{"id":"https://openalex.org/W2591522288","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","title":"Early data on the efficacy and safety of the novel multi-ligand somatostatin analog, SOM230, in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR","display_name":"Early data on the efficacy and safety of the novel multi-ligand somatostatin analog, SOM230, in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2591522288","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","mag":"2591522288"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2005.23.16_suppl.8024","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089225736","display_name":"Larry K. Kvols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"L. Kvols","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842538","display_name":"Kjell \u00d6berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"K. Oberg","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113563325","display_name":"WW de Herder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"W. de Herder","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005448318","display_name":"Lowell Brian Anthony","orcid":"https://orcid.org/0000-0001-7348-7874","observed_orcids":["https://orcid.org/0000-0001-7348-7874"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"L. Anthony","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089648851","display_name":"Joan E. Glusman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"J. Glusman","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050240205","display_name":"Ly-Le Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"L.-L. Tran","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007891817","display_name":"Bertram Wiedenmann","orcid":"https://orcid.org/0000-0002-7890-2552","observed_orcids":["https://orcid.org/0000-0002-7890-2552"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"B. Wiedenmann","raw_affiliation_strings":["H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Lee Moffitt Cancer Ctr &amp; Rsrch Inst, Tampa, FL; Univ Hosp, Uppsala, Sweden; Erasmus Medcl Ctr, Rotterdam, The Netherlands; Louisiana State Univ Medcl Ctr, New Orleans, LA; Novartis Pharmaceuticals Corp, East Hanover, NJ; Univklin Charit\u00e9-Virchow-Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I3019308854","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"16_suppl","first_page":"8024","last_page":"8024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pasireotide","display_name":"pasireotide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metastatic-carcinoid-tumor","display_name":"metastatic carcinoid","score":0.8700000047683716},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.6159999966621399},{"id":"https://openalex.org/keywords/efficacy","display_name":"efficacy","score":0.5590000152587891},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8810710906982422},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.7811190485954285},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7121033668518066},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.605960488319397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5874069929122925},{"id":"https://openalex.org/C2779609023","wikidata":"https://www.wikidata.org/wiki/Q1707877","display_name":"Lanreotide","level":5,"score":0.5427078008651733},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5216796398162842},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5117999911308289},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.4532528817653656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32316941022872925},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12760388851165771},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2005.23.16_suppl.8024","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.8024","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3115718458","https://openalex.org/W2067084033","https://openalex.org/W7099017493","https://openalex.org/W2135503195","https://openalex.org/W2343626715","https://openalex.org/W2085340550","https://openalex.org/W4323527636","https://openalex.org/W1904106665","https://openalex.org/W2399532311","https://openalex.org/W2514485964"],"abstract_inverted_index":{"8024":[0],"Background:":[1],"SOM230":[2,25,95,105,285,314],"is":[3,306],"a":[4,41,50,117,143,172,182,281,316],"novel":[5],"multi-ligand":[6],"somatostatin":[7,16],"analog":[8],"that":[9],"exhibits":[10],"high":[11],"binding":[12],"affinity":[13,33,43],"to":[14,69,116,268,308,324],"four":[15,272],"receptor":[17],"subtypes:":[18],"sst1,2,3":[19],"and":[20,29,36,40,65,83,160,197,213,241,252,258,294,296],"sst5.":[21],"Compared":[22],"with":[23,58,93,150,187],"octreotide,":[24],"has":[26],"30,":[27],"5":[28],"40":[30],"times":[31],"greater":[32],"for":[34,44,167,219,291,319],"sst1,3":[35],"sst5":[37],"receptors,":[38],"respectively,":[39],"comparable":[42],"sst2":[45],"receptors.":[46],"Methods:":[47],"This":[48,304],"was":[49,96,123,132,140,179,223,289,297],"Phase":[51],"II":[52],"open-label,":[53],"multicenter":[54],"study":[55,305],"in":[56,207,225,238,246,301],"patients":[57,73,211,227,273],"metastatic":[59,320],"carcinoid":[60,321],"tumors":[61,322],"whose":[62],"symptoms":[63],"(diarrhea":[64],"flushing)":[66],"were":[67,236,242,261,266],"refractory/resistant":[68,323],"octreotide":[70,325],"LAR.":[71,326],"Enrolled":[72],"had":[74],"histopathologically":[75],"confirmed":[76],"disease,":[77],"elevated":[78],"5-HIAA":[79],"and/or":[80],"CgA":[81],"levels":[82],"at":[84,228],"least":[85],"one":[86],"measurable":[87],"lesion":[88],"(excluding":[89],"bone).":[90],"Symptom":[91],"control":[92,131,135],"subcutaneous":[94],"evaluated":[97],"daily":[98],"using":[99],"patient":[100],"diaries.":[101],"Patients":[102],"initially":[103],"received":[104],"300":[106],"\u03bcg":[107,113,121,231,287],"bid.":[108,232],"Dose":[109],"escalation":[110],"of":[111,119,145,163,175,184,313],"150":[112],"bid,":[114,122],"up":[115],"maximum":[118,278],"1200":[120],"allowed":[124],"every":[125],"3":[126,191],"days":[127,170],"until":[128],"adequate":[129],"symptom":[130],"achieved.":[133],"Adequate":[134],"or":[136,330,333],"partial":[137],"response":[138,178],"(PR)":[139],"defined":[141,180],"as":[142,181,315],"mean":[144,183],"<4":[146],"bowel":[147],"movements":[148],"(BM)/day":[149],"no":[151,188,198],"more":[152,189],"than":[153,190],"6":[154],"BM":[155,192],"on":[156,171,193],"any":[157,194],"given":[158,195],"day,":[159,196],"an":[161],"average":[162],"<2":[164],"flushing":[165,199,295],"episodes/day":[166],"15":[168],"consecutive":[169],"fixed":[173],"dose":[174,279],"SOM230.":[176],"Complete":[177],"\u22643":[185],"BM/day":[186],"episodes.":[200],"Results:":[201],"In":[202],"this":[203],"interim":[204],"analysis":[205],"conducted":[206],"September":[208],"2004,":[209],"21":[210],"(M":[212],"F,":[214],"aged":[215],"40\u201376":[216],"years)":[217],"qualified":[218],"efficacy":[220],"assessment.":[221],"PR":[222],"indicated":[224],"seven":[226],"doses":[229],"450-1200":[230,286],"Adverse":[233],"events":[234],"(AEs)":[235],"assessed":[237],"23":[239],"patients,":[240],"primarily":[243],"gastrointestinal":[244],"(GI)":[245],"nature":[247],"-":[248],"abdominal":[249],"pain":[250],"(35%)":[251],"nausea":[253],"(26%).":[254],"Weight":[255],"loss":[256],"(26%)":[257],"fatigue":[259],"(13%)":[260],"also":[262],"reported.":[263],"Most":[264],"discontinuations":[265],"due":[267],"GI":[269],"AEs":[270],"(n=5);":[271],"discontinued":[274],"after":[275],"they":[276],"reached":[277],"without":[280],"therapeutic":[282],"response.":[283],"Conclusions:":[284],"bid":[288],"effective":[290],"controlling":[292],"diarrhea":[293],"generally":[298],"well":[299],"tolerated":[300],"these":[302],"patients.":[303],"ongoing":[307],"better":[309],"define":[310],"the":[311],"potential":[312],"treatment":[317],"option":[318],"Author":[327],"Disclosure":[328],"Employment":[329],"Leadership":[331],"Consultant":[332],"Advisory":[334],"Role":[335],"Stock":[336],"Ownership":[337],"Honoraria":[338],"Research":[339],"Funding":[340],"Expert":[341],"Testimony":[342],"Other":[343],"Remuneration":[344],"Novartis":[345,346,347,348,349]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-03-03T00:00:00"}
