{"id":"https://openalex.org/W2592096367","doi":null,"title":"Investigating the effects of a 6-month aerobic exercise intervention on brain function and memory in older adults","display_name":"Investigating the effects of a 6-month aerobic exercise intervention on brain function and memory in older adults","publication_year":2016,"publication_date":"2016-04-19","ids":{"openalex":"https://openalex.org/W2592096367","mag":"2592096367"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/90558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/90558","pdf_url":"http://hdl.handle.net/2142/90558","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/90558","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009735690","display_name":"Kristin B Duffy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristin B Duffy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009735690"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.24775527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.36959999799728394,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.36959999799728394,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13471","display_name":"Cognitive Functions and Memory","score":0.17239999771118164,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.9950000047683716},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8610000014305115},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hippocampal-activation","display_name":"hippocampal activation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cardiorespiratory-fitness","display_name":"cardiorespiratory fitness","score":0.9860000014305115},{"id":"https://openalex.org/keywords/memory-retrieval","display_name":"memory retrieval","score":0.6690000295639038},{"id":"https://openalex.org/keywords/walking","display_name":"walking","score":0.6589999794960022},{"id":"https://openalex.org/keywords/dance","display_name":"dance","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nutrition","display_name":"nutrition","score":0.5989999771118164},{"id":"https://openalex.org/keywords/brain-function","display_name":"brain function","score":0.6790000200271606},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.7462462782859802},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5900400876998901},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.5663593411445618},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5441949367523193},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4878082573413849},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4636339843273163},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.40215203166007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3905267119407654},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3349645137786865},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18290206789970398}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/90558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/90558","pdf_url":"http://hdl.handle.net/2142/90558","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2592096367","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/90558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/90558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/90558","pdf_url":"http://hdl.handle.net/2142/90558","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2592096367.pdf","grobid_xml":"https://content.openalex.org/works/W2592096367.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W593507756","https://openalex.org/W1573988570","https://openalex.org/W1901617695","https://openalex.org/W1959902108","https://openalex.org/W1988100039","https://openalex.org/W2012403948","https://openalex.org/W2014781016","https://openalex.org/W2039100706","https://openalex.org/W2052406514","https://openalex.org/W2052644075","https://openalex.org/W2055826719","https://openalex.org/W2057308730","https://openalex.org/W2059389832","https://openalex.org/W2061358809","https://openalex.org/W2071881327","https://openalex.org/W2073196527","https://openalex.org/W2076828848","https://openalex.org/W2105103983","https://openalex.org/W2107501599","https://openalex.org/W2109527205","https://openalex.org/W2110665915","https://openalex.org/W2114354158","https://openalex.org/W2114366958","https://openalex.org/W2119893938","https://openalex.org/W2120864281","https://openalex.org/W2126666119","https://openalex.org/W2131196982","https://openalex.org/W2137606780","https://openalex.org/W2138866872","https://openalex.org/W2140388782","https://openalex.org/W2141037528","https://openalex.org/W2147597108","https://openalex.org/W2147973220","https://openalex.org/W2153038533","https://openalex.org/W2158250395","https://openalex.org/W2158852054","https://openalex.org/W2171853575","https://openalex.org/W2227813149","https://openalex.org/W3041214984","https://openalex.org/W4230026655"],"related_works":["https://openalex.org/W4200041280","https://openalex.org/W7221750313","https://openalex.org/W4212954569","https://openalex.org/W2982339476","https://openalex.org/W3196813228","https://openalex.org/W2324052111","https://openalex.org/W3174236444","https://openalex.org/W3167950838","https://openalex.org/W4244220321","https://openalex.org/W4406906125"],"abstract_inverted_index":{"Episodic":[0],"memory":[1,53,100,176,209,226],"is":[2],"particularly":[3],"susceptible":[4],"to":[5,47,147,225],"age-related":[6],"decline.":[7],"Research":[8],"in":[9,15,21,43,50,104,158,171,175,184,194,208,220,229],"animal":[10,37],"models":[11],"and":[12,52,77,129,131,150,173],"cross-sectional":[13],"studies":[14],"humans":[16,44],"provide":[17],"evidence":[18,35],"that":[19,138,182],"engaging":[20],"aerobic":[22,40,72,95],"exercise":[23,41,73,96],"may":[24,222],"mitigate":[25],"the":[26,85,90,139,148,230],"effects":[27],"of":[28,92,116,232],"aging":[29],"on":[30,98],"memory.":[31,160],"Yet,":[32],"despite":[33],"abundant":[34],"from":[36],"literature,":[38],"many":[39],"interventions":[42],"have":[45],"failed":[46],"demonstrate":[48,214],"improvements":[49,207,228],"learning":[51],"(Erickson":[54],"et":[55,59,63],"al.,":[56,60,64],"2011a;":[57],"Tamura":[58],"2014;":[61],"Ngandu":[62],"2015).":[65],"Further,":[66],"we":[67,88,136,165,179],"know":[68],"little":[69],"about":[70],"how":[71],"affects":[74],"brain":[75],"function":[76],"whether":[78],"functional":[79],"changes":[80],"are":[81],"behaviorally":[82],"relevant.":[83],"In":[84],"present":[86],"study,":[87],"investigated":[89],"effect":[91],"a":[93,215,233],"6-month":[94],"intervention":[97,187],"episodic":[99,159],"retrieval":[101],"using":[102],"fMRI":[103],"healthy":[105],"older":[106,110],"adults.":[107],"Specifically,":[108],"137":[109],"adults":[111],"(60":[112],"-":[113],"80":[114],"years":[115],"age)":[117],"were":[118,154],"randomized":[119],"across":[120,186],"four":[121],"treatment":[122],"groups:":[123],"walking,":[124],"walking":[125,140],"plus":[126],"nutrition,":[127],"dance,":[128],"stretching":[130],"toning":[132],"(active":[133],"control).":[134],"Although":[135],"found":[137,166],"groups":[141],"increased":[142,201],"cardiorespiratory":[143],"fitness":[144],"(CRF)":[145],"relative":[146],"dance":[149],"control":[151],"groups,":[152,188],"there":[153],"no":[155,167],"group":[156],"differences":[157],"Consistent":[161],"with":[162,192,206],"previous":[163],"studies,":[164],"association":[168],"between":[169],"change":[170,174,183,193],"CRF":[172,221],"performance.":[177,210],"However,":[178],"did":[180],"find":[181],"CRF,":[185],"was":[189,204],"positively":[190],"associated":[191,205],"hippocampal":[195,202],"activation":[196,203],"during":[197],"recognition":[198],"'hits'.":[199],"Furthermore,":[200],"Thus,":[211],"these":[212],"results":[213],"mechanism":[216],"by":[217],"which":[218],"increases":[219],"indirectly":[223],"relate":[224],"performance":[227],"absence":[231],"significant":[234],"behavioral":[235],"effect.":[236]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-16T00:00:00"}