{"id":"https://openalex.org/W2593395640","doi":"https://doi.org/10.1186/s41241-017-0015-y","title":"Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy","display_name":"Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy","publication_year":2017,"publication_date":"2017-03-06","ids":{"openalex":"https://openalex.org/W2593395640","doi":"https://doi.org/10.1186/s41241-017-0015-y","mag":"2593395640"},"language":"en","primary_location":{"id":"doi:10.1186/s41241-017-0015-y","doi":"https://doi.org/10.1186/s41241-017-0015-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41241-017-0015-y","pdf_url":"https://appliedcr.biomedcentral.com/track/pdf/10.1186/s41241-017-0015-y","source":{"id":"https://openalex.org/S2764852163","display_name":"Applied cancer research/Applied Cancer Research","issn_l":"1808-5512","issn":["1808-5512","1980-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://appliedcr.biomedcentral.com/track/pdf/10.1186/s41241-017-0015-y","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057826681","display_name":"Pravin D. Potdar","orcid":"https://orcid.org/0000-0002-7829-7831","observed_orcids":["https://orcid.org/0000-0002-7829-7831"]},"institutions":[{"id":"https://openalex.org/I2802099312","display_name":"Jaslok Hospital","ror":"https://ror.org/052w06y65","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802099312"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pravin Potdar","raw_affiliation_strings":["Department of Molecular Medicine and Biology, Jaslok Hospital & Research Centre, 15 Dr. G. DeshmukhMarg, Mumbai, 400026, Maharashtra, India"],"raw_orcid":"https://orcid.org/0000-0002-7829-7831","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Biology, Jaslok Hospital & Research Centre, 15 Dr. G. DeshmukhMarg, Mumbai, 400026, Maharashtra, India","institution_ids":["https://openalex.org/I2802099312"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shahid Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802099312","display_name":"Jaslok Hospital","ror":"https://ror.org/052w06y65","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802099312"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shahid Chaudhary","raw_affiliation_strings":["Department of Molecular Medicine and Biology, Jaslok Hospital & Research Centre, 15 Dr. G. DeshmukhMarg, Mumbai, 400026, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Biology, Jaslok Hospital & Research Centre, 15 Dr. G. DeshmukhMarg, Mumbai, 400026, Maharashtra, India","institution_ids":["https://openalex.org/I2802099312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057826681"],"corresponding_institution_ids":["https://openalex.org/I2802099312"],"apc_list":null,"apc_paid":null,"fwci":0.1948,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.45999833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"37","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/ipsc-reprogramming","display_name":"iPSC reprogramming","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cancer-modeling","display_name":"cancer modeling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.8149999976158142},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/regenerative-cell-therapy","display_name":"regenerative cell therapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8460000157356262},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.94292151927948},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9236389398574829},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5403151512145996},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5292465090751648},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5012428760528564},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4799811542034149},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46446532011032104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45308083295822144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4504004716873169},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.43573644757270813},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.42690059542655945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3621354401111603},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3333667516708374},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31543731689453125},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2881419062614441},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2167137861251831},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2129446566104889},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14538943767547607},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05669206380844116}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s41241-017-0015-y","doi":"https://doi.org/10.1186/s41241-017-0015-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41241-017-0015-y","pdf_url":"https://appliedcr.biomedcentral.com/track/pdf/10.1186/s41241-017-0015-y","source":{"id":"https://openalex.org/S2764852163","display_name":"Applied cancer research/Applied Cancer Research","issn_l":"1808-5512","issn":["1808-5512","1980-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Cancer Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s41241-017-0015-y","doi":"https://doi.org/10.1186/s41241-017-0015-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41241-017-0015-y","pdf_url":"https://appliedcr.biomedcentral.com/track/pdf/10.1186/s41241-017-0015-y","source":{"id":"https://openalex.org/S2764852163","display_name":"Applied cancer research/Applied Cancer Research","issn_l":"1808-5512","issn":["1808-5512","1980-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593395640.pdf","grobid_xml":"https://content.openalex.org/works/W2593395640.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W28383247","https://openalex.org/W1692777765","https://openalex.org/W1841412170","https://openalex.org/W1967025085","https://openalex.org/W1971496676","https://openalex.org/W1973207471","https://openalex.org/W1974773432","https://openalex.org/W1982969769","https://openalex.org/W1988627620","https://openalex.org/W1990110626","https://openalex.org/W1990416052","https://openalex.org/W1992525863","https://openalex.org/W1994711951","https://openalex.org/W2003524961","https://openalex.org/W2015947790","https://openalex.org/W2025728074","https://openalex.org/W2028835848","https://openalex.org/W2033899158","https://openalex.org/W2035121417","https://openalex.org/W2039705224","https://openalex.org/W2041090784","https://openalex.org/W2043163625","https://openalex.org/W2043630499","https://openalex.org/W2046524941","https://openalex.org/W2047015004","https://openalex.org/W2050689355","https://openalex.org/W2058640723","https://openalex.org/W2060530677","https://openalex.org/W2066830592","https://openalex.org/W2068416436","https://openalex.org/W2077303518","https://openalex.org/W2079995359","https://openalex.org/W2086943348","https://openalex.org/W2091037654","https://openalex.org/W2092166052","https://openalex.org/W2097050852","https://openalex.org/W2097236698","https://openalex.org/W2098597036","https://openalex.org/W2106544289","https://openalex.org/W2118599195","https://openalex.org/W2119693254","https://openalex.org/W2121188788","https://openalex.org/W2125987139","https://openalex.org/W2126580353","https://openalex.org/W2138726422","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2147284744","https://openalex.org/W2150919128","https://openalex.org/W2151676353","https://openalex.org/W2153199196","https://openalex.org/W2157439553","https://openalex.org/W2168028214","https://openalex.org/W2327319275","https://openalex.org/W2342219924"],"related_works":["https://openalex.org/W3028909094","https://openalex.org/W2118661959","https://openalex.org/W2562906640","https://openalex.org/W1828724081","https://openalex.org/W2802303168","https://openalex.org/W2072162860","https://openalex.org/W3216798245","https://openalex.org/W7222573266","https://openalex.org/W4394874313","https://openalex.org/W2360631304"],"abstract_inverted_index":{"Induced":[0],"Pluripotent":[1],"Stem":[2],"Cells":[3],"(iPSCs)":[4],"technology":[5,52],"has":[6,27],"catapulted":[7],"the":[8,23,35,47,73,90],"field":[9],"of":[10,16,25,50,59,79],"stem-cell":[11],"biology":[12],"through":[13],"ectopic":[14],"expression":[15],"reprogramming":[17,58],"factors.":[18],"Ever":[19],"since":[20],"its":[21],"discovery,":[22],"potential":[24],"iPSCs":[26,80],"been":[28],"explored":[29],"by":[30],"many":[31],"scientists":[32],"to":[33,63,83],"unravel":[34],"molecular":[36],"mechanism":[37],"responsible":[38],"for":[39,89],"cancer":[40,60,85],"initiation":[41],"and":[42,66,86],"progression.":[43],"Besides":[44],"modeling":[45],"cancer,":[46],"further":[48],"applications":[49,78],"this":[51],"includes":[53],"high-throughput":[54],"drug":[55],"screening,":[56],"epigenetic":[57],"cell":[61,68],"state":[62],"normal,":[64],"immunotherapy":[65],"regenerative":[67],"therapies.":[69],"Here,":[70],"we":[71],"review":[72],"current":[74],"challenges":[75],"on":[76],"clinical":[77],"with":[81],"respect":[82],"understanding":[84],"personalizing":[87],"treatment":[88],"disease.":[91]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-03-16T00:00:00"}