{"id":"https://openalex.org/W2592228154","doi":"https://doi.org/10.1097/aln.0000000000001596","title":"Early Development, Identification of Mode of Action, and Use of Dantrolene Sodium: The Role of Keith Ellis, Ph.D.","display_name":"Early Development, Identification of Mode of Action, and Use of Dantrolene Sodium: The Role of Keith Ellis, Ph.D.","publication_year":2017,"publication_date":"2017-03-08","ids":{"openalex":"https://openalex.org/W2592228154","doi":"https://doi.org/10.1097/aln.0000000000001596","mag":"2592228154","pmid":"https://pubmed.ncbi.nlm.nih.gov/28272142"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000001596","doi":"https://doi.org/10.1097/aln.0000000000001596","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000001596","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046495881","display_name":"Neil Pollock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283092701","display_name":"Saint Barnabas Medical Center","ror":"https://ror.org/024esvk12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283092701"]},{"id":"https://openalex.org/I4210102501","display_name":"Palmerston North Hospital","ror":"https://ror.org/01ctbbh52","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210102501"]}],"countries":["NZ","US"],"is_corresponding":true,"raw_author_name":"Neil A. Pollock","raw_affiliation_strings":["From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","Submitted for publication August 18, 2016. Accepted for publication January 26, 2017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","institution_ids":["https://openalex.org/I1283092701","https://openalex.org/I4210102501"]},{"raw_affiliation_string":"Submitted for publication August 18, 2016. Accepted for publication January 26, 2017","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065030971","display_name":"Roslyn G. Machon","orcid":"https://orcid.org/0009-0000-1882-6925","observed_orcids":["https://orcid.org/0009-0000-1882-6925"]},"institutions":[{"id":"https://openalex.org/I1283092701","display_name":"Saint Barnabas Medical Center","ror":"https://ror.org/024esvk12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283092701"]},{"id":"https://openalex.org/I4210102501","display_name":"Palmerston North Hospital","ror":"https://ror.org/01ctbbh52","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210102501"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Roslyn G. Machon","raw_affiliation_strings":["From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","Submitted for publication August 18, 2016. Accepted for publication January 26, 2017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","institution_ids":["https://openalex.org/I1283092701","https://openalex.org/I4210102501"]},{"raw_affiliation_string":"Submitted for publication August 18, 2016. Accepted for publication January 26, 2017","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024212012","display_name":"Henry R. Rosenberg","orcid":"https://orcid.org/0000-0002-3360-5378","observed_orcids":["https://orcid.org/0000-0002-3360-5378"]},"institutions":[{"id":"https://openalex.org/I1283092701","display_name":"Saint Barnabas Medical Center","ror":"https://ror.org/024esvk12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283092701"]},{"id":"https://openalex.org/I4210102501","display_name":"Palmerston North Hospital","ror":"https://ror.org/01ctbbh52","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210102501"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Henry Rosenberg","raw_affiliation_strings":["From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","Submitted for publication August 18, 2016. Accepted for publication January 26, 2017"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anaesthesia and Intensive Care, Midcentral Health, Palmerston North, New Zealand (N.A.P., R.G.M.); and Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, Livingston, New Jersey (H.R.)","institution_ids":["https://openalex.org/I1283092701","https://openalex.org/I4210102501"]},{"raw_affiliation_string":"Submitted for publication August 18, 2016. Accepted for publication January 26, 2017","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046495881"],"corresponding_institution_ids":["https://openalex.org/I1283092701","https://openalex.org/I4210102501"],"apc_list":null,"apc_paid":null,"fwci":1.0163,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75985272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"126","issue":"5","first_page":"774","last_page":"779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12990","display_name":"Medical History and Innovations","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dantrolene-sodium","display_name":"dantrolene sodium","score":0.9369999766349792},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5630000233650208},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8289999961853027},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.9110000133514404},{"id":"https://openalex.org/keywords/skeletal-muscle-relaxation","display_name":"skeletal muscle relaxation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/malignant-hyperthermia","display_name":"malignant hyperthermia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/porcine-stress-syndrome","display_name":"porcine stress syndrome","score":0.9470000267028809},{"id":"https://openalex.org/keywords/muscle-rigidity","display_name":"muscle rigidity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/history-of-pharmacology","display_name":"history of pharmacology","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9416348934173584},{"id":"https://openalex.org/C2910132651","wikidata":"https://www.wikidata.org/wiki/Q421274","display_name":"Dantrolene Sodium","level":4,"score":0.8608146905899048},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7270749807357788},{"id":"https://openalex.org/C2781460320","wikidata":"https://www.wikidata.org/wiki/Q421274","display_name":"Dantrolene","level":3,"score":0.6669947504997253},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.5901666879653931},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5515989661216736},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.44590675830841064},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2035081684589386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15956366062164307},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003620","descriptor_name":"Dantrolene","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009125","descriptor_name":"Muscle Relaxants, Central","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049674","descriptor_name":"History, 21st Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0000000000001596","doi":"https://doi.org/10.1097/aln.0000000000001596","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000001596","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:28272142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28272142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Biography"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W136161705","https://openalex.org/W148170344","https://openalex.org/W1545077229","https://openalex.org/W1605527521","https://openalex.org/W1963480642","https://openalex.org/W1967645410","https://openalex.org/W1970311357","https://openalex.org/W1972157178","https://openalex.org/W1995677296","https://openalex.org/W2010493628","https://openalex.org/W2011929406","https://openalex.org/W2012859036","https://openalex.org/W2013513622","https://openalex.org/W2029209067","https://openalex.org/W2041557338","https://openalex.org/W2047120941","https://openalex.org/W2052957706","https://openalex.org/W2052967310","https://openalex.org/W2057555152","https://openalex.org/W2062143736","https://openalex.org/W2063334845","https://openalex.org/W2070501169","https://openalex.org/W2083049504","https://openalex.org/W2087040379","https://openalex.org/W2093888172","https://openalex.org/W2094031503","https://openalex.org/W2114747930","https://openalex.org/W2132968710","https://openalex.org/W2135280354","https://openalex.org/W2137894870","https://openalex.org/W2239882814","https://openalex.org/W2317777815","https://openalex.org/W2321639681","https://openalex.org/W2334524426","https://openalex.org/W2411024775","https://openalex.org/W2412250953","https://openalex.org/W2471586775","https://openalex.org/W2885023227","https://openalex.org/W4247625354"],"related_works":["https://openalex.org/W2148269081","https://openalex.org/W939914494","https://openalex.org/W2331783503","https://openalex.org/W3031888008","https://openalex.org/W2068367661","https://openalex.org/W1494697947","https://openalex.org/W2061610042","https://openalex.org/W185981134","https://openalex.org/W31938543","https://openalex.org/W6922668931"],"abstract_inverted_index":{"Dantrolene-a":[0],"nitrofurantoin":[1],"derivative-was":[2],"developed":[3],"by":[4,58,121],"Snyder":[5],"et":[6,47],"al.":[7,48],"in":[8,19,27,98,118],"1967.":[9],"After":[10],"initial":[11],"discovery":[12,100],"of":[13,22,39,53,67,75,101,107],"its":[14],"muscle":[15,29,116],"relaxation":[16],"potential,":[17],"investigations":[18],"a":[20,51,65,95,112],"number":[21,52],"species":[23],"demonstrated":[24],"dose-dependent":[25],"reductions":[26],"skeletal":[28],"tone":[30],"that":[31],"were":[32],"long":[33],"lasting,":[34],"relatively":[35],"nontoxic,":[36],"and":[37,128],"free":[38],"adverse":[40],"effects":[41],"such":[42],"as":[43],"respiratory":[44],"impairment.":[45],"Ellis":[46,71,90],"then":[49],"published":[50],"papers":[54],"investigating":[55],"the":[56,78,86,99,105],"means":[57],"which":[59],"dantrolene":[60,130],"produced":[61],"these":[62],"effects.":[63],"Using":[64],"series":[66],"classic":[68],"physiologic":[69],"models,":[70],"investigated":[72],"potential":[73],"sites":[74],"action":[76],"for":[77,104,133],"new":[79],"drug,":[80],"eventually":[81],"narrowing":[82],"this":[83],"down":[84],"to":[85,93,131],"intracellular":[87],"calcium-release":[88],"mechanism.":[89],"went":[91],"on":[92],"play":[94],"pivotal":[96],"role":[97],"dantrolene's":[102],"effectiveness":[103],"treatment":[106],"malignant":[108],"hyperthermia,":[109],"after":[110],"reading":[111],"scientific":[113],"bulletin":[114],"about":[115],"rigidity":[117],"pigs":[119],"affected":[120],"porcine":[122],"stress":[123],"syndrome,":[124],"contacting":[125],"Gaisford":[126],"Harrison":[127],"sending":[129],"him":[132],"trial.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-03-16T00:00:00"}