{"id":"https://openalex.org/W259351708","doi":null,"title":"ATTENUATION OF mTORC1-DRIVEN SECRETION OF LIPOPROTEINS AND TRIACYLGLYCERIDES BY SHORT CHAIN FATTY ACIDS: MECHANISTIC INSIGHT INTO THE PATHOGENESIS OF HYPERTRIGLYCERIDEMIA","display_name":"ATTENUATION OF mTORC1-DRIVEN SECRETION OF LIPOPROTEINS AND TRIACYLGLYCERIDES BY SHORT CHAIN FATTY ACIDS: MECHANISTIC INSIGHT INTO THE PATHOGENESIS OF HYPERTRIGLYCERIDEMIA","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W259351708","mag":"259351708"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unl.edu:nutritiondiss-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/nutritiondiss/52","pdf_url":"https://digitalcommons.unl.edu/context/nutritiondiss/article/1053/viewcontent/COMPLIANT_unl_nutritiondiss_1053.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unl.edu/context/nutritiondiss/article/1053/viewcontent/COMPLIANT_unl_nutritiondiss_1053.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048430317","display_name":"Joseph L. Roberts","orcid":"https://orcid.org/0000-0001-6839-1173","observed_orcids":["https://orcid.org/0000-0001-6839-1173"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph L. Roberts","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# University of Nebraska-Lincoln#N##TAB##TAB##TAB#"],"raw_orcid":"https://orcid.org/0000-0001-6839-1173","affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# University of Nebraska-Lincoln#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048430317"],"corresponding_institution_ids":["https://openalex.org/I114395901"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00187587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.24210000038146973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.8840000033378601},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.8859999775886536},{"id":"https://openalex.org/keywords/4-phenylbutyrate","display_name":"4-phenylbutyric acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/apolipoprotein-b-secretion","display_name":"apolipoprotein B secretion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/triacylglycerol-secretion","display_name":"triacylglycerol secretion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lipoprotein-secretion","display_name":"lipoprotein secretion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tsc2","display_name":"TSC2","score":0.7170000076293945},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.796999990940094},{"id":"https://openalex.org/keywords/atherogenic-lipoproteins","display_name":"atherogenic lipoproteins","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.6990211009979248},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6298564076423645},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5631468892097473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4650007486343384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4060300290584564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3233277201652527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2614544630050659},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2444290816783905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22412225604057312},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.21330896019935608}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.unl.edu:nutritiondiss-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/nutritiondiss/52","pdf_url":"https://digitalcommons.unl.edu/context/nutritiondiss/article/1053/viewcontent/COMPLIANT_unl_nutritiondiss_1053.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1011.896","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1011.896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article%3D1053%26context%3Dnutritiondiss","raw_type":"text"},{"id":"mag:259351708","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1053&context=nutritiondiss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unl.edu:nutritiondiss-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/nutritiondiss/52","pdf_url":"https://digitalcommons.unl.edu/context/nutritiondiss/article/1053/viewcontent/COMPLIANT_unl_nutritiondiss_1053.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310264","display_name":"University of Nebraska-Lincoln","ror":"https://ror.org/043mer456"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W259351708.pdf","grobid_xml":"https://content.openalex.org/works/W259351708.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W187658765","https://openalex.org/W1573455563","https://openalex.org/W1578642492","https://openalex.org/W1638842993","https://openalex.org/W1964944200","https://openalex.org/W1965660529","https://openalex.org/W1967257827","https://openalex.org/W1973785682","https://openalex.org/W1980467489","https://openalex.org/W1982219839","https://openalex.org/W1988597038","https://openalex.org/W1998265194","https://openalex.org/W2001568034","https://openalex.org/W2006559495","https://openalex.org/W2008186158","https://openalex.org/W2021012077","https://openalex.org/W2023012828","https://openalex.org/W2023819606","https://openalex.org/W2033396762","https://openalex.org/W2040595737","https://openalex.org/W2042334427","https://openalex.org/W2046320133","https://openalex.org/W2048456744","https://openalex.org/W2049042126","https://openalex.org/W2053111050","https://openalex.org/W2054356183","https://openalex.org/W2062769455","https://openalex.org/W2066659565","https://openalex.org/W2066768833","https://openalex.org/W2066917089","https://openalex.org/W2078281362","https://openalex.org/W2082853003","https://openalex.org/W2090063543","https://openalex.org/W2094939361","https://openalex.org/W2101083009","https://openalex.org/W2107674876","https://openalex.org/W2109263914","https://openalex.org/W2118029488","https://openalex.org/W2120514137","https://openalex.org/W2127063807","https://openalex.org/W2131553564","https://openalex.org/W2139173082","https://openalex.org/W2144235090","https://openalex.org/W2147833903","https://openalex.org/W2151544106","https://openalex.org/W2152311269"],"related_works":["https://openalex.org/W2205974638","https://openalex.org/W1273701165","https://openalex.org/W4389024226","https://openalex.org/W4389023397","https://openalex.org/W2982018855","https://openalex.org/W2152826474","https://openalex.org/W3119012952","https://openalex.org/W2996744372","https://openalex.org/W3164043194","https://openalex.org/W2032462280"],"abstract_inverted_index":{"The":[0],"mechanistic":[1],"target":[2],"of":[3,31,42,50,55,68,79,114,171,192,202,278],"rapamycin":[4],"complex":[5,109],"1":[6],"(mTORC1)":[7],"is":[8,25,37,57],"a":[9,59],"serine/threonine":[10],"kinase":[11],"that":[12,84,267],"drives":[13],"several":[14],"anabolic":[15],"processes":[16],"including":[17,47],"lipid":[18,75,152],"synthesis,":[19,21],"protein":[20,134],"and":[22,36,77,133,138,151,155,177,194,220,226,269],"adipogenesis.":[23],"mTORC1":[24,56,119,139,148,172,233,237,283],"highly":[26],"active":[27],"in":[28,34,39,239],"the":[29,40,48,69,168,272,276],"livers":[30],"obese":[32],"rodents,":[33],"overnutrition,":[35],"implicated":[38],"development":[41],"obesity":[43],"related":[44],"metabolic":[45],"disorders,":[46],"overproduction":[49],"atherogenic":[51,279],"lipoproteins.":[52,80],"Direct":[53],"inhibition":[54,67],"not":[58,259],"viable":[60],"treatment":[61],"strategy":[62],"because":[63],"it":[64],"prevents":[65],"feedback":[66],"insulin-signaling":[70],"cascade,":[71],"leading":[72],"to":[73,116,163,249,274],"increased":[74,157,173,262],"synthesis":[76],"secretion":[78,179,191,277],"Thus,":[81],"therapeutic":[82],"approaches":[83],"drive":[85],"catabolic":[86],"pathways":[87],"are":[88],"considered":[89],"promising":[90],"mechanisms":[91],"for":[92],"overcoming":[93],"mTORC1-driven":[94],"anabolism.":[95],"Human":[96],"liver":[97],"HepG2":[98],"cells":[99,197],"were":[100,136,198],"stably":[101],"transduced":[102],"with":[103,200,282],"lentiviral":[104,121],"shRNA":[105,123,129,165,241],"targeting":[106],"tuberous":[107],"sclerosis":[108],"2":[110],"(TSC2,":[111],"upstream":[112],"inhibitor":[113],"mTORC1)":[115],"constitutively":[117],"activate":[118],"or":[120,213],"scramble":[122,164],"as":[124],"negative":[125],"control.":[126],"In":[127,247],"TSC2":[128,131,196,240],"cells,":[130],"gene":[132],"expression":[135],"suppressed,":[137],"activity":[140],"(phospho-p70":[141],"S6K/p70":[142],"S6K)":[143],"was":[144],"subsequently":[145],"increased.":[146],"Hyperactive":[147],"upregulated":[149],"lipogenic":[150],"transport":[153],"genes":[154],"significantly":[156,222],"cellular":[158,255,263],"triacylglycerol":[159,178,252,256],"content":[160,257],"when":[161],"compared":[162],"cells.":[166],"Furthermore,":[167],"constitutive":[169],"activation":[170],"apolipoprotein":[174],"B":[175],"(apoB)":[176],"into":[180],"culture":[181],"media.":[182],"To":[183],"determine":[184],"if":[185],"dietary":[186],"agents":[187],"would":[188],"reverse":[189],"mTORC1-mediated":[190],"lipoproteins":[193,280],"triacylglycerides,":[195],"treated":[199],"one":[201],"two":[203],"short":[204],"chain":[205],"fatty":[206],"acids,":[207],"alpha-lipoic":[208],"acid":[209,215],"(LA;":[210],"200":[211],"\u03bcM)":[212],"4-phenylbutyric":[214],"(PBA;":[216],"8":[217],"mM).":[218],"LA":[219,235,253,268],"PBA":[221,244,270],"decreased":[223,254],"secreted":[224,251],"apoB":[225],"triacylglyceride":[227],"despite":[228],"their":[229],"differential":[230],"effects":[231],"on":[232],"activity;":[234],"repressed":[236],"signaling":[238,284],"cells;":[242],"whereas":[243],"did":[245],"not.":[246],"addition":[248],"lowering":[250],"but":[258],"PBA,":[260],"which":[261],"triacylglycerol.":[264],"We":[265],"conclude":[266],"have":[271],"potential":[273],"lower":[275],"associated":[281],"hyperactivation.":[285],"Advisor:":[286],"Regis":[287],"Moreau":[288]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
