413","https://openalex.org/W1763472475","https://openalex.org/W1996509942","https://openalex.org/W2149220596","https://openalex.org/W7212302660","https://openalex.org/W2170454539","https://openalex.org/W1963528972","https://openalex.org/W1964187464"],"abstract_inverted_index":{"Introduction:":[0],"Platinum-based":[1],"drugs":[2],"are":[3,40],"the":[4,33,36,43,54,66,78,91,104,119,123,164],"mainstay":[5],"of":[6,30,35,46,68,122,130,149,157],"cancer":[7,143],"therapy":[8],"with":[9,14],"potent":[10],"activity":[11,179],"but":[12],"also":[13],"many":[15],"disadvantages,":[16],"including":[17],"tumor":[18,173],"intrinsic":[19],"or":[20],"acquired":[21],"resistance":[22],"and":[23,72,133,186],"numerous":[24],"adverse":[25],"effects.":[26],"The":[27],"main":[28,92],"mechanism":[29],"platinum-resistance":[31],"is":[32],"removal":[34],"platinum-DNA":[37],"adducts":[38],"that":[39,108],"responsible":[41,96],"for":[42,97,115,141],"anticancer":[44],"effect":[45],"platinum":[47],"compounds":[48],"by":[49],"DNA":[50,69,93,177],"repair":[51,70,94,178],"mechanisms.":[52],"Over":[53],"years,":[55],"several":[56],"studies":[57,135],"have":[58,109],"attempted":[59],"to":[60,65,112,137,159,168],"customize":[61,138],"platinum-based":[62,116,139,160],"chemotherapy":[63,140,161],"according":[64],"expression":[67],"components":[71],"determine":[73],"which":[74],"patients":[75,114],"can":[76,180],"obtain":[77],"maximum":[79],"benefit":[80],"from":[81],"treatment.Areas":[82],"covered:":[83],"In":[84,118],"this":[85],"review":[86],"we":[87,125],"will":[88,126],"first":[89],"summarize":[90],"pathways":[95],"protecting":[98],"cell":[99],"genomic":[100],"integrity,":[101],"emphasizing":[102],"on":[103,176],"\u2018damage":[105],"sensor\u2019":[106],"proteins":[107],"been":[110],"used":[111],"select":[113],"chemotherapy.":[117],"second":[120],"part":[121],"review,":[124],"provide":[127],"a":[128],"summary":[129],"our":[131],"prospective":[132],"retrospective":[134],"aiming":[136],"lung":[142],"as":[144,146],"well":[145],"other":[147],"types":[148],"tumors.Expert":[150],"commentary:":[151],"Although":[152],"no":[153],"validated":[154],"predictive":[155],"biomarker":[156],"response":[158],"has":[162],"entered":[163],"routine":[165],"clinical":[166,183],"practice":[167],"date,":[169],"ongoing":[170],"efforts":[171],"towards":[172],"classification":[174],"based":[175],"ultimately":[181],"help":[182],"decision":[184],"making":[185],"improve":[187],"patients\u2019":[188],"outcome.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-03-16T00:00:00"}