{"id":"https://openalex.org/W2593313751","doi":"https://doi.org/10.1182/blood.v110.11.537.537","title":"Pan-Histone Deacetylase (HDAC) Inhibitor LBH589 Depletes CXCR4 Levels and Signaling, Exerting Synergistic Anti-Leukemia Activity in Combination with CXCR4 Antagonists.","display_name":"Pan-Histone Deacetylase (HDAC) Inhibitor LBH589 Depletes CXCR4 Levels and Signaling, Exerting Synergistic Anti-Leukemia Activity in Combination with CXCR4 Antagonists.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2593313751","doi":"https://doi.org/10.1182/blood.v110.11.537.537","mag":"2593313751"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.537.537","doi":"https://doi.org/10.1182/blood.v110.11.537.537","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.537.537","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044723679","display_name":"Aditya Mandawat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Mandawat","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067678169","display_name":"Warren C. Fiskus","orcid":"https://orcid.org/0000-0002-7343-6214","observed_orcids":["https://orcid.org/0000-0002-7343-6214"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren Fiskus","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007974137","display_name":"Andrea U. Jakubowski","orcid":"https://orcid.org/0000-0001-5651-5589","observed_orcids":["https://orcid.org/0000-0001-5651-5589"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Jakubowski","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077507982","display_name":"Rekha Rao","orcid":"https://orcid.org/0000-0002-1873-8738","observed_orcids":["https://orcid.org/0000-0002-1873-8738"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rekha Rao","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398242","display_name":"Zixuan Wang","orcid":"https://orcid.org/0000-0002-0854-5895","observed_orcids":["https://orcid.org/0000-0002-0854-5895","https://orcid.org/0009-0007-8289-1538"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zixuan Wang","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043075583","display_name":"Pravina Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pravina Fernandez","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635299","display_name":"Yongchao Wang","orcid":"https://orcid.org/0000-0002-7862-4097","observed_orcids":["https://orcid.org/0000-0002-7862-4097"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yongchao Wang","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049376902","display_name":"Pearl Lee","orcid":"https://orcid.org/0000-0002-1274-2891","observed_orcids":["https://orcid.org/0000-0002-1274-2891"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearl Lee","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082787","display_name":"Anand Jillela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anand Jillela","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029250422","display_name":"Peter Wisdom Atadja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Atadja","raw_affiliation_strings":["Novartis Institute for Biomedical Research Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Biomedical Research Inc., Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847565","display_name":"Nobutaka Fujii","orcid":"https://orcid.org/0000-0002-2666-0643","observed_orcids":["https://orcid.org/0000-0002-2666-0643"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobutaka Fujii","raw_affiliation_strings":["Department of Medicinal Chemistry, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521004","display_name":"Stephen C. Peiper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen C. Peiper","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079069209","display_name":"Kapil N. Bhalla","orcid":"https://orcid.org/0000-0001-5209-5126","observed_orcids":["https://orcid.org/0000-0001-5209-5126"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kapil Bhalla","raw_affiliation_strings":["MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCG Cancer Center & Department of Pathology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007974137","https://openalex.org/A5029250422","https://openalex.org/A5043075583","https://openalex.org/A5077507982","https://openalex.org/A5100398242","https://openalex.org/A5100635299","https://openalex.org/A5101847565","https://openalex.org/A5108082787"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I25041050"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1673,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63128252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"537","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pan-hdac-inhibitors","display_name":"pan-HDAC inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9440000057220459},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9959999918937683},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/amd3100","display_name":"AMD3100","score":0.8370000123977661},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.6525772213935852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.592665433883667},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5152738094329834},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.46948131918907166},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4683021306991577},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.46714967489242554},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4643820524215698},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4290677011013031},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4183211922645569},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40357282757759094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3891674280166626},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.31495338678359985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24448665976524353},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2434665560722351},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2224666178226471},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21650922298431396},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.13782307505607605},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.13450321555137634},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.12561330199241638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.537.537","doi":"https://doi.org/10.1182/blood.v110.11.537.537","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.537.537","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2297357100","https://openalex.org/W2052227923","https://openalex.org/W1968540083","https://openalex.org/W2185207795","https://openalex.org/W2016703157","https://openalex.org/W2085328048","https://openalex.org/W2140382736","https://openalex.org/W165828477","https://openalex.org/W3191541509","https://openalex.org/W2518829470"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"trafficking":[2],"and":[3,9,36,45,56,62,97,128,141,154,201,223,243,261,273,284,298,316,329,337,340,356,363,385,419],"mobilization":[4],"of":[5,20,43,64,75,82,120,131,166,169,178,195,205,212,241,252,259,271,282,292,296,313,322,334,351,383,417,442,449],"normal":[6],"hematopoietic":[7],"progenitors":[8],"their":[10],"leukemic":[11,83],"counterparts":[12],"is":[13,371,398],"programmed":[14],"in":[15,31,50,60,100,133,147,151,161,171,235,254,290,405,410,439,446],"part":[16],"by":[17,25,214,249,287,403],"chemotactic":[18],"gradients":[19],"CXCL12,":[21,288],"which":[22,232,370],"are":[23,58],"transduced":[24],"CXCR4.":[26,455],"This":[27,245],"mechanism":[28],"also":[29,219,233,379],"results":[30],"decreased":[32,185,311],"sensitivity":[33,81],"to":[34,85,93,115,117,184,207,230,265,294],"pro-apoptotic":[35],"anti-leukemic":[37,86],"agents,":[38],"mediated":[39,176],"through":[40],"CXCR4":[41,57,65,76,95,110,132,159,179,186,206,213,242,375,397,421],"activation":[42],"Akt":[44],"Raf":[46],"phosphorylation":[47,281],"and/or":[48],"harboring":[49],"a":[51,70,107,152,372,399,420,427],"microenvironmental":[52],"niche.":[53],"Both":[54],"CXCL12":[55,170,266],"overexpressed":[59],"AML":[61,149,263,300,323,346,387,406],"expression":[63,96],"has":[66],"been":[67],"associated":[68],"with":[69,77,102,209,276,303,327,348,361],"poor":[71],"prognosis.":[72],"Moreover,":[73],"inhibition":[74],"AMD3100":[78,103,304,330,423],"enhanced":[79],"the":[80,121,134,162,172,203,215,280,414,438,447],"myeloblasts":[84],"agents.":[87],"We":[88],"therefore":[89],"explored":[90],"therapeutic":[91],"mechanisms":[92],"decrease":[94],"tested":[98],"them":[99],"combination":[101,349,416,445],"as":[104,106,144,146,225,227],"well":[105,145,226],"new":[108],"generation":[109],"inverse":[111],"agonist,":[112],"FC131.":[113],"Exposure":[114],"10":[116,167],"50":[118],"nM":[119,168,366],"pan-HDAC":[122],"inhibitor":[123],"LBH589":[124,157,175,192,217,277,328,362,404,418],"(Novartis)":[125],"depleted":[126,158,402],"mRNA":[127,187],"protein":[129,198],"levels":[130,160,180,188,222,270,312],"cultured":[135,260,297,384],"human":[136,450],"acute":[137,431,451],"leukemia":[138,432],"OCI-AML3,":[139],"HL-60":[140,255],"Jurkat":[142],"cells,":[143],"primary":[148,262,299,386],"cells":[150,264,347],"dose":[153],"time-dependent":[155],"manner.":[156],"presence":[163],"or":[164,424],"absence":[165],"culture":[173],"medium.":[174],"depletion":[177,333],"was":[181,246],"partly":[182],"due":[183],"(by":[189],"RT-PCR":[190],"analysis).":[191],"induced":[193,286,380],"acetylation":[194],"heat":[196],"shock":[197],"(hsp)":[199],"90":[200],"attenuated":[202,279],"binding":[204,229],"hsp90":[208],"subsequent":[210],"degradation":[211],"proteasome.":[216],"treatment":[218],"increased":[220,236,268],"hsp70":[221,253],"acetylation,":[224],"its":[228],"CXCR4,":[231,314,335],"resulted":[234],"extra-cellular,":[237],"cell":[238],"surface":[239],"co-localization":[240],"hsp70.":[244],"markedly":[247,267,278],"inhibited":[248],"siRNA-mediated":[250],"knockdown":[251],"cells.":[256,301,324,388,407,433],"While":[257],"exposure":[258],"cytosolic":[269],"p-AKT":[272,315,336],"p-ERK1/2,":[274,317],"co-treatment":[275,326],"AKT":[283],"ERK1/2":[285],"resulting":[289],"apoptosis":[291,321,382],"up":[293],"50%":[295],"Treatment":[302],"(10":[305,365],"uM":[306],"for":[307,367],"24":[308,368],"hours)":[309],"alone":[310],"without":[318],"significantly":[319],"increasing":[320],"Notably,":[325],"caused":[331],"greater":[332],"p-ERK1/2":[338],"levels,":[339],"exerted":[341],"synergistic":[342,381,428,444],"apoptotic":[343],"effects":[344],"against":[345],"indices":[350],"<":[352],"1.0":[353],"utilizing":[354],"isobologram":[355],"median":[357],"effect":[358,429],"analyses.":[359],"Co-treatment":[360],"FC131":[364],"hours),":[369],"more":[373],"potent":[374],"antagonist":[376],"than":[377],"AMD3100,":[378],"Taken":[389],"together,":[390],"these":[391],"findings":[392,412,435],"provide":[393],"direct":[394],"evidence":[395],"that":[396,453],"novel":[400,415],"target":[401],"Furthermore,":[408],"our":[409],"vitro":[411],"highlight":[413],"antagonist,":[422],"FC131,":[425],"exerts":[426],"on":[430],"These":[434],"strongly":[436],"support":[437],"vivo":[440],"testing":[441],"this":[443],"therapy":[448],"leukemias":[452],"express":[454]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-16T00:00:00"}