{"id":"https://openalex.org/W2591484378","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","title":"A mouse model of rectal cancer that mimics the clinical disease.","display_name":"A mouse model of rectal cancer that mimics the clinical disease.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2591484378","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","mag":"2591484378"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.10604","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035456514","display_name":"Hiroyuki Kishimoto","orcid":"https://orcid.org/0000-0001-8174-3508","observed_orcids":["https://orcid.org/0000-0001-8174-3508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kishimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085352614","display_name":"Masashi Momiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Momiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080333862","display_name":"Ryoichi Aki","orcid":"https://orcid.org/0000-0001-7120-5714","observed_orcids":["https://orcid.org/0000-0001-7120-5714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Aki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028615623","display_name":"Hiromichi Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037875479","display_name":"Atsushi Suetsugu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Suetsugu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009960666","display_name":"Michael Bouvet","orcid":"https://orcid.org/0000-0002-0086-2159","observed_orcids":["https://orcid.org/0000-0002-0086-2159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Bouvet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037759613","display_name":"Tadami Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. M. Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"10604","last_page":"10604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.8960000276565552},{"id":"https://openalex.org/keywords/orthotopic-transplantation","display_name":"orthotopic transplantation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6430000066757202},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8503293395042419},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7840805053710938},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6458542346954346},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6401796936988831},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.513388991355896},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.5042823553085327},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.48056891560554504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47394469380378723},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.44420331716537476},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4139682650566101},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.41359904408454895},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3580257296562195},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.23969903588294983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23119762539863586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09884047508239746},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.10604","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.10604","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036491341","https://openalex.org/W2077135335","https://openalex.org/W2326169018","https://openalex.org/W4211022672","https://openalex.org/W4309825814","https://openalex.org/W4407416155","https://openalex.org/W2053713499","https://openalex.org/W151297323","https://openalex.org/W1998002580","https://openalex.org/W2801838529"],"abstract_inverted_index":{"10604":[0],"Background:":[1],"There":[2],"is":[3],"a":[4,7,16],"need":[5],"for":[6,140],"clinically-relevant":[8],"rectal":[9,22,35,51,68,92,122,132],"cancer":[10,23,36,133],"mouse":[11,34],"models.":[12],"We":[13],"have":[14],"developed":[15],"novel":[17],"technique":[18],"to":[19],"orthotopically":[20],"transplant":[21],"cells.":[24],"Methods:":[25],"This":[26,121],"model":[27,124,136],"was":[28,64,94],"established":[29],"by":[30,43,53],"intrarectal":[31],"transplantation":[32,114],"of":[33,49,118,131,142],"cells":[37],"stably":[38],"expressing":[39],"fluorescent":[40],"protein,":[41],"followed":[42],"disrupting":[44],"the":[45,50,67,83,91,126,143],"epithelial":[46],"cell":[47],"layer":[48],"mucosa":[52,69,93],"soaking":[54],"with":[55],"an":[56],"acetic":[57],"acid":[58],"solution.":[59],"Results:":[60],"Early":[61],"stage":[62],"tumor":[63,87,123,144,153],"detected":[65],"on":[66,90],"from":[70],"as":[71,73,147,149],"early":[72],"6":[74],"days":[75],"after":[76,99,113],"transplantation,":[77],"which":[78,151],"then":[79],"became":[80],"invasive":[81],"into":[82],"submucosal":[84],"tissue.":[85],"The":[86,135],"incidence":[88],"(%)":[89],"100%":[95],"at":[96],"4":[97,111],"weeks":[98,112],"transplantation.":[100],"Spontaneous":[101],"lymph":[102],"node":[103],"metastasis":[104,107,146],"and":[105,128,155],"lung":[106],"were":[108],"also":[109],"observed":[110],"in":[115],"over":[116],"90%":[117],"mice.":[119],"Conclusions:":[120],"mimics":[125],"histology":[127],"natural":[129],"course":[130],"accurately.":[134],"will":[137],"be":[138],"useful":[139],"evaluation":[141],"microenvironment,":[145],"well":[148],"agents":[150],"suppress":[152],"growth":[154],"metastasis.":[156]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-03-03T00:00:00"}
