{"id":"https://openalex.org/W2593668024","doi":"https://doi.org/10.1111/echo.13491","title":"Natural history of severe aortic stenosis: Diastolic wall strain as a novel prognostic marker","display_name":"Natural history of severe aortic stenosis: Diastolic wall strain as a novel prognostic marker","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2593668024","doi":"https://doi.org/10.1111/echo.13491","mag":"2593668024","pmid":"https://pubmed.ncbi.nlm.nih.gov/28247566"},"language":"en","primary_location":{"id":"doi:10.1111/echo.13491","doi":"https://doi.org/10.1111/echo.13491","is_oa":false,"landing_page_url":"https://doi.org/10.1111/echo.13491","pdf_url":null,"source":{"id":"https://openalex.org/S127438345","display_name":"Echocardiography","issn_l":"0742-2822","issn":["0742-2822","1540-8175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Echocardiography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039759853","display_name":"Edinrin R. Obasare","orcid":"https://orcid.org/0000-0002-3165-1792","observed_orcids":["https://orcid.org/0000-0002-3165-1792"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edinrin Obasare","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3165-1792","affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019253269","display_name":"Vikas Bhalla","orcid":"https://orcid.org/0000-0001-7578-0986","observed_orcids":["https://orcid.org/0000-0001-7578-0986"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Bhalla","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087218118","display_name":"Deepakraj Gajanana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepakraj Gajanana","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049600495","display_name":"Mary Rodriguez Ziccardi","orcid":"https://orcid.org/0000-0003-4925-838X","observed_orcids":["https://orcid.org/0000-0003-4925-838X"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Rodriguez Ziccardi","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034665587","display_name":"Jose Nicolas Codolosa","orcid":"https://orcid.org/0000-0002-9214-3687","observed_orcids":["https://orcid.org/0000-0002-9214-3687"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose N. Codolosa","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065121906","display_name":"Vincent M. Figueredo","orcid":"https://orcid.org/0000-0003-0301-5649","observed_orcids":["https://orcid.org/0000-0003-0301-5649"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Figueredo","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103716540","display_name":"Dennis Lynn Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Lynn Morris","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035421310","display_name":"Gregg S. Pressman","orcid":"https://orcid.org/0000-0002-0992-1805","observed_orcids":["https://orcid.org/0000-0002-0992-1805"]},"institutions":[{"id":"https://openalex.org/I2801887358","display_name":"Jefferson Einstein Philadelphia Hospital","ror":"https://ror.org/03vzpaf33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801887358","https://openalex.org/I4210111876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregg S. Pressman","raw_affiliation_strings":["Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2801887358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035421310"],"corresponding_institution_ids":["https://openalex.org/I2801887358"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.4163,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65705915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"34","issue":"4","first_page":"484","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.10649999976158142,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-aortic-stenosis","display_name":"severe aortic stenosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/diastolic-wall-strain","display_name":"diastolic wall strain","score":1.0},{"id":"https://openalex.org/keywords/left-ventricular-stiffness","display_name":"left ventricular stiffness","score":0.9649999737739563},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8059999942779541},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.906000018119812},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/left-ventricular-posterior-wall-thickness","display_name":"left ventricular posterior wall thickness","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8489186763763428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8074212074279785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8008685111999512},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6696152687072754},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5770387649536133},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5437293648719788},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.4469901919364929},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3378490209579468},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.24794116616249084}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/echo.13491","doi":"https://doi.org/10.1111/echo.13491","is_oa":false,"landing_page_url":"https://doi.org/10.1111/echo.13491","pdf_url":null,"source":{"id":"https://openalex.org/S127438345","display_name":"Echocardiography","issn_l":"0742-2822","issn":["0742-2822","1540-8175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Echocardiography","raw_type":"journal-article"},{"id":"pmid:28247566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28247566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Echocardiography (Mount Kisco, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W199420291","https://openalex.org/W1717470955","https://openalex.org/W1828851742","https://openalex.org/W1834259859","https://openalex.org/W1984623267","https://openalex.org/W1989846600","https://openalex.org/W1995934832","https://openalex.org/W1999988106","https://openalex.org/W2035725709","https://openalex.org/W2038578901","https://openalex.org/W2038985387","https://openalex.org/W2054649276","https://openalex.org/W2065054962","https://openalex.org/W2075137754","https://openalex.org/W2081440227","https://openalex.org/W2093452583","https://openalex.org/W2109832896","https://openalex.org/W2111765054","https://openalex.org/W2114691945","https://openalex.org/W2118128063","https://openalex.org/W2124624517","https://openalex.org/W2127649963","https://openalex.org/W2135032970","https://openalex.org/W2135349455","https://openalex.org/W2141766684","https://openalex.org/W2149795152","https://openalex.org/W2156425752","https://openalex.org/W2168349150","https://openalex.org/W2318270581","https://openalex.org/W2411636430","https://openalex.org/W2614788422","https://openalex.org/W3022179669","https://openalex.org/W4205993996"],"related_works":["https://openalex.org/W2981837532","https://openalex.org/W4317624894","https://openalex.org/W4281651658","https://openalex.org/W2989924262","https://openalex.org/W2032262027","https://openalex.org/W2903198616","https://openalex.org/W3015657975","https://openalex.org/W2342868834","https://openalex.org/W2928295523","https://openalex.org/W2219875782"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Diastolic":[3],"wall":[4,81,88],"strain":[5],"(DWS)":[6],"has":[7],"been":[8],"proposed":[9],"as":[10,24,75],"a":[11,25,179],"simple":[12],"noninvasive":[13],"measure":[14],"of":[15,28,127,152,176,181,185,196],"left":[16],"ventricular":[17,79,87],"(LV)":[18],"stiffness.":[19],"This":[20],"study":[21,63],"investigated":[22],"DWS":[23,72,101,112,137,175,191],"possible":[26],"predictor":[27,195],"mortality":[29,198],"in":[30,61,83,90,117,199],"severe":[31,202],"aortic":[32,48],"stenosis":[33],"(AS).":[34],"METHODS:":[35],")":[36],"and":[37,56,85,156,183,210],"normal":[38],"ejection":[39],"fraction":[40],"(>55%)":[41],"were":[42,57],"included.":[43],"52":[44],"patients":[45,109,200],"(38%)":[46],"had":[47,178],"valve":[49],"interventions":[50],"or":[51],"poor":[52],"image":[53],"quality":[54],"(n=5)":[55],"excluded":[58],"leaving":[59],"86":[60],"the":[62,103],"group":[64,104],"(84\u00b18":[65],"years,":[66],"70%":[67],"female,":[68],"69%":[69],"African":[70],"American).":[71],"was":[73,105,113],"defined":[74],"(LVPWs-LVPWd)/LVPWs":[76],"where":[77],"LVPWs=left":[78],"posterior":[80],"thickness":[82,89],"systole":[84],"LVPWd=left":[86],"diastole.":[91],"RESULTS:":[92],"Follow-up":[93],"extended":[94],"2.0\u00b11.9":[95],"years":[96],"(median":[97],"1.6":[98],"years).":[99],"Mean":[100],"for":[102,143,174,187,207],"0.21\u00b10.11":[106],"(normal=0.4\u00b10.07).":[107],"In":[108],"who":[110],"died,":[111],"significantly":[114],"lower":[115],"than":[116],"survivors":[118],"(0.18\u00b10.09":[119],"vs":[120],"0.24\u00b10.11,":[121],"P=.02).":[122],"By":[123],"contrast,":[124],"traditional":[125,208],"measures":[126],"diastolic":[128],"dysfunction":[129],"did":[130],"not":[131],"predict":[132],"death.":[133,189],"Regression":[134],"analysis":[135],"showed":[136],"predicted":[138],"death":[139],"even":[140,204],"after":[141,205],"adjusting":[142],"age,":[144],"sex,":[145],"race,":[146],"indexed":[147],"AVA,":[148],"symptoms":[149],"(angina,":[150],"shortness":[151],"breath,":[153],"dizziness,":[154],"syncope),":[155],"clinical":[157,209],"factors":[158],"(creatinine,":[159],"smoking,":[160],"diabetes,":[161],"hypertension,":[162],"hyperlipidemia)":[163],"(HR":[164],"2.5":[165],"[95%":[166],"CI":[167],"1.02-5.90],":[168],"P<.05).":[169],"The":[170],"best":[171],"cutoff":[172],"value":[173],"0.25":[177],"sensitivity":[180],"42%":[182],"specificity":[184],"83%":[186],"predicting":[188],"CONCLUSIONS:":[190],"is":[192],"an":[193],"independent":[194],"all-cause":[197],"with":[201],"AS,":[203],"accounting":[206],"echocardiographic":[211],"parameters.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-16T00:00:00"}