{"id":"https://openalex.org/W2593513209","doi":"https://doi.org/10.1371/journal.pone.0172887","title":"Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification","display_name":"Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification","publication_year":2017,"publication_date":"2017-03-03","ids":{"openalex":"https://openalex.org/W2593513209","doi":"https://doi.org/10.1371/journal.pone.0172887","mag":"2593513209","pmid":"https://pubmed.ncbi.nlm.nih.gov/28257417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336234"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0172887","doi":"https://doi.org/10.1371/journal.pone.0172887","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0172887","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172887&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172887&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039885397","display_name":"Javier U. Chicote","orcid":"https://orcid.org/0000-0001-6771-8584","observed_orcids":["https://orcid.org/0000-0001-6771-8584"]},"institutions":[{"id":"https://openalex.org/I4210101772","display_name":"Institut de Recerca Biom\u00e8dica Catalunya Sud","ror":"https://ror.org/01av3a615","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210101772","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210151664","display_name":"Hospital Universitari Joan XXIII de Tarragona","ror":"https://ror.org/05s4b1t72","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210151664","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier U. Chicote","raw_affiliation_strings":["Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain","institution_ids":["https://openalex.org/I4210101772","https://openalex.org/I4210151664","https://openalex.org/I55952717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011665083","display_name":"Rob DeSalle","orcid":"https://orcid.org/0000-0002-6490-7109","observed_orcids":["https://orcid.org/0000-0002-6490-7109"]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob DeSalle","raw_affiliation_strings":["Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NewYork, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NewYork, United States of America","institution_ids":["https://openalex.org/I1338124936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021395402","display_name":"Antonio Garc\u00eda\u2010Espa\u00f1a","orcid":"https://orcid.org/0000-0002-9957-3161","observed_orcids":["https://orcid.org/0000-0002-9957-3161"]},"institutions":[{"id":"https://openalex.org/I4210101772","display_name":"Institut de Recerca Biom\u00e8dica Catalunya Sud","ror":"https://ror.org/01av3a615","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210101772","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210151664","display_name":"Hospital Universitari Joan XXIII de Tarragona","ror":"https://ror.org/05s4b1t72","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210151664","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Garc\u00eda-Espa\u00f1a","raw_affiliation_strings":["Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain","institution_ids":["https://openalex.org/I4210101772","https://openalex.org/I4210151664","https://openalex.org/I55952717"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021395402"],"corresponding_institution_ids":["https://openalex.org/I4210101772","https://openalex.org/I4210151664","https://openalex.org/I55952717"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2177,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.4787914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"3","first_page":"e0172887","last_page":"e0172887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ptprq","display_name":"PTPRQ","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ptprb","display_name":"PTPRB","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ptprj","display_name":"PTPRJ","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ptpro","display_name":"PTPRO","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dep1","display_name":"DEP1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.6420000195503235},{"id":"https://openalex.org/keywords/phylogenetic-relationships","display_name":"phylogenetic relationships","score":0.777999997138977},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.8889999985694885},{"id":"https://openalex.org/keywords/protostomes","display_name":"protostomes","score":0.5920000076293945},{"id":"https://openalex.org/keywords/deuterostomia","display_name":"deuterostomes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/receptor-structure","display_name":"receptor structure","score":0.4099999964237213},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8103735446929932},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6208000779151917},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5506739020347595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5348495244979858},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5224886536598206},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.5151275396347046},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5131624341011047},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.5033137202262878},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.47016260027885437},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.4583858847618103},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.42705437541007996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3693584203720093},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3351670205593109},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.328029990196228},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.12499329447746277},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.11324700713157654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054630","descriptor_name":"Receptor-Like Protein Tyrosine Phosphatases, Class 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054631","descriptor_name":"Receptor-Like Protein Tyrosine Phosphatases, Class 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0172887","doi":"https://doi.org/10.1371/journal.pone.0172887","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0172887","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172887&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5336234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336234","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:28257417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28257417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:urv.cat:PC:2677","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11797/PC2677","pdf_url":"https://repositori.urv.cat/repositori/getDocument/PC%3A2677?ds=DocumentPrincipal&mime=application/pdf","source":{"id":"https://openalex.org/S7407055111","display_name":"Rovira & Virgili repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1371/journal.pone.0172887","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:65263968967d40e78d7402e1f5060c82","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/65263968967d40e78d7402e1f5060c82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 3, p e0172887 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4722346","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Phosphotyrosine_phosphatase_R3_receptors_Origin_evolution_and_structural_diversification/4722346","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0172887","doi":"https://doi.org/10.1371/journal.pone.0172887","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0172887","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172887&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7125116808","display_name":null,"funder_award_id":"CONSOLIDER 2010 CDS00065","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593513209.pdf","grobid_xml":"https://content.openalex.org/works/W2593513209.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W93053067","https://openalex.org/W1567106388","https://openalex.org/W1599373893","https://openalex.org/W1967566856","https://openalex.org/W1967757328","https://openalex.org/W1983035953","https://openalex.org/W1986420486","https://openalex.org/W1991342515","https://openalex.org/W1991863758","https://openalex.org/W1994817846","https://openalex.org/W2004622806","https://openalex.org/W2019000318","https://openalex.org/W2021235009","https://openalex.org/W2024298562","https://openalex.org/W2027446232","https://openalex.org/W2030441910","https://openalex.org/W2030828466","https://openalex.org/W2030885456","https://openalex.org/W2041345262","https://openalex.org/W2042043287","https://openalex.org/W2043617798","https://openalex.org/W2044393771","https://openalex.org/W2058584441","https://openalex.org/W2073128787","https://openalex.org/W2080175465","https://openalex.org/W2089826853","https://openalex.org/W2098854471","https://openalex.org/W2106620129","https://openalex.org/W2114418309","https://openalex.org/W2118130027","https://openalex.org/W2127816425","https://openalex.org/W2127847431","https://openalex.org/W2143297289","https://openalex.org/W2148639274","https://openalex.org/W2150347786","https://openalex.org/W2151922008","https://openalex.org/W2153544371","https://openalex.org/W2154548959","https://openalex.org/W2157646472","https://openalex.org/W2158238509","https://openalex.org/W2169991618","https://openalex.org/W2175619188","https://openalex.org/W2224056471","https://openalex.org/W2573316962","https://openalex.org/W4255614860","https://openalex.org/W4388253550"],"related_works":["https://openalex.org/W2089826853","https://openalex.org/W1972667760","https://openalex.org/W2058584441","https://openalex.org/W1985981271","https://openalex.org/W4282922455","https://openalex.org/W6987509151","https://openalex.org/W2094526435","https://openalex.org/W2767920606","https://openalex.org/W2397531655","https://openalex.org/W152284321"],"abstract_inverted_index":{"Subtype":[0],"R3":[1,31,51,69,124,133,153,205],"phosphotyrosine":[2],"phosphatase":[3,27],"receptors":[4],"(R3":[5],"RPTPs)":[6],"are":[7,53,126,167,208],"single-spanning":[8],"membrane":[9],"proteins":[10],"characterized":[11],"by":[12],"a":[13,22,138,170,181,231],"unique":[14],"modular":[15],"composition":[16],"of":[17,34,103,163,169,184,198,226,239,243],"extracellular":[18],"fibronectin":[19],"repeats":[20],"and":[21,40,46,67,85,92,109,114,122,145,178,193,200,203,212,229,236],"single":[23,171],"cytoplasmatic":[24],"protein":[25],"tyrosine":[26,44],"(PTP)":[28],"domain.":[29],"Vertebrate":[30],"RPTPs":[32,52,125,134,154],"consist":[33],"five":[35],"members:":[36],"PTPRB,":[37],"PTPRJ,":[38],"PTPRH":[39],"PTPRO,":[41],"which":[42,48],"dephosphorylate":[43],"residues,":[45],"PTPRQ,":[47],"dephosphorylates":[49],"phophoinositides.":[50],"considered":[54],"novel":[55],"therapeutic":[56],"targets":[57],"in":[58,100,159,174,188,210],"several":[59],"pathologies":[60],"such":[61],"as":[62,73,75],"ear":[63],"diseases,":[64],"nephrotic":[65],"syndromes":[66],"cancer.":[68],"RPTP":[70,206],"vertebrate":[71,121],"receptors,":[72],"well":[74],"their":[76,143,147],"known":[77],"invertebrate":[78,123,189],"counterparts":[79],"from":[80,87,94,135],"animal":[81],"models:":[82],"PTP52F,":[83],"PTP10D":[84],"PTP4e":[86],"the":[88,95,101,117,160,196,224],"fruitfly":[89],"Drosophila":[90],"melanogaster":[91],"F44G4.8/DEP-1":[93],"nematode":[96],"Caenorhabditis":[97],"elegans,":[98],"participate":[99],"regulation":[102],"cellular":[104],"activities":[105],"including":[106],"cell":[107],"growth":[108],"differentiation.":[110],"Despite":[111],"sharing":[112],"structural":[113,216],"functional":[115,237],"properties,":[116],"evolutionary":[118,140],"relationships":[119],"between":[120],"not":[127],"fully":[128],"understood.":[129],"Here":[130],"we":[131],"gathered":[132],"organisms":[136],"covering":[137],"broad":[139],"distance,":[141],"annotated":[142],"structure":[144],"analyzed":[146],"phylogenetic":[148],"relationships.":[149],"We":[150],"show":[151],"that":[152],"(i)":[155],"have":[156,213,221],"probably":[157],"originated":[158],"common":[161],"ancestor":[162],"animals":[164],"(metazoans),":[165],"(ii)":[166],"variants":[168],"ancestral":[172,186],"gene":[173,187],"protostomes":[175],"(arthropods,":[176],"annelids":[177],"nematodes);":[179],"(iii)":[180],"likely":[182],"duplication":[183],"this":[185,240],"deuterostomes":[190],"(echinodermes,":[191],"hemichordates":[192],"tunicates)":[194],"generated":[195],"precursors":[197],"PTPRQ":[199],"PTPRB":[201],"genes,":[202],"(iv)":[204],"groups":[207],"monophyletic":[209],"vertebrates":[211],"specific":[214],"conserved":[215],"characteristics.":[217],"These":[218],"findings":[219],"could":[220],"implications":[222],"for":[223,233],"interpretation":[225],"past":[227],"studies":[228,235],"provide":[230],"framework":[232],"future":[234],"analysis":[238],"important":[241],"family":[242],"proteins.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-16T00:00:00"}