{"id":"https://openalex.org/W2591657227","doi":null,"title":"Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS","display_name":"Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS","publication_year":2007,"publication_date":"2007-12-17","ids":{"openalex":"https://openalex.org/W2591657227","mag":"2591657227"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/25989","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-01122008-105708/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100760888","display_name":"Song Zhao","orcid":"https://orcid.org/0000-0003-0277-2365","observed_orcids":["https://orcid.org/0000-0003-0277-2365"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Song Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0277-2365","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100760888"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.890999972820282},{"id":"https://openalex.org/keywords/cdc25c","display_name":"Cdc25C","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cdc2-kinase","display_name":"cdc2 kinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cis-trans-isomerization","display_name":"cis-trans isomerization","score":0.7630000114440918},{"id":"https://openalex.org/keywords/conformational-specificity","display_name":"conformational specificity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.328000009059906},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cancer-drug-targets","display_name":"cancer drug targets","score":0.5490000247955322},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C154472170","wikidata":"https://www.wikidata.org/wiki/Q18030556","display_name":"PIN1","level":4,"score":0.7943215370178223},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.764186680316925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5458453893661499},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5358636975288391},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5050283074378967},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4684945046901703},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.455686092376709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44241464138031006},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43947601318359375},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2761191129684448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21775799989700317},{"id":"https://openalex.org/C2781264208","wikidata":"https://www.wikidata.org/wiki/Q118026","display_name":"Isomerase","level":3,"score":0.18312838673591614},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.08248886466026306},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/25989","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-01122008-105708/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2591657227","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/25989","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":281,"referenced_works":["https://openalex.org/W14542710","https://openalex.org/W26964787","https://openalex.org/W88512482","https://openalex.org/W112159188","https://openalex.org/W171936907","https://openalex.org/W244824792","https://openalex.org/W262890394","https://openalex.org/W1164935966","https://openalex.org/W1240112909","https://openalex.org/W1494248298","https://openalex.org/W1494730433","https://openalex.org/W1514833389","https://openalex.org/W1525189334","https://openalex.org/W1541944730","https://openalex.org/W1555327017","https://openalex.org/W1557338439","https://openalex.org/W1569560439","https://openalex.org/W1588942219","https://openalex.org/W1600771042","https://openalex.org/W1607286065","https://openalex.org/W1612324382","https://openalex.org/W1656231611","https://openalex.org/W1878741782","https://openalex.org/W1942192923","https://openalex.org/W1966604955","https://openalex.org/W1966870645","https://openalex.org/W1966975974","https://openalex.org/W1967769149","https://openalex.org/W1968069432","https://openalex.org/W1968150128","https://openalex.org/W1968983628","https://openalex.org/W1969758781","https://openalex.org/W1969971113","https://openalex.org/W1970391832","https://openalex.org/W1970446261","https://openalex.org/W1970663233","https://openalex.org/W1971501793","https://openalex.org/W1971758334","https://openalex.org/W1971977518","https://openalex.org/W1972084979","https://openalex.org/W1973108416","https://openalex.org/W1974036368","https://openalex.org/W1974174816","https://openalex.org/W1974698351","https://openalex.org/W1974877011","https://openalex.org/W1976129849","https://openalex.org/W1977322122","https://openalex.org/W1978252580","https://openalex.org/W1978265027","https://openalex.org/W1978329718","https://openalex.org/W1978696795","https://openalex.org/W1978892474","https://openalex.org/W1979528872","https://openalex.org/W1979998896","https://openalex.org/W1980075416","https://openalex.org/W1981978551","https://openalex.org/W1982137838","https://openalex.org/W1982801021","https://openalex.org/W1983608874","https://openalex.org/W1983741980","https://openalex.org/W1984252886","https://openalex.org/W1984809587","https://openalex.org/W1985008832","https://openalex.org/W1985131241","https://openalex.org/W1985239419","https://openalex.org/W1985382224","https://openalex.org/W1989223012","https://openalex.org/W1991444138","https://openalex.org/W1992014003","https://openalex.org/W1992518514","https://openalex.org/W1992859406","https://openalex.org/W1993031156","https://openalex.org/W1993228812","https://openalex.org/W1993870517","https://openalex.org/W1994804829","https://openalex.org/W1995006320","https://openalex.org/W1995424235","https://openalex.org/W1996324631","https://openalex.org/W1996641691","https://openalex.org/W1996969987","https://openalex.org/W1997292282","https://openalex.org/W1998017058","https://openalex.org/W1998353260","https://openalex.org/W1998765326","https://openalex.org/W1999054269","https://openalex.org/W1999210337","https://openalex.org/W1999448894","https://openalex.org/W2001934640","https://openalex.org/W2004653449","https://openalex.org/W2005174079","https://openalex.org/W2005199549","https://openalex.org/W2005355917","https://openalex.org/W2005941883","https://openalex.org/W2007972675","https://openalex.org/W2008683084","https://openalex.org/W2009556803","https://openalex.org/W2009637522","https://openalex.org/W2010414017","https://openalex.org/W2012831097","https://openalex.org/W2014216543","https://openalex.org/W2014446189","https://openalex.org/W2014620140","https://openalex.org/W2014944254","https://openalex.org/W2015051247","https://openalex.org/W2015141538","https://openalex.org/W2015761686","https://openalex.org/W2015956088","https://openalex.org/W2016602175","https://openalex.org/W2017639307","https://openalex.org/W2018275786","https://openalex.org/W2018376198","https://openalex.org/W2019087484","https://openalex.org/W2019511807","https://openalex.org/W2020208200","https://openalex.org/W2020257412","https://openalex.org/W2020298904","https://openalex.org/W2020442337","https://openalex.org/W2021274263","https://openalex.org/W2021436012","https://openalex.org/W2023042597","https://openalex.org/W2024626861","https://openalex.org/W2025418623","https://openalex.org/W2025472327","https://openalex.org/W2027056746","https://openalex.org/W2028869260","https://openalex.org/W2030159720","https://openalex.org/W2031588422","https://openalex.org/W2032233949","https://openalex.org/W2032359283","https://openalex.org/W2034701183","https://openalex.org/W2039457120","https://openalex.org/W2039461477","https://openalex.org/W2040283862","https://openalex.org/W2040404064","https://openalex.org/W2040777218","https://openalex.org/W2040951785","https://openalex.org/W2041053673","https://openalex.org/W2041316505","https://openalex.org/W2043035995","https://openalex.org/W2043118195","https://openalex.org/W2043473595","https://openalex.org/W2045295833","https://openalex.org/W2046388743","https://openalex.org/W2046461084","https://openalex.org/W2046894860","https://openalex.org/W2047007872","https://openalex.org/W2047300770","https://openalex.org/W2048470036","https://openalex.org/W2050000741","https://openalex.org/W2050779639","https://openalex.org/W2052750950","https://openalex.org/W2052769401","https://openalex.org/W2053949782","https://openalex.org/W2054292493","https://openalex.org/W2054685448","https://openalex.org/W2055204256","https://openalex.org/W2055872653","https://openalex.org/W2056184329","https://openalex.org/W2058609749","https://openalex.org/W2060492314","https://openalex.org/W2060688504","https://openalex.org/W2061266047","https://openalex.org/W2061803752","https://openalex.org/W2062264053","https://openalex.org/W2062370426","https://openalex.org/W2062371417","https://openalex.org/W2062639699","https://openalex.org/W2063394559","https://openalex.org/W2064685101","https://openalex.org/W2064697586","https://openalex.org/W2064767787","https://openalex.org/W2065021958","https://openalex.org/W2065447230","https://openalex.org/W2065797900","https://openalex.org/W2066061693","https://openalex.org/W2067356629","https://openalex.org/W2067405360","https://openalex.org/W2067435429","https://openalex.org/W2068034418","https://openalex.org/W2069497533","https://openalex.org/W2070830434","https://openalex.org/W2071551783","https://openalex.org/W2071911426","https://openalex.org/W2072142700","https://openalex.org/W2072991061","https://openalex.org/W2073048383","https://openalex.org/W2073161317","https://openalex.org/W2073401456","https://openalex.org/W2074419543","https://openalex.org/W2075503558","https://openalex.org/W2076314401","https://openalex.org/W2077978055","https://openalex.org/W2078297860","https://openalex.org/W2079590857","https://openalex.org/W2081180485","https://openalex.org/W2081702130","https://openalex.org/W2082622136","https://openalex.org/W2084188731","https://openalex.org/W2085039483","https://openalex.org/W2085294032","https://openalex.org/W2086186867","https://openalex.org/W2087353647","https://openalex.org/W2088896406","https://openalex.org/W2088978383","https://openalex.org/W2089119006","https://openalex.org/W2089161481","https://openalex.org/W2089242991","https://openalex.org/W2089243562","https://openalex.org/W2089346967","https://openalex.org/W2090248730","https://openalex.org/W2090806203","https://openalex.org/W2091455173","https://openalex.org/W2091526158","https://openalex.org/W2091975352","https://openalex.org/W2092108176","https://openalex.org/W2093258807","https://openalex.org/W2094871139","https://openalex.org/W2095539974","https://openalex.org/W2105214585","https://openalex.org/W2105657039","https://openalex.org/W2109025431","https://openalex.org/W2109188826","https://openalex.org/W2109519854","https://openalex.org/W2113675798","https://openalex.org/W2116931858","https://openalex.org/W2117560381","https://openalex.org/W2119392004","https://openalex.org/W2121612064","https://openalex.org/W2123090800","https://openalex.org/W2123485598","https://openalex.org/W2124315200","https://openalex.org/W2124842862","https://openalex.org/W2125330937","https://openalex.org/W2126043496","https://openalex.org/W2126076288","https://openalex.org/W2126469537","https://openalex.org/W2126950244","https://openalex.org/W2128451304","https://openalex.org/W2131741443","https://openalex.org/W2132095420","https://openalex.org/W2132385852","https://openalex.org/W2132820021","https://openalex.org/W2134538218","https://openalex.org/W2138206116","https://openalex.org/W2140490890","https://openalex.org/W2142713587","https://openalex.org/W2144979740","https://openalex.org/W2145752157","https://openalex.org/W2155158959","https://openalex.org/W2156182193","https://openalex.org/W2156480395","https://openalex.org/W2159671224","https://openalex.org/W2160090073","https://openalex.org/W2160763205","https://openalex.org/W2161098331","https://openalex.org/W2165611390","https://openalex.org/W2165923048","https://openalex.org/W2167837360","https://openalex.org/W2169162804","https://openalex.org/W2169364535","https://openalex.org/W2192138573","https://openalex.org/W2244707975","https://openalex.org/W2308119260","https://openalex.org/W2316970929","https://openalex.org/W2331377560","https://openalex.org/W2339933533","https://openalex.org/W2347115132","https://openalex.org/W2394979701","https://openalex.org/W2406686776","https://openalex.org/W2409039558","https://openalex.org/W2415080910","https://openalex.org/W2444366478","https://openalex.org/W2506713900","https://openalex.org/W2614496215","https://openalex.org/W2950590087","https://openalex.org/W2951065937","https://openalex.org/W2952545462","https://openalex.org/W2952573149","https://openalex.org/W2953196125","https://openalex.org/W4292820908","https://openalex.org/W4295216797"],"related_works":["https://openalex.org/W45463977","https://openalex.org/W2286446088","https://openalex.org/W2064179386","https://openalex.org/W4403998807","https://openalex.org/W2464810884","https://openalex.org/W1983745682","https://openalex.org/W2767806350","https://openalex.org/W2902709378","https://openalex.org/W7011748365","https://openalex.org/W7095860108"],"abstract_inverted_index":{"The":[0,256],"phosphorylation-dependent":[1],"PPIase":[2],"(peptidyl":[3],"prolyl":[4],"isomerase),":[5],"Pin1":[6,59,77,89,99,122,129,264,303,320,328],"(Protein":[7],"interacting":[8],"with":[9,161,248],"NIMA#1),":[10],"has":[11,100],"been":[12,53],"found":[13,170],"to":[14,63,117,177,209,226,295],"regulate":[15],"cell":[16,34,71,212],"cycle":[17,35],"through":[18],"a":[19,67,93,107,260,330],"simple":[20],"conformational":[21],"change,":[22],"the":[23,74,119,126,131,134,159,182,201,211,215,228,296,299,311],"cis-trans":[24],"isomerization":[25],"of":[26,32,57,69,76,128,136,154,185,214,218,231,237,298],"phospho-Ser/Thr-Pro":[27],"amide":[28,139],"bonds.":[29],"A":[30],"variety":[31,68],"key":[33],"regulatory":[36],"phosphoproteins,":[37],"including":[38],"Cdc25":[39],"phosphatase,Cdc27,":[40],"p53":[41],"oncogene,":[42,44],"c-Myc":[43],"Wee1":[45],"kinase,":[46,48,198],"Myt1":[47],"and":[49,73,105,123,125,142,194,240,252],"NIMA":[50],"kinas,":[51],"have":[52],"confirmed":[54],"as":[55,92,314,329],"substrates":[56],"Pin1.":[58,205,238],"was":[60,163,169,174,224,281],"also":[61,323],"observed":[62],"be":[64,192],"overexpressed":[65],"in":[66,130,250],"cancer":[70,83,275],"lines,":[72],"inhibitors":[75,217],"showed":[78,259],"antiproliferative":[79,270],"activities":[80],"towards":[81,263,272,302],"these":[82,155],"cells.":[84],"These":[85,306],"results":[86,307],"implied":[87],"that":[88,171],"might":[90],"serve":[91],"potential":[94,108,331],"anti-cancer":[95],"drug":[96,333],"target.":[97,334],"Besides,":[98],"an":[101,207,315],"important":[102],"neuroprotective":[103],"function":[104],"represents":[106],"new":[109],"therapeutic":[110],"agent":[111],"for":[112,133,204,319,327],"Alzheimer's":[113],"disease.":[114],"In":[115,206],"order":[116],"understand":[118],"interaction":[120],"between":[121],"Cdc25c":[124,179,186],"role":[127],"mechanism":[132],"regulation":[135],"mitosis,":[137],"two":[138,147,156],"isosteres,":[140],"Ser-\u03a8[(Z)CH=C]-Pro-OH":[141],"Ser-\u03a8[(E)CH=C]-Pro-OH":[143],"were":[144,244],"incorporated":[145],"into":[146],"peptidomimetics":[148,157],"derived":[149],"from":[150],"human":[151],"Cdc25c.":[152],"Phosphorylation":[153],"by":[158,196,284],"incubation":[160],"Cdc2":[162,172,197],"studied":[164],"using":[165],"LC-MS/MS":[166],"technique.":[167],"It":[168],"kinase":[173],"conformationally":[175],"specific":[176],"its":[178,188,241,285],"substrate.":[180],"Only":[181],"trans":[183],"conformer":[184],"at":[187],"Ser168-Pro":[189],"position":[190],"can":[191],"recognized":[193],"phosphorylated":[195],"thereby":[199],"creating":[200],"binding":[202],"site":[203],"effort":[208],"improve":[210],"permeability":[213],"charged":[216,257,300],"Pin1,":[219],"bisPOM":[220,242,286,312],"(pivaloyloxymethyl)":[221],"prodrug":[222,243,287,317],"moiety":[223],"introduced":[225],"mask":[227],"phosphate":[229],"group":[230],"Fmoc-pSer-\u03a8[(Z)CH=C]-Pro-(2)-N-(3)-ethylaminoindole,":[232],"which":[233,292],"is":[234,293],"one":[235],"inhibitor":[236,258,301],"Fmoc-pSer-\u03a8[(Z)CH=C]-Pro-(2)-N-(3)-ethylaminoindole":[239],"synthesized":[245],"efficiently":[246],"starting":[247],"Boc-Ser-\u03a8[(Z)CH=C]-Pro-OH":[249],"24%":[251],"12%":[253],"yields":[254],"respectively.":[255],"moderate":[261],"inhibition":[262],"(IC50":[265,277,288],"=":[266,278,289],"28.3":[267],"\u03bcM).":[268],"Its":[269],"activity":[271],"A2780":[273],"ovarian":[274],"cells":[276],"46.2":[279],"\u03bcM)":[280],"significantly":[282],"improved":[283],"26.9":[290],"\u03bcM),":[291],"comparable":[294],"IC50":[297],"enzymatic":[304],"activity.":[305],"not":[308],"only":[309],"established":[310],"strategy":[313],"efficient":[316],"choice":[318],"inhibitors,":[321],"but":[322],"added":[324],"additional":[325],"evidence":[326],"anticancer":[332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-16T00:00:00"}