{"id":"https://openalex.org/W2593783784","doi":"https://doi.org/10.1007/s40262-017-0516-6","title":"Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis","display_name":"Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis","publication_year":2017,"publication_date":"2017-03-02","ids":{"openalex":"https://openalex.org/W2593783784","doi":"https://doi.org/10.1007/s40262-017-0516-6","mag":"2593783784","pmid":"https://pubmed.ncbi.nlm.nih.gov/28255849","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591805"},"language":"en","primary_location":{"id":"doi:10.1007/s40262-017-0516-6","doi":"https://doi.org/10.1007/s40262-017-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-017-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-017-0516-6.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-017-0516-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003508947","display_name":"Radojka M. Savi\u0107","orcid":"https://orcid.org/0000-0003-3143-5579","observed_orcids":["https://orcid.org/0000-0003-3143-5579","https://orcid.org/0009-0001-3093-9081"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radojka M. Savic","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana M. Novakovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ana M. Novakovic","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103376787","display_name":"Marianne Ekblom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Ekblom","raw_affiliation_strings":["Persson Ekblom Sarl, St-Prex, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Persson Ekblom Sarl, St-Prex, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047819865","display_name":"Alain Munafo","orcid":"https://orcid.org/0000-0002-9019-7956","observed_orcids":["https://orcid.org/0000-0002-9019-7956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Munafo","raw_affiliation_strings":["Merck Institute for Pharmacometrics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Institute for Pharmacometrics, Lausanne, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070310610","display_name":"Mats O. Karlsson","orcid":"https://orcid.org/0000-0003-1258-8297","observed_orcids":["https://orcid.org/0000-0003-1258-8297"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Mats O. Karlsson","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden. mats.karlsson@farmbio.uu.se","Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden. mats.karlsson@farmbio.uu.se","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070310610"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":2.7911,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89644751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"10","first_page":"1245","last_page":"1253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.9599999785423279},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6610000133514404},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interferon-beta-1a","display_name":"interferon beta-1a","score":0.9470000267028809},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9610000252723694},{"id":"https://openalex.org/keywords/three-compartment-model","display_name":"three-compartment model","score":0.7879999876022339},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/covariate-modeling","display_name":"covariate modeling","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8236918449401855},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6785551905632019},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5817173719406128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5577419996261597},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5518333911895752},{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.4731879234313965},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4650852084159851},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.36425313353538513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34555482864379883},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017338","descriptor_name":"Cladribine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017338","descriptor_name":"Cladribine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1007/s40262-017-0516-6","doi":"https://doi.org/10.1007/s40262-017-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-017-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-017-0516-6.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5591805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5591805","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Pharmacokinet","raw_type":"Text"},{"id":"pmid:28255849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28255849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:DiVA.org:uu-315633","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315633","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1ph095g6","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1ph095g6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical pharmacokinetics, vol 56, iss 10","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1ph095g6","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1ph095g6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacokinetics, vol 56, iss 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s40262-017-0516-6","doi":"https://doi.org/10.1007/s40262-017-0516-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-017-0516-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-017-0516-6.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593783784.pdf","grobid_xml":"https://content.openalex.org/works/W2593783784.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1555920164","https://openalex.org/W1606334449","https://openalex.org/W1910669649","https://openalex.org/W1966560563","https://openalex.org/W1986157879","https://openalex.org/W2003048901","https://openalex.org/W2016149155","https://openalex.org/W2118285512","https://openalex.org/W2139204856","https://openalex.org/W2242069468","https://openalex.org/W4285719527","https://openalex.org/W6738588474"],"related_works":["https://openalex.org/W2823433919","https://openalex.org/W1606334449","https://openalex.org/W54400639","https://openalex.org/W1966560563","https://openalex.org/W2141085818","https://openalex.org/W2263947346","https://openalex.org/W1578612793","https://openalex.org/W2590400320","https://openalex.org/W4389460808","https://openalex.org/W2025938931"],"abstract_inverted_index":{"The":[0,86],"aims":[1],"of":[2,11,34,79,91,115,146,169,203,231,248],"this":[3],"study":[4,263],"were":[5,83,131],"to":[6,218],"characterize":[7],"the":[8,32,43,144,166,201],"concentration\u2013time":[9],"course":[10],"cladribine":[12],"(CdA)":[13],"and":[14,26,63,68,75,81,94,97,172,189,208,238,245],"its":[15],"main":[16],"metabolite":[17],"2-chloroadenine":[18],"(CAde),":[19],"estimate":[20],"interindividual":[21],"variability":[22,30],"in":[23,31,50,122,165,228,233],"pharmacokinetics":[24],"(PK),":[25],"identify":[27],"covariates":[28],"explaining":[29],"PK":[33,38,129,145,242],"CdA.":[35],"This":[36],"population":[37],"analysis":[39,87],"was":[40,154,216],"based":[41],"on":[42,255],"combined":[44],"dataset":[45],"from":[46,101],"four":[47],"clinical":[48,72],"studies":[49],"patients":[51,103,175],"with":[52,104,124,156,176,214,250],"multiple":[53],"sclerosis":[54],"(MS):":[55],"three":[56],"phase":[57,70],"I":[58],"studies,":[59],"including":[60],"one":[61,64,69],"food":[62],"drug\u2013drug":[65],"interaction":[66],"study,":[67],"III":[71],"study.":[73],"Plasma":[74],"urine":[76,98],"concentration":[77,99],"data":[78,130],"CdA":[80,93,116,128,148,204,237,251],"CAde":[82,95,239],"modeled":[84],"simultaneously.":[85],"comprised":[88],"a":[89,118,135,139,163],"total":[90,167,234],"2619":[92],"plasma":[96],"observations":[100],"173":[102],"MS":[105],"who":[106],"received":[107],"an":[108,210,229],"intravenous":[109,244],"infusion":[110],"or":[111,121],"oral":[112,246],"tablet":[113],"doses":[114],"as":[117],"single":[119],"agent":[120],"combination":[123],"interferon":[125],"(IFN)":[126],"\u03b2-1a.":[127],"best":[132,142],"described":[133,143],"by":[134,206,225],"three-compartment":[136],"model,":[137],"while":[138],"one-compartment":[140],"model":[141],"CAde.":[147],"renal":[149,196,252],"clearance":[150,158,168],"(CL":[151,159,178,184,191,222],"R":[152,221],")":[153,224],"correlated":[155],"creatinine":[157],"CR":[160,179,185,192,257],"),":[161],"predicting":[162],"decrease":[164],"19%,":[170],"30%":[171],"40%":[173],"for":[174,262],"mild":[177],"=":[180,186,193],"65":[181],"ml/min),":[182],"moderate":[183],"40":[187],"ml/min)":[188,195],"severe":[190],"20":[194],"impairment,":[197],"respectively.":[198],"Food":[199],"decreased":[200],"extent":[202],"absorption":[205,211],"11.2%":[207],"caused":[209],"delay.":[212],"Coadministration":[213],"IFN\u03b2-1a":[215],"found":[217],"increase":[219,230],"non-CL":[220],"NR":[223],"21%,":[226],"resulting":[227],"11%":[232],"clearance.":[235],"Both":[236],"displayed":[240],"linear":[241],"after":[243],"administration":[247],"CdA,":[249],"function":[253],"depending":[254],"CL":[256],".":[258],"Trial":[259],"registration":[260],"number":[261],"25643:":[264],"NCT00213135.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}
