{"id":"https://openalex.org/W2592087028","doi":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","title":"Long-Term Effects of DMPO on Switching Macrophage\u2019s Phenotype in the Obese Adiopose Tissue","display_name":"Long-Term Effects of DMPO on Switching Macrophage\u2019s Phenotype in the Obese Adiopose Tissue","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2592087028","doi":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","mag":"2592087028"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2016.10.140","doi":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067286899","display_name":"Marcos David Munoz","orcid":"https://orcid.org/0000-0002-4126-1720","observed_orcids":["https://orcid.org/0000-0002-4126-1720"]},"institutions":[{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcos D Munoz","raw_affiliation_strings":["Conicet-Unsl, San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conicet-Unsl, San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066383848","display_name":"Mar\u00eda Cecilia Della Vedova","orcid":"https://orcid.org/0000-0002-4619-0482","observed_orcids":["https://orcid.org/0000-0002-4619-0482"]},"institutions":[{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria C Della Vedova","raw_affiliation_strings":["Conicet-Unsl, San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conicet-Unsl, San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011568208","display_name":"Sergio E. Alvarez","orcid":"https://orcid.org/0000-0002-4609-7835","observed_orcids":["https://orcid.org/0000-0002-4609-7835"]},"institutions":[{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sergio E Alvarez","raw_affiliation_strings":["Conicet-Unsl, San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conicet-Unsl, San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Floyd","raw_affiliation_strings":["OMRFf, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OMRFf, Oklahoma City, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012867758","display_name":"Sandra Gomez-Mejiba","orcid":"https://orcid.org/0000-0002-8515-0483","observed_orcids":["https://orcid.org/0000-0002-8515-0483"]},"institutions":[{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sandra E Gomez Mejiba","raw_affiliation_strings":["Conicet-Unsl, San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conicet-Unsl, San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044996878","display_name":"Dar\u00edo C. Ram\u00edrez","orcid":"https://orcid.org/0000-0001-6725-3326","observed_orcids":["https://orcid.org/0000-0001-6725-3326"]},"institutions":[{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dario C Ramirez","raw_affiliation_strings":["Conicet-Unsl, San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conicet-Unsl, San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24631755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":null,"first_page":"S54","last_page":"S54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dmpo","display_name":"DMPO","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adipose-tissue-macrophages","display_name":"adipose tissue macrophages","score":0.8259999752044678},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6169999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.875},{"id":"https://openalex.org/keywords/irf7","display_name":"IRF7","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.921999990940094},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9459999799728394},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nitrone-spin-traps","display_name":"nitrone spin traps","score":0.7730000019073486},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7236217856407166},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6780959367752075},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6165194511413574},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5763461589813232},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5605564117431641},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5331807732582092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.530483067035675},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4904015064239502},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.4781164526939392},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.43288522958755493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42437028884887695},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35746216773986816},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33832815289497375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3379361033439636},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.18189683556556702},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16125726699829102},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10708841681480408},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2016.10.140","doi":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2016.10.140","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3082505801","https://openalex.org/W7011582575","https://openalex.org/W7030147707","https://openalex.org/W2794947390","https://openalex.org/W4404432553","https://openalex.org/W7120630773","https://openalex.org/W7169703735","https://openalex.org/W2804581558","https://openalex.org/W2013543828","https://openalex.org/W2145697808"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-03-16T00:00:00"}