{"id":"https://openalex.org/W2592987264","doi":"https://doi.org/10.1534/g3.116.038612","title":"Time-Variant Genetic Effects as a Cause for Preterm Birth: Insights from a Population of Maternal Cousins in Sweden","display_name":"Time-Variant Genetic Effects as a Cause for Preterm Birth: Insights from a Population of Maternal Cousins in Sweden","publication_year":2017,"publication_date":"2017-03-02","ids":{"openalex":"https://openalex.org/W2592987264","doi":"https://doi.org/10.1534/g3.116.038612","mag":"2592987264","pmid":"https://pubmed.ncbi.nlm.nih.gov/28250013","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5386882"},"language":"en","primary_location":{"id":"doi:10.1534/g3.116.038612","doi":"https://doi.org/10.1534/g3.116.038612","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.116.038612","pdf_url":"https://www.g3journal.org/content/ggg/7/4/1349.full.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.g3journal.org/content/ggg/7/4/1349.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077104442","display_name":"Julius Juodakis","orcid":"https://orcid.org/0000-0001-5600-974X","observed_orcids":["https://orcid.org/0000-0001-5600-974X"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Julius Juodakis","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104491083","display_name":"Jonas Ba\u010delis","orcid":"https://orcid.org/0000-0002-2450-732X","observed_orcids":["https://orcid.org/0000-0002-2450-732X"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Bacelis","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Sahlgrenska University Hospital \u00d6stra, 416 85 Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Sahlgrenska University Hospital \u00d6stra, 416 85 Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326060","display_name":"Ge Zhang","orcid":"https://orcid.org/0000-0002-0543-2254","observed_orcids":["https://orcid.org/0000-0002-0543-2254"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4405268727","display_name":"March of Dimes Prematurity Research Center Ohio Collaborative","ror":"https://ror.org/01w50ym34","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268727"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Zhang","raw_affiliation_strings":["Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","Human Genetics Division, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Human Genetics Division, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio 45229","institution_ids":["https://openalex.org/I4405268727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080833691","display_name":"Louis J. Muglia","orcid":"https://orcid.org/0000-0002-0301-8770","observed_orcids":["https://orcid.org/0000-0002-0301-8770"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4405268727","display_name":"March of Dimes Prematurity Research Center Ohio Collaborative","ror":"https://ror.org/01w50ym34","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268727"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis J Muglia","raw_affiliation_strings":["Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children\u2019s Hospital Medical Center, Ohio 45229","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio 45229","institution_ids":["https://openalex.org/I4405268727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091876255","display_name":"Bo Jacobsson","orcid":"https://orcid.org/0000-0001-5079-2374","observed_orcids":["https://orcid.org/0000-0001-5079-2374"]},"institutions":[{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"government","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Bo Jacobsson","raw_affiliation_strings":["Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Norwegian Institute of Public Health, 0473 Oslo, Norway","Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Norwegian Institute of Public Health, 0473 Oslo, Norway","institution_ids":["https://openalex.org/I1333353642"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077104442"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":2709,"currency":"USD","value_usd":2709},"apc_paid":{"value":2709,"currency":"USD","value_usd":2709},"fwci":0.5432,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65546966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"7","issue":"4","first_page":"1349","last_page":"1356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.8600000143051147},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"genetic architecture","score":0.4449999928474426},{"id":"https://openalex.org/keywords/time-to-event-modeling","display_name":"time-to-event modeling","score":0.621999979019165},{"id":"https://openalex.org/keywords/neonatal-mortality","display_name":"neonatal mortality","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.7241559028625488},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5393971800804138},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4991428852081299},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.49490660429000854},{"id":"https://openalex.org/C49261128","wikidata":"https://www.wikidata.org/wiki/Q1132455","display_name":"Hazard","level":2,"score":0.4654885530471802},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.45181846618652344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43986037373542786},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.43846654891967773},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4159236550331116},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.36574023962020874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2601737082004547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2580081820487976},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.22212055325508118},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2041659951210022},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.18491709232330322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12137386202812195},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08794108033180237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036801","descriptor_name":"Parturition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1534/g3.116.038612","doi":"https://doi.org/10.1534/g3.116.038612","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.116.038612","pdf_url":"https://www.g3journal.org/content/ggg/7/4/1349.full.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5386882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5386882","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"},{"id":"pmid:28250013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28250013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:brage.bibsys.no:11250/2446275","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11250/2446275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"1349-1356","raw_type":"Peer reviewed"},{"id":"pmh:oai:doaj.org/article:9b07d9c04b754cda983e2b87f34af6c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9b07d9c04b754cda983e2b87f34af6c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"G3: Genes, Genomes, Genetics, Vol 7, Iss 4, Pp 1349-1356 (2017)","raw_type":"article"},{"id":"pmh:oai:fhi.brage.unit.no:11250/2446275","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/2446275","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1349-1356","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1534/g3.116.038612","doi":"https://doi.org/10.1534/g3.116.038612","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.116.038612","pdf_url":"https://www.g3journal.org/content/ggg/7/4/1349.full.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2592987264.pdf","grobid_xml":"https://content.openalex.org/works/W2592987264.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1757411051","https://openalex.org/W1965954202","https://openalex.org/W1980091257","https://openalex.org/W1985419446","https://openalex.org/W1989123468","https://openalex.org/W1990578031","https://openalex.org/W1999543886","https://openalex.org/W2011921816","https://openalex.org/W2016466384","https://openalex.org/W2031368992","https://openalex.org/W2074498980","https://openalex.org/W2088896077","https://openalex.org/W2097998348","https://openalex.org/W2101170938","https://openalex.org/W2102441424","https://openalex.org/W2105658895","https://openalex.org/W2105845983","https://openalex.org/W2106468247","https://openalex.org/W2107505472","https://openalex.org/W2119259412","https://openalex.org/W2124139154","https://openalex.org/W2126923896","https://openalex.org/W2129979051","https://openalex.org/W2130891446","https://openalex.org/W2137514719","https://openalex.org/W2139400710","https://openalex.org/W2139852278","https://openalex.org/W2146276926","https://openalex.org/W2146768128","https://openalex.org/W2152412794","https://openalex.org/W2156695500","https://openalex.org/W2160936184","https://openalex.org/W2162547226","https://openalex.org/W2169996935","https://openalex.org/W2201515662","https://openalex.org/W2233165203","https://openalex.org/W2284170594","https://openalex.org/W2284511765","https://openalex.org/W2344260988","https://openalex.org/W2377410957","https://openalex.org/W2413995244","https://openalex.org/W2481870492","https://openalex.org/W4247799630"],"related_works":["https://openalex.org/W2036558798","https://openalex.org/W6921560875","https://openalex.org/W2137514719","https://openalex.org/W4376872204","https://openalex.org/W4393946504","https://openalex.org/W4402677937","https://openalex.org/W4392316004","https://openalex.org/W2138428633","https://openalex.org/W2122593938","https://openalex.org/W1980091257"],"abstract_inverted_index":{"Abstract":[0],"Preterm":[1],"delivery":[2],"(PTD)":[3],"is":[4],"the":[5,21,50,61,85,92,123,131,138,150,166,176,188],"leading":[6],"cause":[7],"of":[8,42,52,87,107,130,137,140,178,181],"neonatal":[9],"mortality":[10],"worldwide,":[11],"yet":[12],"its":[13],"etiology":[14],"remains":[15],"largely":[16],"unexplained.":[17],"We":[18,44,163],"propose":[19],"that":[20,83,114,165],"genetic":[22,81,189],"factors":[23,82,132],"controlling":[24],"this":[25,46],"trait":[26],"could":[27],"act":[28],"in":[29,57,98],"a":[30,39,76],"nonuniform":[31],"manner":[32],"during":[33],"pregnancy,":[34],"with":[35,79],"each":[36],"factor":[37],"having":[38],"unique":[40],"\u201cwindow":[41],"sensitivity.\u201d":[43],"test":[45],"hypothesis":[47],"by":[48,156],"modeling":[49],"distribution":[51],"gestational":[53],"ages":[54],"(GAs)":[55],"observed":[56,127],"maternal":[58],"cousins":[59],"from":[60],"Swedish":[62],"Medical":[63],"Birth":[64],"Register":[65],"(MBR)":[66],"(n":[67],"=":[68],"35,541":[69],"pairs).":[70],"The":[71],"models":[72,113],"were":[73,115,146],"built":[74],"using":[75],"time-to-event":[77],"framework,":[78],"simulated":[80],"increase":[84],"hazard":[86],"birth":[88],"either":[89],"uniformly":[90],"across":[91],"pregnancy":[93],"(constant":[94],"effect)":[95],"or":[96],"only":[97],"particular":[99],"windows":[100],"(varying":[101],"effect).":[102],"By":[103],"including":[104],"various":[105],"combinations":[106],"these":[108],"factors,":[109],"we":[110],"obtained":[111],"four":[112],"then":[116],"optimized":[117],"and":[118,168,183],"compared.":[119],"Best":[120],"fit":[121],"to":[122,148,152],"clinical":[124],"data":[125],"was":[126],"when":[128],"most":[129],"had":[133],"time-variant":[134],"effects,":[135],"independently":[136],"number":[139],"loci":[141,155],"simulated.":[142],"Finally,":[143],"power":[144],"simulations":[145],"performed":[147],"assess":[149],"ability":[151],"discover":[153],"varying-effect":[154],"usual":[157],"methods":[158],"for":[159,175],"genome-wide":[160],"association":[161],"testing.":[162],"believe":[164],"tools":[167],"concepts":[169],"presented":[170],"here":[171],"should":[172],"prove":[173],"useful":[174],"design":[177],"future":[179],"studies":[180],"PTD":[182],"provide":[184],"new":[185],"insights":[186],"into":[187],"architecture":[190],"determining":[191],"human":[192],"GA.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}