{"id":"https://openalex.org/W2592501657","doi":null,"title":"Development of a collagen-based model for testing nanoparticle drug delivery to tumors","display_name":"Development of a collagen-based model for testing nanoparticle drug delivery to tumors","publication_year":2016,"publication_date":"2016-07-18","ids":{"openalex":"https://openalex.org/W2592501657","mag":"2592501657"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/55404","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/55404","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Undergraduate Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019923803","display_name":"Manuela Sushnitha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manuela Sushnitha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019923803"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.12460000067949295,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6460000276565552},{"id":"https://openalex.org/keywords/collagen-matrix","display_name":"collagen matrix","score":0.671999990940094},{"id":"https://openalex.org/keywords/enhanced-permeability-and-retention-effect","display_name":"enhanced permeability and retention effect","score":0.7770000100135803},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7760000228881836},{"id":"https://openalex.org/keywords/in-vitro-cancer-models","display_name":"in vitro tumor model","score":0.7789999842643738},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.643953800201416},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5293772220611572},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4487263262271881},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3792531192302704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35410428047180176},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3354477882385254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2767878770828247},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26361197233200073}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/55404","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/55404","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Undergraduate Thesis"},{"id":"mag:2592501657","doi":null,"is_oa":false,"landing_page_url":"https://smartech.gatech.edu/bitstream/1853/55404/1/SUSHNITHA-UNDERGRADUATERESEARCHOPTIONTHESIS-2016.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043739827","https://openalex.org/W2883554173","https://openalex.org/W2054039833","https://openalex.org/W4252038118","https://openalex.org/W1970427360","https://openalex.org/W2017284196","https://openalex.org/W7027946216","https://openalex.org/W2340545982","https://openalex.org/W3017187167","https://openalex.org/W2913544089"],"abstract_inverted_index":{"Cancer":[0],"continues":[1],"to":[2,15,137,166],"take":[3],"many":[4],"lives":[5],"each":[6],"year":[7],"and":[8,28,61,65],"has":[9,99,145],"posed":[10],"a":[11,37,116,173,185],"seemingly":[12],"insurmountable":[13],"challenge":[14],"scientists":[16],"around":[17],"the":[18,55,58,74,82,93,121,130,147,155,182],"world.":[19],"Traditional":[20],"methods":[21,43,152],"of":[22,44,57,76,89,92,108,118,132,175,184],"treatment,":[23],"including":[24,120],"chemotherapy,":[25],"are":[26,40,113],"ineffective":[27],"result":[29],"in":[30,68,102,111,142,156,161],"undesirable":[31],"effects":[32],"on":[33],"healthy":[34],"tissue.":[35],"As":[36],"result,":[38],"researchers":[39],"seeking":[41],"new":[42,150],"targeted":[45,104],"therapy":[46],"that":[47,125,153,177],"will":[48],"kill":[49],"only":[50],"tumor":[51,84,94,158],"cells.":[52],"Stemming":[53],"from":[54],"discovery":[56],"Enhanced":[59],"Permeability":[60],"Retention":[62],"(EPR)":[63],"effect":[64],"recent":[66],"advances":[67],"nanotechnology,":[69],"one":[70],"such":[71],"method":[72,98],"involves":[73],"use":[75],"nanoparticles":[77],"as":[78],"drug":[79,191],"carriers":[80],"into":[81,139],"core":[83],"tissue":[85],"by":[86,115,171],"taking":[87],"advantage":[88],"characteristic":[90],"features":[91],"vasculature.":[95],"Although":[96],"this":[97],"shown":[100],"promise":[101],"inducing":[103],"effects,":[105],"effective":[106],"distribution":[107],"these":[109,169],"particles":[110],"vivo":[112,157],"inhibited":[114],"host":[117],"factors,":[119],"dense":[122],"collagen":[123],"matrix":[124],"makes":[126],"up":[127],"tumors.":[128],"Furthermore,":[129],"failure":[131],"animal":[133],"model":[134,154],"study":[135,164],"results":[136],"translate":[138],"positive":[140],"outcomes":[141],"human":[143],"trials":[144],"warranted":[146],"need":[148],"for":[149,181,189],"testing":[151],"conditions":[159],"seen":[160],"patients.":[162],"This":[163],"aims":[165],"address":[167],"both":[168],"issues":[170],"developing":[172],"basis":[174],"experiments":[176],"can":[178],"be":[179],"utilized":[180],"development":[183],"collagen-based":[186],"microfluidic":[187],"device":[188],"nanoparticle-based":[190],"delivery":[192],"testing.":[193]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2017-03-16T00:00:00"}
