{"id":"https://openalex.org/W2594446333","doi":"https://doi.org/10.1158/2326-6074.tumimm16-a04","title":"Abstract A04: An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system","display_name":"Abstract A04: An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system","publication_year":2017,"publication_date":"2017-02-28","ids":{"openalex":"https://openalex.org/W2594446333","doi":"https://doi.org/10.1158/2326-6074.tumimm16-a04","mag":"2594446333"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.tumimm16-a04","doi":"https://doi.org/10.1158/2326-6074.tumimm16-a04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm16-a04","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024894867","display_name":"Kwangmin Choi","orcid":"https://orcid.org/0000-0003-4671-962X","observed_orcids":["https://orcid.org/0000-0003-4671-962X"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangmin Choi","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061302509","display_name":"Kakajan Komurov","orcid":"https://orcid.org/0000-0003-4834-9845","observed_orcids":["https://orcid.org/0000-0003-4834-9845"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kakajan Komurov","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082318363","display_name":"Jonathan S. Fletcher","orcid":"https://orcid.org/0000-0001-7301-7549","observed_orcids":["https://orcid.org/0000-0001-7301-7549"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Fletcher","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059889069","display_name":"Edwin Jousma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Jousma","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073333838","display_name":"Jos\u00e9 A. Cancelas","orcid":"https://orcid.org/0000-0002-1291-7233","observed_orcids":["https://orcid.org/0000-0002-1291-7233"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A. Cancelas","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064741667","display_name":"Jianqiang Wu","orcid":"https://orcid.org/0000-0002-4239-5659","observed_orcids":["https://orcid.org/0000-0002-4239-5659"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianqiang Wu","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057851992","display_name":"Nancy Ratner","orcid":"https://orcid.org/0000-0001-5030-9354","observed_orcids":["https://orcid.org/0000-0001-5030-9354"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Ratner","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3_Supplement","first_page":"A04","last_page":"A04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibroma","display_name":"neurofibroma","score":0.996999979019165},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.7329999804496765},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.765999972820282},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.4659999907016754},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5350000262260437},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.902999997138977},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/benign-peripheral-nerve-tumor","display_name":"benign peripheral nerve tumor","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2777831590","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Neurofibroma","level":3,"score":0.8818985223770142},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.6092671751976013},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6037205457687378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5900850296020508},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5456536412239075},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.506503701210022},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.47842198610305786},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.4760425090789795},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.46436023712158203},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4497888684272766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44543930888175964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43056467175483704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40883976221084595},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3796319365501404},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.2873297929763794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2810667157173157},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22773122787475586},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17933818697929382},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.14034795761108398},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10669559240341187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10563349723815918},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.tumimm16-a04","doi":"https://doi.org/10.1158/2326-6074.tumimm16-a04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm16-a04","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2594459336","https://openalex.org/W2794443735","https://openalex.org/W2990308149","https://openalex.org/W4296564555","https://openalex.org/W3006758202","https://openalex.org/W4362593334","https://openalex.org/W2031651726","https://openalex.org/W2055697275","https://openalex.org/W7029466522","https://openalex.org/W4411578512"],"abstract_inverted_index":{"Abstract":[0],"Neurofibromas":[1,47],"are":[2,43],"benign":[3,201],"peripheral":[4,236],"nerve":[5,63],"tumors":[6],"driven":[7],"by":[8,162],"NF1":[9],"loss":[10],"in":[11,40,55,89,167,185,194,200,233],"Schwann":[12,127,227],"cells":[13,39,228,232],"(SCs).":[14],"Current":[15],"evidence":[16],"suggests":[17],"that":[18],"an":[19],"inflammatory":[20,222],"environment":[21],"is":[22],"critical":[23],"for":[24],"neurofibroma":[25,41,103,226],"development":[26],"and":[27,37,58,64,121,126,135,138,144,154,165,188,190,229,250],"growth,":[28],"however":[29],"the":[30,113,148,234,243],"roles":[31],"of":[32,107,242],"intercellular":[33],"interactions":[34,180],"between":[35,124],"SCs":[36,57,81,179],"other":[38],"microenvironment":[42],"not":[44],"clear":[45],"yet.":[46],"contain":[48],"numerous":[49],"macrophages.":[50],"We":[51],"analyzed":[52],"gene":[53,99,114,223],"expression":[54,115,153],"FACS-sorted":[56],"macrophages":[59,83,95,125,230],"from":[60,70,86,231],"wild":[61],"type":[62],"neurofibroma.":[65],"Nerve":[66],"macrophage":[67,73],"transcriptomes":[68],"differed":[69,85],"previously":[71,132],"defined":[72],"sub-populations.":[74],"In":[75,92],"1-month-old":[76],"Nf1":[77,177],"mutant":[78,178],"nerve,":[79],"neither":[80],"nor":[82],"significantly":[84,97],"their":[87],"counterparts":[88],"normal":[90,235],"mice.":[91],"7-month-old":[93],"neurofibromas,":[94],"showed":[96],"altered":[98],"expression,":[100],"as":[101],"did":[102],"SCs.":[104],"Computational":[105],"reconstruction":[106],"SC-macrophage":[108],"molecular":[109],"networks":[110],"based":[111],"on":[112,247],"data":[116,149],"revealed":[117],"extensive":[118],"inflammatory-associated":[119],"signaling":[120],"possible":[122],"interplay":[123],"cells.":[128],"Among":[129],"these":[130],"were":[131,160],"implicated":[133],"pathways":[134],"novel":[136],"paracrine":[137],"autocrine":[139],"loops":[140],"involving":[141],"cytokines,":[142],"chemokines,":[143],"growth":[145],"factors.":[146],"Specifically,":[147],"predicted":[150],"increased":[151],"cytokine":[152],"imbalanced":[155],"type-I/type-II":[156],"interferon":[157],"signaling,":[158],"which":[159,183,195],"confirmed":[161],"protein":[163],"profiling,":[164],"normalized":[166],"neurofibroma-bearing":[168],"mice":[169],"treated":[170],"with":[171,181],"PEGylated":[172],"interferon-\u03b12b.":[173],"These":[174],"studies":[175],"identify":[176],"macrophages,":[182],"result":[184],"chronic":[186],"inflammation":[187],"neurofibroma,":[189],"provide":[191],"a":[192],"system":[193],"to":[196],"study":[197],"early":[198],"changes":[199],"tumorigenesis.":[202],"Citation":[203],"Format:":[204],"Kwangmin":[205],"Choi,":[206],"Kakajan":[207],"Komurov,":[208],"Jonathan":[209],"S.":[210],"Fletcher,":[211],"Edwin":[212],"Jousma,":[213],"Jose":[214],"A.":[215],"Cancelas,":[216],"Jianqiang":[217],"Wu,":[218],"Nancy":[219],"Ratner.":[220],"An":[221],"signature":[224],"distinguishes":[225],"nervous":[237],"system.":[238],"[abstract].":[239],"In:":[240],"Proceedings":[241],"AACR":[244],"Special":[245],"Conference":[246],"Tumor":[248],"Immunology":[249],"Immunotherapy;":[251],"2016":[252],"Oct":[253],"20-23;":[254],"Boston,":[255],"MA.":[256],"Philadelphia":[257],"(PA):":[258],"AACR;":[259],"Cancer":[260],"Immunol":[261],"Res":[262],"2017;5(3":[263],"Suppl):Abstract":[264],"nr":[265],"A04.":[266]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2017-03-16T00:00:00"}