{"id":"https://openalex.org/W2591856290","doi":"https://doi.org/10.1299/jbse.17-00118","title":"Cellular traction forces increase during consecutive mechanical stretching following traction force attenuation","display_name":"Cellular traction forces increase during consecutive mechanical stretching following traction force attenuation","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2591856290","doi":"https://doi.org/10.1299/jbse.17-00118","mag":"2591856290"},"language":"en","primary_location":{"id":"doi:10.1299/jbse.17-00118","doi":"https://doi.org/10.1299/jbse.17-00118","is_oa":true,"landing_page_url":"https://doi.org/10.1299/jbse.17-00118","pdf_url":"https://www.jstage.jst.go.jp/article/jbse/12/3/12_17-00118/_pdf","source":{"id":"https://openalex.org/S122673828","display_name":"Journal of Biomechanical Science and Engineering","issn_l":"1880-9863","issn":["1880-9863"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313571","host_organization_name":"Japan Society Mechanical Engineers","host_organization_lineage":["https://openalex.org/P4310313571"],"host_organization_lineage_names":["Japan Society Mechanical Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Science and Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jstage.jst.go.jp/article/jbse/12/3/12_17-00118/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030511864","display_name":"Akira Tsukamoto","orcid":"https://orcid.org/0000-0002-3230-3570","observed_orcids":["https://orcid.org/0000-0002-3230-3570"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira TSUKAMOTO","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katie R. RYAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katie R. RYAN","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003671747","display_name":"Yusuke Mitsuoka","orcid":"https://orcid.org/0000-0001-6187-2660","observed_orcids":["https://orcid.org/0000-0001-6187-2660"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke MITSUOKA","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101765584","display_name":"Katsuko Sakai Furukawa","orcid":"https://orcid.org/0000-0002-0655-6558","observed_orcids":["https://orcid.org/0000-0002-0655-6558"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuko S. FURUKAWA","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108554495","display_name":"Takashi Ushida","orcid":"https://orcid.org/0000-0003-4805-1897","observed_orcids":["https://orcid.org/0000-0003-4805-1897"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi USHIDA","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":80000,"currency":"JPY","value_usd":602},"apc_paid":{"value":80000,"currency":"JPY","value_usd":602},"fwci":0.1465,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46453492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"3","first_page":"17","last_page":"00118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-traction-forces","display_name":"cellular traction forces","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mechanical-stretching","display_name":"mechanical stretch","score":0.9459999799728394},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.777999997138977},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9110000133514404},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adherent-cells","display_name":"adherent cells","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.40700000524520874},{"id":"https://openalex.org/keywords/strain-dependent-response","display_name":"strain-dependent response","score":0.32199999690055847},{"id":"https://openalex.org/keywords/actin-dynamics","display_name":"actin dynamics","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C38834483","wikidata":"https://www.wikidata.org/wiki/Q17000223","display_name":"Traction (geology)","level":2,"score":0.8728551864624023},{"id":"https://openalex.org/C32520587","wikidata":"https://www.wikidata.org/wiki/Q2142522","display_name":"Tractive force","level":2,"score":0.8598769307136536},{"id":"https://openalex.org/C2781099445","wikidata":"https://www.wikidata.org/wiki/Q4121060","display_name":"Stress fiber","level":4,"score":0.6299664974212646},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4728044867515564},{"id":"https://openalex.org/C184652730","wikidata":"https://www.wikidata.org/wiki/Q2357982","display_name":"Attenuation","level":2,"score":0.428960919380188},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.40046244859695435},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3941460847854614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3334381580352783},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2005150020122528},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1547769010066986},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13395097851753235},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.12420821189880371},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08913666009902954},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.08912542462348938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08362048864364624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1299/jbse.17-00118","doi":"https://doi.org/10.1299/jbse.17-00118","is_oa":true,"landing_page_url":"https://doi.org/10.1299/jbse.17-00118","pdf_url":"https://www.jstage.jst.go.jp/article/jbse/12/3/12_17-00118/_pdf","source":{"id":"https://openalex.org/S122673828","display_name":"Journal of Biomechanical Science and Engineering","issn_l":"1880-9863","issn":["1880-9863"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313571","host_organization_name":"Japan Society Mechanical Engineers","host_organization_lineage":["https://openalex.org/P4310313571"],"host_organization_lineage_names":["Japan Society Mechanical Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Science and Engineering","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3aba5db00eea4fcfa21afd813320f53b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3aba5db00eea4fcfa21afd813320f53b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomechanical Science and Engineering, Vol 12, Iss 3, Pp 17-00118-17-00118 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1299/jbse.17-00118","doi":"https://doi.org/10.1299/jbse.17-00118","is_oa":true,"landing_page_url":"https://doi.org/10.1299/jbse.17-00118","pdf_url":"https://www.jstage.jst.go.jp/article/jbse/12/3/12_17-00118/_pdf","source":{"id":"https://openalex.org/S122673828","display_name":"Journal of Biomechanical Science and Engineering","issn_l":"1880-9863","issn":["1880-9863"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313571","host_organization_name":"Japan Society Mechanical Engineers","host_organization_lineage":["https://openalex.org/P4310313571"],"host_organization_lineage_names":["Japan Society Mechanical Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Science and Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3095527405","display_name":"\u5f15\u5f35\u5fdc\u529b\u304a\u3088\u3073\u9759\u6c34\u5727\u4e0b\u306b\u304a\u3051\u308b\u57f9\u990a\u7d30\u80de\u306e\u529b\u5b66\u523a\u6fc0\u53d7\u5bb9\u306e\u6642\u7a7a\u9593\u7684\u89e3\u6790","funder_award_id":"15F15104","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G435160027","display_name":"Control mechanism of cell differentiation by combining mechanics with topology","funder_award_id":"15H01800","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4769503613","display_name":"Spatiotemporal control of physical stimuli in spontaneously formed intracellular mechanical fields","funder_award_id":"17K20093","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8929602395","display_name":"Analyzing cellular bandpass filtering with real-time traction force microscopy","funder_award_id":"25820017","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2591856290.pdf","grobid_xml":"https://content.openalex.org/works/W2591856290.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1968671910","https://openalex.org/W1985356640","https://openalex.org/W1992090959","https://openalex.org/W1994696873","https://openalex.org/W2019663832","https://openalex.org/W2030603051","https://openalex.org/W2030907797","https://openalex.org/W2037865364","https://openalex.org/W2042080188","https://openalex.org/W2052400143","https://openalex.org/W2060065908","https://openalex.org/W2062190708","https://openalex.org/W2064883155","https://openalex.org/W2082285095","https://openalex.org/W2090116084","https://openalex.org/W2093081064","https://openalex.org/W2097542158","https://openalex.org/W2101121415","https://openalex.org/W2101837915","https://openalex.org/W2110834542","https://openalex.org/W2113123074","https://openalex.org/W2122283306","https://openalex.org/W2134763908","https://openalex.org/W2137809380","https://openalex.org/W2143871084","https://openalex.org/W2160591240","https://openalex.org/W2162489950","https://openalex.org/W2168445385","https://openalex.org/W2171906125","https://openalex.org/W6600137863","https://openalex.org/W6600160826","https://openalex.org/W6600270888","https://openalex.org/W6601141708","https://openalex.org/W6601795639","https://openalex.org/W6604698154","https://openalex.org/W6628712958","https://openalex.org/W6725619944","https://openalex.org/W6735882311","https://openalex.org/W6738588597","https://openalex.org/W6809972494"],"related_works":["https://openalex.org/W2343968558","https://openalex.org/W2743566243","https://openalex.org/W2019663832","https://openalex.org/W1985164725","https://openalex.org/W2067388055","https://openalex.org/W2009924450","https://openalex.org/W3089200599","https://openalex.org/W2903719613","https://openalex.org/W7096635500","https://openalex.org/W2057112611"],"abstract_inverted_index":{"Adherent":[0],"cells":[1,78,103,124,142,183],"generate":[2],"traction":[3,58,66,86,106,138,153,166,186],"forces,":[4,107],"which":[5],"are":[6,27,68,79,95,143],"generated":[7,25,197],"by":[8,151,170,198],"and":[9,33,49,64,70,94],"transmitted":[10],"along":[11],"the":[12,16,163],"actin":[13],"cytoskeleton":[14],"to":[15,43,73,89,91,115,145,147,184],"underlying":[17],"external":[18],"substrate":[19],"via":[20],"focal":[21],"adhesions.":[22],"These":[23],"cell":[24,31,35],"forces":[26,67,87,120],"fundamental":[28],"for":[29],"maintaining":[30],"shape":[32],"driving":[34],"migration":[36],"as":[37,39,47],"well":[38],"triggering":[40],"signaling":[41],"pathways":[42],"promote":[44],"processes":[45],"such":[46],"differentiation":[48],"proliferation.":[50],"Here":[51],"we":[52,100],"investigate":[53,101],"how":[54],"mechanical":[55,62,117,131,149,178],"stretch":[56],"affects":[57],"forces.":[59],"Following":[60],"moderate":[61],"stretching":[63,150],"release,":[65],"increased":[69],"then":[71],"return":[72,90],"basal":[74,92],"levels.":[75],"However,":[76],"when":[77],"stretched":[80],"with":[81,159],"relatively":[82],"large":[83,110],"strains,":[84],">10%,":[85],"fail":[88],"levels":[93],"attenuated.":[96],"In":[97],"this":[98],"study,":[99],"whether":[102],"experiencing":[104],"attenuated":[105],"following":[108,125,194],"a":[109,126,171,189],"strain,":[111],"can":[112],"still":[113],"respond":[114,146],"subsequent":[116],"stretching.":[118,179],"Traction":[119],"were":[121],"measured":[122],"in":[123,130,173],"consecutive":[127,148],"12%":[128],"increase":[129,185],"stretch.":[132],"We":[133],"show":[134],"that,":[135],"even":[136],"after":[137],"force":[139,167,187],"attenuation":[140,164],"occurs,":[141],"able":[144],"increasing":[152],"force.":[154],"Visualization":[155],"of":[156,165,182,192],"stress":[157,174,200],"fibers,":[158],"GFP-actin,":[160],"indicates":[161],"that":[162,202],"is":[168],"accompanied":[169],"decrease":[172],"fiber":[175],"integrity":[176],"during":[177,188],"The":[180],"ability":[181],"second":[190],"round":[191],"stretching,":[193],"attenuation,":[195],"maybe":[196],"intact":[199],"fibers":[201],"escape":[203],"damage.":[204]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-03-16T00:00:00"}
