{"id":"https://openalex.org/W2593296804","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","title":"Abstract P4-11-01: A genetic model of mammary gland fibrosis and cancer risk","display_name":"Abstract P4-11-01: A genetic model of mammary gland fibrosis and cancer risk","publication_year":2017,"publication_date":"2017-02-15","ids":{"openalex":"https://openalex.org/W2593296804","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","mag":"2593296804"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs16-p4-11-01","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074960198","display_name":"Jiayi Wu","orcid":"https://orcid.org/0000-0002-4819-2190","observed_orcids":["https://orcid.org/0000-0002-4819-2190","https://orcid.org/0009-0001-4980-1111","https://orcid.org/0009-0009-3728-0505"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Wu","raw_affiliation_strings":["University of Illinois, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035689487","display_name":"David L. Crowe","orcid":"https://orcid.org/0000-0003-0941-2602","observed_orcids":["https://orcid.org/0000-0003-0941-2602"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Crowe","raw_affiliation_strings":["University of Illinois, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"4_Supplement","first_page":"P4","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.8539999723434448},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.800000011920929},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/luminal-progenitor-cells","display_name":"luminal progenitor cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mammary-gland-regeneration","display_name":"mammary gland regeneration","score":0.6290000081062317},{"id":"https://openalex.org/keywords/alternative-lengthening-of-telomeres","display_name":"alternative lengthening of telomeres","score":0.8500000238418579},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6919999718666077},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8589472770690918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6801203489303589},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5764089822769165},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5369868278503418},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5088620185852051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5034274458885193},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4932517409324646},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4912554621696472},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48435792326927185},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48132312297821045},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.42199140787124634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3956589996814728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3602333962917328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3559933006763458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15759602189064026},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13637515902519226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09198465943336487},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs16-p4-11-01","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs16-p4-11-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2900785075","https://openalex.org/W2741069235","https://openalex.org/W2142991019","https://openalex.org/W2888190435","https://openalex.org/W2060645136","https://openalex.org/W2061198525","https://openalex.org/W2161322128","https://openalex.org/W2755444936","https://openalex.org/W2287038445","https://openalex.org/W2103861086"],"abstract_inverted_index":{"Abstract":[0],"Ductal":[1],"cells":[2,11,22,30,53,197],"of":[3,15,36,111,121,260,280,290],"the":[4,34,72,94,108,119,215,227,291],"mammary":[5,9,126,137,169,179,235,281],"gland":[6,127,138,282],"arise":[7],"from":[8,71,93,160],"stem":[10,263],"(MSC)":[12],"and":[13,23,64,90,129,152,155,191,206,223,244,268,284],"consist":[14],"estrogen":[16],"receptor":[17],"a":[18,24,252],"negative":[19],"(ER-)":[20],"luminal":[21,27,38],"small":[25],"ER+":[26,241],"population.":[28],"Luminal":[29],"are":[31,43,115],"maintained":[32,224],"by":[33],"proliferation":[35],"ER-":[37],"progenitor":[39],"(LP)":[40],"cells,":[41],"which":[42,58],"expanded":[44],"in":[45,102,136,234,238,254],"basal":[46],"subtype":[47],"breast":[48,51,79,105],"cancer.":[49],"Human":[50],"LP":[52,196],"exhibit":[54],"telomere":[55,122,147,183,203],"DNA":[56,73,95,123,148,184,204,231],"damage,":[57],"is":[59,100],"associated":[60],"with":[61,77],"mammographic":[62,261],"density":[63],"increased":[65,146,192],"cancer":[66,80,266,285],"risk.":[67],"Short":[68],"telomeres":[69,89,225],"resulting":[70],"damage":[74,96,124,149,185,232],"response":[75,186,205,233],"correlate":[76],"aggressive":[78],"phenotypes.":[81],"Telomeric":[82],"repeat":[83],"factor":[84],"2":[85],"(TRF2)":[86],"binds":[87],"to":[88,166,173,208,246],"protects":[91],"them":[92],"response.":[97],"TRF2":[98,134,143,161,177],"expression":[99,135,144],"reduced":[101],"most":[103],"human":[104],"cancers":[106],"but":[107,187,200],"phenotypic":[109],"advantages":[110],"this":[112],"genetic":[113,278],"alteration":[114],"unknown.":[116],"To":[117],"determine":[118],"effects":[120],"on":[125],"function":[128],"tumor":[130],"phenotype,":[131],"we":[132],"deleted":[133],"epithelium.":[139],"Mammary":[140],"glands":[141,163,170],"lacking":[142],"exhibited":[145,188,201],"response,":[150],"histopathological":[151],"functional":[153],"degeneration,":[154],"prominent":[156],"ductal":[157],"fibrosis.":[158],"MSC":[159,218],"deficient":[162,178],"were":[164],"unable":[165],"completely":[167],"regenerate":[168],"following":[171,211],"transplantation":[172],"cleared":[174],"fat":[175],"pads.":[176],"tumors":[180,210,236],"also":[181],"demonstrated":[182],"rapid":[189],"onset":[190],"proliferation.":[193],"Tumor":[194],"derived":[195],"underwent":[198],"expansion":[199],"high":[202],"failed":[207],"form":[209],"transplantation.":[212],"In":[213],"contrast,":[214],"severely":[216],"depleted":[217],"population":[219],"was":[220],"highly":[221],"tumorigenic":[222],"via":[226],"ALT":[228],"mechanism.":[229],"Telomere":[230],"resulted":[237],"p53":[239],"dependent":[240],"cellular":[242],"differentiation":[243],"sensitivity":[245],"anti-estrogen":[247],"therapy.":[248],"Our":[249],"results":[250],"provide":[251],"new":[253],"vivo":[255],"model":[256,279],"for":[257],"exploring":[258],"mechanisms":[259],"density,":[262],"cell":[264],"differentiation,":[265],"risk,":[267],"therapeutic":[269],"sensitivity.":[270],"Citation":[271],"Format:":[272],"Wu":[273],"J,":[274],"Crowe":[275],"D.":[276],"A":[277],"fibrosis":[283],"risk":[286],"[abstract].":[287],"In:":[288],"Proceedings":[289],"2016":[292,298],"San":[293,301],"Antonio":[294],"Breast":[295],"Cancer":[296,307],"Symposium;":[297],"Dec":[299],"6-10;":[300],"Antonio,":[302],"TX.":[303],"Philadelphia":[304],"(PA):":[305],"AACR;":[306],"Res":[308],"2017;77(4":[309],"Suppl):Abstract":[310],"nr":[311],"P4-11-01.":[312]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2017-03-16T00:00:00"}