{"id":"https://openalex.org/W2593550812","doi":null,"title":"Hippocampal BDNF Mediates Recovery From Chronic Stress-Induced Spatial Reference Memory Deficits","display_name":"Hippocampal BDNF Mediates Recovery From Chronic Stress-Induced Spatial Reference Memory Deficits","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2593550812","mag":"2593550812"},"language":"en","primary_location":{"id":"pmh:item:20916","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.20916","pdf_url":"https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/c7/104333/Ortiz_asu_0010N_13412.pdf?versionId=3fVo_fpJtBLUUMBQnH.5VpZz2cJCYNDR&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ4RPQUAGHK%2F20260818%2Fus-west-2%2Fs3%2Faws4_request&X-Amz-Date=20260818T140307Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=6589c8b3201419fed0daf51c25864c56f137e7534c2188b290dbbdb48640f43a","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/c7/104333/Ortiz_asu_0010N_13412.pdf?versionId=3fVo_fpJtBLUUMBQnH.5VpZz2cJCYNDR&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ4RPQUAGHK%2F20260818%2Fus-west-2%2Fs3%2Faws4_request&X-Amz-Date=20260818T140307Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=6589c8b3201419fed0daf51c25864c56f137e7534c2188b290dbbdb48640f43a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035997439","display_name":"J. Bryce Ortiz","orcid":"https://orcid.org/0000-0002-3126-9171","observed_orcids":["https://orcid.org/0000-0002-3126-9171"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Bryce Ortiz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3126-9171","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035997439"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chronic-restraint-stress","display_name":"chronic restraint stress","score":0.8240000009536743},{"id":"https://openalex.org/keywords/spatial-reference-memory","display_name":"spatial reference memory","score":0.7710000276565552},{"id":"https://openalex.org/keywords/spatial-working-memory","display_name":"spatial working memory","score":0.628000020980835},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7789999842643738},{"id":"https://openalex.org/keywords/stress-recovery","display_name":"stress recovery","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8709999918937683},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/radial-arm-water-maze","display_name":"radial arm water maze","score":0.9079999923706055},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7264915704727173},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6077966094017029},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.597667932510376},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5307970643043518},{"id":"https://openalex.org/C2277912","wikidata":"https://www.wikidata.org/wiki/Q5347383","display_name":"Effects of stress on memory","level":4,"score":0.46533408761024475},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4639351963996887},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.4516347050666809},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.4316539168357849},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.4006701409816742},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1916925609111786},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.17636260390281677},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.15658870339393616}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:item:20916","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.20916","pdf_url":"https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/c7/104333/Ortiz_asu_0010N_13412.pdf?versionId=3fVo_fpJtBLUUMBQnH.5VpZz2cJCYNDR&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ4RPQUAGHK%2F20260818%2Fus-west-2%2Fs3%2Faws4_request&X-Amz-Date=20260818T140307Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=6589c8b3201419fed0daf51c25864c56f137e7534c2188b290dbbdb48640f43a","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},{"id":"mag:2593550812","doi":null,"is_oa":false,"landing_page_url":"https://repository.asu.edu/items/20916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:item:20916","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.20916","pdf_url":"https://d1rbsgppyrdqq4.cloudfront.net/s3fs-public/c7/104333/Ortiz_asu_0010N_13412.pdf?versionId=3fVo_fpJtBLUUMBQnH.5VpZz2cJCYNDR&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIASBVQ3ZQ4RPQUAGHK%2F20260818%2Fus-west-2%2Fs3%2Faws4_request&X-Amz-Date=20260818T140307Z&X-Amz-SignedHeaders=host&X-Amz-Expires=120&X-Amz-Signature=6589c8b3201419fed0daf51c25864c56f137e7534c2188b290dbbdb48640f43a","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593550812.pdf","grobid_xml":"https://content.openalex.org/works/W2593550812.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1634993844","https://openalex.org/W1965232611","https://openalex.org/W1966100684","https://openalex.org/W1966579742","https://openalex.org/W1969693529","https://openalex.org/W1977249405","https://openalex.org/W1979987497","https://openalex.org/W1981381216","https://openalex.org/W1987433942","https://openalex.org/W1989053030","https://openalex.org/W1992115299","https://openalex.org/W1994253126","https://openalex.org/W1997388818","https://openalex.org/W2000808878","https://openalex.org/W2003050811","https://openalex.org/W2003665687","https://openalex.org/W2005344985","https://openalex.org/W2008620918","https://openalex.org/W2012423618","https://openalex.org/W2024583667","https://openalex.org/W2026679280","https://openalex.org/W2029863311","https://openalex.org/W2044183295","https://openalex.org/W2045721936","https://openalex.org/W2046960533","https://openalex.org/W2048560630","https://openalex.org/W2049511526","https://openalex.org/W2057658065","https://openalex.org/W2058006510","https://openalex.org/W2063641803","https://openalex.org/W2063978988","https://openalex.org/W2067017935","https://openalex.org/W2069312841","https://openalex.org/W2070993776","https://openalex.org/W2075455339","https://openalex.org/W2082464174","https://openalex.org/W2083534510","https://openalex.org/W2089198034","https://openalex.org/W2091076521","https://openalex.org/W2103506573","https://openalex.org/W2104417544","https://openalex.org/W2104419734","https://openalex.org/W2113122815","https://openalex.org/W2117586879","https://openalex.org/W2117830068","https://openalex.org/W2122882370","https://openalex.org/W2123637685","https://openalex.org/W2127012092","https://openalex.org/W2131612987","https://openalex.org/W2134878072","https://openalex.org/W2145493769","https://openalex.org/W2145674449","https://openalex.org/W2148044264","https://openalex.org/W2161050830","https://openalex.org/W2163639252","https://openalex.org/W2163815564"],"related_works":["https://openalex.org/W2166662745","https://openalex.org/W2886833162","https://openalex.org/W2044183295","https://openalex.org/W1898751679","https://openalex.org/W7002058395","https://openalex.org/W2351647834","https://openalex.org/W2155712489","https://openalex.org/W1975047942","https://openalex.org/W2975567922","https://openalex.org/W3176918696"],"abstract_inverted_index":{"abstract:":[0],"Chronic":[1],"restraint":[2],"stress":[3,171,214],"impairs":[4],"hippocampal-mediated":[5],"spatial":[6,39,98,152,165,208,235],"learning":[7,99],"and":[8,95,100],"memory,":[9],"which":[10],"improves":[11],"following":[12,116,167],"a":[13,26,68,103,117],"post-stress":[14,119],"recovery":[15,35,120,168,230],"period.":[16],"Here,":[17],"we":[18],"investigated":[19],"whether":[20],"brain":[21],"derived":[22],"neurotrophic":[23],"factor":[24],"(BDNF),":[25],"protein":[27,81],"important":[28],"for":[29,60,78,97,197,228],"hippocampal":[30,224,233],"function,":[31],"would":[32],"alter":[33],"the":[34,49,57,75,126,133,139,151,161,175,184,188,198,229,239],"from":[36,169,231],"chronic":[37,170],"stress-induced":[38,232],"memory":[40,101,134,154,166,200,210,236,241],"deficits.":[41],"Adult":[42],"male":[43],"Sprague-Dawley":[44],"rats":[45],"were":[46,88,195,211],"infused":[47],"into":[48],"hippocampus":[50],"with":[51,72,174],"adeno-":[52],"associated":[53],"viral":[54,144,217],"vectors":[55],"containing":[56,74],"coding":[58,76],"sequence":[59,70],"short":[61],"interfering":[62],"(si)RNA":[63],"directed":[64],"against":[65,177],"BDNF":[66,225],"or":[67,115,191,216],"scrambled":[69],"(Scr),":[71],"both":[73],"information":[77],"green":[79],"fluorescent":[80],"to":[82,187],"aid":[83],"in":[84,138,150,164,238],"anatomical":[85],"localization.":[86],"Rats":[87,137],"then":[89],"chronically":[90],"restrained":[91],"(wire":[92],"mesh,":[93],"6h/d/21d)":[94],"assessed":[96],"using":[102],"radial":[104],"arm":[105],"water":[106],"maze":[107],"(RAWM)":[108],"either":[109],"immediately":[110],"after":[111],"stressor":[112],"cessation":[113],"(Str-Imm)":[114],"21-day":[118],"period":[121],"(Str-Rec).":[122],"All":[123],"groups":[124],"learned":[125],"RAWM":[127,185],"task":[128],"similarly,":[129],"but":[130],"differed":[131],"on":[132,183],"retention":[135],"trial.":[136],"Str-Imm":[140],"group,":[141],"regardless":[142],"of":[143],"vector":[145,218],"contents,":[146],"committed":[147],"more":[148],"errors":[149,205],"reference":[153,199,240],"domain":[155,201],"than":[156],"did":[157],"non-stressed":[158,189],"controls.":[159],"Importantly,":[160],"typical":[162],"improvement":[163],"was":[172],"blocked":[173],"siRNA":[176],"BDNF,":[178],"as":[179,202],"Str-Rec-siRNA":[180],"performed":[181],"worse":[182],"compared":[186],"controls":[190],"Str-Rec-Scr.":[192],"These":[193,220],"effects":[194],"specific":[196],"repeated":[203],"entry":[204],"that":[206,223],"reflect":[207],"working":[209],"unaffected":[212],"by":[213],"condition":[215],"contents.":[219],"results":[221],"demonstrate":[222],"is":[226],"necessary":[227],"dependent":[234],"deficits":[237],"domain.":[242]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-03-16T00:00:00"}
