{"id":"https://openalex.org/W2592964827","doi":"https://doi.org/10.1097/sap.0000000000001032","title":"Plasticity of Auricular Cartilage in Response to Hormone Therapy","display_name":"Plasticity of Auricular Cartilage in Response to Hormone Therapy","publication_year":2017,"publication_date":"2017-03-07","ids":{"openalex":"https://openalex.org/W2592964827","doi":"https://doi.org/10.1097/sap.0000000000001032","mag":"2592964827","pmid":"https://pubmed.ncbi.nlm.nih.gov/28272149"},"language":"en","primary_location":{"id":"doi:10.1097/sap.0000000000001032","doi":"https://doi.org/10.1097/sap.0000000000001032","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000001032","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066174541","display_name":"Patrick S. Cottler","orcid":"https://orcid.org/0000-0002-2542-6142","observed_orcids":["https://orcid.org/0000-0002-2542-6142"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick S. Cottler","raw_affiliation_strings":["From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","Conflicts of interest and sources of funding: None declared","Received October 7, 2016, and accepted for publication, after revision December 6, 2016","Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"Conflicts of interest and sources of funding: None declared","institution_ids":[]},{"raw_affiliation_string":"Received October 7, 2016, and accepted for publication, after revision December 6, 2016","institution_ids":[]},{"raw_affiliation_string":"Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021628304","display_name":"Matthew D. McLeod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. McLeod","raw_affiliation_strings":["Conflicts of interest and sources of funding: None declared","the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","Received October 7, 2016, and accepted for publication, after revision December 6, 2016","Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conflicts of interest and sources of funding: None declared","institution_ids":[]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"Received October 7, 2016, and accepted for publication, after revision December 6, 2016","institution_ids":[]},{"raw_affiliation_string":"Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021974860","display_name":"Jesse I. Payton","orcid":"https://orcid.org/0000-0003-3156-0505","observed_orcids":["https://orcid.org/0000-0003-3156-0505"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse I. Payton","raw_affiliation_strings":["Conflicts of interest and sources of funding: None declared","the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","Received October 7, 2016, and accepted for publication, after revision December 6, 2016","Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conflicts of interest and sources of funding: None declared","institution_ids":[]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"Received October 7, 2016, and accepted for publication, after revision December 6, 2016","institution_ids":[]},{"raw_affiliation_string":"Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023091538","display_name":"Angela Pi\u00f1eros-Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Pineros-Fernandez","raw_affiliation_strings":["Conflicts of interest and sources of funding: None declared","the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","Received October 7, 2016, and accepted for publication, after revision December 6, 2016","Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conflicts of interest and sources of funding: None declared","institution_ids":[]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"Received October 7, 2016, and accepted for publication, after revision December 6, 2016","institution_ids":[]},{"raw_affiliation_string":"Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066055947","display_name":"Jonathan S. Black","orcid":"https://orcid.org/0000-0003-0103-2912","observed_orcids":["https://orcid.org/0000-0003-0103-2912"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Black","raw_affiliation_strings":["Conflicts of interest and sources of funding: None declared","the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","Received October 7, 2016, and accepted for publication, after revision December 6, 2016","Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conflicts of interest and sources of funding: None declared","institution_ids":[]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"From the Department of Plastic Surgery, University of Virginia Medical Center, Charlottesville, VA","institution_ids":["https://openalex.org/I4210134211"]},{"raw_affiliation_string":"Received October 7, 2016, and accepted for publication, after revision December 6, 2016","institution_ids":[]},{"raw_affiliation_string":"Reprints: Patrick S. Cottler, PhD, Department of Plastic Surgery University of Virginia Health System P.O. Box 800376 Charlottesville, VA 22908. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"This article was presented in the resident section of the 59th Annual Meeting of the Southeastern Society of Plastic and Reconstructive Surgeons on June 12, 2016 in Lake Buena Vista, FL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.116,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76071886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"78","issue":"6S","first_page":"S311","last_page":"S314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11866","display_name":"Reconstructive Facial Surgery Techniques","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11866","display_name":"Reconstructive Facial Surgery Techniques","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auricular-cartilage","display_name":"auricular cartilage","score":0.8159999847412109},{"id":"https://openalex.org/keywords/auricular-deformity","display_name":"ear deformity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/topical-estrogen","display_name":"topical estrogen","score":0.7250000238418579},{"id":"https://openalex.org/keywords/splinting","display_name":"splinting","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.7310000061988831},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cartilage-thickness","display_name":"cartilage thickness","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5049999952316284},{"id":"https://openalex.org/keywords/maternal-estrogen","display_name":"maternal estrogen","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.952136754989624},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6953620910644531},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6283428072929382},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.561500608921051},{"id":"https://openalex.org/C2778623055","wikidata":"https://www.wikidata.org/wiki/Q1992685","display_name":"Splint (medicine)","level":2,"score":0.4832933247089386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42513251304626465},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35224074125289917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.253290057182312},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1866130232810974},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.16820892691612244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1235094964504242},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004425","descriptor_name":"Ear Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004425","descriptor_name":"Ear Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004425","descriptor_name":"Ear Cartilage","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013165","descriptor_name":"Splints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054644","descriptor_name":"Ear Auricle","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/sap.0000000000001032","doi":"https://doi.org/10.1097/sap.0000000000001032","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000001032","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},{"id":"pmid:28272149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28272149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of plastic surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W76292813","https://openalex.org/W81009989","https://openalex.org/W1495047586","https://openalex.org/W1940995548","https://openalex.org/W1975484973","https://openalex.org/W2008239595","https://openalex.org/W2017679770","https://openalex.org/W2030061075","https://openalex.org/W2041522034","https://openalex.org/W2051264564","https://openalex.org/W2094021134","https://openalex.org/W2099540110","https://openalex.org/W2105025819","https://openalex.org/W2154297460","https://openalex.org/W2418491184","https://openalex.org/W2587471856","https://openalex.org/W3157336084","https://openalex.org/W4236484287","https://openalex.org/W4238223060","https://openalex.org/W4244216329"],"related_works":["https://openalex.org/W4212981714","https://openalex.org/W3024584946","https://openalex.org/W2088413917","https://openalex.org/W2038168537","https://openalex.org/W1980821089","https://openalex.org/W2019858149","https://openalex.org/W6988506796","https://openalex.org/W7160494369","https://openalex.org/W4225985525","https://openalex.org/W2154297460"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Correction":[1],"of":[2,15,32,48,57,66,93,113,125,130,209,214,222,273,289,320,325],"auricular":[3,98,126,306],"deformities":[4,68],"can":[5],"be":[6,21],"accomplished":[7],"through":[8],"splinting":[9,240,272],"within":[10],"the":[11,29,46,49,74,91,111,184,226,233,281,285,297,318,323,332],"first":[12],"few":[13],"weeks":[14],"life.":[16],"This":[17],"is":[18,43,60],"hypothesized":[19],"to":[20,23,76,96,182,212,217,239,276,280,340],"due":[22],"retained":[24,185],"circulating":[25],"maternal":[26],"estrogens":[27],"decreasing":[28],"structural":[30],"density":[31],"collagen;":[33],"however,":[34],"this":[35,101,290],"has":[36,73],"not":[37],"been":[38],"fully":[39],"tested.":[40],"Cartilage":[41],"elasticity":[42],"dependent":[44],"on":[45],"concentration":[47],"proteoglycan":[50,58],"aggregate,":[51,59],"and":[52,80,109,137,139,146,178,235,246,268,295,322,335],"hyaluronic":[53],"acid,":[54],"a":[55,114,201,206,218,277,300,312],"constituent":[56],"increased":[61,203,263],"by":[62,225],"estrogens.":[63],"Nonsurgical":[64],"correction":[65],"these":[67],"in":[69,121,256],"more":[70,115,313],"developed":[71],"patients":[72],"potential":[75],"change":[77,279],"clinical":[78],"practice":[79],"eliminate":[81],"surgical":[82],"risks.":[83],"Previous":[84],"studies":[85],"have":[86,104],"demonstrated":[87,110],"preliminary":[88],"promise":[89],"with":[90,241,259,262,271],"use":[92],"injectable":[94],"estrogen":[95,119,157,321],"treat":[97],"deformities.":[99,307],"For":[100],"study,":[102],"we":[103],"validated":[105],"an":[106,141],"animal":[107],"model":[108],"feasibility":[112],"therapeutically":[116],"appropriate":[117],"topical":[118,156],"treatment":[120,270],"restoring":[122],"neonatal":[123],"plasticity":[124],"cartilage.":[127],"METHODS:":[128],"Ears":[129],"12":[131],"New":[132],"Zealand":[133],"rabbits":[134],"were":[135,172,180,189],"folded":[136,207],"splinted,":[138],"assigned":[140],"experimental":[142],"group":[143],"(estrogen,":[144],"placebo,":[145],"untreated":[147],"control)":[148],"(n":[149],"=":[150],"8":[151,197],"ears).":[152],"Treatment":[153],"ears":[154,199,237,257,274],"received":[155,167],"or":[158],"placebo":[159,269],"cream":[160],"daily":[161],"for":[162,192,299,304],"4":[163],"weeks,":[164,177],"whereas":[165],"controls":[166],"no":[168],"treatment.":[169],"The":[170,196,287],"splints":[171],"removed":[173],"following":[174],"2":[175],"additional":[176],"photographs":[179],"taken":[181,191],"calculate":[183],"fold":[186],"angle.":[187],"Biopsies":[188],"also":[190],"histologic":[193],"analysis.":[194],"RESULTS:":[195],"control":[198],"showed":[200],"statistically":[202],"angle":[204],"from":[205],"orientation":[208],"46.6":[210],"degrees":[211,224,245],"return":[213],"ear":[215],"position":[216,221],"normal":[219],"upright":[220],"151.2":[223],"fourth":[227],"day":[228],"after":[229],"splint":[230],"removal.":[231],"Both":[232],"estrogen-treated":[234],"placebo-treated":[236],"responded":[238],"maintained":[242],"folding":[243],"(36.6":[244],"32.5":[247],"degrees,":[248],"respectively).":[249],"Auricular":[250],"cartilage":[251,282],"thickness":[252],"trended":[253],"toward":[254],"thicker":[255],"treated":[258],"estrogen,":[260],"consistent":[261],"matrix":[264],"components.":[265],"CONCLUSIONS:":[266],"Estrogen":[267],"lead":[275],"significant":[278],"configuration,":[283],"validating":[284],"model.":[286],"results":[288],"study":[291,316],"are":[292],"very":[293],"encouraging":[294],"provide":[296],"foundation":[298],"noninvasive":[301],"therapeutic":[302],"approach":[303],"correcting":[305],"Future":[308],"work":[309],"will":[310],"include":[311],"detailed":[314],"mechanistic":[315],"evaluating":[317,331],"dosing":[319],"efficiency":[324],"dermal":[326],"penetration":[327],"as":[328,330],"well":[329],"long-term":[333],"outcomes":[334],"molecular":[336],"mechanism-associated":[337],"cartilaginous":[338],"responses":[339],"estrogen.":[341]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-03-16T00:00:00"}
