{"id":"https://openalex.org/W2592058755","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","title":"Abstract P3-04-08: The role of HER2 mutations in resistance to endocrine therapy in ER+ breast cancer","display_name":"Abstract P3-04-08: The role of HER2 mutations in resistance to endocrine therapy in ER+ breast cancer","publication_year":2017,"publication_date":"2017-02-15","ids":{"openalex":"https://openalex.org/W2592058755","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","mag":"2592058755"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs16-p3-04-08","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044389479","display_name":"Utthara Nayar","orcid":"https://orcid.org/0000-0002-9024-6084","observed_orcids":["https://orcid.org/0000-0002-9024-6084"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U Nayar","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","Broad Institute of MIT and Harvard, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083324690","display_name":"Ofir Cohen","orcid":"https://orcid.org/0000-0002-0043-6838","observed_orcids":["https://orcid.org/0000-0002-0043-6838"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Cohen","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","Broad Institute of MIT and Harvard, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016290452","display_name":"Cheonguen Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Oh","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","Broad Institute of MIT and Harvard, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068721624","display_name":"Nikhil Wagle","orcid":"https://orcid.org/0000-0003-3332-9438","observed_orcids":["https://orcid.org/0000-0003-3332-9438"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Wagle","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","Broad Institute of MIT and Harvard, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"4_Supplement","first_page":"P3","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-mutation","display_name":"HER2 mutation","score":1.0},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.6729999780654907},{"id":"https://openalex.org/keywords/fulvestrant-resistance","display_name":"fulvestrant resistance","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tamoxifen-resistance","display_name":"tamoxifen resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.5709999799728394},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.7520717978477478},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.662991464138031},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6503039598464966},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5837069749832153},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5661335587501526},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.55443274974823},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5193911194801331},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.48487386107444763},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.4805603325366974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4491703510284424},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.428315132856369},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4242766499519348},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4188153147697449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.398894339799881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.366970956325531},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33029037714004517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1439601182937622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11029115319252014}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs16-p3-04-08","doi":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs16-p3-04-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362525704","https://openalex.org/W2887323483","https://openalex.org/W2903143832","https://openalex.org/W2887302004","https://openalex.org/W779403461","https://openalex.org/W2039143946","https://openalex.org/W2944564412","https://openalex.org/W2768030020","https://openalex.org/W2605660842","https://openalex.org/W1607879668"],"abstract_inverted_index":{"Abstract":[0],"Resistance":[1],"to":[2,90,95,196,213,238,295],"endocrine":[3,38,147,214,273,296],"therapies":[4,215],"in":[5,52,57,62,68,127,146,165,174,216,249,265,293,298],"estrogen":[6],"receptor":[7],"positive":[8],"(ER+)":[9],"metastatic":[10,32,41,130],"breast":[11,42,152,220,300],"cancer":[12,153,301],"is":[13,24,242],"widespread,":[14],"and":[15,66,82,88,93,157,181,198],"understanding":[16],"the":[17,53,58,63,69,73,77,100,123,128,141,161,235,306],"mechanisms":[18],"whereby":[19],"these":[20,110,202,254],"tumors":[21,269],"acquire":[22],"resistance":[23,195,212,241,274,294],"a":[25,116,258],"critical":[26],"need.":[27],"Through":[28],"whole-exome":[29],"sequencing":[30,114],"of":[31,72,76,109,115,143,194,224,290,305],"tumor":[33,119],"biopsies":[34],"from":[35,253],"patients":[36,217,266],"with":[37,184,210,218,267],"resistant":[39,94],"ER+":[40,151,219,299],"cancer,":[43],"we":[44,149],"identified":[45],"13":[46],"different":[47],"HER2":[48,124,144,162,206,236,247,276,291],"mutations,":[49],"including":[50],"five":[51],"kinase":[54,78],"domain,":[55,60,65],"four":[56],"signaling":[59],"three":[61],"extracellular":[64],"one":[67],"transmembrane":[70],"region":[71],"protein.":[74],"Two":[75],"domain":[79],"mutations":[80,102,125,145,207,248,292],"(L755S":[81],"V777L)":[83],"have":[84,103,271],"been":[85,105],"previously":[86],"described":[87],"shown":[89],"be":[91],"activating":[92],"reversible":[96],"anti-HER2":[97,226],"targeted":[98],"therapies;":[99],"remaining":[101],"not":[104,121],"reported.":[106],"In":[107,187],"several":[108,189],"patients,":[111],"whole":[112],"exome":[113],"pre-treatment":[117],"primary":[118],"did":[120],"identify":[122],"seen":[126],"corresponding":[129],"tumor,":[131],"suggesting":[132],"that":[133,205,233,270],"they":[134],"were":[135],"acquired":[136,211,272],"during":[137],"therapy.":[138],"To":[139],"examine":[140],"role":[142,289],"resistance,":[148],"generated":[150],"cell":[154],"lines":[155],"(MCF7":[156],"T47D)":[158],"stably":[159],"expressing":[160],"mutants":[163,170,190],"observed":[164],"our":[166],"clinical":[167,259],"data.":[168],"Several":[169],"promoted":[171],"enhanced":[172],"growth":[173],"charcoal":[175],"dextran-stripped":[176],"media,":[177],"which":[178],"lacks":[179],"estradiol":[180],"mimics":[182],"treatment":[183],"aromatase":[185],"inhibitor.":[186],"addition,":[188],"conferred":[191],"varying":[192],"degrees":[193],"fulvestrant":[197],"tamoxifen.":[199],"Taken":[200],"together,":[201],"results":[203,252],"suggest":[204],"are":[208],"associated":[209],"cancer.":[221],"The":[222,251,288],"ability":[223],"irreversible":[225],"agents":[227,232],"as":[228,230],"well":[229],"other":[231],"target":[234],"pathway":[237],"overcome":[239],"this":[240],"being":[243],"tested":[244],"for":[245,261],"individual":[246],"vitro.":[250],"studies":[255],"may":[256],"provide":[257],"rationale":[260],"therapeutic":[262],"combination":[263],"strategies":[264],"refractory":[268],"through":[275],"mutations.":[277],"Citation":[278],"Format:":[279],"Nayar":[280],"U,":[281],"Cohen":[282],"O,":[283],"Oh":[284],"C,":[285],"Wagle":[286],"N.":[287],"therapy":[297],"[abstract].":[302],"In:":[303],"Proceedings":[304],"2016":[307,313],"San":[308,316],"Antonio":[309],"Breast":[310],"Cancer":[311,322],"Symposium;":[312],"Dec":[314],"6-10;":[315],"Antonio,":[317],"TX.":[318],"Philadelphia":[319],"(PA):":[320],"AACR;":[321],"Res":[323],"2017;77(4":[324],"Suppl):Abstract":[325],"nr":[326],"P3-04-08.":[327]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-03-16T00:00:00"}