{"id":"https://openalex.org/W2591680457","doi":"https://doi.org/10.1038/srep43441","title":"Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox","display_name":"Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox","publication_year":2017,"publication_date":"2017-02-27","ids":{"openalex":"https://openalex.org/W2591680457","doi":"https://doi.org/10.1038/srep43441","mag":"2591680457","pmid":"https://pubmed.ncbi.nlm.nih.gov/28240310","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5327488"},"language":"en","primary_location":{"id":"doi:10.1038/srep43441","doi":"https://doi.org/10.1038/srep43441","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep43441","pdf_url":"https://www.nature.com/articles/srep43441.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep43441.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062291020","display_name":"Bharatwaj Sowrirajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharatwaj Sowrirajan","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102728579","display_name":"Yoshiro Saito","orcid":"https://orcid.org/0000-0002-0559-5889","observed_orcids":["https://orcid.org/0000-0002-0559-5889"]},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiro Saito","raw_affiliation_strings":["Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan","Department of Medical Life Systems, Systems Life Sciences laboratory, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan","institution_ids":["https://openalex.org/I133984924"]},{"raw_affiliation_string":"Department of Medical Life Systems, Systems Life Sciences laboratory, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan","institution_ids":["https://openalex.org/I133984924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612484","display_name":"Deepak Poudyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Poudyal","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009595543","display_name":"Hongyan Sui","orcid":"https://orcid.org/0000-0002-4341-0929","observed_orcids":["https://orcid.org/0000-0002-4341-0929"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyan Sui","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088738110","display_name":"Suk See De Ravin","orcid":"https://orcid.org/0000-0002-9800-774X","observed_orcids":["https://orcid.org/0000-0002-9800-774X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suk See DeRavin","raw_affiliation_strings":["Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20802, USA","Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20802, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20802, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20802, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030398856","display_name":"Hiromi Imamichi","orcid":"https://orcid.org/0000-0001-6709-3297","observed_orcids":["https://orcid.org/0000-0001-6709-3297"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiromi Imamichi","raw_affiliation_strings":["Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091115576","display_name":"Toyotaka Sato","orcid":"https://orcid.org/0000-0001-7223-1623","observed_orcids":["https://orcid.org/0000-0001-7223-1623"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toyotaka Sato","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018910683","display_name":"Douglas Byron Kuhns","orcid":"https://orcid.org/0000-0002-9971-0760","observed_orcids":["https://orcid.org/0000-0002-9971-0760"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas B. Kuhns","raw_affiliation_strings":["Neutrophil Monitoring Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Neutrophil Monitoring Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neutrophil Monitoring Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Neutrophil Monitoring Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053192871","display_name":"Noriko Noguchi","orcid":"https://orcid.org/0000-0002-5288-3373","observed_orcids":["https://orcid.org/0000-0002-5288-3373"]},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Noguchi","raw_affiliation_strings":["Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan","Department of Medical Life Systems, Systems Life Sciences laboratory, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan","institution_ids":["https://openalex.org/I133984924"]},{"raw_affiliation_string":"Department of Medical Life Systems, Systems Life Sciences laboratory, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan","institution_ids":["https://openalex.org/I133984924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013149726","display_name":"Harry L. Malech","orcid":"https://orcid.org/0000-0001-5874-5775","observed_orcids":["https://orcid.org/0000-0001-5874-5775"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry L. Malech","raw_affiliation_strings":["Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20802, USA","Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20802, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20802, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20802, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017815904","display_name":"Henry Clifford Lane","orcid":"https://orcid.org/0000-0001-9509-1045","observed_orcids":["https://orcid.org/0000-0001-9509-1045"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Clifford Lane","raw_affiliation_strings":["Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089434852","display_name":"Tomozumi Imamichi","orcid":"https://orcid.org/0000-0002-1474-1796","observed_orcids":["https://orcid.org/0000-0002-1474-1796","https://orcid.org/0009-0007-0910-5297"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tomozumi Imamichi","raw_affiliation_strings":["Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, 21702, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5089434852"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.1133,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.74083879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"43441","last_page":"43441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-27","display_name":"IL-27","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9909999966621399},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8759999871253967},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.902999997138977},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/extracellular-superoxide-dismutase","display_name":"extracellular superoxide dismutase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.7029479742050171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6681007742881775},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6225841641426086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5036012530326843},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47401151061058044},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4710001051425934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42140209674835205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38786447048187256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2580682635307312}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep43441","doi":"https://doi.org/10.1038/srep43441","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep43441","pdf_url":"https://www.nature.com/articles/srep43441.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5327488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5327488","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28240310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28240310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep43441","doi":"https://doi.org/10.1038/srep43441","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep43441","pdf_url":"https://www.nature.com/articles/srep43441.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1521411027","display_name":null,"funder_award_id":"No. HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2462534994","display_name":null,"funder_award_id":"Contract No.,HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2474977437","display_name":null,"funder_award_id":"Contract No. HHSN261200800001E.","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3373065118","display_name":"Screening of in vivo essential factor inhibiters for multi-drug resistant bacteria","funder_award_id":"17K15688","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4585269469","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5867949827","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6069527395","display_name":"Selenium-transport mechanism of selenoprotein P","funder_award_id":"25292078","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2591680457.pdf","grobid_xml":"https://content.openalex.org/works/W2591680457.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W57761904","https://openalex.org/W1488600638","https://openalex.org/W1589212151","https://openalex.org/W1591325634","https://openalex.org/W1887520422","https://openalex.org/W1899758583","https://openalex.org/W1965202946","https://openalex.org/W1969901996","https://openalex.org/W1970928392","https://openalex.org/W1977786762","https://openalex.org/W1979026515","https://openalex.org/W1982424156","https://openalex.org/W1988230895","https://openalex.org/W1996024251","https://openalex.org/W1997948093","https://openalex.org/W2013561452","https://openalex.org/W2014582520","https://openalex.org/W2016956768","https://openalex.org/W2020482563","https://openalex.org/W2022645113","https://openalex.org/W2037105562","https://openalex.org/W2038550540","https://openalex.org/W2057592601","https://openalex.org/W2060273459","https://openalex.org/W2068556120","https://openalex.org/W2078647306","https://openalex.org/W2083973986","https://openalex.org/W2084699108","https://openalex.org/W2085356010","https://openalex.org/W2085765334","https://openalex.org/W2086589495","https://openalex.org/W2090253573","https://openalex.org/W2100820895","https://openalex.org/W2102619095","https://openalex.org/W2104109524","https://openalex.org/W2111980183","https://openalex.org/W2119120508","https://openalex.org/W2119986617","https://openalex.org/W2123318646","https://openalex.org/W2124765964","https://openalex.org/W2128728003","https://openalex.org/W2129292145","https://openalex.org/W2132696478","https://openalex.org/W2145735900","https://openalex.org/W2149189075","https://openalex.org/W2151948277","https://openalex.org/W2156014352","https://openalex.org/W2156697154","https://openalex.org/W2165042671","https://openalex.org/W2166182274","https://openalex.org/W2191169263","https://openalex.org/W2319967189","https://openalex.org/W2414061256","https://openalex.org/W2514919331","https://openalex.org/W4242182607"],"related_works":["https://openalex.org/W2768268189","https://openalex.org/W7100022005","https://openalex.org/W1974842738","https://openalex.org/W1998470844","https://openalex.org/W2986181482","https://openalex.org/W1596208789","https://openalex.org/W4206244493","https://openalex.org/W2047771008","https://openalex.org/W2091509360","https://openalex.org/W2343739444"],"abstract_inverted_index":{"Abstract":[0],"Interleukin":[1],"(IL)-27,":[2],"a":[3,120,169,179,188],"member":[4],"of":[5,19,48,57,69,96,118,123,135,154,171,182],"the":[6,17,20,46,67,70,94,116,124,131],"IL-12":[7],"cytokine":[8,32],"family,":[9],"plays":[10,164],"an":[11,30,165],"important":[12,166],"and":[13,39,44,83,108,130,185],"diverse":[14],"role":[15,167],"in":[16,105,113,133,158,168],"function":[18],"immune":[21],"system.":[22],"We":[23,140],"have":[24],"previously":[25],"demonstrated":[26],"that":[27,88,143,176],"IL-27":[28,89,144,177],"is":[29,90,145,178],"anti-viral":[31],"which":[33],"inhibits":[34],"HIV-1,":[35],"HIV-2,":[36],"Influenza":[37],"virus":[38,42],"herpes":[40],"simplex":[41],"infection,":[43],"enhances":[45],"potential":[47,72,95],"reactive":[49],"oxygen":[50],"species":[51],"(ROS)":[52],"generating":[53],"activity":[54],"during":[55,101,152],"differentiation":[56,102,153],"monocytes":[58,155],"to":[59,92,147],"macrophages.":[60,161],"In":[61],"this":[62],"study,":[63],"we":[64],"further":[65],"investigated":[66],"mechanism":[68],"enhanced":[71],"for":[73],"ROS":[74,125,163,183],"generation":[75],"by":[76],"IL-27.":[77],"Real":[78],"time":[79],"PCR,":[80],"western":[81],"blot":[82],"knock":[84],"down":[85],"assays":[86],"demonstrate":[87,142,175],"able":[91,146],"enhance":[93],"superoxide":[97,150],"production":[98],"not":[99,157],"only":[100],"but":[103,156],"also":[104,141],"terminally":[106],"differentiated-macrophages":[107],"immature":[109],"dendritic":[110],"cells":[111],"(iDC)":[112],"association":[114],"with":[115],"induction":[117,184],"p47phox,":[119],"cytosolic":[121],"component":[122],"producing":[126],"enzyme,":[127],"NADPH":[128],"oxidase,":[129],"increase":[132],"amounts":[134],"phosphorylated":[136],"p47phox":[137],"upon":[138],"stimulation.":[139],"induce":[148],"extracellular":[149],"dismutase":[151],"terminal":[159],"differentiated":[160],"Since":[162],"variety":[170],"inflammation,":[172],"our":[173],"data":[174],"potent":[180],"regulator":[181],"may":[186],"be":[187],"novel":[189],"therapeutic":[190],"target.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}