{"id":"https://openalex.org/W2592265370","doi":"https://doi.org/10.1182/blood.v116.21.820.820","title":"Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model","display_name":"Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2592265370","doi":"https://doi.org/10.1182/blood.v116.21.820.820","mag":"2592265370"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.820.820","doi":"https://doi.org/10.1182/blood.v116.21.820.820","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.820.820","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011450008","display_name":"Erik I. Tucker","orcid":"https://orcid.org/0000-0003-0532-113X","observed_orcids":["https://orcid.org/0000-0003-0532-113X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erik I Tucker","raw_affiliation_strings":["Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003485109","display_name":"Melani Helm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094792","display_name":"Aronora (United States)","ror":"https://ror.org/00vrz7m04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melani Helm","raw_affiliation_strings":["Aronora, LLC, Beaverton, OR, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aronora, LLC, Beaverton, OR, USA,","institution_ids":["https://openalex.org/I4210094792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978437","display_name":"Owen J. T. McCarty","orcid":"https://orcid.org/0000-0001-9481-0124","observed_orcids":["https://orcid.org/0000-0001-9481-0124"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Owen JT McCarty","raw_affiliation_strings":["Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103574752","display_name":"Sawan Hurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sawan Hurst","raw_affiliation_strings":["Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021496734","display_name":"David Gailani","orcid":"https://orcid.org/0000-0001-8142-8014","observed_orcids":["https://orcid.org/0000-0001-8142-8014"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gailani","raw_affiliation_strings":["Hematology/ Oncology Division, Vanderbilt University, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/ Oncology Division, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036237322","display_name":"Andr\u00e1s Gruber","orcid":"https://orcid.org/0000-0001-6212-2247","observed_orcids":["https://orcid.org/0000-0001-6212-2247"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andras Gruber","raw_affiliation_strings":["Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA,","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011450008","https://openalex.org/A5036237322","https://openalex.org/A5050978437","https://openalex.org/A5103574752"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1424,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58800068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"820","last_page":"820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9039999842643738},{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":0.8050000071525574},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5379999876022339},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.5080000162124634},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.5090000033378601},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.414000004529953},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4869999885559082},{"id":"https://openalex.org/keywords/aptt-prolongation","display_name":"aPTT prolongation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7675700187683105},{"id":"https://openalex.org/C2776217217","wikidata":"https://www.wikidata.org/wiki/Q611571","display_name":"Bleeding diathesis","level":3,"score":0.7565284967422485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6972557306289673},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.6823858618736267},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.6701096296310425},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.6677756905555725},{"id":"https://openalex.org/C2909910413","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Consumptive Coagulopathy","level":3,"score":0.5668860077857971},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5354329347610474},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.48574215173721313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4755361080169678},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.4736897945404053},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.4657365381717682},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.4233914613723755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3663891553878784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3438108563423157},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2709292769432068}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.820.820","doi":"https://doi.org/10.1182/blood.v116.21.820.820","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.820.820","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2573243003","https://openalex.org/W2106478756","https://openalex.org/W1984763915","https://openalex.org/W946024238","https://openalex.org/W2313919223","https://openalex.org/W2917214053","https://openalex.org/W4411730297","https://openalex.org/W4414572435","https://openalex.org/W2594452697","https://openalex.org/W2907083185"],"abstract_inverted_index":{"Abstract":[0,1],"820":[2],"Sepsis":[3],"results":[4,63,495],"in":[5,20,49,68,103,124,144,156,179,192,217,310,345,360,388,449,480,512],"a":[6,21,76,152,197,407,528],"systemic":[7],"inflammatory":[8],"state":[9],"that":[10,35,71,131,147,205,462,497,520],"is":[11,92,517],"frequently":[12],"accompanied":[13],"by":[14,66,225,233,321,331,502,507],"intravascular":[15,29],"coagulation":[16,38],"and":[17,25,51,83,113,119,146,177,213,260,290,302,313,324,326,334,367,378,393,418,424,434,458],"fibrinolysis,":[18],"resulting":[19],"coagulopathy":[22,102,176,464],"with":[23,264,338,357,475,483,527],"thrombotic":[24,80],"hemorrhagic":[26],"components":[27],"(disseminated":[28],"coagulation\u2013":[30],"DIC).":[31],"We":[32],"have":[33],"shown":[34,216],"the":[36,88,139,170,183,193,207,221,244,256,346,389,394,441,459,490],"plasma":[37],"protease":[39],"factor":[40,226],"XI":[41],"(FXI)":[42],"contributes":[43],"substantially":[44],"to":[45,57,97,99,138,142,159,174,219,249,403,453,536],"experimental":[46],"thrombus":[47],"formation":[48],"baboons":[50],"mice,":[52,107],"but":[53],"does":[54],"not":[55,229],"appear":[56],"be":[58,134,151,404,466,510],"essential":[59],"for":[60,251,278,285,288,292,297,421,430,445],"hemostasis.":[61],"These":[62],"are":[64],"supported":[65],"studies":[67],"human":[69],"populations":[70],"show":[72],"FXI":[73,95,109,132,149,173,191,201,224,470,505,523],"deficiency":[74,110],"confers":[75],"decreased":[77],"risk":[78,530],"of":[79,116,172,211,223,238,246,385,391,398,500,522,531],"ischemic":[81],"stroke":[82],"deep":[84],"venous":[85],"thrombosis,":[86],"while":[87,108,228,365,486],"associated":[89],"bleeding":[90,413,481,492,533],"diathesis":[91],"often":[93],"mild.":[94],"appears":[96],"contribute":[98],"lethal":[100],"consumptive":[101,175,463],"protein":[104,161],"C":[105,162],"deficient":[106],"reduces":[111],"DIC":[112,143,526],"prolongs":[114],"survival":[115,282],"surgical":[117],"cecal-ligation":[118],"puncture":[120],"(CLP)-induced":[121],"abdominal":[122],"sepsis":[123,180,187,392,451],"mice.":[125],"Taken":[126],"together,":[127],"these":[128],"data":[129,460],"suggest":[130,496],"may":[133,150,465,524],"an":[135],"important":[136],"contributor":[137],"response":[140],"leading":[141],"sepsis,":[145],"inhibiting":[148,231,504],"safer":[153],"therapeutic":[154,498],"alternative":[155],"this":[157],"setting":[158],"activated":[160],"(APC),":[163],"which":[164],"can":[165],"exacerbate":[166],"hemorrhage.":[167],"To":[168,189],"investigate":[169],"contribution":[171],"mortality":[178],"we":[181,195],"used":[182],"standard":[184],"CLP":[185,353],"polymicrobial":[186],"model.":[188],"inhibit":[190,220],"mouse,":[194],"developed":[196],"new":[198],"murine":[199],"anti-mouse":[200],"monoclonal":[202],"antibody":[203],"(14E11)":[204],"targets":[206],"Apple":[208],"2":[209],"domain":[210],"FXI,":[212,501],"has":[214],"been":[215],"vitro":[218],"activation":[222,232,506],"XIIa,":[227],"significantly":[230,488],"thrombin.":[234],"A":[235],"single":[236],"injection":[237],"14E11":[239,273,293,298,314,368,386,425,446,476],"(4":[240,274],"mg/kg,":[241,270,275],"SC)":[242,276],"prolonged":[243,489],"aPTT":[245],"mice":[247,261,295,316,363,448,473],"up":[248],"3-fold":[250],"48":[252],"hrs.":[253],"Following":[254],"CLP,":[255,307],"abdomen":[257],"was":[258,283,443],"closed":[259],"were":[262,319,329,343,415],"treated":[263,294,315,348,369,426,447,474],"vehicle":[265,347,433,454,484],"(PBS,":[266],"SC),":[267,271],"APC":[268,301,366,400,431,456,487],"(6":[269],"or":[272,455,542],"(n=20":[277],"each":[279],"group).":[280],"Overall":[281],"45%":[284],"vehicle,":[286,311,422],"15%":[287],"APC,":[289,312,423],"80%":[291],"(P<0.001":[296],"vs.":[299,432],"both":[300],"vehicle).":[303],"24":[304,350],"hrs":[305,351],"after":[306,352,437],"platelet":[308],"count":[309],"(n=8":[317],"each)":[318],"lower":[320,330,529],"24\u00b17%,":[322],"25\u00b15%,":[323],"12\u00b16%,":[325],"leukocyte":[327],"counts":[328],"51\u00b115%,":[332],"42\u00b114%,":[333],"43\u00b113%":[335],"respectively,":[336],"compared":[337,356,452,482,535],"baseline.":[339],"Thrombin/antithrombin":[340],"complex":[341],"levels":[342,376],"higher":[344],"group":[349],"(5.0\u00b11.2":[354],"\u03bcg/L)":[355],"2.2\u00b10.2":[358],"\u03bcg/L":[359],"normal":[361],"healthy":[362],"(P<0.05),":[364],"groups":[370],"showed":[371,477],"only":[372],"moderately":[373],"elevated":[374],"TAT":[375],"(2.6\u00b10.2":[377],"2.7\u00b10.4":[379],"\u03bcg/L,":[380],"respectively).":[381],"The":[382,494],"pharmacological":[383],"effects":[384],"later":[387],"course":[390],"apparent":[395],"poor":[396],"outcome":[397,442],"early":[399],"treatment":[401],"remain":[402],"evaluated.":[405],"In":[406,439],"separate":[408],"cohort":[409],"(n=12":[410],"each),":[411],"tail-clip":[412],"times":[414],"12.8\u00b11.0,":[416],"17.9\u00b11.8,":[417],"12.1\u00b11.7":[419],"min":[420],"animals":[427],"respectively":[428],"(P<0.05":[429],"14E11)":[435],"30min":[436],"injection.":[438],"summary,":[440],"better":[444],"CLP-induced":[450],"treatment,":[457,485],"indicate":[461],"less":[467],"severe":[468],"following":[469],"inhibition.":[471],"Furthermore,":[472],"no":[478],"increase":[479],"tail":[491],"time.":[493],"inhibition":[499,521],"specifically":[503],"FXIIa,":[508],"could":[509],"beneficial":[511],"treating":[513],"sepsis-related":[514],"DIC.":[515],"It":[516],"also":[518],"possible":[519],"limit":[525],"exacerbating":[532],"when":[534],"anticoagulant":[537],"therapies":[538],"such":[539],"as":[540],"heparin":[541],"APC.":[543],"Disclosures:":[544],"Tucker:":[545],"Aronora,LLC:":[546],"Employment,":[547],"Equity":[548,557],"Ownership,":[549,558],"Patents":[550,559],"&":[551,560],"Royalties.":[552,561],"Helm:Aronora,LLC:":[553],"Employment.":[554],"Gruber:Aronora,LLC:":[555],"Consultancy,":[556]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-03-16T00:00:00"}
