{"id":"https://openalex.org/W2591900734","doi":"https://doi.org/10.1101/110981","title":"Do maternal antibodies facilitate hemagglutinin imprinting to influenza A viruses encountered early in childhood?","display_name":"Do maternal antibodies facilitate hemagglutinin imprinting to influenza A viruses encountered early in childhood?","publication_year":2017,"publication_date":"2017-02-22","ids":{"openalex":"https://openalex.org/W2591900734","doi":"https://doi.org/10.1101/110981","mag":"2591900734"},"language":"en","primary_location":{"id":"doi:10.1101/110981","doi":"https://doi.org/10.1101/110981","is_oa":true,"landing_page_url":"https://doi.org/10.1101/110981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/22/110981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/22/110981.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050424068","display_name":"Katelyn M. Gostic","orcid":"https://orcid.org/0000-0002-9369-6371","observed_orcids":["https://orcid.org/0000-0002-9369-6371"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn M. Gostic","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056795800","display_name":"Monique R. Ambrose","orcid":"https://orcid.org/0000-0002-2886-7912","observed_orcids":["https://orcid.org/0000-0002-2886-7912"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique Ambrose","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA"],"raw_orcid":"https://orcid.org/0000-0002-2886-7912","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019663083","display_name":"Michael Worobey","orcid":"https://orcid.org/0000-0002-3578-1367","observed_orcids":["https://orcid.org/0000-0002-3578-1367"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Worobey","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA","Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 8571, USA"],"raw_orcid":"https://orcid.org/0000-0002-3578-1367","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 8571, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052657259","display_name":"James O. Lloyd\u2010Smith","orcid":"https://orcid.org/0000-0001-7941-502X","observed_orcids":["https://orcid.org/0000-0001-7941-502X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I874236823","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I874236823"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James O. Lloyd-Smith","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","Fogarty International Center, National Institutes of Health, Bethesda, MD, 20892, USA"],"raw_orcid":"https://orcid.org/0000-0001-7941-502X","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Fogarty International Center, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I874236823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019663083","https://openalex.org/A5052657259"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I138006243","https://openalex.org/I161318765","https://openalex.org/I874236823"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-antibodies","display_name":"maternal antibodies","score":0.7390000224113464},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/original-antigenic-sin","display_name":"original antigenic sin","score":0.996999979019165},{"id":"https://openalex.org/keywords/zoonotic-influenza","display_name":"zoonotic influenza","score":0.8799999952316284},{"id":"https://openalex.org/keywords/immune-imprinting","display_name":"immune imprinting","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.7273245453834534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6160869002342224},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.5835234522819519},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5406361222267151},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5272955894470215},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5136967897415161},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5109816789627075},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46383532881736755},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.45549046993255615},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45310187339782715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40298715233802795},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.2235243320465088},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1721615195274353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15550681948661804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08806911110877991},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/110981","doi":"https://doi.org/10.1101/110981","is_oa":true,"landing_page_url":"https://doi.org/10.1101/110981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/22/110981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/110981","doi":"https://doi.org/10.1101/110981","is_oa":true,"landing_page_url":"https://doi.org/10.1101/110981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/22/110981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2591900734.pdf","grobid_xml":"https://content.openalex.org/works/W2591900734.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1487412740","https://openalex.org/W1977666122","https://openalex.org/W2002340325","https://openalex.org/W2013492992","https://openalex.org/W2100620897","https://openalex.org/W2117278984","https://openalex.org/W2165641175","https://openalex.org/W2327035065","https://openalex.org/W2557207823","https://openalex.org/W2573825602","https://openalex.org/W2588062276","https://openalex.org/W2588220069","https://openalex.org/W2588912037"],"related_works":["https://openalex.org/W2588062276","https://openalex.org/W2588912037","https://openalex.org/W7135058654","https://openalex.org/W4230618011","https://openalex.org/W2805679220","https://openalex.org/W4307777884","https://openalex.org/W4366238938","https://openalex.org/W2912098487","https://openalex.org/W2989731979","https://openalex.org/W7171930951"],"abstract_inverted_index":{"In":[0,142],"a":[1,11],"recent":[2,114],"study,":[3],"we":[4],"showed":[5,50],"evidence":[6],"for":[7],"childhood":[8,41,102,125],"HA":[9,53],"imprinting,":[10],"phenomenon":[12],"in":[13,29,40,76,157],"which":[14],"children":[15,150],"develop":[16],"preferential,":[17],"lifelong":[18],"immune":[19,65,72,103],"memory":[20],"against":[21],"zoonotic":[22],"influenza":[23,37,81,140,154],"viruses":[24],"with":[25],"hemagglutinin":[26],"(HA)":[27],"antigens":[28],"the":[30,35,60,97,132,158],"same":[31],"phylogenetic":[32],"group":[33],"as":[34],"first":[36,159],"virus":[38,156],"encountered":[39],"(Gostic":[42],"et":[43,87],"al.":[44,88],"2016).":[45],"Although":[46],"our":[47],"original":[48,91],"study":[49],"strong,":[51],"population-level":[52],"imprinting":[54,66,104,126,146],"effects,":[55],"it":[56],"did":[57],"not":[58],"resolve":[59],"underlying":[61,99],"immunological":[62],"mechanisms.":[63],"Similar":[64],"phenomena,":[67],"where":[68],"individuals":[69],"preferentially":[70],"recall":[71],"responses":[73],"primed":[74],"early":[75],"life,":[77,162],"also":[78],"influence":[79],"seasonal":[80],"epidemiology":[82],"via":[83],"antigenic":[84,92],"seniority":[85],"(Lessler":[86],"2012)":[89],"and":[90,139],"sin":[93],"(Francis":[94],"1960),":[95],"yet":[96],"mechanisms":[98],"all":[100],"these":[101,124],"phenomena":[105],"remain":[106],"poorly":[107],"understood":[108],"(Cobey":[109],"&":[110],"Hensley":[111],"2017).":[112],"A":[113,155],"letter":[115],"from":[116],"Dr.":[117],"H.":[118],"Lemke":[119],"(Lemke":[120],"2017)":[121],"suggested":[122],"that":[123,145,149],"effects":[127],"might":[128],"be":[129],"mediated":[130],"by":[131],"combined":[133],"action":[134],"of":[135,161],"maternal":[136,164],"antibodies":[137,165],"(mAbs)":[138],"antigen.":[141],"other":[143],"words,":[144],"may":[147],"require":[148],"are":[151,166],"exposed":[152],"to":[153],"year":[160],"while":[163],"still":[167],"present.":[168]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-03-16T00:00:00"}
