{"id":"https://openalex.org/W2593884500","doi":"https://doi.org/10.2217/fmeb2013.14.25","title":"Novel approaches to restore vision in end-stage age-related macular degeneration","display_name":"Novel approaches to restore vision in end-stage age-related macular degeneration","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2593884500","doi":"https://doi.org/10.2217/fmeb2013.14.25","mag":"2593884500"},"language":"en","primary_location":{"id":"doi:10.2217/fmeb2013.14.25","doi":"https://doi.org/10.2217/fmeb2013.14.25","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmeb2013.14.25","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Age-Related Macular Degeneration","raw_type":"other"},"volume":{"id":"https://openalex.org/W2487500551","display_name":"Current Issues in Age-Related Macular Degeneration"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075781178","display_name":"Mandeep S. Singh","orcid":"https://orcid.org/0000-0003-1749-0088","observed_orcids":["https://orcid.org/0000-0003-1749-0088"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mandeep S Singh","raw_affiliation_strings":["Mandeep S Singh is a clinical ophthalmologist specializing in vitreoretinal diseases at the Oxford Eye Hospital (UK), and is a graduate (DPhil) candidate at the Nuffield Laboratory of Ophthalmology, University of Oxford (UK). He earned his Bachelor of Medicine and Bachelor of Surgery degrees in Singapore in 2001, and was admitted as a fellow of the Royal College of Surgeons of Edinburgh (UK) in 2009 upon completion of specialty training in ophthalmology. He has received a number of awards including the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mandeep S Singh is a clinical ophthalmologist specializing in vitreoretinal diseases at the Oxford Eye Hospital (UK), and is a graduate (DPhil) candidate at the Nuffield Laboratory of Ophthalmology, University of Oxford (UK). He earned his Bachelor of Medicine and Bachelor of Surgery degrees in Singapore in 2001, and was admitted as a fellow of the Royal College of Surgeons of Edinburgh (UK) in 2009 upon completion of specialty training in ophthalmology. He has received a number of awards including the","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011376600","display_name":"Samantha Roshani De Silva","orcid":"https://orcid.org/0000-0002-4455-2814","observed_orcids":["https://orcid.org/0000-0002-4455-2814"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Samantha R de Silva","raw_affiliation_strings":["Samantha R de Silva graduated from the University of Oxford Medical School (UK) and undertook postgraduate training in medicine, before embarking on a career in ophthalmology. She is a specialist trainee at the John Radcliffe Hospital (Oxford, UK) with a focus in medical retina. Currently holding a Wellcome Trust clinical research training fellowship, she is based in the Nuffield Laboratory of Ophthalmology, University of Oxford, working on gene therapy for the treatment of end-stage retinal degeneration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samantha R de Silva graduated from the University of Oxford Medical School (UK) and undertook postgraduate training in medicine, before embarking on a career in ophthalmology. She is a specialist trainee at the John Radcliffe Hospital (Oxford, UK) with a focus in medical retina. Currently holding a Wellcome Trust clinical research training fellowship, she is based in the Nuffield Laboratory of Ophthalmology, University of Oxford, working on gene therapy for the treatment of end-stage retinal degeneration","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"158","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9710000157356262},{"id":"https://openalex.org/keywords/geographic-atrophy","display_name":"geographic atrophy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/end-stage-disease","display_name":"end-stage disease","score":0.6399999856948853},{"id":"https://openalex.org/keywords/vision-restoration","display_name":"vision restoration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium-degeneration","display_name":"retinal pigment epithelium degeneration","score":0.8960000276565552},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7419830560684204},{"id":"https://openalex.org/C20387591","wikidata":"https://www.wikidata.org/wiki/Q930752","display_name":"Specialty","level":2,"score":0.593153178691864},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5906996726989746},{"id":"https://openalex.org/C2777626052","wikidata":"https://www.wikidata.org/wiki/Q516445","display_name":"Bachelor","level":2,"score":0.5606933832168579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5411021709442139},{"id":"https://openalex.org/C2777867650","wikidata":"https://www.wikidata.org/wiki/Q131647","display_name":"Medal","level":2,"score":0.5376206040382385},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4194333553314209},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.4128468334674835},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.26917606592178345},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1878199577331543},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.14689913392066956},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.14049670100212097},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.09109744429588318},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2217/fmeb2013.14.25","doi":"https://doi.org/10.2217/fmeb2013.14.25","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmeb2013.14.25","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Age-Related Macular Degeneration","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1031519011","https://openalex.org/W1508315241","https://openalex.org/W1551060678","https://openalex.org/W1967476129","https://openalex.org/W1972642682","https://openalex.org/W1972762672","https://openalex.org/W1980429584","https://openalex.org/W1987767450","https://openalex.org/W2001999644","https://openalex.org/W2011634069","https://openalex.org/W2011690901","https://openalex.org/W2012271461","https://openalex.org/W2013744830","https://openalex.org/W2014261579","https://openalex.org/W2020849143","https://openalex.org/W2024323852","https://openalex.org/W2026920679","https://openalex.org/W2028450035","https://openalex.org/W2038570603","https://openalex.org/W2045048112","https://openalex.org/W2046569411","https://openalex.org/W2050279879","https://openalex.org/W2051509380","https://openalex.org/W2055810811","https://openalex.org/W2069110097","https://openalex.org/W2070628315","https://openalex.org/W2074314696","https://openalex.org/W2087291853","https://openalex.org/W2088682369","https://openalex.org/W2091315047","https://openalex.org/W2091864167","https://openalex.org/W2092167465","https://openalex.org/W2100396704","https://openalex.org/W2102264927","https://openalex.org/W2105161755","https://openalex.org/W2109006034","https://openalex.org/W2109583860","https://openalex.org/W2116544039","https://openalex.org/W2125987139","https://openalex.org/W2128803651","https://openalex.org/W2138977668","https://openalex.org/W2146078700","https://openalex.org/W2148211969","https://openalex.org/W2153411657","https://openalex.org/W2155668458","https://openalex.org/W2158310183","https://openalex.org/W2158326388","https://openalex.org/W2162759106","https://openalex.org/W2165124201","https://openalex.org/W2171460754"],"related_works":["https://openalex.org/W2392772670","https://openalex.org/W4400218534","https://openalex.org/W2962942154","https://openalex.org/W2491415351","https://openalex.org/W4407151385","https://openalex.org/W2417545362","https://openalex.org/W4256107229","https://openalex.org/W2180452487","https://openalex.org/W4408163231","https://openalex.org/W2969895557"],"abstract_inverted_index":{"A":[0],"key":[1],"challenge":[2],"in":[3,13,80,122],"age-related":[4],"macular":[5],"degeneration":[6,46,61,83],"treatment":[7],"is":[8,43,62,74,92,97],"to":[9,29,45,55,76,87,105],"restore":[10,30],"central":[11,36,124],"vision":[12],"the":[14,35,48,56,82,123],"end":[15],"stage":[16],"of":[17,47,58,84,89,101],"disease.":[18],"For":[19,94],"patients":[20],"with":[21],"geographic":[22,39],"atrophy,":[23],"no":[24],"treatments":[25,102],"are":[26],"currently":[27],"available":[28],"visual":[31,112],"acuity":[32,113],"by":[33],"regenerating":[34],"retina.":[37,125],"The":[38,72],"atrophy":[40,69],"disease":[41],"process":[42],"due":[44],"retinal":[49,66],"pigment":[50,67],"epithelium,":[51],"which":[52,81,91,104],"ultimately":[53],"leads":[54,86],"loss":[57,88],"photoreceptors.":[59],"Photoreceptor":[60],"largely":[63],"inevitable":[64],"once":[65,115],"epithelium":[68],"has":[70],"occurred.":[71],"situation":[73],"analogous":[75],"other":[77],"neurological":[78],"diseases":[79],"neurons":[85],"function,":[90],"irreversible.":[93],"now,":[95],"there":[96],"a":[98],"relative":[99],"lack":[100],"through":[103],"reinstate":[106],"foveal":[107],"photoreception":[108],"\u2013":[109,114],"and":[110],"hence":[111],"native":[116],"rods":[117],"and/or":[118],"cones":[119],"have":[120],"degenerated":[121]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-03-16T00:00:00"}