{"id":"https://openalex.org/W2593489114","doi":"https://doi.org/10.1182/blood.v128.22.803.803","title":"Dysregulated Aid/Apobec Family Proteins Promote Genomic Instability in Multiple Myeloma","display_name":"Dysregulated Aid/Apobec Family Proteins Promote Genomic Instability in Multiple Myeloma","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2593489114","doi":"https://doi.org/10.1182/blood.v128.22.803.803","mag":"2593489114"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.803.803","doi":"https://doi.org/10.1182/blood.v128.22.803.803","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.803.803","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112389374","display_name":"Srikanth Talluri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srikanth Talluri","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041668980","display_name":"Mehmet Samur","orcid":"https://orcid.org/0000-0002-9978-5682","observed_orcids":["https://orcid.org/0000-0002-9978-5682"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Kemal Samur","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036264384","display_name":"Leutz Buon","orcid":"https://orcid.org/0009-0000-5990-1936","observed_orcids":["https://orcid.org/0009-0000-5990-1936"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leutz Buon","raw_affiliation_strings":["The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015568221","display_name":"Megan Stekla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stekla A Megan","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051370438","display_name":"Purushothama Nanjappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purushothama Nanjappa","raw_affiliation_strings":["The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056254084","display_name":"RAO H. PRABHALA","orcid":"https://orcid.org/0000-0002-6375-0437","observed_orcids":["https://orcid.org/0000-0002-6375-0437"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rao Prabhala","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","VA Boston Health Care System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Health Care System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":["Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA","VA Boston Health Care System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Health Care System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.1763035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"128","issue":"22","first_page":"803","last_page":"803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/apobec-deaminases","display_name":"APOBEC deaminases","score":0.7789999842643738},{"id":"https://openalex.org/keywords/aid","display_name":"AID","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cytidine-deaminase","display_name":"cytidine deaminase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8429999947547913},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7870000004768372},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/apobec3a","display_name":"APOBEC3A","score":0.5849999785423279},{"id":"https://openalex.org/keywords/apobec3b","display_name":"APOBEC3B","score":0.9440000057220459},{"id":"https://openalex.org/keywords/apobec3c","display_name":"APOBEC3C","score":0.9139999747276306},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mutation-burden","display_name":"mutational burden","score":0.453000009059906},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776162770","wikidata":"https://www.wikidata.org/wiki/Q4653351","display_name":"APOBEC","level":4,"score":0.9922497272491455},{"id":"https://openalex.org/C2776985229","wikidata":"https://www.wikidata.org/wiki/Q18021211","display_name":"Cytidine deaminase","level":3,"score":0.8053494691848755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6415817737579346},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.5455999374389648},{"id":"https://openalex.org/C27082348","wikidata":"https://www.wikidata.org/wiki/Q21108149","display_name":"Activation-induced (cytidine) deaminase","level":5,"score":0.5207809805870056},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4570361375808716},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39578670263290405},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3764064311981201},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34012657403945923},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.25828781723976135},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.21637141704559326},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.17665508389472961}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.803.803","doi":"https://doi.org/10.1182/blood.v128.22.803.803","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.803.803","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3084841004","https://openalex.org/W2909261016","https://openalex.org/W3204759237","https://openalex.org/W2944771142","https://openalex.org/W2985664280","https://openalex.org/W2620427317","https://openalex.org/W4389233838","https://openalex.org/W2600049592","https://openalex.org/W4405039089","https://openalex.org/W3181612406"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"AID/APOBEC":[2],"family":[3,178],"of":[4,44,71,122,132,138,157,175,204,232,242,254,266,302,339,387,399,436,472,503,505,515],"cytidine":[5,196],"deaminase":[6,197],"proteins":[7,257,389],"includes":[8],"AID":[9,29],"(activity":[10],"induced":[11],"deaminase),":[12],"and":[13,27,40,65,102,166,184,193,208,240,262,271,285,308,310,322,328,343,362,382,409,424,440,474,492,495],"10":[14],"related":[15],"APOBEC":[16,87,105,139,177,234,256,315,329,358,383,388,497],"enzymes":[17],"(A1,":[18],"A2,":[19],"A3A,":[20,181],"A3B,":[21,182],"A3C,":[22,183],"A3D,":[23],"A3F,":[24],"A3G,":[25],"A3H":[26],"A4).":[28],"has":[30,125],"been":[31,57,127],"well-studied":[32],"for":[33,117,334,460],"its":[34],"role":[35,116],"in":[36,62,66,81,91,113,120,129,150,199,225,258,269,277,299,360,369,378,391,394,395,478],"somatic":[37,123],"hyper":[38],"mutation":[39,89,106,312],"class":[41],"switch":[42],"recombination":[43],"immunoglobulin":[45],"genes":[46,427],"whereas":[47],"APOBECs":[48,72,147,222,437,489],"(apolipoprotein":[49],"B":[50],"mRNA":[51,63],"editing":[52,64],"enzyme,":[53],"catalytic":[54],"polypeptide-like)":[55],"have":[56,60,84,464],"shown":[58,86],"to":[59,144,214,453],"roles":[61],"antiviral":[67],"immunity.":[68],"Dysregulated":[69],"activity":[70,198,372,377,398,408,447,498],"causes":[73],"C":[74],">T":[75],"transitions":[76],"or":[77],"C>G,":[78],"C>A":[79],"transversions":[80],"DNA.":[82],"We":[83,186,227,250,352,402],"recently":[85],"signature":[88,107,140],"pattern":[90],"multiple":[92],"myeloma":[93,159,167,205,259,416],"(MM)":[94],"genomes":[95],"(Bolli":[96],"et":[97],"al":[98],"Nat.":[99],"Comm.":[100],"2014),":[101],"interestingly,":[103],"the":[104,118,230,264,300,320,337,355,400,426,501,516],"correlates":[108],"with":[109,293,318,431,444],"sub":[110],"clonal":[111,521],"diversity":[112],"myeloma.":[114,226],"A":[115],"AID/APOBECs":[119],"generation":[121],"mutations":[124,141,491],"also":[126,403,465],"proposed":[128],"a":[130,189,202],"variety":[131],"other":[133,363],"cancers":[134],"based":[135],"on":[136,236,513],"identification":[137],"In":[142,482],"order":[143],"understand":[145],"which":[146],"are":[148,223],"dysregulated":[149,224,488],"myeloma,":[151],"we":[152,374,463],"performed":[153],"RNA":[154],"sequencing":[155],"analysis":[156,171],"primary":[158],"cells":[160,212,216,273,331,417],"from":[161,201,217,380,415,419],"409":[162],"newly-diagnosed":[163],"MM":[164,361],"patients":[165,421],"cell":[168,206,260],"lines.":[169],"Our":[170,291],"showed":[172,296,324],"elevated":[173,233],"expression":[174,411,429,435,471],"several":[176],"members;":[179],"mainly":[180],"A3G.":[185],"then":[187,228],"optimized":[188],"plasmid-based":[190],"functional":[191],"assay":[192],"found":[194],"high":[195,445],"extracts":[200,379],"number":[203,304,342,458],"lines":[207,261],"patient":[209,462],"derived":[210,418],"CD138+":[211,215],"compared":[213],"healthy":[218],"donors,":[219],"suggesting":[220,450],"that":[221,325,487],"investigated":[229,263,354],"impact":[231],"expression/function":[235],"overall":[237,311],"genome":[238,288,347],"maintenance":[239],"acquisition":[241,265,338],"genomic":[243,267,456,476,493,507],"changes":[244,268,305,345],"(such":[245],"as":[246,518,520],"amplifications,":[247],"deletions)":[248,309],"overtime.":[249],"used":[251],"shRNA-mediated":[252],"knockdown":[253,272,330,384],"specific":[255],"control":[270,327,381],"during":[274],"their":[275,451],"growth":[276],"culture,":[278],"using":[279,412],"SNP":[280,321],"(Single":[281],"Nucleotide":[282],"Polymorphism)":[283],"arrays":[284],"WGS":[286,323],"(whole":[287],"sequencing)":[289],"platforms.":[290],"results":[292],"both":[294,319],"approaches":[295],"significant":[297,467],"reduction":[298,393],"accumulation":[301,504],"copy":[303,341,457],"(both":[306],"amplifications":[307],"load":[313],"after":[314],"knockdown.":[316],"Evaluation":[317],"when":[326],"were":[332,348],"cultured":[333],"three":[335],"weeks,":[336],"new":[340],"mutational":[344],"throughout":[346],"reduced":[349],"by":[350],"~50%.":[351],"next":[353],"relationship":[356],"between":[357,406,469],"expression/activity":[359],"DNA":[364],"repair":[365],"pathways.":[366],"Using":[367],"an":[368],"vitro":[370,396],"HR":[371,376,397,407,432,446],"assay,":[373],"measured":[375],"cells.":[385],"Depletion":[386],"resulted":[390],"50-80%":[392],"extracts.":[401],"evaluated":[404],"correlation":[405,468],"gene":[410],"RNA-seq":[413],"data":[414,510],"100":[420],"at":[422],"diagnosis":[423],"identified":[425],"whose":[428],"correlated":[430,443],"activity.":[433],"Elevated":[434],"3D,":[438],"3G":[439],"3F":[441],"significantly":[442],"(R=0.3;":[448],"P\u22640.02),":[449],"relevance":[452],"HR.":[454],"Analyzing":[455],"information":[459],"each":[461],"observed":[466],"higher":[470],"A3G":[473],"increased":[475],"instability":[477],"this":[479],"dataset":[480],"(P=0.0045).":[481],"summary,":[483],"our":[484],"study":[485],"shows":[486],"induce":[490],"instability,":[494],"inhibiting":[496],"could":[499],"reduce":[500],"rate":[502],"ongoing":[506],"changes.":[508],"This":[509],"sheds":[511],"light":[512],"biology":[514],"disease":[517],"well":[519],"evolution.":[522],"Disclosures":[523],"Munshi:":[524],"Amgen:":[525],"Consultancy;":[526,532,534,536,538],"Oncopep:":[527],"Patents":[528],"&":[529],"Royalties;":[530],"Celgene:":[531],"Janssen:":[533],"Takeda:":[535],"Merck:":[537],"Pfizer:":[539],"Consultancy.":[540]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-16T00:00:00"}