{"id":"https://openalex.org/W2593410185","doi":null,"title":"Effect of high dose fish oil supplementation on cerebral blood flow and cognitive performance in patients with mild cognitive impairment: a proof of concept study","display_name":"Effect of high dose fish oil supplementation on cerebral blood flow and cognitive performance in patients with mild cognitive impairment: a proof of concept study","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2593410185","mag":"2593410185"},"language":"en","primary_location":{"id":"pmh:oai:library.wur.nl:wurpubs/449968","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/effect-of-high-dose-fish-oil-supplementation-on-cerebral-blood-fl","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging Research & Clinical Practice 2 (2013) 4","raw_type":"Article/Letter to editor"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.wur.nl/en/publications/effect-of-high-dose-fish-oil-supplementation-on-cerebral-blood-fl","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010462242","display_name":"Ondine van de Rest","orcid":"https://orcid.org/0000-0002-4632-7418","observed_orcids":["https://orcid.org/0000-0002-4632-7418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ondine van de Rest","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4632-7418","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012964731","display_name":"Jurgen A.H.R. Claassen","orcid":"https://orcid.org/0000-0002-1778-8151","observed_orcids":["https://orcid.org/0000-0002-1778-8151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jurgen A.H.R. Claassen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1778-8151","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003017256","display_name":"Roy P. C. Kessels","orcid":"https://orcid.org/0000-0001-9500-9793","observed_orcids":["https://orcid.org/0000-0001-9500-9793","https://orcid.org/0000-0002-7107-8900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.P.C. Kessels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7107-8900","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024313662","display_name":"Johanna Marianne Geleijnse","orcid":"https://orcid.org/0000-0001-7638-0589","observed_orcids":["https://orcid.org/0000-0001-7638-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna M. Geleijnse","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7638-0589","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029136789","display_name":"Marcel G. M. Olde Rikkert","orcid":"https://orcid.org/0000-0003-1397-1677","observed_orcids":["https://orcid.org/0000-0003-1397-1677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcel G. M. Olde Rikkert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1397-1677","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063231545","display_name":"C.P.G.M. de Groot","orcid":"https://orcid.org/0000-0003-2778-2789","observed_orcids":["https://orcid.org/0000-0003-2778-2789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.P.G.M. de Groot","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2778-2789","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"4","first_page":"325","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fish-oil-supplementation","display_name":"fish oil supplementation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cortical-oxygenation","display_name":"cortical oxygenation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8769999742507935},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.8840000033378601},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.6859999895095825},{"id":"https://openalex.org/keywords/reaction-time","display_name":"reaction time","score":0.7179999947547913},{"id":"https://openalex.org/keywords/age-related-cognitive-decline","display_name":"age-related cognitive decline","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.6909724473953247},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6809886693954468},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.6590229272842407},{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.6349349021911621},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.572913646697998},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.563901960849762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5611279010772705},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.5582460761070251},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5556363463401794},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5215725302696228},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.4841249883174896},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47705283761024475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3800452947616577},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.3570469617843628},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.34580567479133606},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3275038003921509},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.1881987750530243},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11263880133628845},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08483988046646118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07970431447029114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07278132438659668},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:library.wur.nl:wurpubs/449968","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/effect-of-high-dose-fish-oil-supplementation-on-cerebral-blood-fl","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging Research & Clinical Practice 2 (2013) 4","raw_type":"Article/Letter to editor"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/449968","doi":null,"is_oa":false,"landing_page_url":"https://research.wur.nl/en/publications/effect-of-high-dose-fish-oil-supplementation-on-cerebral-blood-fl","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging Research &amp; Clinical Practice, 2(4), 325 - 332","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2593410185","doi":null,"is_oa":false,"landing_page_url":"http://library.wur.nl/WebQuery/wurpubs/449968","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:library.wur.nl:wurpubs/449968","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/effect-of-high-dose-fish-oil-supplementation-on-cerebral-blood-fl","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Aging Research & Clinical Practice 2 (2013) 4","raw_type":"Article/Letter to editor"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1492341255","https://openalex.org/W1505426793","https://openalex.org/W1608805670","https://openalex.org/W1847168837","https://openalex.org/W1967506636","https://openalex.org/W2010181024","https://openalex.org/W2031721411","https://openalex.org/W2043140303","https://openalex.org/W2055821827","https://openalex.org/W2073748140","https://openalex.org/W2078601079","https://openalex.org/W2079183773","https://openalex.org/W2094472277","https://openalex.org/W2098825532","https://openalex.org/W2106888831","https://openalex.org/W2111774300","https://openalex.org/W2117083718","https://openalex.org/W2121934251","https://openalex.org/W2122320288","https://openalex.org/W2124956656","https://openalex.org/W2127258285","https://openalex.org/W2127805507","https://openalex.org/W2131422017","https://openalex.org/W2134645492","https://openalex.org/W2138904731","https://openalex.org/W2139268937","https://openalex.org/W2144750999","https://openalex.org/W2159122349","https://openalex.org/W2162294352","https://openalex.org/W2171051145","https://openalex.org/W2317416673"],"related_works":["https://openalex.org/W2124956656","https://openalex.org/W2075373003","https://openalex.org/W2886667022","https://openalex.org/W2568423394","https://openalex.org/W2054485086","https://openalex.org/W4319939149","https://openalex.org/W3209599660","https://openalex.org/W3161273440","https://openalex.org/W2253888111","https://openalex.org/W7112549081"],"abstract_inverted_index":{"Objective:":[0],"The":[1],"current":[2],"study":[3],"aimed":[4],"to":[5],"examine":[6],"the":[7,59,155,164,168],"effect":[8,142,189],"of":[9,22,39,61,64,73,154],"n-3":[10],"polyunsaturated":[11],"fatty":[12],"acids":[13],"(PUFAs)":[14],"on":[15,87,143,152,190],"cerebral":[16,88,144,191],"blood":[17,89,96,112,147,193],"flow":[18,90,97],"and":[19,35,91,98,106,130,167],"age-related":[20],"loss":[21],"cognitive":[23,30,92,196],"functioning":[24],"in":[25,50,177],"subjects":[26,150],"diagnosed":[27],"with":[28,42,67,111,135,182],"mild":[29],"impairment":[31],"(MCI).":[32],"Design,":[33],"setting":[34],"participants:":[36],"A":[37],"total":[38],"20":[40],"patients":[41],"single":[43],"or":[44,84,146,195],"multiple":[45],"domain":[46],"MCI":[47,178],"took":[48],"part":[49],"this":[51,173],"randomized,":[52],"double-blind,":[53],"placebo-controlled":[54],"trial,":[55],"wherein":[56],"we":[57],"investigated":[58],"effects":[60],"four":[62,185],"weeks":[63,139,186],"daily":[65,180],"supplementation":[66,134,181],"either":[68],"a":[69],"high":[70],"pharmacological":[71],"dose":[72],"3":[74],"g":[75],"eicosapentaenoic":[76],"acid":[77,81],"(EPA)":[78],"plus":[79],"docosahexaenoic":[80],"(DHA)":[82],"(n=10)":[83,86],"placebo":[85,169],"performance.":[93],"Measurements:":[94],"Cerebral":[95],"cortical":[99],"oxygenation":[100],"were":[101],"measured":[102],"by":[103,121],"Transcranial":[104],"Doppler":[105],"Near":[107],"Infrared":[108],"Spectroscopy":[109],"together":[110],"pressure":[113],"measurements":[114],"using":[115],"Finapres.":[116],"Cognitive":[117],"function":[118],"was":[119,160],"assessed":[120],"sensitive":[122],"neuropsychological":[123,156],"tests":[124],"measuring":[125],"reaction":[126],"times,":[127],"episodic":[128],"memory":[129],"attention.":[131],"Results:":[132],"Daily":[133],"EPA+DHA":[136,183],"for":[137,184],"4":[138],"had":[140,187],"no":[141,161,188],"hemodynamics":[145],"pressure.":[148],"All":[149],"improved":[151],"most":[153],"tests,":[157],"but":[158],"there":[159],"difference":[162],"between":[163],"fish":[165],"oil":[166],"groups.":[170],"Conclusions:":[171],"In":[172],"randomized":[174],"controlled":[175],"trial":[176],"patients,":[179],"hemodynamics,":[192],"pressure,":[194],"performance":[197]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-03-16T00:00:00"}
