{"id":"https://openalex.org/W2594023631","doi":"https://doi.org/10.18632/oncotarget.15874","title":"Search for rare protein altering variants influencing susceptibility to multiple myeloma","display_name":"Search for rare protein altering variants influencing susceptibility to multiple myeloma","publication_year":2017,"publication_date":"2017-03-03","ids":{"openalex":"https://openalex.org/W2594023631","doi":"https://doi.org/10.18632/oncotarget.15874","mag":"2594023631","pmid":"https://pubmed.ncbi.nlm.nih.gov/28404951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5482649"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.15874","doi":"https://doi.org/10.18632/oncotarget.15874","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.15874","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.15874","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053825274","display_name":"Matthew Scales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Scales","raw_affiliation_strings":["Centre of Bioinformatics and Systems Biology, Department of Life Sciences, Imperial College London, London, UK","Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Bioinformatics and Systems Biology, Department of Life Sciences, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084782084","display_name":"Daniel Chubb","orcid":"https://orcid.org/0000-0002-3813-0981","observed_orcids":["https://orcid.org/0000-0002-3813-0981"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Chubb","raw_affiliation_strings":["Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064859301","display_name":"Sara E. Dobbins","orcid":"https://orcid.org/0000-0001-5320-3467","observed_orcids":["https://orcid.org/0000-0001-5320-3467"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara E. Dobbins","raw_affiliation_strings":["Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108460251","display_name":"David C. Johnson","orcid":"https://orcid.org/0000-0003-0887-3343","observed_orcids":["https://orcid.org/0000-0003-0887-3343"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David C. Johnson","raw_affiliation_strings":["Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035433129","display_name":"Ni Li","orcid":"https://orcid.org/0000-0001-5530-7745","observed_orcids":["https://orcid.org/0000-0001-5530-7745","https://orcid.org/0000-0001-9351-7823","https://orcid.org/0009-0005-5122-9272","https://orcid.org/0009-0006-4752-4604"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ni Li","raw_affiliation_strings":["Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023619547","display_name":"Michael J.E. Sternberg","orcid":"https://orcid.org/0000-0002-1884-5445","observed_orcids":["https://orcid.org/0000-0002-1884-5445"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J. Sternberg","raw_affiliation_strings":["Centre of Bioinformatics and Systems Biology, Department of Life Sciences, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Bioinformatics and Systems Biology, Department of Life Sciences, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067089658","display_name":"Neils Weinhold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neils Weinhold","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Caleb Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Stein","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081247376","display_name":"Graham Hunter Jackson","orcid":"https://orcid.org/0000-0003-0756-969X","observed_orcids":["https://orcid.org/0000-0003-0756-969X"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham Jackson","raw_affiliation_strings":["Department of Haematology, Newcastle University, Newcastle, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faith E. Davies","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Walker","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Wardell","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022550644","display_name":"Richard S. Houlston","orcid":"https://orcid.org/0000-0002-5268-0242","observed_orcids":["https://orcid.org/0000-0002-5268-0242"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard S. Houlston","raw_affiliation_strings":["Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth J. Morgan","raw_affiliation_strings":["The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":{"value":2463,"currency":"EUR","value_usd":2656},"fwci":2.0827,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87182648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"22","first_page":"36203","last_page":"36210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6259999871253967},{"id":"https://openalex.org/keywords/kif18a","display_name":"KIF18A","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gene-burden-analysis","display_name":"gene burden analysis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/low-frequency-alleles","display_name":"low-frequency alleles","score":0.8090000152587891},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7979999780654907},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.8180000185966492},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.733018696308136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5329771041870117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4565555453300476},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42727139592170715},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34610500931739807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32337719202041626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29823482036590576}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.15874","doi":"https://doi.org/10.18632/oncotarget.15874","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.15874","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4330914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5482649","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5482649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5482649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:28404951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28404951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/48428","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/48428","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"36210","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.15874","doi":"https://doi.org/10.18632/oncotarget.15874","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.15874","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1789679470","display_name":"META-DAC - Managing Ethico-social and Technical issues and Administration of Data Access Committee","funder_award_id":"MR/N01104X/2","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2103660547","display_name":"META-DAC - Managing Ethico-social and Technical issues and Administration of Data Access Committee","funder_award_id":"MR/N01104X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1857035178","https://openalex.org/W1987507232","https://openalex.org/W2003213259","https://openalex.org/W2011830133","https://openalex.org/W2058827066","https://openalex.org/W2060965924","https://openalex.org/W2104526022","https://openalex.org/W2104570606","https://openalex.org/W2108495564","https://openalex.org/W2119180969","https://openalex.org/W2128016314","https://openalex.org/W2128476271","https://openalex.org/W2130224033","https://openalex.org/W2131715067","https://openalex.org/W2133212095","https://openalex.org/W2144759168","https://openalex.org/W2154866190","https://openalex.org/W2155165473","https://openalex.org/W2157752701","https://openalex.org/W2168133698","https://openalex.org/W2169846247","https://openalex.org/W2202451199","https://openalex.org/W2392622562","https://openalex.org/W2402369199","https://openalex.org/W2467557936","https://openalex.org/W2582743722","https://openalex.org/W2609515889"],"related_works":["https://openalex.org/W2556663537","https://openalex.org/W3135320242","https://openalex.org/W4380029589","https://openalex.org/W4416407598","https://openalex.org/W2939638848","https://openalex.org/W3096706567","https://openalex.org/W2168152307","https://openalex.org/W2884526616","https://openalex.org/W6945977298","https://openalex.org/W7000878051"],"abstract_inverted_index":{"//":[0],"Matthew":[1],"Scales":[2],"1,":[3,18,60],"2":[4,28,81],",":[5,9,14,20,24,29,33,37,41,46,51,56],"Daniel":[6],"Chubb":[7],"1":[8,13,23,67],"Sara":[10],"E.":[11,43],"Dobbins":[12],"David":[15],"C.":[16],"Johnson":[17],"3":[19,61,97],"Ni":[21],"Li":[22],"Michael":[25],"J.":[26,64],"Sternberg":[27],"Neils":[30],"Weinhold":[31],"4":[32,36,45,50,55,66,110],"Caleb":[34],"Stein":[35],"Graham":[38],"Jackson":[39],"5":[40,124],"Faith":[42],"Davies":[44],"Brian":[47],"A.":[48],"Walker":[49],"Christopher":[52],"P.":[53],"Wardell":[54],"Richard":[57,134],"S.":[58,135],"Houlston":[59],"and":[62,71,85,199,207,262,300],"Gareth":[63],"Morgan":[65],"Division":[68,98],"of":[69,75,83,89,99,104,115,126,166,178,186,264,279,284,308],"Genetics":[70],"Epidemiology,":[72],"The":[73,102,111,159],"Institute":[74,103],"Cancer":[76,105],"Research,":[77,106],"Sutton,":[78,107],"Surrey,":[79,108],"UK":[80,96,109,131],"Centre":[82],"Bioinformatics":[84],"Systems":[86],"Biology,":[87],"Department":[88,125],"Life":[90],"Sciences,":[91,119],"Imperial":[92],"College":[93],"London,":[94,95],"Molecular":[100],"Pathology,":[101],"Myeloma":[112],"Institute,":[113],"University":[114],"Arkansas":[116],"for":[117,304],"Medical":[118],"Little":[120],"Rock,":[121],"Arkansas,":[122],"USA":[123],"Haematology,":[127],"Newcastle":[128],"University,":[129],"Newcastle,":[130],"Correspondence":[132],"to:":[133],"Houlston,":[136],"email:":[137],"richard.houlston@icr.ac.uk":[138],"Keywords:":[139],"multiple":[140,168],"myeloma,":[141],"inherited":[142,164],"risk,":[143],"exome":[144,192],"sequencing":[145,193],"Received:":[146],"September":[147],"30,":[148],"2016":[149],"Accepted:":[150],"January":[151],"28,":[152],"2017":[153,157],"Published:":[154],"March":[155],"03,":[156],"ABSTRACT":[158],"genetic":[160],"basis":[161],"underlying":[162],"the":[163,176,184,245,306],"risk":[165,185,263],"developing":[167,187],"myeloma":[169],"(MM)":[170],"is":[171],"largely":[172],"unknown.":[173],"To":[174],"examine":[175],"impact":[177,307],"rare":[179],"protein":[180],"altering":[181],"variants":[182],"on":[183,195],"MM":[188,197,265,285,310],"we":[189,235],"analyzed":[190],"high-coverage":[191],"data":[194],"513":[196],"cases":[198],"1,569":[200],"healthy":[201],"controls,":[202],"performing":[203],"both":[204],"single":[205],"variant":[206],"gene":[208,232,250],"burden":[209,233],"tests.":[210],"We":[211],"did":[212,236],"not":[213],"identify":[214,238],"any":[215],"recurrent":[216],"coding":[217],"low-frequency":[218],"alleles":[219],"(1\u20135%)":[220],"with":[221,228,291],"moderate":[222],"effect":[223],"that":[224],"were":[225],"statistically":[226],"associated":[227,290],"MM.":[229],"In":[230],"a":[231,239,254,276,302],"analysis":[234,272],"however":[237],"promising":[240],"relationship":[241],"between":[242],"variation":[243],"in":[244,256],"marrow":[246],"kinetochore":[247],"microtubule":[248],"stromal":[249],"KIF18A,":[251],"which":[252],"plays":[253],"role":[255],"control":[257],"mitotic":[258],"chromosome":[259],"positioning":[260],"dynamics,":[261],"(":[266],"P":[267],"=3.6x10":[268],"\u22126":[269],").":[270],"Further":[271],"showed":[273],"KIF18A":[274],"displays":[275],"distinct":[277],"pattern":[278],"expression":[280],"across":[281],"molecular":[282],"subgroups":[283],"as":[286,288],"well":[287],"being":[289],"patient":[292],"survival.":[293],"Our":[294],"results":[295],"inform":[296],"future":[297],"study":[298],"design":[299],"provide":[301],"resource":[303],"contextualizing":[305],"candidate":[309],"susceptibility":[311],"genes.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-03-16T00:00:00"}
