{"id":"https://openalex.org/W2591347876","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","title":"Germ-line BRCA mutations in high-grade ovarian cancer: A case for routine BRCA mutation screening after a diagnosis of invasive ovarian cancer.","display_name":"Germ-line BRCA mutations in high-grade ovarian cancer: A case for routine BRCA mutation screening after a diagnosis of invasive ovarian cancer.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2591347876","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","mag":"2591347876"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.5026","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030304907","display_name":"Kathryn Alsop","orcid":"https://orcid.org/0000-0002-4107-3041","observed_orcids":["https://orcid.org/0000-0002-4107-3041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Alsop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057552010","display_name":"Si\u00e1n Fereday","orcid":"https://orcid.org/0000-0002-8559-8579","observed_orcids":["https://orcid.org/0000-0002-8559-8579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Fereday","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012452800","display_name":"Cliff J. Meldrum","orcid":"https://orcid.org/0000-0002-5685-1918","observed_orcids":["https://orcid.org/0000-0002-5685-1918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Meldrum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023643377","display_name":"Anna DeFazio","orcid":"https://orcid.org/0000-0003-0057-4744","observed_orcids":["https://orcid.org/0000-0003-0057-4744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. deFazio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015618057","display_name":"Penelope M. Webb","orcid":"https://orcid.org/0000-0003-0733-5930","observed_orcids":["https://orcid.org/0000-0003-0733-5930","https://orcid.org/0000-0002-6171-3579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Webb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103220093","display_name":"Michael J. Birrer","orcid":"https://orcid.org/0000-0002-3861-4521","observed_orcids":["https://orcid.org/0000-0002-3861-4521","https://orcid.org/0000-0001-6464-4225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. J. Birrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894535","display_name":"Michael Leonard Friedlander","orcid":"https://orcid.org/0000-0003-3090-795X","observed_orcids":["https://orcid.org/0000-0003-3090-795X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Friedlander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088637763","display_name":"Stephen B. Fox","orcid":"https://orcid.org/0000-0002-7648-8896","observed_orcids":["https://orcid.org/0000-0002-7648-8896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. B. Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025082628","display_name":"David D.L. Bowtell","orcid":"https://orcid.org/0000-0001-9089-7525","observed_orcids":["https://orcid.org/0000-0001-9089-7525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Bowtell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Mitchell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"The Australian Ovarian Cancer Study (AOCS) Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"The Australian Ovarian Cancer Study (AOCS) Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"5026","last_page":"5026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germline-brca1-mutation","display_name":"germline BRCA1 mutation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/germline-brca2-mutation","display_name":"germline BRCA2 mutation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.8389999866485596},{"id":"https://openalex.org/keywords/platinum-chemotherapy-response","display_name":"platinum chemotherapy response","score":0.7250000238418579},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.6959999799728394},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.746999979019165},{"id":"https://openalex.org/keywords/family-history-of-cancer","display_name":"family history of cancer","score":0.6320000290870667},{"id":"https://openalex.org/keywords/early-onset-breast-cancer","display_name":"early-onset breast cancer","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8167991638183594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8074334859848022},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.7425524592399597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.644041895866394},{"id":"https://openalex.org/C2777249960","wikidata":"https://www.wikidata.org/wiki/Q4818922","display_name":"Fallopian tube cancer","level":4,"score":0.6150424480438232},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5954650044441223},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5612789392471313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5559534430503845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5057797431945801},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.5007543563842773},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48194432258605957},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45531851053237915},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.4449359178543091},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4137926697731018},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.36585530638694763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18875890970230103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10268163681030273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09732532501220703},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.5026","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.5026","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135525536","https://openalex.org/W2955431612","https://openalex.org/W2968639929","https://openalex.org/W2116186978","https://openalex.org/W2690930797","https://openalex.org/W1976960104","https://openalex.org/W3030154634","https://openalex.org/W3008182811","https://openalex.org/W2886713202","https://openalex.org/W2762091508"],"abstract_inverted_index":{"5026":[0],"Background:":[1],"It":[2],"has":[3,290],"been":[4],"accepted":[5],"that":[6],"5-10%":[7],"of":[8,42,62,74,157,177,194,200,233,251],"all":[9,283],"invasive":[10,110,262],"epithelial":[11,111],"ovarian":[12,78,97,182,263,284],"cancer":[13,23,98,183,264,285],"cases":[14],"can":[15],"be":[16,280],"attributed":[17],"to":[18,32,59,143,207,226,228,238,274],"hereditary":[19],"pathogenic":[20,65,164],"mutations":[21,166,187,258],"in":[22,68,151,179,261],"predisposition":[24],"genes.":[25],"Consequently":[26],"genetic":[27],"testing":[28,278],"is":[29],"mostly":[30],"offered":[31],"those":[33],"patients":[34,286],"who":[35],"also":[36],"have":[37],"a":[38,69],"strong":[39],"family":[40],"history":[41],"relevant":[43],"cancers":[44],"or":[45,114],"specific":[46],"ancestry.":[47],"We":[48],"investigated":[49],"the":[50,56,85,170,180],"frequency":[51,176],"and":[52,126,134,148,222,265,272,293],"clinical":[53,146,295],"characteristics,":[54],"including":[55,155],"treatment":[57,210,248],"response":[58,147,273],"platinum":[60,209,229,240,247],"therapeutics,":[61],"germline":[63,165],"BRCA1/2":[64,105,257],"mutation":[66,175,195,234,252,288],"carriers":[67,196,203],"large":[70],"population-based":[71],"prospective":[72],"cohort":[73],"Australian":[75,86,181],"women":[76,92,236],"with":[77,109,190,268],"cancer.":[79,161],"Methods:":[80],"Participants":[81],"were":[82,102,167,188,204,223],"ascertained":[83],"from":[84,122],"Ovarian":[87],"Cancer":[88],"Study":[89],"which":[90],"recruited":[91],"presenting":[93],"for":[94,96,104,172,282],"surgery":[95],"between":[99],"2002-2006.":[100],"Women":[101],"eligible":[103],"genotyping":[106],"if":[107],"diagnosed":[108],"ovarian,":[112],"peritoneal":[113],"fallopian":[115],"tube":[116],"tumors.":[117],"Mucinous":[118],"histology":[119],"was":[120,129,141],"excluded":[121],"analysis.":[123],"Full":[124],"BRCA1":[125],"BRCA2":[127],"analysis":[128],"done":[130],"by":[131],"gene":[132],"sequencing":[133],"multiplex":[135],"ligation-dependent":[136],"probe":[137],"amplification.":[138],"Germline":[139],"status":[140,289],"related":[142],"tumor":[144],"features,":[145],"potential":[149],"familiality":[150],"first":[152],"degree":[153],"relatives,":[154],"incidences":[156],"early":[158],"onset":[159],"breast":[160],"Results:":[162],"134":[163],"identified":[168],"within":[169],"cohort,":[171],"an":[173],"overall":[174,270],"13.3%":[178],"population.":[184],"113":[185],"(84.3%)":[186],"associated":[189,267],"serous":[191],"histology.":[192],"57%":[193],"had":[197,214],"no":[198],"evidence":[199],"familiality.":[201],"Mutation":[202],"more":[205,224],"responsive":[206],"primary":[208,246],"than":[211],"non-carriers":[212],"(87.4%":[213],">6":[215],"months":[216,244],"progression":[217],"free":[218],"survival,":[219],"versus":[220,249],"68.4%),":[221],"likely":[225],"respond":[227],"upon":[230],"relapse":[231],"(86%":[232],"positive":[235],"responded":[237],"secondary":[239],"after":[241,245],"relapsing":[242],"<6":[243],"60%":[250],"negative":[253],"women).":[254],"Conclusions:":[255],"Pathogenic":[256],"are":[259,266],"common":[260],"improved":[269],"survival":[271],"systemic":[275],"chemotherapy.":[276],"BRCA":[277],"should":[279],"implemented":[281],"as":[287],"important":[291],"prognostic":[292],"therapeutic":[294],"utility.":[296]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-03T00:00:00"}
