{"id":"https://openalex.org/W2591669237","doi":"https://doi.org/10.1080/17460441.2017.1304378","title":"The preclinical discovery and development of quetiapine for the treatment of mania and depression","display_name":"The preclinical discovery and development of quetiapine for the treatment of mania and depression","publication_year":2017,"publication_date":"2017-03-08","ids":{"openalex":"https://openalex.org/W2591669237","doi":"https://doi.org/10.1080/17460441.2017.1304378","mag":"2591669237","pmid":"https://pubmed.ncbi.nlm.nih.gov/28271741"},"language":"en","primary_location":{"id":"doi:10.1080/17460441.2017.1304378","doi":"https://doi.org/10.1080/17460441.2017.1304378","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460441.2017.1304378","pdf_url":null,"source":{"id":"https://openalex.org/S142541038","display_name":"Expert Opinion on Drug Discovery","issn_l":"1746-0441","issn":["1746-0441","1746-045X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064363926","display_name":"Aline Silva de Miranda","orcid":"https://orcid.org/0000-0003-2811-7924","observed_orcids":["https://orcid.org/0000-0003-2811-7924"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Aline Silva de Miranda","raw_affiliation_strings":["a Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil","b Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas , Universidade Federal de Minas Gerais , Belo Horizonte , Brasil","Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"b Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas , Universidade Federal de Minas Gerais , Belo Horizonte , Brasil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006709429","display_name":"Fabr\u00edcio A. Moreira","orcid":"https://orcid.org/0000-0002-0824-7302","observed_orcids":["https://orcid.org/0000-0002-0824-7302"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabr\u00edcio A. Moreira","raw_affiliation_strings":["c Laborat\u00f3rio de Neuropsicofarmacologia, Departamento de Farmacologia, Instituto de Ci\u00eancias Biol\u00f3gicas , Universidade Federal de Minas Gerais , Belo Horizonte , Brasil","Laborat\u00f3rio de Neuropsicofarmacologia, Departamento de Farmacologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Laborat\u00f3rio de Neuropsicofarmacologia, Departamento de Farmacologia, Instituto de Ci\u00eancias Biol\u00f3gicas , Universidade Federal de Minas Gerais , Belo Horizonte , Brasil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Laborat\u00f3rio de Neuropsicofarmacologia, Departamento de Farmacologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040845311","display_name":"Ant\u00f4nio L\u00facio Teixeira","orcid":"https://orcid.org/0000-0002-9621-5422","observed_orcids":["https://orcid.org/0000-0002-9621-5422"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Ant\u00f4nio L\u00facio Teixeira","raw_affiliation_strings":["a Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil","d Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, McGovern Medical School , University of Texas Health Science Center at Houston , Houston , TX , USA","Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"d Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, McGovern Medical School , University of Texas Health Science Center at Houston , Houston , TX , USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064363926"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":null,"apc_paid":null,"fwci":0.8979,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73539592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"5","first_page":"525","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mania","display_name":"mania","score":0.9610000252723694},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.7720000147819519},{"id":"https://openalex.org/keywords/norquetiapine","display_name":"norquetiapine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neurotransmitter-systems","display_name":"neurotransmitter systems","score":0.8899999856948853},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.5730000138282776},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.44999998807907104},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.6830130815505981},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6529123187065125},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.651542603969574},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.5667539834976196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5217519998550415},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5198055505752563},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.4414439797401428},{"id":"https://openalex.org/C2781246090","wikidata":"https://www.wikidata.org/wiki/Q7836908","display_name":"Treatment of bipolar disorder","level":5,"score":0.4335516393184662},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.4236573576927185},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38108980655670166},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.31605273485183716},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.2017725110054016},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.18945461511611938}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/17460441.2017.1304378","doi":"https://doi.org/10.1080/17460441.2017.1304378","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460441.2017.1304378","pdf_url":null,"source":{"id":"https://openalex.org/S142541038","display_name":"Expert Opinion on Drug Discovery","issn_l":"1746-0441","issn":["1746-0441","1746-045X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Discovery","raw_type":"journal-article"},{"id":"pmid:28271741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28271741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug discovery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W3049811","https://openalex.org/W59829318","https://openalex.org/W121491609","https://openalex.org/W301655089","https://openalex.org/W1480066549","https://openalex.org/W1487716462","https://openalex.org/W1518446047","https://openalex.org/W1574195882","https://openalex.org/W1736583785","https://openalex.org/W1763741883","https://openalex.org/W1768641973","https://openalex.org/W1950195723","https://openalex.org/W1963890972","https://openalex.org/W1964259517","https://openalex.org/W1964773692","https://openalex.org/W1964879405","https://openalex.org/W1965632145","https://openalex.org/W1968524760","https://openalex.org/W1972414416","https://openalex.org/W1973895407","https://openalex.org/W1973907714","https://openalex.org/W1979295630","https://openalex.org/W1979999703","https://openalex.org/W1980719669","https://openalex.org/W1981641543","https://openalex.org/W1983769159","https://openalex.org/W1984615306","https://openalex.org/W1989190407","https://openalex.org/W1993236628","https://openalex.org/W1995358122","https://openalex.org/W1997191446","https://openalex.org/W2001083762","https://openalex.org/W2003326238","https://openalex.org/W2006880977","https://openalex.org/W2007609934","https://openalex.org/W2009033786","https://openalex.org/W2009352908","https://openalex.org/W2009915820","https://openalex.org/W2012661386","https://openalex.org/W2015477517","https://openalex.org/W2016563708","https://openalex.org/W2018734015","https://openalex.org/W2021267204","https://openalex.org/W2021435402","https://openalex.org/W2027085413","https://openalex.org/W2028249314","https://openalex.org/W2028846654","https://openalex.org/W2035738053","https://openalex.org/W2039570386","https://openalex.org/W2042169557","https://openalex.org/W2042740180","https://openalex.org/W2043799782","https://openalex.org/W2050908419","https://openalex.org/W2052605136","https://openalex.org/W2055470737","https://openalex.org/W2058445857","https://openalex.org/W2058738521","https://openalex.org/W2059359840","https://openalex.org/W2059519261","https://openalex.org/W2059641389","https://openalex.org/W2059962099","https://openalex.org/W2060417841","https://openalex.org/W2060446687","https://openalex.org/W2061850641","https://openalex.org/W2063367712","https://openalex.org/W2065068254","https://openalex.org/W2065851063","https://openalex.org/W2066482264","https://openalex.org/W2066671649","https://openalex.org/W2068776254","https://openalex.org/W2069849124","https://openalex.org/W2071532773","https://openalex.org/W2074852398","https://openalex.org/W2075158318","https://openalex.org/W2076450575","https://openalex.org/W2077183950","https://openalex.org/W2080350725","https://openalex.org/W2090844409","https://openalex.org/W2091671806","https://openalex.org/W2092742946","https://openalex.org/W2098547840","https://openalex.org/W2099576957","https://openalex.org/W2100233372","https://openalex.org/W2100748988","https://openalex.org/W2105659365","https://openalex.org/W2110637027","https://openalex.org/W2110696099","https://openalex.org/W2111528871","https://openalex.org/W2112894153","https://openalex.org/W2113176870","https://openalex.org/W2113580630","https://openalex.org/W2116642975","https://openalex.org/W2118005924","https://openalex.org/W2121009723","https://openalex.org/W2121417064","https://openalex.org/W2121640875","https://openalex.org/W2122710476","https://openalex.org/W2123981584","https://openalex.org/W2125073267","https://openalex.org/W2126547332","https://openalex.org/W2131167630","https://openalex.org/W2136826032","https://openalex.org/W2137044087","https://openalex.org/W2141900936","https://openalex.org/W2147015928","https://openalex.org/W2151197117","https://openalex.org/W2151774618","https://openalex.org/W2153381163","https://openalex.org/W2154321896","https://openalex.org/W2157430893","https://openalex.org/W2160517210","https://openalex.org/W2161282771","https://openalex.org/W2163445625","https://openalex.org/W2164398896","https://openalex.org/W2166423384","https://openalex.org/W2166945572","https://openalex.org/W2209378722","https://openalex.org/W2322189579","https://openalex.org/W2323680035","https://openalex.org/W2404177337","https://openalex.org/W4414041363"],"related_works":["https://openalex.org/W176219544","https://openalex.org/W2125073267","https://openalex.org/W111142656","https://openalex.org/W7218306163","https://openalex.org/W305610961","https://openalex.org/W2519804969","https://openalex.org/W2553628616","https://openalex.org/W134927359","https://openalex.org/W2041275333","https://openalex.org/W2022697937"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Bipolar":[1,15],"disorder":[2,16,42],"is":[3],"a":[4],"chronic":[5],"disabling":[6],"condition":[7],"characterized":[8],"by":[9],"alternating":[10],"manic":[11],"and":[12,28,35,70,92,116,171],"depressive":[13],"episodes.":[14],"has":[17],"been":[18],"associated":[19],"with":[20,101],"functional":[21],"impairment,":[22],"poor":[23],"quality":[24],"of":[25,52,61,73,95,97,124,141,143,162,180],"life,":[26],"morbidity":[27],"mortality.":[29],"Despite":[30],"its":[31,102],"significant":[32],"clinical,":[33],"social":[34],"economic":[36],"burden,":[37],"treatment":[38,60],"options":[39],"for":[40,166],"bipolar":[41,167],"are":[43,152,175],"still":[44,153],"limited.":[45],"Several":[46],"clinical":[47],"trials":[48],"have":[49,132],"shown":[50],"efficacy":[51],"the":[53,59,65,68,83,90,125,137,160,181],"atypical":[54],"antipsychotic":[55],"quetiapine":[56],"(QTP)":[57],"in":[58,185],"this":[62],"condition.":[63],"However,":[64],"mechanisms":[66,94,140],"underlying":[67],"antidepressant":[69,91,139],"anti-manic":[71,93,150],"effects":[72,151],"QTP":[74,107,118,182],"remain":[75],"poorly":[76],"understood.":[77],"Areas":[78],"covered:":[79],"The":[80,178],"article":[81],"provides":[82],"emerging":[84],"evidence":[85],"from":[86],"pre-clinical":[87,146],"studies":[88,131,147,174],"regarding":[89],"action":[96,142],"QTP.":[98],"In":[99],"combination":[100],"primary":[103],"active":[104],"metabolite":[105,183],"norquetiapine,":[106],"modulates":[108],"several":[109],"neurotransmitter":[110],"systems,":[111],"including":[112],"serotonin,":[113],"dopamine,":[114],"noradrenaline":[115],"histamine.":[117],"also":[119,189],"seems":[120],"to":[121,159,191],"influence":[122],"mediators":[123],"immune":[126,170],"system.":[127],"Expert":[128],"opinion:":[129],"Pre-clinical":[130],"provided":[133],"valuable":[134],"information":[135],"on":[136,148],"potential":[138],"QTP,":[144],"but":[145],"QTP's":[149],"scarce.":[154],"A":[155],"major":[156],"problem":[157],"refers":[158],"lack":[161],"valid":[163],"experimental":[164],"models":[165],"disorder.":[168],"Additionally,":[169],"genetic":[172],"based":[173],"largely":[176],"descriptive.":[177],"role":[179],"norquetiapine":[184],"modulating":[186],"non-neurotransmitter":[187],"systems":[188],"needs":[190],"be":[192],"further":[193],"addressed.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-16T00:00:00"}