{"id":"https://openalex.org/W2594437752","doi":"https://doi.org/10.3892/ijmm.2017.2918","title":"Regulation of Runx2 by microRNA-9 and microRNA-10 modulates the osteogenic differentiation of mesenchymal stem cells","display_name":"Regulation of Runx2 by microRNA-9 and microRNA-10 modulates the osteogenic differentiation of mesenchymal stem cells","publication_year":2017,"publication_date":"2017-03-10","ids":{"openalex":"https://openalex.org/W2594437752","doi":"https://doi.org/10.3892/ijmm.2017.2918","mag":"2594437752","pmid":"https://pubmed.ncbi.nlm.nih.gov/28290608"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2017.2918","doi":"https://doi.org/10.3892/ijmm.2017.2918","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2017.2918","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2017.2918/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijmm.2017.2918/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044782497","display_name":"Hong Luo","orcid":"https://orcid.org/0000-0002-9501-651X","observed_orcids":["https://orcid.org/0000-0002-9501-651X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Luo","raw_affiliation_strings":["Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038926003","display_name":"Hualin Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hualin Gao","raw_affiliation_strings":["Department of Anesthesiology, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453032","display_name":"Fang Liu","orcid":"https://orcid.org/0000-0001-9488-5310","observed_orcids":["https://orcid.org/0000-0001-9488-5310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Liu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082988117","display_name":"Bing Qing Qiu","orcid":"https://orcid.org/0000-0002-4162-9951","observed_orcids":["https://orcid.org/0000-0002-4162-9951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Qiu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Guizhou Orthopaedics Hospital, Guiyang, Guizhou 550001, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.70995849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"4","first_page":"1046","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.22020000219345093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.1476999968290329,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-9","display_name":"miR-9","score":0.9490000009536743},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/osteogenic-induction","display_name":"osteogenic induction","score":0.5699999928474426},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.8610138893127441},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7209555506706238},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6488972902297974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6406815052032471},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5424573421478271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5169752836227417},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5053187012672424},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3904470205307007},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3785039782524109},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09738925099372864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.2017.2918","doi":"https://doi.org/10.3892/ijmm.2017.2918","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2017.2918","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2017.2918/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:28290608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28290608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijmm.2017.2918","doi":"https://doi.org/10.3892/ijmm.2017.2918","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2017.2918","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2017.2918/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2594437752.pdf","grobid_xml":"https://content.openalex.org/works/W2594437752.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1523128476","https://openalex.org/W1568687554","https://openalex.org/W1579543028","https://openalex.org/W1608017777","https://openalex.org/W1984762468","https://openalex.org/W1986086252","https://openalex.org/W1986433875","https://openalex.org/W2016763472","https://openalex.org/W2021053451","https://openalex.org/W2025309753","https://openalex.org/W2082127388","https://openalex.org/W2101499363","https://openalex.org/W2120466825","https://openalex.org/W2126873568","https://openalex.org/W2127686290","https://openalex.org/W2149242237","https://openalex.org/W2154274801","https://openalex.org/W2159999899","https://openalex.org/W2165091962","https://openalex.org/W2165868202","https://openalex.org/W2175239220","https://openalex.org/W2263450284","https://openalex.org/W2269839701","https://openalex.org/W2271729036","https://openalex.org/W2274565482","https://openalex.org/W2294441425","https://openalex.org/W2402519340","https://openalex.org/W2406899853","https://openalex.org/W2413664317","https://openalex.org/W2786972656","https://openalex.org/W4318470741","https://openalex.org/W6694179152","https://openalex.org/W6715557952"],"related_works":["https://openalex.org/W2598220367","https://openalex.org/W3020970945","https://openalex.org/W2105051867","https://openalex.org/W4281613482","https://openalex.org/W3207074890","https://openalex.org/W2365108508","https://openalex.org/W2794852870","https://openalex.org/W2789439634","https://openalex.org/W2985153525","https://openalex.org/W2555729175"],"abstract_inverted_index":{"Currently,":[0],"the":[1,8,21,28,54,58,67,74,88,117,126,131,147,180],"use":[2],"of":[3,10,20,24,30,34,40,69,77,90,119,128,136,149,182],"stem":[4,25,81],"cell":[5],"transplantation":[6],"for":[7],"treatment":[9],"osteoporosis":[11],"is":[12,27],"a":[13],"popular":[14],"research":[15],"topic.":[16],"In":[17],"general,":[18],"promotion":[19],"osteogenic":[22,41,55,75,91,111,132],"differentiation":[23,76,181],"cells":[26,82],"goal":[29],"researchers.":[31],"MicroRNAs":[32],"(miRNAs":[33],"miRs)":[35],"are":[36],"critical":[37],"regulatory":[38],"factors":[39],"induction,":[42],"and":[43,45,71,84,96,105,122,134,143,155,173],"miR\u20119":[44,70,101,129,137,142,172],"miR\u201110":[46,72,144,174],"have":[47],"been":[48],"substantiated":[49],"to":[50,86],"be":[51],"involved":[52],"in":[53,73,178],"process,":[56],"yet":[57],"underlying":[59],"mechanisms":[60],"remain":[61],"unclear.":[62],"The":[63],"present":[64],"study":[65],"investigated":[66],"role":[68],"bone":[78],"marrow-derived":[79],"mesenchymal":[80],"(BMSCs)":[83],"aimed":[85],"elucidate":[87],"mechanism":[89],"differentiation.":[92,112],"Using":[93],"MTT":[94],"assay":[95],"RT-PCR,":[97],"we":[98,169],"found":[99],"that":[100,171],"expression":[102,107,148],"was":[103,108],"upregulated":[104],"miR-10":[106],"downregulated":[109],"during":[110],"Moreover,":[113],"as":[114],"shown":[115],"by":[116,161],"results":[118],"mineralization":[120],"analysis":[121],"western":[123,162],"blot":[124,163],"analysis,":[125],"overexpression":[127,135],"enhanced":[130],"abilities":[133],"inhibited":[138],"these":[139,167],"abilities.":[140],"Furthermore,":[141],"also":[145],"affected":[146],"Runt\u2011related":[150],"transcription":[151],"factor":[152],"2":[153],"(Runx2)":[154],"extracellular":[156],"signal-regulated":[157],"kinase":[158],"(ERK)":[159],"pathway":[160],"analysis.":[164],"Based":[165],"on":[166],"results,":[168],"conclude":[170],"play":[175],"key":[176],"roles":[177],"regulating":[179],"BMSCs.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}
