{"id":"https://openalex.org/W2593595133","doi":"https://doi.org/10.1093/ntr/ntx062","title":"Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice","display_name":"Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice","publication_year":2017,"publication_date":"2017-03-07","ids":{"openalex":"https://openalex.org/W2593595133","doi":"https://doi.org/10.1093/ntr/ntx062","mag":"2593595133","pmid":"https://pubmed.ncbi.nlm.nih.gov/28340238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5896544"},"language":"en","primary_location":{"id":"doi:10.1093/ntr/ntx062","doi":"https://doi.org/10.1093/ntr/ntx062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ntr/ntx062","pdf_url":"https://academic.oup.com/ntr/article-pdf/19/9/1033/24367131/ntx062.pdf","source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & Tobacco Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ntr/article-pdf/19/9/1033/24367131/ntx062.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011392113","display_name":"Jeffrey E. Gotts","orcid":"https://orcid.org/0000-0002-6269-8753","observed_orcids":["https://orcid.org/0000-0002-6269-8753"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey E Gotts","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064708000","display_name":"Jason Anthony Abbott","orcid":"https://orcid.org/0000-0002-4406-3121","observed_orcids":["https://orcid.org/0000-0002-4406-3121"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Abbott","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668570","display_name":"Xiaohui Fang","orcid":"https://orcid.org/0000-0003-2731-5021","observed_orcids":["https://orcid.org/0000-0003-2731-5021"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Fang","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089224064","display_name":"Haru Yanagisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haru Yanagisawa","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070754174","display_name":"Naoki Takasaka","orcid":"https://orcid.org/0000-0002-3016-233X","observed_orcids":["https://orcid.org/0000-0002-3016-233X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoki Takasaka","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041863997","display_name":"Stephen L. Nishimura","orcid":"https://orcid.org/0000-0003-2312-4113","observed_orcids":["https://orcid.org/0000-0003-2312-4113"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L Nishimura","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062212651","display_name":"Carolyn S. Calfee","orcid":"https://orcid.org/0000-0001-9208-6865","observed_orcids":["https://orcid.org/0000-0001-9208-6865"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn S Calfee","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Matthay","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011392113"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5392,"currency":"USD","value_usd":5392},"apc_paid":null,"fwci":2.2909,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.88156344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"9","first_page":"1033","last_page":"1039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke-exposure","display_name":"cigarette smoke exposure","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endotoxin-induced-lung-injury","display_name":"endotoxin-induced lung injury","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.9670000076293945},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neutrophilia","display_name":"neutrophilia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/second-hit","display_name":"second hit","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7987173199653625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7551152110099792},{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.7528295516967773},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7308220863342285},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.6588714122772217},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.6271219849586487},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5050409436225891},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.501664400100708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4718221127986908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4508882462978363},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.4490143954753876},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41676443815231323},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37116891145706177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3170802593231201},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.08616229891777039}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014028","descriptor_name":"Tobacco Smoke Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/ntr/ntx062","doi":"https://doi.org/10.1093/ntr/ntx062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ntr/ntx062","pdf_url":"https://academic.oup.com/ntr/article-pdf/19/9/1033/24367131/ntx062.pdf","source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & Tobacco Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5070177","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5896544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5896544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5896544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine Tob Res","raw_type":"Text"},{"id":"pmid:28340238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28340238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9nw9b9pz","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9nw9b9pz","pdf_url":"https://escholarship.org/content/qt9nw9b9pz/qt9nw9b9pz.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nicotine & Tobacco Research, vol 19, iss 9","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9nw9b9pz","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9nw9b9pz","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, vol 19, iss 9","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/ntr/ntx062","doi":"https://doi.org/10.1093/ntr/ntx062","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ntr/ntx062","pdf_url":"https://academic.oup.com/ntr/article-pdf/19/9/1033/24367131/ntx062.pdf","source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & Tobacco Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2571159024","display_name":null,"funder_award_id":"1P50CA180890","funder_id":"https://openalex.org/F4320337661","funder_display_name":"Center for Tobacco Products"},{"id":"https://openalex.org/G5807527562","display_name":null,"funder_award_id":"R37-HL-51856","funder_id":"https://openalex.org/F4320308294","funder_display_name":"Tobacco-Related Disease Research Program"},{"id":"https://openalex.org/G6043160594","display_name":"Improved Models to Inform Tobacco Product Regulation","funder_award_id":"P50CA180890","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7040773111","display_name":null,"funder_award_id":"24RT-0020","funder_id":"https://openalex.org/F4320308294","funder_display_name":"Tobacco-Related Disease Research Program"},{"id":"https://openalex.org/G7397529080","display_name":null,"funder_award_id":"R01-HL-51854","funder_id":"https://openalex.org/F4320308294","funder_display_name":"Tobacco-Related Disease Research Program"},{"id":"https://openalex.org/G8055508284","display_name":"Lung Fluid Balance and Mesenchymal Stem Cells","funder_award_id":"R01HL051854","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000161121","display_name":null,"funder_award_id":"HL51856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G904655290","display_name":"Resolution of Clinical Lung Injury","funder_award_id":"R37HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320308590","display_name":"University of California","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337661","display_name":"Center for Tobacco Products","ror":"https://ror.org/034xvzb47"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593595133.pdf","grobid_xml":"https://content.openalex.org/works/W2593595133.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1553502400","https://openalex.org/W1816622697","https://openalex.org/W1861083212","https://openalex.org/W1921068641","https://openalex.org/W1964906546","https://openalex.org/W1979836769","https://openalex.org/W1981953333","https://openalex.org/W1986932429","https://openalex.org/W1991149613","https://openalex.org/W1998901595","https://openalex.org/W2007473062","https://openalex.org/W2007739830","https://openalex.org/W2011582754","https://openalex.org/W2019549413","https://openalex.org/W2020102380","https://openalex.org/W2030208822","https://openalex.org/W2036568786","https://openalex.org/W2037969580","https://openalex.org/W2038813054","https://openalex.org/W2040180460","https://openalex.org/W2064434867","https://openalex.org/W2064775635","https://openalex.org/W2068854215","https://openalex.org/W2073264366","https://openalex.org/W2077726738","https://openalex.org/W2090999713","https://openalex.org/W2092616294","https://openalex.org/W2097812456","https://openalex.org/W2100234391","https://openalex.org/W2110463517","https://openalex.org/W2115672224","https://openalex.org/W2115802113","https://openalex.org/W2117983612","https://openalex.org/W2120094753","https://openalex.org/W2123077733","https://openalex.org/W2124018534","https://openalex.org/W2132040583","https://openalex.org/W2144222001","https://openalex.org/W2146323311","https://openalex.org/W2149711010","https://openalex.org/W2153156760","https://openalex.org/W2157048558","https://openalex.org/W2163240112","https://openalex.org/W2170822548","https://openalex.org/W2292713941","https://openalex.org/W2321320809","https://openalex.org/W2468339089","https://openalex.org/W2620241325","https://openalex.org/W2621586846","https://openalex.org/W4232139259","https://openalex.org/W4239777125","https://openalex.org/W6659668667","https://openalex.org/W6682390054"],"related_works":["https://openalex.org/W2123282532","https://openalex.org/W2292713941","https://openalex.org/W4302275694","https://openalex.org/W3126898282","https://openalex.org/W2060849426","https://openalex.org/W2790132064","https://openalex.org/W4210676473","https://openalex.org/W2555467097","https://openalex.org/W1894360771","https://openalex.org/W7139131019"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Cigarette":[1],"smoking":[2],"(CS)":[3],"remains":[4],"a":[5,72,168,177,233,246,278,281],"major":[6],"public":[7],"health":[8],"concern":[9],"and":[10,113,118,129,134,151,165,241,312],"has":[11],"recently":[12],"been":[13],"associated":[14],"with":[15,184,229],"an":[16,158,185],"increased":[17,39,210,286],"risk":[18,287],"of":[19,205,248,288,306,315],"developing":[20,289],"acute":[21,206,274,303],"respiratory":[22],"distress":[23],"syndrome":[24],"(ARDS).":[25],"Bronchoalveolar":[26],"lavage":[27],"(BAL)":[28],"experiments":[29],"in":[30,64,71,100,124,130,145,160,180,187,198,213,227,235,239,291],"human":[31],"volunteers":[32],"have":[33,243],"demonstrated":[34],"that":[35,54,195,218,256,262,283],"active":[36],"smokers":[37,240],"develop":[38],"alveolar-epithelial":[40],"barrier":[41],"permeability":[42],"to":[43,76,176,224],"protein":[44],"after":[45],"inhaling":[46],"lipopolysaccharide":[47],"(LPS).":[48],"Here":[49],"we":[50],"tested":[51],"the":[52,101,203,271,285,302],"hypothesis":[53],"short-term":[55,257],"whole-body":[56],"CS":[57,77,105,196,258],"exposure":[58,197,259],"would":[59],"increase":[60,159,186],"LPS-induced":[61],"lung":[62,111,119,125,163,207,211,237,250,266,272,317],"edema":[63,147],"mice.":[65],"METHODS:":[66],"Adult":[67],"mice":[68,97,155,201,216],"were":[69,98,122],"exposed":[70],"Teague":[73],"TE-10":[74],"machine":[75],"from":[78,277],"3R4F":[79],"cigarettes":[80],"at":[81,260],"100":[82],"mg/m3":[83],"total":[84],"suspended":[85],"particulates":[86],"for":[87,273,300],"12":[88],"days,":[89],"then":[90],"given":[91],"LPS":[92,141,172],"or":[93],"saline":[94],"intratracheally.":[95],"Control":[96],"housed":[99],"same":[102],"room":[103],"without":[104],"exposure.":[106],"Post-mortem":[107],"measurements":[108],"included":[109],"gravimetric":[110,149],"water":[112],"BAL":[114,161],"protein,":[115],"cell":[116],"counts,":[117],"histology.":[120],"Cytokines":[121],"measured":[123],"homogenate":[126],"by":[127,132,148],"ELISA":[128],"plasma":[131,166],"Luminex":[133],"ELISA.":[135],"RESULTS:":[136],"In":[137],"CS-exposed":[138,154,181,214],"mice,":[139,182],"intratracheal":[140],"caused":[142],"greater":[143,178],"increases":[144,202],"pulmonary":[146,304],"measurement":[150],"histologic":[152],"scoring.":[153],"also":[156],"had":[157],"neutrophilia,":[162],"IL-6,":[164],"CXCL9,":[167],"T-cell":[169],"chemoattractant.":[170],"Intratracheal":[171],"concentrated":[173],"blood":[174],"hemoglobin":[175],"degree":[179],"consistent":[183],"systemic":[188],"vascular":[189],"permeability.":[190],"CONCLUSIONS:":[191],"These":[192],"results":[193,254],"demonstrate":[194],"endotoxin":[199],"injured":[200],"severity":[204],"injury.":[208,251,318],"The":[209],"IL-6":[212],"LPS-injured":[215],"indicates":[217],"this":[219],"potent":[220],"cytokine,":[221],"previously":[222],"shown":[223],"predict":[225],"mortality":[226],"patients":[228,292],"ARDS,":[230],"may":[231,242,268,297],"play":[232],"role":[234],"exacerbating":[236],"injury":[238,267],"utility":[244],"as":[245],"biomarker":[247],"tobacco-related":[249,316],"IMPLICATIONS:":[252],"Our":[253],"suggest":[255],"levels":[261],"cause":[263],"no":[264],"overt":[265],"still":[269],"prime":[270],"inflammatory":[275],"damage":[276],"\"second":[279],"hit\",":[280],"finding":[282],"mirrors":[284],"ARDS":[290],"who":[293],"smoke.":[294],"This":[295],"model":[296],"be":[298],"useful":[299],"evaluating":[301],"toxicity":[305],"existing":[307],"and/or":[308],"novel":[309],"tobacco":[310],"products":[311],"identifying":[313],"biomarkers":[314]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-03-16T00:00:00"}