{"id":"https://openalex.org/W2594450353","doi":null,"title":"Circulating tumor cells in prostate cancer: beyond enumeration.","display_name":"Circulating tumor cells in prostate cancer: beyond enumeration.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2594450353","mag":"2594450353","pmid":"https://pubmed.ncbi.nlm.nih.gov/28212371"},"language":"en","primary_location":{"id":"pmid:28212371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28212371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071100764","display_name":"Jie\u2010Fu Chen","orcid":"https://orcid.org/0000-0002-4036-6969","observed_orcids":["https://orcid.org/0000-0002-4036-6969"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie-Fu Chen","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024045619","display_name":"Yi\u2010Tsung Lu","orcid":"https://orcid.org/0000-0001-6407-8921","observed_orcids":["https://orcid.org/0000-0001-6407-8921"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I2799932517","display_name":"John H. Stroger, Jr. Hospital of Cook County","ror":"https://ror.org/05626m728","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799932517"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Tsung Lu","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I2799932517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035846267","display_name":"Shirley H. Cheng","orcid":"https://orcid.org/0000-0002-4717-4636","observed_orcids":["https://orcid.org/0000-0002-4717-4636"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley Cheng","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060371571","display_name":"Hsian\u2010Rong Tseng","orcid":"https://orcid.org/0000-0003-0942-5905","observed_orcids":["https://orcid.org/0000-0003-0942-5905"]},"institutions":[{"id":"https://openalex.org/I142207940","display_name":"California NanoSystems Institute","ror":"https://ror.org/00q7fqf35","country_code":"US","type":"facility","lineage":["https://openalex.org/I142207940","https://openalex.org/I154570441","https://openalex.org/I161318765"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsian-Rong Tseng","raw_affiliation_strings":["California Nanosystems Institute, University of California, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Nanosystems Institute, University of California, Los Angeles, California","institution_ids":["https://openalex.org/I142207940","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050649350","display_name":"Robert A. Figlin","orcid":"https://orcid.org/0000-0002-6323-6075","observed_orcids":["https://orcid.org/0000-0002-6323-6075"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Figlin","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036138286","display_name":"Edwin M. Posadas","orcid":"https://orcid.org/0000-0001-8649-1346","observed_orcids":["https://orcid.org/0000-0001-8649-1346"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin M Posadas","raw_affiliation_strings":["Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8078,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84927032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"63","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.24240000545978546,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ctc-enumeration","display_name":"CTC enumeration","score":0.8379999995231628},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.9810000061988831},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.891941487789154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8889526128768921},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7713253498077393},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.5668813586235046},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5512149333953857},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5150284767150879},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4763607978820801},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.45425015687942505},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4527015686035156},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.448572039604187},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.44309088587760925},{"id":"https://openalex.org/C156340839","wikidata":"https://www.wikidata.org/wiki/Q2704791","display_name":"Enumeration","level":2,"score":0.4370110332965851},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42488640546798706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32470113039016724},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.19673380255699158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.053835898637771606},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28212371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28212371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},{"id":"mag:2594450353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28212371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1558034062","https://openalex.org/W1578291413","https://openalex.org/W1582446028","https://openalex.org/W1594190228","https://openalex.org/W1648325620","https://openalex.org/W1701091641","https://openalex.org/W1835655851","https://openalex.org/W1844925317","https://openalex.org/W1860852185","https://openalex.org/W1925793994","https://openalex.org/W1965491427","https://openalex.org/W1968562444","https://openalex.org/W1978091112","https://openalex.org/W1978776690","https://openalex.org/W1979055605","https://openalex.org/W1984736273","https://openalex.org/W1993913242","https://openalex.org/W1994847090","https://openalex.org/W1998680055","https://openalex.org/W2000649281","https://openalex.org/W2001883065","https://openalex.org/W2007387433","https://openalex.org/W2009569945","https://openalex.org/W2014565905","https://openalex.org/W2032518018","https://openalex.org/W2032682565","https://openalex.org/W2041353834","https://openalex.org/W2041993682","https://openalex.org/W2050547995","https://openalex.org/W2050827942","https://openalex.org/W2053961194","https://openalex.org/W2057306577","https://openalex.org/W2059381583","https://openalex.org/W2063870109","https://openalex.org/W2073017550","https://openalex.org/W2073358150","https://openalex.org/W2077438659","https://openalex.org/W2082206904","https://openalex.org/W2082239705","https://openalex.org/W2085847636","https://openalex.org/W2086923565","https://openalex.org/W2091102810","https://openalex.org/W2095726486","https://openalex.org/W2097226696","https://openalex.org/W2098383521","https://openalex.org/W2100115202","https://openalex.org/W2101606728","https://openalex.org/W2101818435","https://openalex.org/W2103793201","https://openalex.org/W2104457974","https://openalex.org/W2109974873","https://openalex.org/W2111304055","https://openalex.org/W2111976640","https://openalex.org/W2112244123","https://openalex.org/W2113092779","https://openalex.org/W2113756065","https://openalex.org/W2117098158","https://openalex.org/W2120227082","https://openalex.org/W2123870972","https://openalex.org/W2125111314","https://openalex.org/W2129128353","https://openalex.org/W2131109308","https://openalex.org/W2131456094","https://openalex.org/W2131948940","https://openalex.org/W2132317169","https://openalex.org/W2140168733","https://openalex.org/W2141420424","https://openalex.org/W2144769242","https://openalex.org/W2148998801","https://openalex.org/W2149131962","https://openalex.org/W2149573463","https://openalex.org/W2149937232","https://openalex.org/W2156923287","https://openalex.org/W2157980218","https://openalex.org/W2159703296","https://openalex.org/W2162685940","https://openalex.org/W2166324735","https://openalex.org/W2171255137","https://openalex.org/W2177480367","https://openalex.org/W2185706465","https://openalex.org/W2207498669","https://openalex.org/W2403998898","https://openalex.org/W2411757338","https://openalex.org/W2419426348","https://openalex.org/W2422782152","https://openalex.org/W2431963657","https://openalex.org/W2460040603","https://openalex.org/W2462140105","https://openalex.org/W2469417826","https://openalex.org/W2538407824"],"related_works":["https://openalex.org/W2519760410","https://openalex.org/W1998800342","https://openalex.org/W2907445134","https://openalex.org/W2079494033","https://openalex.org/W2623081751","https://openalex.org/W1661862144","https://openalex.org/W3197614171","https://openalex.org/W7124423379","https://openalex.org/W978682254","https://openalex.org/W2315881333"],"abstract_inverted_index":{"Circulating":[0],"tumor":[1,17,87],"cells":[2,10],"(CTCs)":[3],"are":[4],"a":[5,33,83],"population":[6],"of":[7,27,47,58,65,77,92,109],"rare":[8],"cancer":[9],"that":[11,45,55,104],"have":[12,39,67,98],"detached":[13],"from":[14],"the":[15,23,59,90,107],"primary":[16],"and/or":[18],"metastatic":[19],"lesions":[20],"and":[21,36,62,89],"entered":[22],"peripheral":[24],"circulation.":[25],"Enumeration":[26],"CTCs":[28,66,103],"has":[29],"demonstrated":[30],"value":[31],"as":[32,75],"prognostic":[34],"biomarker,":[35],"newer":[37],"studies":[38],"pointed":[40],"to":[41,71,85,94],"information":[42],"beyond":[43],"enumeration":[44],"is":[46],"critical":[48],"importance":[49],"in":[50],"prostate":[51,112],"cancer.":[52,113],"Technologic":[53],"advances":[54,81],"permit":[56],"examination":[57],"morphology,":[60],"function,":[61],"molecular":[63],"content":[64],"made":[68],"it":[69],"possible":[70],"measure":[72],"these":[73],"factors":[74],"part":[76],"liquid":[78],"biopsy.":[79],"These":[80],"provide":[82],"way":[84],"study":[86],"evolution":[88],"development":[91],"resistance":[93],"therapy.":[95],"Recent":[96],"breakthroughs":[97],"created":[99],"new":[100],"applications":[101],"for":[102],"will":[105],"affect":[106],"care":[108],"patients":[110],"with":[111]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}