{"id":"https://openalex.org/W2592397661","doi":null,"title":"Whsc1l1 Regulates Estrogen Receptor Activity In Sum44 Breast Cancer Cells","display_name":"Whsc1l1 Regulates Estrogen Receptor Activity In Sum44 Breast Cancer Cells","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2592397661","mag":"2592397661"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2640","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103738160","display_name":"Jonathan Curtis Irish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan Curtis Irish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103738160"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/luminal-b","display_name":"luminal B","score":0.8880000114440918},{"id":"https://openalex.org/keywords/histone-lysine-methyltransferase","display_name":"histone lysine methyltransferase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pwwp-domain","display_name":"PWWP domain","score":0.6790000200271606},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.33000001311302185},{"id":"https://openalex.org/keywords/hormone-resistance","display_name":"hormone resistance","score":0.5149999856948853},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.5640000104904175},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.31200000643730164},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.515999972820282},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.5189999938011169},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.670312225818634},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6323304772377014},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5413565039634705},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45249292254447937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4010668396949768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3720305263996124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3473464250564575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3375084102153778}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2640","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:2592397661","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2640&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2640","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1641","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2592397661.pdf","grobid_xml":"https://content.openalex.org/works/W2592397661.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W47601428","https://openalex.org/W1497845415","https://openalex.org/W1533191645","https://openalex.org/W1540264737","https://openalex.org/W1590242757","https://openalex.org/W1933350662","https://openalex.org/W1965490540","https://openalex.org/W1968931043","https://openalex.org/W1969233368","https://openalex.org/W1971270113","https://openalex.org/W1973817726","https://openalex.org/W1974112332","https://openalex.org/W1974747095","https://openalex.org/W1981615602","https://openalex.org/W1984249881","https://openalex.org/W1992682395","https://openalex.org/W1996778928","https://openalex.org/W1999952815","https://openalex.org/W2001320007","https://openalex.org/W2001928546","https://openalex.org/W2005895632","https://openalex.org/W2007256480","https://openalex.org/W2010031978","https://openalex.org/W2011181841","https://openalex.org/W2012627860","https://openalex.org/W2014397920","https://openalex.org/W2014677321","https://openalex.org/W2015416439","https://openalex.org/W2017414046","https://openalex.org/W2019380047","https://openalex.org/W2020998737","https://openalex.org/W2022919182","https://openalex.org/W2024161072","https://openalex.org/W2031946492","https://openalex.org/W2039551265","https://openalex.org/W2047116486","https://openalex.org/W2049488119","https://openalex.org/W2051406511","https://openalex.org/W2052285628","https://openalex.org/W2052576920","https://openalex.org/W2052842503","https://openalex.org/W2054938702","https://openalex.org/W2058945120","https://openalex.org/W2061805545","https://openalex.org/W2068673721","https://openalex.org/W2080954244","https://openalex.org/W2082117763","https://openalex.org/W2086376086","https://openalex.org/W2089689396","https://openalex.org/W2090590520","https://openalex.org/W2091473810","https://openalex.org/W2091605994","https://openalex.org/W2092794927","https://openalex.org/W2092798305","https://openalex.org/W2097255042","https://openalex.org/W2106482095","https://openalex.org/W2108643617","https://openalex.org/W2116343581","https://openalex.org/W2117810384","https://openalex.org/W2124839856","https://openalex.org/W2125987139","https://openalex.org/W2127617517","https://openalex.org/W2131658210","https://openalex.org/W2131994307","https://openalex.org/W2137825579","https://openalex.org/W2139232339","https://openalex.org/W2140729960","https://openalex.org/W2141393790","https://openalex.org/W2144792857","https://openalex.org/W2146074268","https://openalex.org/W2155826575","https://openalex.org/W2156134501","https://openalex.org/W2158674200","https://openalex.org/W2165957545","https://openalex.org/W2166311434","https://openalex.org/W2179438025","https://openalex.org/W2185127129","https://openalex.org/W2228518708","https://openalex.org/W2334221514","https://openalex.org/W2341178074","https://openalex.org/W2409525301"],"related_works":["https://openalex.org/W2400399169","https://openalex.org/W2281588018","https://openalex.org/W2502857866","https://openalex.org/W2406493607","https://openalex.org/W2073614108","https://openalex.org/W2088118569","https://openalex.org/W1924058490","https://openalex.org/W2005667229","https://openalex.org/W2116343581","https://openalex.org/W4220887653"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,6,13,20,43,57,131,148,192,326,359,1032],"is":[2,160,202,215,317,348,373,382,399,895,910,922,931,1093,1105],"the":[3,8,90,98,114,120,167,175,199,210,219,231,240,270,274,280,285,331,376,391,515,529,545,560,571,577,746,765,794,809,886,890,900,943,959,970,976,992,995,1007,1016,1026,1052,1064,1115,1170,1185,1188],"most":[4,203],"common":[5],"and":[7,72,109,136,142,261,283,289,292,302,312,337,432,450,457,492,639,683,827,907,930,934,975,988,1004,1015,1062,1142],"second":[9],"leading":[10],"cause":[11],"of":[12,37,53,89,92,100,116,138,162,174,178,184,198,209,218,222,233,243,266,273,342,355,366,379,394,423,446,467,481,489,514,531,612,673,677,685,692,730,739,745,761,767,775,796,811,877,893,899,917,945,962,972,980,994,1019,1028,1051,1056,1067,1075,1083,1138,1159,1163,1167,1174,1187],"death":[14],"in":[15,58,83,110,145,166,182,206,279,330,387,409,544,559,609,619,655,680,695,699,716,732,749,764,781,786,793,808,820,833,849,871,881,885,904,952,969,998,1010,1058,1136],"women.":[16],"While":[17,596,942],"ER-positive":[18,351,1030,1046],"breast":[19,56,130,147,186,207,314,325,358,928,999,1031],"subtypes":[21,132],"are":[22,33,955],"initially":[23],"well-managed":[24],"by":[25,585,591,623,919,1129,1132],"targeted":[26],"therapies":[27,67],"targeting":[28,103],"estrogen":[29,578,658,747,901,965,974,983,996],"signaling,":[30],"many":[31],"women":[32],"suffering":[34],"from":[35,361],"recurrence":[36,52],"a":[38,93,146,216,234,298,303,349,362,367,383,433,462,500,519,602,696,923,1108,1111],"more":[39,46],"aggressive,":[40],"hormone":[41,54],"insensitive":[42,669],"5":[44],"or":[45],"years":[47],"after":[48],"initial":[49],"remission.":[50],"Late":[51],"resistant":[55],"patients":[59],"who":[60],"were":[61,538,556,632,818],"previously":[62],"successfully":[63],"treated":[64,837],"with":[65,369,505,593,637,652,689,708,771,798,838],"anti-estrogen":[66],"worsens":[68],"overall":[69],"long-term":[70],"outcomes,":[71],"specific":[73,106,392],"oncogenic":[74,879],"mutations":[75],"may":[76,95,990,1177],"be":[77,541,667,1080,1123,1150],"driving":[78,140,385],"late":[79],"recurring":[80],"aggressive":[81,370],"disease":[82],"these":[84,905,1175],"patients.":[85],"More":[86],"complete":[87],"characterization":[88,137],"oncogenome":[91],"tumor":[94,313],"allow":[96],"for":[97,256,269,477,576,728,777,897,925,1110],"possibility":[99],"customized":[101],"therapy":[102],"each":[104],"patient's":[105],"oncogene-activating":[107],"mutations,":[108],"doing":[111],"so":[112],"increase":[113,698,785],"probability":[115],"durable":[117],"remission":[118],"over":[119],"long":[121,281],"term.":[122],"Basic":[123],"research":[124],"on":[125,239,528,605,949],"cell":[126,327,346,352,496,1035],"lines":[127,328,497],"modeling":[128],"different":[129,1112],"makes":[133],"possible":[134],"discovery":[135],"novel":[139],"oncogenes":[141],"their":[143],"context":[144],"subtype":[149],"model.":[150],"The":[151,247,263,344,1048],"Wolf":[152],"Hirschhorn":[153],"Syndrome":[154],"Candidate":[155],"1-Like":[156],"1":[157],"gene":[158,249,1084,1098,1146],"(WHSC1L1)":[159],"one":[161],"approximately":[163,783],"50":[164],"genes":[165,537,555,1176],"chromosome":[168,179],"8p11-p12":[169,200],"amplicon,":[170],"an":[171,397,407,414,782],"amplified":[172],"region":[173,201],"short":[176,264,377,891,1054],"arm":[177],"8":[180],"found":[181,205,443,511,539,628,663,754],"12-15%":[183],"human":[185],"cancers,":[187],"as":[188,190,195,396,406,621,645,647,657,1107,1169],"well":[189],"other":[191],"types":[193],"such":[194],"lung.":[196],"Amplification":[197],"often":[204],"cancers":[208,1000],"luminal":[211,356,926],"B":[212,357,927],"subtype.":[213],"WHSC1L1":[214,248,267,335,439,449,473,494,524,562,598,878,894,986,1002,1057],"member":[217],"NSD":[220],"family":[221],"histone":[223,244,1101,1130],"lysine":[224],"methyltransferases,":[225],"SET":[226,287],"domain-containing":[227],"proteins":[228],"which":[229,254,574,862,1118,1134],"catalyze":[230],"addition":[232],"methyl":[235],"group":[236],"to":[237,499,540,550,567,635,666,670,702,713,759,867,869,913,937,964,982,1013,1022,1044,1122,1125,1152,1180,1184],"lysines":[238],"amino-terminal":[241],"tail":[242],"H3":[245],"subunits.":[246],"expresses":[250,935],"two":[251,257],"known":[252,374],"isoforms":[253,341,440,1074,1162,1173],"code":[255],"distinct":[258],"proteins,":[259],"WHSC1L1-long":[260],"WHSC1L1-short.":[262],"isoform":[265,378,892,1055],"codes":[268,575],"first":[271],"647":[272],"1437":[275],"amino":[276],"acids":[277],"present":[278],"isoform,":[282],"lacks":[284],"catalytic":[286],"domain":[288,301],"several":[290],"PHD":[291],"PWWP":[293,300],"chromatin":[294,870,914,1014,1076,1165,1181],"interacting":[295],"domains,":[296],"containing":[297],"single":[299],"recently":[304],"characterized":[305],"acidic":[306],"transactivation":[307],"domain.":[308],"In":[309],"both":[310,340,438,447,468],"normal":[311],"tissue,":[315],"WHSC1L1-short":[316,395,404,424,451,459,491,516,546,586,613,674,724,740,855,950,1092],"expressed":[318,534,543,558],"at":[319,841],"greater":[320,520],"levels":[321,608],"than":[322,465,522,1039],"WHSC1L1-long.":[323],"Several":[324],"established":[329],"Ethier":[332],"lab":[333],"harbor":[334],"amplifications":[336],"also":[338,600,662,1178],"overexpress":[339],"WHSC1L1.":[343],"SUM44":[345,388,410,455,482,490,502,564,620,630,664,678,686,717,733,750,821,834,851,872,882,921,953,981,1020,1068],"line":[347,353,503,1036],"highly":[350,932],"model":[354,417,434,924],"isolated":[360],"pleural":[363],"effusion":[364],"metastasis":[365],"patient":[368],"disease.":[371,1047],"It":[372,1148],"that":[375,418,435,444,458,472,512,629,640,723,755,854,889,908,985,1071,1091],"WHSC1L1,":[380],"WHSC1L1-short,":[381,1133],"potent":[384],"oncogene":[386,408],"cells,":[389,411,483,734,852,906],"however":[390],"mechanism":[393],"oncomodifier":[398],"not":[400,956,1095],"known.":[401],"To":[402],"investigate":[403],"function":[405],"we":[412,484,510,735,753],"developed":[413],"shRNA":[415,506],"knockdown":[416,445,460,466,495,513,547,563,599,611,738,856],"specifically":[419],"knocked":[420,436],"down":[421,437],"expression":[422,474,487,729,860,898,947,1061,1099],"through":[425,1100,1140],"its":[426],"unique":[427],"3'":[428],"UTR":[429],"sequence":[430],"(shWHSC1L1-short),":[431],"(shWHSC1L1-total).":[441],"We":[442,626,661],"total":[448,493,523,561,597],"alone":[452,517,614],"negatively":[453],"affected":[454,741],"proliferation,":[456],"had":[461,518,601],"larger":[463],"effect":[464,604],"isoforms.":[469],"After":[470,721],"finding":[471],"was":[475,582,589,726,757,831,847,857],"required":[476,727,896],"typical":[478],"proliferation":[479,641,656,676,700,706,1065],"rates":[480],"performed":[485],"genome-wide":[486,742],"profiling":[488],"relative":[498,549,566],"control":[501,719,850],"transduced":[504],"against":[507],"lacZ.":[508],"Again":[509],"affect":[521],"knockdown,":[525],"this":[526],"time":[527],"number":[530],"significantly":[532,583],"differentially":[533,542,557],"genes;":[535],"1131":[536],"cells":[548,565,631,665,679,688,823,836,883,954,1021,1043,1069],"shLacZ":[551,568,718],"control,":[552],"while":[553],"238":[554],"control.":[569],"Interestingly,":[570,1086],"ESR1":[572],"gene,":[573],"receptor":[579,748,902,940,997],"alpha":[580,903],"protein,":[581],"downregulated":[584],"knockdown.":[587],"This":[588],"confirmed":[590],"immunoblotting":[592],"ERa":[594,606,618,731,756,787,812,815,829,845,859,865,909,918,946,963,1011,1023,1060],"antibody.":[595],"negative":[603,977,1017],"protein":[607],"SUM44,":[610],"almost":[615],"completely":[616],"abrogated":[617],"measured":[622],"western":[624],"blot.":[625],"subsequently":[627],"extremely":[633],"sensitive":[634],"treatment":[636,684],"beta-estradiol,":[638,704],"actually":[642],"decreased":[643,707],"upon":[644],"little":[646,936],"100":[648],"picomolar":[649],"beta-estradiol":[650,693,710,776,840],"treatment,":[651],"dose-dependent":[653],"decreases":[654],"concentrations":[659,691,711],"increased.":[660],"relatively":[668],"Tamoxifen.":[671],"Knockdown":[672],"reduced":[675],"estrogen-free":[681,825],"conditions,":[682,826],"shWHSC1L1-short":[687,822,835,873],"increasing":[690,709],"resulted":[694,780,884],"marginal":[697],"up":[701],"100pM":[703],"then":[705],"similar":[712],"results":[714,1135],"seen":[715,1009],"cells.":[720,751,874],"observing":[722],"overexpression":[725,951,989],"asked":[736],"whether":[737],"binding":[743,758,788,802,816,830,846,961,1012,1156],"patterns":[744],"Interestingly":[752],"thousands":[760],"genomic":[762],"loci":[763,842],"absence":[766,795,971],"exogenous":[768,973],"estrogen.":[769,920],"Treatment":[770],"high":[772],"doses":[773],"(10nM)":[774],"45":[778],"minutes":[779],"even":[784],"across":[789],"sites":[790,817],"already":[791],"bound":[792,911],"estrogen,":[797],"some":[799],"additional":[800,1034],"weak":[801,828],"sites,":[803],"but":[804,1103],"no":[805,938],"significant":[806],"changes":[807],"pattern":[810],"binding.":[813],"No":[814],"detected":[819,832],"under":[824],"10nM":[839],"where":[843],"strong":[844],"observed":[848],"suggesting":[853],"reducing":[858],"levels,":[861],"made":[863],"less":[864],"available":[866],"bind":[868,1179],"Our":[875],"investigation":[876],"activity":[880],"interesting":[887],"observation":[888],"extensively":[912],"without":[915],"activation":[916,1137],"cancer,":[929],"ER-positive,":[933],"progesterone":[939],"(PR).":[941],"implications":[944],"dependence":[948],"yet":[957],"clear,":[958],"extensive":[960],"response":[966,979,1018],"elements":[967],"(ERE's)":[968],"proliferative":[978],"indicate":[984],"amplification":[987,1003],"alter":[991],"biology":[993],"harboring":[1001],"overexpression.":[1005],"Additionally,":[1006],"differences":[1008],"agonists":[1024],"illustrate":[1025],"importance":[1027],"researching":[1029],"using":[1033,1041],"models":[1037],"rather":[1038],"consistently":[1040],"MCF7":[1042],"represent":[1045],"dominant":[1049],"role":[1050],"catalytically-inactive":[1053],"regulating":[1059,1096],"maintaining":[1063],"rate":[1066],"suggests":[1070],"catalytically":[1072,1160,1171,1189],"inactive":[1073,1161,1172],"modifying":[1077],"enzymes":[1078],"can":[1079],"important":[1081,1151],"regulators":[1082],"expression.":[1085],"recent":[1087],"work":[1088],"has":[1089,1119],"shown":[1090,1121],"likely":[1094],"target":[1097,1145],"methylation,":[1102],"instead":[1104],"acting":[1106],"co-factor":[1109],"chromatin-binding":[1113],"complex,":[1114,1117],"BRD4-CHD8":[1116],"been":[1120],"recruited":[1124],"superenhancer":[1126],"regions":[1127],"(marked":[1128],"acetylation)":[1131],"pTEFb":[1139],"BRD4":[1141],"directly":[1143],"activates":[1144],"transcription.":[1147],"will":[1149],"avoid":[1153],"assumptions":[1154],"about":[1155],"substrate":[1157,1186],"identities":[1158],"future":[1164],"modifiers":[1166],"interest,":[1168],"substrates":[1182],"unrelated":[1183],"active":[1190],"isoform.":[1191]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-03-16T00:00:00"}